Program 12th

Meeting of the IBCN September 25-27

th, 2014, Vancouver, Canada

THURSDAY, SEPTEMBER 25TH, 2014

19.00 Welcome Dinner Cactus Club, Yaletown (357 Davie St)

FRIDAY, SEPTEMBER 26TH, 2014

Introduction Topic Speaker

07:30 – 08:00 Registration/Light breakfast 08:00 – 08:15 Welcome to IBCN Meeting Goebell/Kamat

08:15 – 08:20 Welcome to Vancouver /VPC Black

Keynotes Topic Chair: Kamat

Molecular Classification of Urothelial Carcinoma 08:20 – 08:40 The Lund molecular taxonomy Gottfrid Sjödahl

08:40 – 09:00 Intrinsic basal and luminal subtypes David McConkey

09:00 – 09:30 Discussion

Project Updates

Topic Chair: Kiemeney

09:30 – 09:40 Projects on urinary markers Schmitz-Dräger

09:40 – 10:00 Phases Reporting and Assessment Optimization (PHARAO)

Goebell

10:00 – 10:15 T1-substaging Bas van Rhijn 10:15 – 10:30 COST Action proposal: REMARKABLE Sita Vermeulen

Coffee Break 10:30 – 11:00

Research

Topic (10 min talk, 5 mins Q&A)

Chair: Nawroth

11:00 – 11:15 Whole transcriptome analysis of paraffin embedded BC by RNAseq

Alex Zlotta

11:15 – 11:30 Methylation markers in high risk BC Sia Daneshmand 11:30 – 11:45 Epigenomic alterations in NMIBC Bharati Bapat

11:45 – 12:00 DNA methylation in muscle-invasive BC Kerstin Junker 12:00 – 12:15 Comprehensive molecular profiling to

predict response and provide targets

Michiel van der Heijden

12:15 – 12:30 Predicting response to immunotherapy Ashish Kamat

12:30 – 12:45 PI3K signaling in BC: implications for therapy design

Roman Nawroth

12:45 – 13:00 Using placental malaria tropism to target human bladder cancer

Mads Daugaard

Program 12th

Meeting of the IBCN September 25-27

th, 2014, Vancouver, Canada

FRIDAY, SEPTEMBER 26TH, 2014

Lunch Break 13:00 – 13:45

Research

Topic (10 min talk, 5 mins Q&A)

Chair: Schmitz-Dräger

13:45 – 14:00 FOXA1 is required for urothelial differentiation

David DeGraff

14:00 – 14:15 Notch2 promotes bladder cancer progression

Peter Black

14:15 – 14:30 HER-targeting in urothelial cancer: a translational paradigm

Petros Grivas

14:30 – 14:45 mTORC2 signaling in bladder cancer invasion

Donna Hansel

14:45 – 15:00 Targeting the tumor microenvironment in bladder cancer: gem/cis + rapamycin

Jonathan Wright

15:00 – 15:30 Biology of bladder cancer metastasis Colin Dinney

Bazaar Discussion – Open Forum Collaborations 15:30 – 17:00

Advocacy Topic Chair: Kamat

17:00 – 17:10 Patient Advocacy in USA Diane Zipursky Quale

17:10 – 17:20 Patient Advocacy in Canada Ken Bagshaw

17:20 – 17:30 Discussion

General Assembly – Members Only 17:30– 18:00

Reconvene for Dinner 19:00 La Pentola della Quercia (Opus Hotel)

Program 12th

Meeting of the IBCN September 25-27

th, 2014, Vancouver, Canada

SATURDAY, SEPTEMBER 27TH, 2014

Light Breakfast 08:30 – 09:00

Keynote Lecture

Topic Chair: Kiemeney

09:00 – 09:30 Molecular Epidemiology of BC Nathaniel Rothman

09:30 – 09:45 Discussion

Pipeline Talks Topic Chair: Black

09:45 – 10:00 Roche Canada Bryn Coventry

10:00 – 10:15 GenomeDx Biosciences Nicholas Erho

Working Group Challenges

Topic Chair: Kiemeney

10:15 – 10:25 Group 1: Molecular Markers Zwarthoff 10:25 – 10:35 Group 2: Advanced Disease Black

10:35 – 10:45 Group 3: PHARAO Schmitz-Dräger /Goebell

Coffee Break 10:45 – 11:00

Research Topic (10 min talk, 5 mins Q&A)

Chair: Goebell

11:00 – 11:15 Replication of published germline prognostic/predictive markers

Bart Kiemeney

11:15 – 11:30 Impact of BCG strains on immune response

Molly Ingersoll

11:30 – 11:45 Urine diagnostics for NMIBC Ellen Zwarthoff 11:45 – 12:00 L-Selectin (CD62-L) as a potential

marker of metastatic disease John Taylor

12:00 – 12:15 New IHC markers for urothelial disease Charles Guo

12:15 – 12:30 Shed ALCAM as a biomarker for BC Peter Clark 12:30 – 12:45 Hyperthermia-induced impairment of

homologous recombination Joost Boormans

12:45 – 13.00 Exploring therapeutic BC predictive tools

Marta Sanchez-Carbayo

13:00 – 13:15 Deoxyctidine kinase and resistance to gemcitabine in bladder cancer

Anne Kiltie

Bazaar Discussion – Open Forum Collaborations 13:15 – 13:45

Lunch Break 13:45 – 14:30

Program 12th

Meeting of the IBCN September 25-27

th, 2014, Vancouver, Canada

SATURDAY, SEPTEMBER 27TH, 2014

Break-out session for Working Groups 14:30 – 15:30

Location

Group 1: Molecular Markers Rm TBA

Group 2: Advanced Disease Rm TBA Group 3: PHARAO Rm TBA

Working Group Reports

Topic Chair: Nawroth

15:30 – 15:45 Group 1: Molecular Markers Schmitz-Dräger

15:45 – 16:00 Group 2: Advanced Disease Black

16:00 – 16:15 Group 3: PHARAO Goebell

Wrap-Up & Closing Remarks

16:15 – 16:30 Goebell and Schmitz-Dräger

Getting from Opus Hotel to Medical Student Alumni Centre

Upon exiting the front door of

the Opus Hotel, turn right

(downhill) on to Davie St and

cross the street at the light;

enter the “Yaletown/

Roundhouse” station.

Enter the station and stamp

your travel ticket before

boarding the train towards

“YVR-Airport”. Travel 2 stops

(only 3 minutes) and

disembark at “Broadway-City Hall” station.

Exit the station and walk up the hill on Cambie. Turn turn right on 10th

Avenue, walk 2 blocks to Heather and turn left (up hill). The Medical

Student Alumni Centre is at the corner of 12th Ave and Heather.

Total travel time door-to-door approximately 20 minutes.

THURSDAY DINNER

Across street from Opus Hotel 357 Davie Street Tel 604.685.8070

Dress: casual

1900 Reception

1930 Dinner

FRIDAY DINNER

In the Opus Hotel 350 Davie Street Tel 604.642.0557

Dress: business casual

1900 Reception

1930 Dinner

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