Idoxuridine: Successful Results Against Genital Condyloma Acuminatum

Eleven women with widespread condyloma acuminatum of the genital tract randomly received treatment with either idoxuridine (IOU) 0.25% ointment (5 patients) or placebo ointment (6 patients) in a double-blind trial. Ointment was applied to the lesions twice daily for 1 week. The idoxuridine patients had macroscopic and colposcopic disappearance of condylomas, and no cells typical of condyloma were found cytologically, following treatment. No side effects were observed . There were no recurrences in the idoxuridine group during 3 months' follow-up. Among the placebo patients there was no change in 4 and progression in 1.

'Topical IDU therapy thus seems to be effective and non-toxic; . . , However, cryosurgery might be better in pregnancy since IDU induces congenital anomalies in animals.' Hasumi. K. et al.: Lancet 1: 968 (28 Apr 1984).

10 INPHARMA OJ 26 May 1984 0156-2703/84/0526-0010/ 0$01.00/ 0 © ADIS Press