IBRO-APRC Kerman Associate School of Neurosciencekmu.ac.ir/Images/UserFiles/998/file/IBRO-new.pdf · sharing their information and bridging gaps in knowledge. We are confident that

IBRO-APRC Kerman Associate School of Neuroscience August 27 - September 1, 2017

IBRO-APRC Kerman Associate School of Neuroscience

"Learning and memory: molecular, electrophysiological and computational

approaches"

Kerman, Iran

August 27 - September 1, 2017

School Website URL: http://knrc.en.kmu.ac.ir/Default9.aspx?Id=77

Organizer: Prof. Vahid Sheibani

Kerman Neuroscience Research Center, Kerman University of Medical Science

http://knrc.en.kmu.ac.ir/Default9.aspx?Id=77


Content Welcome Message ............................................................................................................................. 1

Organizing Committee ....................................................................................................................... 2

Hosts and Sponsors ............................................................................................................................ 3

Aims and Scope .................................................................................................................................. 4

Welcome ceremony program ............................................................................................................ 6

IBRO School participants .................................................................................................................... 7

Laboratories Schedule ........................................................................................................................ 8

Abstracts Titles ................................................................................................................................... 9

Academic Staff .................................................................................................................................. 14

Lectures Schedule............................................................................................................................. 16

Biosketches ....................................................................................................................................... 18

Closing Ceremony Program .............................................................................................................. 37

Daily Program ................................................................................................................................... 38

Lab Mentors ..................................................................................................................................... 43

Scientific and Organizing Assistants ................................................................................................. 44

Guidance Map .................................................................................................................................. 45

Note .................................................................................................................................................. 47

1


Welcome Message Dear Professors and Students

It will be an honor for us to welcome you to the 1st Kerman IBRO-APRC Associate School at

Neuroscience Research Center. IBRO has been well-known among the neuroscience

community, through different means such as journals (Neuroscience and IBRO Reports),

IBRO congresses, visiting lecture team programs as well as IBRO schools.

Currently, IBRO’s vast network of 75000 scientists and dedicated to promote collaborative

research and increase global awareness. IBRO is now one of the largest organizations with

a mission to develop collaborative research and interchange scientific information through

building partnership with scientific societies. As a result of numerous events held by our

community, we have over 5000 alumni. In addition, 20-25 schools are organized annually,

providing the opportunity for the students to communicate and expand their horizon by

sharing their information and bridging gaps in knowledge.

We are confident that the 1st Kerman IBRO-APRC Associate School of Neuroscience is a

significant turning point for brain research in Iran. It is also an arena for expanding scientific

networks. It would also be a valuable opportunity to attract potential neuroscientists who

are pursuing advancements in brain sciences.

It is our pleasure to be hosting outstanding scientists from Iran, Australia, Netherlands and

Switzerland. In addition to our invited speakers we will have 27 young scientists from Iran,

Japan, India, Malaysia, Pakistan, Bangladesh, Thailand, and Armenia.

We would like to welcome all the delegates to this program and also thank our colleagues

for their efforts and cooperation. We hope all the participants update their knowledge and

enjoy their stay in Kerman.

Aliakbar Haghdoost, MD, PhD Vahid Sheibani, PhD

2


Organizing Committee

Honorary Director: Aliakbar Haghdoost

MD, PhD, Chancellor of Kerman University of Medical Sciences,

Kerman, Iran

Director: Vahid Sheibani PhD, Head of Kerman Neuroscience Research Center, Kerman, Iran

General secretaries: Mohammadreza Afarinesh

PhD, Kerman Neuroscience Research Center, Kerman, Iran

Saeed Esmaeili Mahani

PhD, Department of Physiology, Faculty of Science, Shaheed

Bahonar University of Kerman

Scientific Secretaries: Mohammad Shabani

PhD, Deputy of research, Kerman Neuroscience Research Center,

Kerman, Iran

Khadijeh Esmaeilpour PhD, Kerman Neuroscience Research Center, Kerman, Iran

Executive Secretary: Meysam Ahmadi

PhD, Kerman Neuroscience Research Center, Kerman, Iran

Contact Person:

Dr. Khadijeh Esmaeilpour

Tel: +98-343-2264225

Fax: +98-343-2264198 E-mail: [email protected], [email protected]

mailto:[email protected]


3


Hosts and Sponsors

IBRO-APRC

Vice Chancellor for Research, Kerman University of Medical Sciences

Kerman Neuroscience Research Center (KNRC)

Iranian Neuroscience Society (INS)

Cognitive Sciences and Technologies Council of Iran (CSTC)

Stem Cells Science and Technology Council of Iran

Iranian Society of Physiology & Pharmacology (ISPP)

Shahid Bahonar University of Kerman

4


Aims and Scope The purpose of this school is to provide an opportunity for MSc and PhD students in the

Asia-Pacific region to gain the latest fundamental and technological developments of

transdisciplinary research on learning and memory function with 3 main separate line of

focus on molecular, electrophysiological and computational approaches by reputable

researchers (local and abroad).

Description:

The school provides five full days with 10 lectures and opportunities to participate in a

variety of laboratory projects. Hands on experience with molecular methods (Western

Blot and PCR), electrophysiology (Patch clamp, field potential and single unit recording),

cognition and EEG/ERP, electronic microscope (TEM) and analysis software packages will

provide the audience with a unique opportunity to experience date acquisition and

analysis under the supervision of senior investigators and professors. There will be group

discussions during the school about the lectures and detailed questions-answer sessions.

Last day of the school is devoted to poster presentation. Participants will enjoy a full day

of cultural visit in Kerman city on the sixth day of the school.

Laboratory projects will focus on the following themes:

Electrophysiology (Neuronal activity and synaptic plasticity)

- In-vivo field potential recording

- In-vitro field potential recording

- Single unit recording

- Patch clamp recording

Molecular Biology

- Western Blotting

- PCR

Cognition

- DMST in monkey

- EEG/ERP

Behavioral task in rodent

- Open field

- Morris water maze

- Radial maze

5


- Zero maze

- Shuttle Box

- Elevated plus maze

- Novel object recognition

- Startle reflex

Transmission Electron Microscope (TEM)

- Structure of TEM

- Specimen preparation for TEM

Program Summary:

• Lectures: Keynote lectures by renowned international scientists and invited lectures by

national scientists.

• Labs: Introductory laboratory sessions in neuroscience and discussion session by the

invited speakers.

• Students’ poster presentations

Who should apply to this School?

MSc and Ph.D. students from the Asia-Pacific region will only be accepted. Preference will

be given to students who have experience in laboratory work and publications. Students

will be selected on the basis of their academic record and written statements concerning

their interest in neuroscience and how they expect to benefit from participating in the

School. The selection process will be coordinated by the IBRO Asia-Pacific Regional

Committee

What costs will be covered for selected applicants?

Travel, accommodation, and meals

Application deadline: May 5, 2017 (11:59 p.m. CET)

For all enquiries, please contact Dr. Khadijeh Esmaeilpour

at [email protected]


6


Welcome ceremony program

Date: 27 August, 2017, 8:30 - 11:45

Venue: Kerman, Tehran Road, Firouzeh Crossroad, Mellat Bank Hall

8:30 - 9:30 Registration

9:30 - 9:45 Quran and national anthem of the Islamic Republic of Iran

9:45 - 10:15 Welcome speech by IBRO School honorary president (Prof. Aliakbar Haghdoost)

Welcome speech by IBRO School Director (Prof. Vahid Sheibani)

10:15 - 10:30 A video clip introducing Kerman Neuroscience Research Center

10:30 - 11 Introducing the IBRO School students

11 - 11:30 Music performance

11:30 - 11:45 Group Photo

11:45 - 12 Tea Break

12 - 13 Open ceremony lecture by Prof. Fereshteh Motamedi

7


IBRO School participants

Group 1 Row Name country/city Gender Email 1-1 Ahmed Pakistan/quette Male [email protected]

1-2 Azade Eskandary Iran/Ahwaz Female [email protected]

1-3 Mahsa Tashakori Miyanroudi

Iran/Tehran Female [email protected]

Group 2 2-1 Akib Khan Bangladesh/Dhaka Male [email protected]

2-2 Fatemeh Ayoobi Iran/Rafsanjan Female [email protected]

2-3 Maryam Naseh Iran/Shiraz Female [email protected]

2-4 Sara sadeghi gharaje –daghi

Iran/Tehran Female [email protected]

Group 3 3-1 Anthony Ariza Japan/Nagoya Male [email protected]

3-2 Elham Abbasloo Iran/Kerman Female [email protected]

3-3 Maryam Arab Firouzjaei

Iran/Shiraz Female [email protected]

Group 4 4-1 Bahman Sadeghi Iran/Tehran Male [email protected]

4-2 Zainab Pakistan/Quetta Female [email protected]

4-3 Nasrin Jangjoo Ghalat Iran/Tehran Female [email protected]

Group 5 5-1 Danial Ramandi Iran/mashhad Male [email protected]

5-2 Farzaneh Bagheri Iran/damghan Female [email protected]

5-3 Kamini Vijeepallam Malaysia/kuala Lampur

Female [email protected]

5-4 Sahar Seifzadeh Iran/Urmia Female [email protected]

Group 6 6-1 Irina Danielyan Armenia Female [email protected]

6-2 Nahid Roohi Iran/Tehran Female [email protected]

6-3 Zahra Reisi Vanani Iran/semnan Female [email protected]

Group 7 7-1 Sunil Kumar Prabhakar India/India Male [email protected]

7-2 Farideh Moeinvaziri Iran/Tehran Female [email protected]

7-3 Nastaran Zamani Iran/borujerd Female [email protected]

7-4 Sedigheh Amiresmaili Iran/ Kerman Female [email protected]

Group 8 8-1 Nidhi India/Hisar Female [email protected]

8-2 Razieh Jaberi Iran/Tehran Female [email protected]

8-3 Rodiya Manor Thailand/Hat Yai Female [email protected]


8


Laboratories Schedule Sunday Monday Tuesday Wednesday Thursday

Laboratory Session

1 (15 - 16:15)

Session 2

(16:15- 17:30)

Session 1

(15 - 16:15)

Session 2

(16:15- 17:30)

Session 1

(15 - 16:15)

Session 2

(16:15- 17:30)

Session 1

(15 - 16:15)

Session 2

(16:15- 17:30)

15-17:30

Molecular Neuroscience Lab

Group 1 Group 2 Group 3 Group 4 Group 5 Group 6 Group 7 Group 8 -

Intracellular Electrophysiology

Lab


Sensory Processing Lab


EEG/ERP Lab Group 4 Group 3 Group 2 Group 1 Group 8 Group 7 Group 6 Group 5 -

Cell Culture Lab Group 5 Group 6 Group 7 Group 8 Group 1 Group 2 Group 3 Group 4 -

Electrophysiology Lab


Electron Microscope Lab


Behavioral Neuroscience Lab


Cognitive Neuroscience

Research Center

- - - - - - - - All Groups

9


Abstracts Titles Name Affiliation

Ahmed CIIT Abbottbad, Pakistan

Titl

e Effects of Selected Synthetic Heterocyclic Compounds on Alcohol Withdrawal, its Withdrawal Induced Hyperalgesia and Deprssion in Murine model

Name Affiliation

Akib Khan University of Dhaka

Titl

e Effect of chronic traffic noise exposure on auditory attention and expression levels of dopamine associated genes in mice brain frontal cortex and striatum

Name Affiliation

Anthony Ariza Nagoya University Graduate School of Medicine

Titl

e Proteomics-based identification of Serum Response Factor Co-activator MKL2 regulates transcription activity by phosphorylation in striatal neurons

Name Affiliation

Azade Eskandary Shahid Chamran University

Titl

e The effect of donepezile on electrophysiology of CA1 hippocampus and interaction with lovastatin on spatial memory

Name Affiliation

Bahman Sadeghi Shahid Beheshti University of Medical Sciences, School of Medicine,

department of Physiology

Titl

e

Alleviation of impairment of long-term potentiation through postsynaptic mechanisms underlying neural plasticity augmentation in hippocampal dentate gyrus and CA1 of streptozotocin-induced Alzheimer’s disease: ghrelin enhanced Bcl-2 expression and inhibited mitochondrial apoptosis

Name Affiliation

Danial Ramandi Ferdowsi University of Mashhad

Titl

e Effect of glutamate neurotransmission in hippocampus on cognitive flexibility of normal and epileptic individuals

10


Abstracts Titles

Name Affiliation

Elham Abbasloo Physiology Research Center, Institute of Neuropharmacology,

Kerman University of Medical Sciences, Kerman, Iran

Titl

e The anti-inflammatory properties of Satureja khuzistanica Jamzad essential oil attenuate the effects of traumatic brain injuries in rats

Name Affiliation

Farideh Moeinvaziri Department of Genetic at reproductive Biomedicine Research Center,

Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

Titl

e

Molecular biology of CCAAT-NFY transcription factor

Name Affiliation

Farzaneh Bagheri School of Biology Damghan University

Titl

e

Melatonin improves ethanol induced motor deficits in rats

Name Affiliation

Fatemeh Ayoobi Physiology and Pharmacology Research Center, Rafsanjan Medical Sciences

Titl

e

The effect of achillea milefolium on multiple sclerosis

Name Affiliation

Kamini Vijeepallam Department of Pharmacology, Faculty of Medicine, University Malaya, Kuala

Lumpur

Titl

e Kratom (Mitragyna Speciosa) leave extract attenuates the rewarding effect of ethanol in conditioned place preference in mice

11


Abstracts Titles

Name Affiliation

Maryam Naseh Department of Biology, College of Science, Shiraz University, Shiraz, Iran

Titl

e

Dual effects of eugenol on the neuronal excitability: An in vitro study

Name Affiliation

Maryam Arab Firouzjaei

Shiraz University of Medical Sciences

Titl

e

Synaptic plasticity and memory deficits in rat model of acute kidney injury

Name Affiliation

Sunil Kumar Prabhakar

Bannari Amman Institute of Technology India

Titl

e Extreme learning machines; genetic algorithm and neural networks(MLP) for classification of epilepsy risk levels from EEG signals

Name Affiliation

Nahid Roohi Department of Physiology, Tarbiat Modares University of Medical

Sciences, Tehran, iran

Titl

e

Microinjection of the mGluR5 antagonist MTEP into the nucleus accumbens attenuates the acquisition but not expression of morphine-induced conditioned place preference in rats

Name Affiliation

Nasrin Jangjoo Ghalat Tarbiat Modares University

Titl

e

Investigating the effect of Satureja Khuzistanica hydroalcoholic extract on morphine-induced seeking addictive behavior in male rats and on morphine induced neuroinflammation in primary neuron-glia co-culture

Name Affiliation

Nastaran Zamani Shahid Chamran University of Ahvaz

Titl

e

The effect of memantine on response properties of hippocampal CA1 neurons and its interaction with docosahexaenoic acid on spatial memory in Alzheimer disease model in adult male rats

12


Abstracts Titles

Name Affiliation

Nidhi Guru Jambheshwar University of Science & Technology Hisar, Haryana, India

Titl

e Changes in histopathological profile of cerebral cortex in acute, subacute and chronic phases of

traumatic brain injury in mice

Name Affiliation

Razieh Jaberi Royan Institute, Tehran

Titl

e Characterization of isolated neural stem cells from adult rhesus macaque monkeys

subventricular zone

Name Affiliation

Rodiya Manor Prince of Songkla University, Thailand

Titl

e

Desynchronization of alpha oscillation by visual attention

Name Affiliation Mahsa Tashakori

Miyanroudi Physiology department, Iran university of medical sciences

Titl

e

Histological Changes Caused by the toxic effects of silver nanoparticles in the liver and kidney

Name Affiliation

Sara Sadeghi Gharaje-Daghi Azad University, North Tehran Branch

Titl

e Effects of orexin-1 receptors in ventral tegmental area and nucleus accumbens on the induction of antinociceptive responses by lateral hypothalamus stimulation in rat

13


Abstracts Titles

Name Affiliation

Sahar Seifzadeh Young Researchers and Elite Club, Qazvin Branch, Islamic Azad University, Qazvin,

Iran

Titl

e Modified cue-based brain computer interface system

Name Affiliation

Zahra Reisi Vanani Semnan University of Medical Sciences

Titl

e Functional interaction between orexin-1 and 2 and CB1 receptors located in the periaqueductal gray in

antinociception induced by chemical stimulation of the lateral hypothalamus in the tail flick test in rats

Name Affiliation

Zainab COMSATS, IIT, Abbottabad Campus, Pakistan

Titl

e

Effects of coumarins on murine model of vincristine induced neuropathic pain

Name Affiliation

Sedigheh Amiresmaili Physiology Research center, institute of Neuropharmacology, Kerman University of

Medical Sciences, Kerman, Iran

Titl

e The effect of intra-ventral hippocampus administration of TRPV1 agonist and antagonist on spatial learning and memory in male rats.

Name Affiliation

Irina Danielyan Armenian State Pedagogical University

Titl

e

Noninvasive diagnosis of neurodegenerative and malignant changes in organism

14


Academic Staff Molecular Neuroscience Lab

Heads: Dr. Saeed Esmaeili Mahani [email protected]

Dr. Fatemeh Nouri [email protected]

Assistant: Dr. Elham Haghparast [email protected]

Lily Mohammadipoor [email protected]

kiana Rafiepour [email protected]

Intracellular Electrophysiology Lab

Head: Dr. Mohammad Shabani [email protected]

Assistants: Dr. Mahshid Tahamtan [email protected]

Effat Ramshini [email protected]

Fatemeh Mohammadi [email protected]

Sensory Processing Lab

Heads: Prof. Vahid Sheibani [email protected]

Dr. Mohammad Reza Afarinesh [email protected]

Assistants: Dr. Vahid Hajali [email protected]

Dr. Akram Nezhadi [email protected]

Faezeh Shafiei [email protected]

EEG/ERP Lab

Heads: Dr. Shahrzad Mazhari [email protected]

Dr. Ali Mohammad Pourrahimi [email protected]

Assistant: Sara Sardari [email protected]

Cell Culture Lab

Heads: Prof. Hossein Eskandari [email protected]

Dr. Meysam Ahmadi Zeydabadi [email protected]

Assistant: Marzie Esmaeeli [email protected]

Electrophysiology Lab

Heads: Dr. Khadijeh Esmaeilpour [email protected]

Assistant: Mohammad Amin Rajizadeh [email protected]

Electron Microscope Lab

Head: Dr. Majid Asadi-Shekaari [email protected]

Assistant: Farzaneh Vafaee Bagheri [email protected]

Behavioral Neuroscience Lab

Heads: Prof. Gholamreza Sepehri [email protected]

Dr. Khadijeh Esmaeilpour [email protected]

Assistants: Shahrnaz Parsania [email protected]

Sina Motamedy [email protected]








15


Primate Cognitive Neuroscience Lab

Heads: Prof. Vahid Sheibani [email protected]

Prof. Farshad Alizadeh Mansouri [email protected]

Assistants: Shahab Zarei [email protected]

Marzieh Mowlavi [email protected]

Sadegh Ghasemian [email protected]

Rodent Cognitive Behavioral and Electrophysiology Lab

Head: Dr. Mohammad Reza Afarinesh [email protected]

Assistants: Dr. Fatemeh Nouri [email protected]

Mansoureh Sabzalizadeh [email protected]

Dr. Shokouh Arjmand [email protected]



16


Lectures Schedule Lecturer Affiliation Time/Date

Prof. Fereshteh Motamedi Shahid Beheshti University of Medical Sciences, Tehran, Iran

27 August 12 - 13

Titl

e

Optogenetics and its applications in neuroscience research

Lecturer Affiliation Time/Date Prof. Farshad Alizadeh

Mansouri Monash University, Australia 28 August

9 - 10

Titl

e

The role of prefrontal cortex in cognitive flexibility and executive control of behaviour in primates

Lecturer Affiliation Time/Date Dr. Mohammad Rohani Rasoul Akram Hospital Tehran, Iran

28 August 10 - 10:30

Titl

e

New neurosurgical approaches in treatment of movement disorders

Lecturer Affiliation Time/Date Prof. Hossein Baharvand Royan Institute for Stem Cell Biology and

Technology, ACECR, Tehran, Iran 28 August

11 - 12

Titl

e

Neurodevelopmental biology: From stem cells to neural cells

Lecturer Affiliation Time/Date Prof. Seyed Noureddin Nematollahi-Mahani


28 August 12 - 12:30

Titl

e

Current state of stem cell therapy for SCI patients

Lecturer Affiliation Time/Date Dr. Bechara Saab University of Zurich, Zürich 29 August

9 - 10

Titl

e

Therapeutic Potential of Fostering Curiosity as a Novel Treatment for Neurological Disorders

Lecturer Affiliation Time/Date Prof. Abbas Pardakhty


29 August

10 - 10:30

Titl

e

Nano lipid vesicles for transport of therapeutic agent through BBB

Lecturer Affiliation Time/Date Prof. Saeed Semnanian Tarbiat Modares University, Tehran, Iran

29 August

11 - 12

Titl

e

Orexinergic mechanisms in drug addiction and pain modulation

Lecturer Affiliation Time/Date Dr. Khadijeh Esmaeilpour

Kerman Neuroscience Research Center, Kerman, Iran

29 August

12 - 12:30

Titl

e

Effect of low frequency electrical stimulation on seizure-induced impairments in learning and memory

https://www.researchgate.net/institution/Shahid_Beheshti_University_of_Medical_Sciences

http://www.royaninstitute.org/cmsen/index.php?option=com_content&task=section&id=17&Itemid=438

http://www.royaninstitute.org/cmsen/index.php?option=com_content&task=section&id=17&Itemid=438

https://www.researchgate.net/institution/Kerman_University_of_Medical_Sciences

https://www.researchgate.net/institution/University_of_Zurich

https://scholar.google.com/citations?view_op=view_org&hl=en&org=3453467253819981642


17


Lectures Schedule

Lecturer Affiliation Time/Date Prof. Ehsan Arabzadeh Australian National University, Australia

30 August

9 - 10

Titl

e

Efficient sensory processing in the rodent vibrissal cortex

Lecturer Affiliation Time/Date Dr. Mohammad Nami University of Medical Sciences, Shiraz, Iran

30 August 10 - 10:30

Titl

e

The interface of learning-memory and sleep neural dynamics

Lecturer Affiliation Time/Date Dr. Houshang Amiri VU University Medical Center , Amsterdam

30 August

11 - 12

Titl

e

Magnetic Resonance Physics and Applications in Neuroscience

Lecturer Affiliation Time/Date Dr. Shahrzad Mazhari Kerman Neuroscience Research Center, Kerman, Iran

30 August

12 - 12:30

Titl

e

Mental imagery in schizophrenia

Lecturer Affiliation Time/Date Dr. Niels Eijkelkamp University Medical Center Utrecht

31 August 9 - 10

Titl

e

Neuro-immune crosstalk in chronic pain

Lecturer Affiliation Time/Date Dr. Saeed Esmaeili Mahani Shahid Bahonar University of Kerman, Kerman, Iran

31 August

10 - 10:30

Titl

e

Protective strategies against neurodegenerative disease: Novel therapeutic approach for Parkinson's disease

Lecturer Affiliation Time/Date Prof. Javad Mirnajafi-

Zadeh Tarbiat Modares University

31 August 11 - 12

Titl

e

Neural hyperexcitability and synaptic plasticity

Lecturer Affiliation Time/Date Prof. Vahid Sheibani Kerman Neuroscience Research Center, Kerman, Iran

31 August

12 - 12:30

Titl

e

Cognitive Dysfunction Related to Paradoxical Sleep Deprivation in Female Rats: Effect of Exercise



https://www.researchgate.net/institution/VU_University_Medical_Center2


18


Biosketches

Fereshteh Motamedi, PhD

E-mail: [email protected]

[email protected]

Affiliation: Shahid Beheshti University or Medical Sciences, Tehran, Iran

Bibliography Received PhD degree from the University of Missouri – Columbia, USA. She has been the president of the Federation of Asian- Oceanic Neuroscience Societies FAONS (2000-2002), and President of several Tehran IBRO associate and advanced schools, and has served as a council member in the IBRO Asian Pacific committee (APRC) and has been Iranian representative at the IBRO governing council. Currently she is Prof of Physiology and Neuroscience at the Faculty of Medicine and director of Neuroscience research center at the Shahid Beheshti University of Medical sciences, Tehran, Iran. Abstract Optogenetics and its application in neuroscience research Optogenetics is a new area of research in neuroscience and is a technique in which genes that express light sensitive proteins are introduced into specific types of brain cells in order to monitor and control well defined events and activities in these cells using light signals. The ability to turn on or turn off electrical activity in a precisely defined set of cells in selected parts of the brain allows researchers to gain insights into not only the causal mechanisms behind the organ’s normal workings but also the defects in function that accompany brain disorders. In this lecture, the application of optogenetics in neuroscience research will be discussed in detail.



19


Farshad Mansouri, PhD


Affiliation: Department of Physiology. School of BioMedical Sciences, Monash University, Melbourne, Australia

Bibliography

Farshad Mansouri obtained BSc. In Biology (Zoology), MSc. In Medical Physiology and PhD in Neurophysiology. He joined Cognitive Brain Mapping laboratory at RIKEN Brain Science Institute (Wako, Japan) in 1997. Since 1997 he has been investigating the neural basis of executive control and cognitive flexibility by establishing a close animal analog of Wisconsin Card Sorting Test (WCST). The WCST is a multi-faceted test which is routinely used in clinic to assess cognitive flexibility. Patients with prefrontal cortex damage or psychological disorders such as schizophrenia show impairment in the WCST.

He was a staff scientist at RIKEN institute (2002-2012). He joined the Physiology Department in October 2012. He has established a cognitive neuroscience laboratory to continue and expand his previous studies on the structure and function of the prefrontal cortex. Techniques used in his laboratory include behavioural and electrophysiology studies in animal models and psychophysical and brain stimulation studies in humans. His findings have been published as two research papers in Science magazine (2007 and 2009), one in Nature Reviews Neuroscience (2009) and one in PNAS (2015), Nature Reviews Neuroscience (2017, In press).

Abstract

“In a complex and changing environment, the validity of rules or goals might change in terms of their associated reward and cost, and we often face the necessity to make a strategic decision to adaptively shift between these behavioural goals. Such a decision entails assessment of the value (cost and benefit) of current and alternative rules or reward resources for the individual, and also for the group. A distributed neural network involving prefrontal and medial frontal cortices regulates the use of cognitive resources to optimize exploitation of current reward resources, while minimizing the associated cost. Recent studies suggest that dorsolateral prefrontal, orbitofrontal and anterior cingulate cortices are involved in optimizing the exploitation of the current reward sources however, the most rostral part of the prefrontal cortex (frontopolar cortex) plays a crucial role in adjusting the tendency for exploitation, versus exploration of other alternative resources, by re-distribution of our cognitive resources.”

20


Mohammad Rohani, Neurologist, Fellowship of movement disorders


Affiliation: Associate professor of neurology, Iran University of Medical Sciences

Bibliography

Date of birth: 26/10/1974

Place of birth: Kerman, Iran

Medical degree: 1993-2000, Tehran University of Medical Sciences, Tehran, Iran

Neurology residency: 2002-2006, Iran University of Medical Sciences, Tehran, Iran

Fellowship of movement disorders: 2016-2017, University of Toronto, Toronto, Canada. Faculty member of Iran University of Medical Sciences: 2006-2017

Fields of interest: Deep brain stimulation in movement disorders and neurodegenerative diseases with brain iron accumulation.

Abstract

While there is no breakthrough progress in the medical treatment of Parkinson’s disease and other movement disorders, in the past decades several remarkable achievements happened in the surgical field of movement disorders. The main ones are deep brain stimulation (DBS), gamma knife and MRI-guided focused ultrasound ablative surgeries.

The application of these technologies is growing exponentially and in addition to tremor, dystonia and Parkinsonism, psychiatric diseases such as obsessive-compulsive disease and major depression are being considered new targets for DBS. Novel DBS devices are being adopted such as electrodes with longer stimulating surface to stimulate multiple targets and steering electrodes to minimize stimulation side effects. New pulse generators have been developed which record neurons and stimulate as needed (closed-loop DBS). In this review, the above technologies will be discussed in more detail.

21


Hossein Baharvand, PhD


Affiliation: Royan Institute

Bibliography

Hossein Baharvand is distinguished Professor and Director of Royan Institute for Stem Cell Biology and Technology. He received his Ph.D. in Cell and Developmental Biology from Khwarizmi University in 2004. He is the founder of Royan institute for stem cell biology and technology in 2010. For the first time, he generated the mouse and human embryonic stem cells (2003) and induced pluripotent stem cells (2008) in Iran. This has enabled his team to pursue many avenues of research into translational research and regenerative medicine. He has focused his research interests on improving the translational research and regenerative medicine mainly through the understanding of Stem Cells and Developmental Biology and Biologically Inspired Engineering. He is the editor of four international books which were published by Springer (2010 and 2012) and John Wiley, USA (2015). He has published 283 international and 102 national peer-reviewed papers, as well as seven chapters in international books, seven books in Persian, and eight translated English text books into Persian. He has received 29 international and national awards including 10th (2004), 12th (2006), and 17th (2012) annual Razi research award, 26th Khwarizmi International Award (2013), 27th annual book of the year of the Islamic republic of Iran (2010) and UNESCO prize (2014) for research in life sciences aimed at improving the quality of human life with his stem cell research and its numerous applications in regenerative medicine.

Abstract

Constructing Neural Stem cells

In recent years, cell transplantation has drawn tremendous interest as a novel approach to maintaining or even restoring function of neuro-degenerative and trauma disease. Many researchers have sought to differentiate pluripotent stem cells or transdifferentiate somatic cells into neural lineage cells. Some of these neural lineage cells have been reported to contribute replacement neural disease through cell transplantation of in vitro generated cell of interest or via in vivo reprogramming in preclinical neural injury models. Here, I consider approaches in induced differentiation of pluripotent stem cells and somatic cell trans-differentiation towards neural stem fate. I also discussing some of the unresolved issues and challenges that preclude their future applications.

22


Seyed Noureddin Nematollahi-mahani, PhD


Affiliation: Department of Anatomy, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Bibliography

SN Nematollahi-mahani Received his BS in medical lab sciences from Isfahan University of Medical Sciences. Then, he studied Anatomy in Tehran University of Medical Sciences to receive MA. He received his PhD and post-doctoral in Anatomy and ovarian follicle development from Tarbiat Modares University and Yamagata University, respectively. He is a faculty member of Kerman University of Medical Sciences from 1997. He is interested in preimplantation embryo development, Stem cell application for regenerative medicine and mechanisms underlying their effects, and therapeutic usage of some traditional remedies in Iran.

Abstract

current state of stem cell therapy for SCI patients

Spinal Cord Injury (SCI) with a worldwide occurrence of 150000 to 200000 is a harmful condition that results in different stages of disability. Fixation of injured vertebrae, administration of glucocorticoids and physiotherapy procedures have little impact on the treatment of SCI. Stem cells therapy have been proposed as a recent method for SCI treatment. These cells through their capacity to differentiate to different cell types including neural lineage cells, production of various growth factors, and angiogenic factors have been proposed for the treatment of SCI. However, the method of cell delivery, Type of stem cell, milieu at which the cell delivery happens, and some other factors are amongst the major concerns in the success of SCI treatment which will be discussed in the session.

23


Bechara Saab, PhD

Email: [email protected]

[email protected]

[email protected]

Affiliation: University of Zurich, Mobio Interactive

Bibliography

Dr Saab is the Chief Scientific Officer of Mobio Interactive where he is developing digital tools for the treatment of psychiatric disorders. As a Principal Investigator of Neuroscience at the University of Zurich Hospital for Psychiatry, his laboratory focused on understanding brain circuits and molecules critical for the etiology and treatment of neurological disorders, with a particular emphasis on the relationship between the motivation to explore and mental illness.

Abstract

Curiosity is a fundamental motivator that is essential to efficient learning and mental wellbeing. The research of my lab had revealed profound deficits in curiosity associated with neurological disorder-like phenotypes in mice, including depression-like and epilepsy-like conditions. Using in vivo electrophysiology and optogenetics in the freely-behaving animal, we have also discovered important neuromodulatory circuits innervating the hippocampus that serve to modulate the motivation for mice to explore novel space. This talk will focus on the potential for controlling glutamatergic and dopaminergic innervation of the hippocampus as a therapeutic means to treat neurological disorders in humans.




24


Abbas Pardakhty, Professor of Pharmaceutics

E-mail: [email protected] [email protected]

Affiliation: Pharmaceutics Research Centre, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran

Bibliography

Abbas Pardakhty, Pharm. D/PhD, was born in Kerman, Iran, in 1968. His main area of research is new drug delivery systems design and formulation, especially lipid-based ones. He is a member of ministry of health (MOH) board of pharmaceutics and also board of medicinal nanotechnology. He’s also one of Kerman Innovation Centre founders and member of editorial board of 5 international pharmaceutical journals. He has collaboration with Strathclyde University (UK), Genève University (Switzerland), Eastern Mediterranean University (North Cyprus) and Kerman Cognitive Neuroscience Research Centre (Iran).

Abstract

BBB transport of therapeutic agents by lipid-based drug delivery systems

The blood–brain barrier (BBB) allows the passage of water, some gases, and lipid-soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function. However, transport of many active therapeutic compounds through this barrier is difficult and in some cases impossible, and many attempts have been done to overcome this natural barrier. Different techniques such as tight junction opening, transport system-mediated drug delivery, transport vectors, adsorptive/endogenous-mediated transcytosis and Cell-mediated drug transport have been tested to deliver active pharmaceutical ingredients into CNS tissue. In this review, we will focus on lipid-based drug delivery systems including liposomes, niosomes, micelles, solid lipid nanoparticles (SLNs) nano-emulsions as the most studied formulations for drug delivery to brain. New functionalized lipid vesicular systems, gemini surfactants’ structures and niosomal formulations will be more detailed discussed and challenges and new aspects in this field will be viewed.



25


Saeed Semnanian. MD, PhD


Affiliation: Physiology Department, Tarbiat Modares University Official and Personal

Bibliography

Professor of physiology, Tarbiat Modares university

Education: Medical Doctor- Shaheed Beheshti Medical Sciences University, Tehran, Iran, 1976

Physiology PhD- Shaheed Beheshti Medical Sciences University, Tehran, Iran, 1986

Scientific field of interest:

- Study on the basic mechanisms on pain in brainstem structures such as Locus Coeruleus and

Paragigantocellularis

- Opiate and dependency studies

Thesis Supervision of 52 MSc and PhD and Post Doc, Physiology and Biophysics students.

More than 230 presentations in national and international congresses

Author and translator of 7 books

160 articles published in Iranian and international Journals

Abstract


Orexin neuropeptides have a remarkable role in drug addiction and pain modulation. The locus coeruleus (LC) receives dense orexinergic fibers and express mainly the orexin receptors type-1 (OXR1). LC is also a key brain region involved in opioid tolerance and dependence as well as pain modulation. However, the role of orexinergic transmission at the LC nucleus in these situations is unclear.

26


We have studied the role of orexinergic input to the LC on naloxone-induced morphine withdrawal syndrome and pain modulation, using behavioral, extracellular and whole-cell patch clamp recording techniques in rats. Our results have demonstrated that central administration of OXR1 antagonist (SB-334867) inhibits the development of morphine analgesic tolerance. In other words, OXR1 blockade by SB-334867 prevents the development of morphine analgesic tolerance. During formalin test, activation of OXR1 receptors in LC can induce analgesia and the blockade of OXR1 receptors is associated with hyperalgesia. Moreover, the results indicate that intra LC microinjection of SB-334867 prior to each morphine injection or prior to naloxone administration reduce the severity of naloxone-induced morphine withdrawal symptoms. We also used whole-cell patch clamp recording in rat horizontal slices containing LC nucleus to examine the effect of orexin on synaptic transmission. The results showed that in vitro application of orexin-A increases LC spontaneous firing rate and paired-pulse ratio (PPR). It also decreases spontaneous excitatory postsynaptic currents (sEPSCs) frequency of LC neurons, but did not change the sEPSCs amplitude. Our electrophysiological data indicate that orexin-A application decrease evoked excitatory postsynaptic currents (eEPSCs) and evoke inhibitory postsynaptic currents (eIPSCs) in LC neurons synapses. It is concluded that orexinergic transmission in the locus coeruleus appears to be involved in the drug addiction and pain modulation. Also, the in vitro results provide supporting evidences for a critical role of orexin signaling in LC neurons. It can be deduced that these changes in excitatory synaptic transmission may be elicited by presynaptic rather than presynaptic mechanisms.

27


Khadijeh Esmaeilpour, PhD


Affiliation: Kerman Neuroscience Research Center

Bibliography

Dr Khadijeh Esmaeilpour (was born in 1984 in Kerman, Iran) got her PhD in neuroscience in 2016 in Kerman university of medical science, she started her scientific activity as a researcher since 2009 and as a faculty member in Neuroscience Research Center since 2016. She is interested in finding the mechanisms involved in seizure-induced changes in synaptic transmission and synaptic plasticity, by using electrophysiological methods. Recently she focused on effect of Low Frequency Stimulation on cognitive impairment induced by electrical kindling. Just now, she is the head of both behavioural and electrophysiology lab.

Abstract

Application of low-frequency stimulation (LFS) can improve learning and memory in kindled animals. Considering the important role of long-term potentiation (LTP) in learning and memory, in the present study the effectiveness of LFS on kindling-induced impairment in LTP induction was investigated in hippocampal CA1 area at different times post kindling stimulations. Animals were kindled via electrical stimulation of hippocampal CA1 area in a semi-rapid manner (12 stimulations per day). One group of animals received four trials of LFS at 30 s, 6 h, 24 h, and 30 h following the last kindling stimulation. Each LFS consisted of 4 packages at 5 min intervals; each package contained 200 monophasic square wave pulses of 0.1 ms duration at 1 Hz. The kindled, kindled + LFS and LFS groups were divided into four subgroups in which hippocampal slices were prepared at 48 h, 1 week, 2 weeks, and 1 month following the last kindling stimulation respectively. Extracellular evoked field excitatory postsynaptic potentials (fEPSPs) were recorded in the stratum radiatum of the CA1 area of the slice. Obtained results showed that LTP was not induced in kindled animals. However, application of LFS overcame the kindling-induced impairment in LTP generation in CA1 area of the hippocampus. This improving effect remained up to one week after the last kindling stimulation and extended to one month by increasing the number of applied LFS packages.

28


Ehsan Arabzadeh, PhD


Affiliation: Eccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University

Bibliography

Ehsan Arabzadeh is a group leader at the Eccles Institute of Neuroscience, John Curtin School of Medical Research, at the Australian National University. He studied medicine in Tehran University (1994-2001), Tehran, Iran and received his PhD in Neuroscience from the International School for Advanced Studies, Trieste, Italy (2001-2005). In 2006 Ehsan was awarded a Human Frontiers Science Program Long-term fellowship. In 2011, he won the AW Campbell Award from the Australasian Neuroscience Society for the best contribution to neuroscience by an early career researcher. In 2015, he was appointed a member of the Australian Research Council College of Experts in Biological Sciences. His research group, the Neural Coding Lab, studies sensory processing at the level of single cells and cortical circuits.

Abstract

A principal goal of neuroscience is to understand how neuronal activity in sensory cortex generates an efficient representation of the external world. Rodents use their vibrissae to explore the environment and to collect information about the location, shape, size and texture of objects around them. The rodent vibrissal touch system provides a good model for sensory processing due to its functional efficiency and well-studied cortical circuitry. In this talk, I present an overview of the physiological properties of neurons in the vibrissal system, the behavioural modes of operation of the system, and how the neuronal codes in the sensory cortex account for the rat’s efficient detection and discrimination capacities in a sensory decision-making paradigm.

29


Mohammad Nami. MD, PhD


Affiliation: Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences

Bibliography

Mohammad Nami (born in October 30th 1978, Tehran) is an Iranian medical doctor and neuroscientist. His medical specialty is on neuroscience and he has a fellowship on sleep disorders. He is currently the head of the neuroscience department at Shiraz University of Medical Sciences. He is among the university's top-rated scholars due to his numerous scientific articles and speeches in international congresses and he has been recognized as the top-rated contributor in numerous international neuroscience congresses. He is the chief editor of two international and interdisciplinary journals (JAMSAT, Neuroscience Research Letters) and currently, he is the lead at the Iranian neuroscience Society in Fars province. The Neuroscience Lab (NSL/SUMS) is now a proper place for interdisciplinary studies of brain, thanks to his team and his efforts. Dr. Nami has always been active and interested in traditional Iranian country music, especially in singing. He has been a Dale Carnegie’s alumnus since 2014 and yearns to gain further expertise in the field of organizational and leadership training. He is also passionate about the concept of “Neuro-leadership” and how our brain potentials drive our behavior as leaders to inspire others.

Abstract

Our vulnerable brain under sleep loss; footprints of sleep deprivation in neurodegenerative diseases

Inadequate sleep has become an integral part of the competitive life for many people, meanwhile, the devastating long-term effects of sleep loss are being explained in the literature. In experimental models for total sleep deprivation (TSD) and chronic partial sleep restriction (CPSR), such stress leads to the emergence of cognitive impairments. This is hypothesized to result from a consequent neuroinflammation which may also hasten the neurodegenerative processes. Neuroinflammatory markers such as tumor necrosis factor-alpha (TNF-α) are thought to be potential culprits in SD-induced neurodegeneration. A translational view on the linkage between the cellular-molecular adverse consequences of sleep loss and clinical neurodegenerative conditions is currently gaining momentum. Once clinicians wake up to the fact that sleep is so intimately linked to the most common neurodegenerative diseases, they may be in a better position to detect these debilitating neurological conditions at an early stage, and perhaps remediate them in a timely manner.

30


Houshang Amiri, PhD


Affiliation: Department of Radiology & Nuclear Medicine VU University Medical Center, Amsterdam

Bibliography

Dr. Houshang Amiri is a Magnetic Resonance (MR) application specialist. He received his

PhD degree in 2010 from Milan University in Italy after which he conducted MR image

analysis for studying brain aging using diffusion tensor imaging (DTI). In 2011, as a

neuroimaging fellow, he joined Departments of Cognitive Neuroscience and Radiology at

Radboud University Medical Center in the Netherlands. During this 4-year position, Dr.

Amiri contributed in both education and research in a number of projects, e.g. psychiatric

disorders such as OCD, stress and anxiety. Currently, he is part of Prof. Frederik Barkhof’s

group at the VU University Medical Center in Amsterdam where he is carrying out a

research on Multiple Sclerosis (MS) patients. The aim of his research is to establish a

standard method for measurement of brain atrophy is MS.

Abstract

Magnetic resonance imaging (MRI) offers high-quality imaging of soft tissues like the brain.

MRI is a non-invasive technique due to the absence of radiation and offers high spatial

resolution and contrast as well as higher sensitivity and specificity than other imaging

modalities. The importance of MRI has been proven in various types of neurological

conditions. Specifically, rapidly growing MR technology makes detection of both

anatomical and physiological alterations possible, which makes it particularly attractive to

study detailed evolutions in the brain. In this lecture, first an introduction to the MR physics

will be given and then some advanced MR techniques such as magnetic resonance

spectroscopy (MRS) and diffusion tensor imaging (DTI) will be discussed. Finally, Some MR

applications in various neurological conditions will be introduced.


31


Shahrzad Mazhari, MD, PhD

Email: [email protected], [email protected]

Affiliation: Neurosciences Research centre, Kerman University of Medical Sciences, Kerman, IRAN

Bibliography:

Dr Shahrzad Mazhari obtained her doctorate in Medicine from Kerman University of Medical Sciences and then continued her education in Psychiatry specialty at Shiraz University of Medical Sciences. After that she was awarded an International Postgraduate Research Scholarship (IPRS) from University of Western Australia toward doing a clinical PhD in Neuropsychiatry in the Center for Clinical Research in Neuropsychiatry at the University of Western Australia. After completing her PhD in 2010 she moved back to Iran and started her work at Kerman University of Medical Sciences as faculty member. Now, she is an associate professor in Psychiatry and the head of EEG/ERP lab in Neurosciences Research center. She is interested in cognitive deficits in mental disorders such as schizophrenia, using event-related potentials (ERPs). She has supervised several postgraduate students in the field of psychiatry and neuroscience. Recently, she has focused on visual/auditory neglect and extinction in schizophrenia.

Abstract:

Mental rotation in schizophrenia

Mental rotation impairment has been reported in schizophrenia. However, there is scarce of evidence about its cognitive and electrophysiological correlates in patients with schizophrenia, as well as the effects of medications and symptoms on performance of the patients. We aimed to address these issues through three separate studies, by comparing the performances of schizophrenia patients with controls on Hand Rotation tasks. Using Brief Assessment of Cognition (BACS) in study 1, the results indicated that deficits in speed of information processing and ability to reasoning and problem solving were important parameters for performing hand rotation tasks in the patients. Using event related potentials (ERPs) in study 2, schizophrenia patients showed significantly reduced rotation-related negativity (RRN) amplitude for mental rotation effect. Finally, the results of study 3 demonstrated an intermediate level of performance of first-degree relatives of schizophrenia patients compared to that of patients and the control group on hand rotation task. These results indicate compromised mental rotation ability at behavioural and neuronal level in schizophrenia, which might be a trait marker for schizophrenia.


32


Niels Eijkelkamp, PhD


nielseijkelkam [email protected]

Affiliation: University Medical Center Utrecht (UMCU)

Bibliography:

Dr. Eijkelkamp is a researcher in the field of pain. He worked in the area of brain, behaviour and immunity and the last 10 years his work mainly focusses on unravelling mechanisms of chronic pain. Currently he works at the University Medical Center Utrecht, The Netherlands. He has worked on stress and wound healing at the Ohio State University. Previously he worked for 2 years on sensory transduction and signaling pathways in chronic pain at the University College London. He works extensively with multiple models of chronic pain and he has combined cell biology, biochemical, and electrophysiology technique for translational and fundamental studies. The current main focus of his work is to identify novel pain genes and unravel the contribution of immune cells and their mediators in chronic pain.

Abstract:

We are interested in the neurobiology of chronic pain and focus primarily on the peripheral sensory nervous system and the spinal cord. We aim at understanding which neuro-immune interactions are important contributors to chronic pain development and which of those could potentially be targeted to prevent debilitating painful conditions. We do basic work and aim to translate our research into the clinic. I will present some recent work of our lab that indicates that chronic pain is not only direct consequences of chances in the nervous system but that aberrations in neuro-immune interactions contribute to chronic pain. I will discuss how mechano-transduction in sensory neurons is measured and how immune mediators control these. In addition, I will show some intriguing data indicating that macrophages play different roles in the regulation of pain and that immune approaches can be used to target the nervous system to treat chronic pain.



33


Saeed Esmaeili-Mahani, Associate Professor of Medical Physiology

E-mail: [email protected], [email protected]

Affiliation:

- Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman. Kerman, Iran.

- Laboratory of Molecular Neuroscience, Kerman Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences. Kerman, Iran

Bibliography

Dr. Mahani grew up in Mahan, Kerman where he attended Shariati High School. He received his B.A. in Nursing from Kerman University of Medical Sciences in 1997, his MS.c. in Medical Physiology from Kerman University of Medical Sciences and his Ph.D. in Medical Physiology from Shahid Beheshti Medical University in 2007. He did post-doctoral fellowship research with Prof. Noriaki Koibuchi at Gunma University in the Japan. After postdoctoral training, he joined the faculty at Shahid Bahonar University of Kerman, where he is associate Professor of Physiology and head of department. He has trained over 50 graduate students and published over 100 articles and reviews, with continuous grant support since 2008. Dr. Mahani's research examines the neurodegenerative processes. His work has revealed that the newly evolved signal transductions that underlie mental performance which regulated at the molecular level, conferring vulnerability in mental illness and age-related cognitive disorders such as Parkinson's Disease. Mahani's research has led to finding the role of neurosteroids and orexin signalling in pain- and toxin-induced neural damage, motor and sensory impairment and cognitive disorders in animal models.

Abstract

Parkinson’s disease (PD) is a complex neurodegenerative chronic disorder affecting the dopaminergic system. Although the pathogenesis of PD has not been completely known, the mitochondrial impairment, oxidative stress, apoptosis and chemicals and genetic factors have been reported as its pathogenesis.


34


Currently, the main barrier to progress against PD is the lack of a meaningful neuroprotective treatment that can be applied after the disease. Therefore, new strategies are needed that halt or slow down neurodegeneration . Therefore, in our studies the effects of natural compounds, neurosteroids and neuropeptides were assessed on in vitro and in vivo PD models. To simulate PD, 6-hydroxydopamine (6-OHDA) was added to Human Neuroblastoma SH-SY5Y Cells on injected into the rat's substantia nigra. The data showed that oleuropein has protective effects against cell model of PD through its anti-oxidant and anti-apoptotic properties. In addition, allopregnanolone and apelin significantly inhibited DAergic cell damage and apoptosis and improved PD-induced cognitive and motor impairment. Orexin-A protective effects against 6-OHDA-induced neurotoxicity are performed via its receptors, PKC and PI3K signaling pathways. Taken together, neuroprotective strategy in PD stays an important but elusive purpose. The results provide some interesting cues regarding the effects of drugs and their useful area of research, and the possible utility of them as neuroprotector agents in future treatment of PD.

https://www.ncbi.nlm.nih.gov/pubmed/27814668

https://www.ncbi.nlm.nih.gov/pubmed/27814668

35


Javad Mirnajafi-Zadeh, PhD


Affiliation: Tarbiat Modares University

Bibliography

Dr. Javad Mirnajafi-Zadeh (was borne in 1968 in Kerman, Iran) got his PhD in Physiology in 1996 from Tarbiat Modares University (TMU) in Tehran, Iran and works as a faculty member in Physiology department of TMU. He is also a visiting researcher in RIKEN/Brain Science Institute in Japan. He is interested in finding the mechanisms involved in seizure-induced changes in synaptic transmission and synaptic plasticity, by using different electrophysiological methods. Recently, he focused on investigating the anticonvulsant actions of deep brain stimulation and its effectiveness on cognitive impairments and his recent articles mainly address this subject. Just now, he is the head of Physiology department in TMU, the head of epilepsy lab, 1st vice president of FAOPS (Federation of Asian-Oceania in Physiological Sciences) and a member of Iranian Society of Neuroscience.

Abstract

One of the most important feature of the mammalian brain is its plastic ability especially in the level of its synapses, a phenomenon which is called synaptic plasticity. In this manner, the experiences affect the neural circuitry and thereby can modify on future thought, behavior, and feeling. Synaptic plasticity involves several changes at the level of molecules such as different neurotransmitters, neuromodulators, receptors and ions. Through these changes the efficacy of a particular synapse can increase or decrease. The efficacy of a synapse can be changed either presynaptically or postsynaptically. Although there are some common features in induction of synaptic plasticity, however, some differences may also be observed depending on the location of synapses and the history of its previous activity. The occurrence of different features of synaptic plasticity (such as long-term potentiation (LTP)) may affect some behavioral aspects such as learning and memory.

36


Vahid Sheibani, Professor of Physiology

E-mail: [email protected] and [email protected]

Affiliation: Neuroscience Research Centre Kerman University of Medical Sciences Kerman, Iran

Bibliography

Vahid Sheibani was born in Kerman, Iran, in 1966. He achieved his PhD in Medical physiology from Shaheed Beheshti Medical University in 2002. He joins Kerman University of Medical Science as a faculty member of department of physiology and now he is the head of Kerman Neuroscience Research Centre. Vahid is a member of ministry of health board of neuroscience. He published more than 120 national and international articles and won national RAZI Festival and Kerman University Afzalipour awards in 2017. His primary research interest is understanding the neural basis of cognitive deficits (i.e. learning and memory dysfunction) induced by some neurodegenerative disease and sleep deprivation. In addition to the above achievement he has recently focused on primate cognition in collaboration with RIKEN Brian science institute (Japan) and Brasilia University (Brazil). He is also one of the founders of Kerman Cognitive Neuroscience Research Centre.

Abstract

Inadequate sleep or sleep deprivation is a common problem in our societies predominantly in menopausal women. Previous studies have demonstrated the positive effects of physical exercise on memory impairments induced by sleep deprivation in male rats. The aim of current short presentation is to review the effects of forced or voluntary exercise on cognitive dysfunctions in female rats following paradoxical sleep deprivation (PSD). Forced or voluntary exercises for 4week by treadmill or running wheel in Intact and ovariectomized (OVX) female rats were used. The multiple platform method was applied for the induction of PSD. The cognitive functions were evaluated by using behavioural, electrophysiological and molecular methods. Our studies showed that physical exercise alleviated the PSD-induced learning and memory, LTP induction and maintenance impairments and also compensated the decrease BDNF level in OVX Rats. Voluntary exercise before PSD improved long term learning and memory and novel object recognition memory impairments in intact and OVX rats. These results confirmed the negative effect of PSD on cognitive functions and forced or voluntary exercise seems to protect rats.

37


Closing Ceremony Program

Date: 31 August, 2017, 18:45 - 20:45

Venue: Kerman, Haft Bagh Expy, Kerman Cognitive Neuroscience Research

Centre

- Video clip about the 2017 kerman associate IBRO school

- Distribution of Certificates

- Listening to comments and suggestions made by lecturers and IBRO

students

- Announcement of the best poster presentation

- Election by IBRO School students to choose the class president and the

class secretary

- Collection of the student’s evaluation forms

- Group photo

- Dinner

38


Daily Program Su

nd

ay (

27

th A

UG

) Time Program

8:30 - 9:30 Registration

9:30 - 11:45

Welcome Ceremony


12 - 13

Prof. Fereshteh Motamedi

Optogenetics and its applications in neuroscience research

13 - 15 Lunch Break - Rest

15 - 17:30

Lab Visiting

17:30 - 17:45 Tea Break

17:45 - 18:15

Group Discussion

39


Mo

nd

ay (

28

th A

UG

) Time Program

9 - 10

Prof. Farshad Mansouri

The role of prefrontal cortex in cognitive flexibility and executive control of behaviour in primates

10 - 10:30

Dr. Mohammad Rohani

New neurosurgical approaches in treatment of movement disorders


11 - 12

Prof. Hossein Baharvand

Neurodevelopmental biology: From stem cells to neural cells

12 - 12:30

Prof. Seyed Noureddin Nematollahi-Mahani

Current state of stem cell therapy for SCI patients". Warm regards

12:30 - 15 Lunch Break - Rest

15 - 17:30

Lab Visiting

17:30 - 17:45 Tea Break

17:45 - 18:15

Group Discussion

18:15 - 20 City Visit (Fathabad Garden)

https://www.researchgate.net/profile/Seyed_Noureddin_Nematollahi-Mahani

40


Tue

sday

(2

9th

AU

G)

Time Program

9 - 10

Dr. Bechara Saab

Therapeutic Potential of Fostering Curiosity as a Novel Treatment for Neurological

Disorders

10 - 10:30

Prof. Abbas Pardakhty

Nano lipid vesicles for transport of therapeutic agent through BBB

11 - 11:30 Tea Break

11 - 12

Prof. Saeed Semnanian


12 - 12:30

Dr. Khadijeh Esmaeilpour

Effect of low frequency electrical stimulation on seizure-induced impairments in learning and memory


15 - 17:30

Lab Visiting

17:30 - 17:45 Tea Break - Rest

17:45 - 18:15

Group Discussion

18:15 - 20 City Visit (Bazaar)

41


We

dn

esd

ay (

30

th A

UG

)

Time Program

9 - 10

Prof. Ehsan Arabzadeh

Efficient sensory processing in the rodent vibrissal cortex

10 - 10:30

Dr. Mohammad Nami

The interface of learning-memory and sleep neural dynamics


11 - 12

Dr. Houshang Amiri

Magnetic Resonance Physics and Applications in Neuroscience

12 - 12:30

Dr. Shahrzad Mazhari

Mental imagery in schizophernia


15 - 17:30

Lab Visiting

17:30 - 17:45 Tea Break

17:45 - 18-15

Group Discussion

18:15 - 20 City Visit (Yakhdan Moayedi, Jabalieh Dome, Museum)

42


Thu

rsd

ay (

31

th A

UG

) Time Program

9 - 10

Dr. Niels Eijkelkamp

Neuro-immune crosstalk in chronic pain

10 - 10:30

Dr. Saeed Esmaeili Mahani

Protective strategies against neurodegenerative disease: Novel therapeutic approach

for Parkinson's disease

11 - 11:30 Tea Break

11 - 12

Prof. Javad Mirnajafi-Zadeh

Neural hyperexcitability and synaptic plasticity

12 - 12:30

Prof. Vahid Sheibani

Cognitive Dysfunction Related to Paradoxical Sleep Deprivation in Female Rats: Effect of

Exercise

12:30 - 15 Lunch Break

15 - 17:30

Lab Visiting

(Cognitive Neuroscience Research Center)

17:30 - 17:45 Tea Break

17:45 - 18:45

Poster presentation

18:45 - 20:45

Closing Ceremony

Frid

ay

(1

th S

epte

mb

er)

Time Program

9 - 14

Trip to Mahan

(Shazdeh Garden, Shah Nematollah Vali Shrine)

43


Lab Mentors Name Email Affiliation

Prof. Hossein Eskandari [email protected] Kerman Neuroscience Research Center

Prof. Farshad Alizadeh Mansouri [email protected] Monash University, Australia and Kerman Neuroscience Research Center

Prof. Nozar Nakhaei [email protected] Kerman Neuroscience Research Center

Prof. Vahid Sheibani [email protected] Kerman Neuroscience Research Center

Prof. Gholamreza Sepehri [email protected] Kerman Neuroscience Research Center

Dr. Mohammad Shabani [email protected] Kerman Neuroscience Research Center

Dr. Shahrzad Mazhari [email protected] Kerman Neuroscience Research Center

Dr. Saeed Esmaeili Mahani [email protected] Shahid Bahonar University of Kerman

Dr. Majid Asadi-Shekaari [email protected] Kerman Neuroscience Research Center

Dr. Ali Mohammad Pourrahimi [email protected] Kerman Neuroscience Research Center

Dr. Mohammad Reza Afarinesh [email protected] Kerman Neuroscience Research Center

Dr. Meysam Ahmadi Zeydabadi [email protected] Kerman Neuroscience Research Center

Dr. Fatemeh Nouri [email protected] Kerman Neuroscience Research Center

Dr. Khadijeh Esmaeilpour [email protected] Kerman Neuroscience Research Center










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Scientific and Organizing Assistants Name Email Affiliation

Dr. Shokouh Arjmand [email protected] Kerman Neuroscience Research Center

Mahdiyeh Barjesteh [email protected] Kerman University of Medical Sciences

Mohammad Abbas Bejeshk [email protected] Kerman Neuroscience Research Center

Kouros Divsalar [email protected] Kerman Neuroscience Research Center

Marzie Esmaeeli [email protected] Kerman Neuroscience Research Center

Mazyar Fathi [email protected] Kerman Neuroscience Research Center

Sadegh Ghasemian [email protected] Kerman Neuroscience Research Center

Dr. Elham Haghparast [email protected] Shahid Bahonar University of Kerman

Dr. Vahid Hajali [email protected] Mashhad University of Medical Sciences

Maryam Jam [email protected] Kerman Neuroscience Research Center

Sara Joushi [email protected] Kerman Neuroscience Research Center

Fereshteh Lohrasbinejad [email protected] Kerman Neuroscience Research Center

Fatemeh Mafi [email protected] Kerman Neuroscience Research Center

Fatemeh Mohammadi [email protected] Kerman Neuroscience Research Center

Lily Mohammadipoor [email protected] Kerman Neuroscience Research Center

Fatemeh Mohtashami [email protected] Kerman Neuroscience Research Center

Marzieh Mowlavi [email protected] Kerman Neuroscience Research Center

Sina Motamedy [email protected] Kerman Neuroscience Research Center

Dr. Akram Nezhadi [email protected] AJA University of medical Sciences

Shahrnaz Parsania [email protected] Kerman Neuroscience Research Center

kiana Rafiepour [email protected] Kerman Neuroscience Research Center

Mohammad Amin Rajizadeh [email protected] Kerman Neuroscience Research Center

Effat Ramshini [email protected] Kerman University of Medical Sciences

Saeed Rohani [email protected] Kerman Neuroscience Research Center

Mansoureh Sabzalizadeh [email protected] Kerman Neuroscience Research Center

Robabeh Sadeghi Golkhatmi [email protected] Kerman Neuroscience Research Center

Sara Sardari [email protected] Kerman Neuroscience Research Center

Faezeh Shafiei [email protected] Kerman Neuroscience Research Center

Saeed Sheikhshoaee [email protected] Kerman Neuroscience Research Center

Reza Sheikhzadeh [email protected] Kerman Neuroscience Research Center

Dr. Mahshid Tahamtan [email protected] Shiraz University of Medical Sciences

Farzaneh Vafaee Bagheri [email protected] Shiraz University of Medical Sciences

Shahab Zarei [email protected] Kerman Neuroscience Research Center






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Documents

IBRO-APRC Kerman Associate School of Neurosciencekmu.ac.ir/Images/UserFiles/998/file/IBRO-new.pdf · sharing their information and bridging gaps in knowledge. We are confident that