. . I . . . . . -

. . . .- - . . ,.

. . . . , . . -

- .

. .

6 I ? - I -

I

-700229 . % 4 - .r, .

. . - 1 . .

f ! L -

. . . L -4

CE-3607 , . . . . . ._ . . .

' I .

. . . . . . - / . . . . . . . . . . . . - . . . .... . . -* . .

- , .i, .. - ._ .. . , . - . ._ . ' . . . . . . .

- ,,. e . . ./ - . -. - - . . . . > , b . . . . . . .

I.' ' .. . . . . . ..... . : -. . . . .

. - A .

. ._ ~

.. , , .I__ . J I .

1 . - . .

r

.' -

. . ~. . _ .

. . .

!

- .

.. . v-.. - ......-. . , . . . .

- _ : .

-5 ,

- 1 !

i

i 1 !

t

: a . 8 '

O G O I q 8 I

- * -

-11-

L

clr

. .

m f* N 1.

u c o e m 0 0. 0 0 0 0

0 0

-. 0

. .

9

I

I

I

I

I

b

I

I

I

I

I

8

I

I

I

I

I

I

I

I

I

I

I

I

I

I

I

I

I

I

I

I

.-I

1

I

I

I

I

a.

0 0 0

c ? *

0 0 T-

* r(

m m o 0 0 e 9

' . r ( - m (u rc

0 0 u - - m .

r--

o m -% 0 0

0 9

0 0 0 6 0

00

r4 0:

. - . .r.

m N * 0

tu LCI 0 C

9 0

U'

t,

-.

s 3'

-12 - 0 (d . --_ --

0 al ad

(d

d

E m * 0 0 4 n E

3 0 s ':

P C 4%

C 9 0

C d

P w P & 0 0 0) CI

c

-- - .

L.

W 0

a x w & al 3

C 0

r3 &

C W U C 0 U

.r( Y

c)

. . _.

m

u) ' V ? f

e n c r X

rn .L

?;

3 TI

-.' 3 C

u u)

C C U

.L

e

CI c

0 m

u 5 u

C

'tl 0

n 4

c

_-

a.

7

E .L

4 L1 0

-- " 3

i -. c " - L.

d

c 2 C. - c c c

1 9 8 4

. b

-108-

APPENDIX 5

Reconstruction of whole - __ - rib fromidivided samples. - _- Original . data -- were consulted and computational and typographic error8 corrected.

P u conc Sample %dose weight in

Case No. Sample (%k 1 ( R) sample

Sternum 0.0047 4.38 Rib, cortex 0.0016 1.0125 0.001 6

Marrow & spiculesa 0.0160 0.8292 - 0.0133

Whole rib (calculated) 0.0079 I .963 0.0155

Per io s t eum 0.0046 0 -1215 0.00056

Chi - 2 Rib, cortex - Ivlarrow

,:.a Whole rib (calculated)

C a l - i Rib, cortex

Per io s teurn

Trabeculae

Marrow Whole rib (caiculated)

0.021 0 0.0196 O:G2&f~ - 0.007- 7 C.0048

0.03i9 0 . 0 2 9 3

0.0081

0.43 - .'

0 2 0 6 5

0.6365

9 -0 0.445

6.84

0.0090

0.0040

0 -001 3

0.065 0.002C16 0.0269 0.019 0.113

.. az l i i . 2 Origin of marrow sample noted as rib i2 it~.nsr;:!,"iLTld,tion {Ref. 47).

Whole rib sample weighed before d i v i s i x i:i:.> :si;? ErparaTe samples. b .

O O U 1 9 8 5

i

f i 3 4

1

I i t

-. I

. .

- . .

Bone Marrow -- -- .0096 e" A210 -- .a90 -0187

&bus (Frag. bead) -- -- -- .0107# -- -- -- -- Liver Rib (Cortex) P P k l l ?

Vertebra Sternum I

Rib (Whole) Pcrlosteurn (Rlb)

Spleen

Kidney Thyroid A&-em1

Lung

P u c r e a s

Goruua

Lymph Node

Tee& (Av. of 7 )

Heart

Large k-testme

SJmU Intestinc

Xuscle and skln

Blood

B d x e

Total

.0320

-- --

.om I' 4070' .a050 I

-- .0007

.oooa -000 1

. O W

.0005

.0002 v i - * - .ab03

3 ' 1

-- .oooo .oO02

.wo 1

.OOOO

-- -- --

4 8 % .01Q6 I -- -- -- -_

.oo 10

.OO 14

.0054

-0034 --

.OD 16

.0322

.0009

.030 1 --

.oo 11

.G3O 1

.MI0 I

.ooo 1 I . * , - - - - . --

.OD6

.om *- e

.eon ' ;0071

.0052

.0037

.002 1

.OO 15

-00 14

-00 13

.0011

.mo9

- .OOO7 .M)o7

-- .0003

. w 2

.0002

-000 1 --

.0001(7) --

K. L5 200 0.4 c LO LO LO - 0.8

0.6

0.5

0.5 -- 0.2 0.1

0.1

0.1 -- -- --

300

SO

14 850 85 -- 700 -- 350 rzv3:

38,500

5,400

9.601)

10,000

I

( I 'The various subjects recelved the Lollovlrg doses of plutonium: Jip-fr = 5 3p-D = 6.3 - - - . .< Hp-11 I 8.5 clg; Chi. I I 65 G ; Chl. LI e 94.9 c; Hp-12 4.7 pg;-Cd. I = 103 3

E g l l 5 days; Chi. 1 155 days; CL. 11 16 &ys; HP-12 5 days; Czl. I 4 days.

dlstr. In a 70 Kg. rmn.

E -_. .

( 2 ) T u s u e s were obtained at the following t t m s a l te r tnjectlon: ; ~ a y s ~ ' & p - I ) 456 d3ys; ..

(3'Calculated by dlnamg 'Rig of tissue by %/g of body weigh. II a unit dose of Pu VZLS equally

(4)Eerrmnn h c o , hlemorvldum to AEC, July 21, 1047, Project Sc~cdard MLlan.

(5)Assumpaon made that vertebra, sternum and whole r!S repmsent avcregs bme of skeletal system.

("Bone marrow not included in torsi recovery because bone samples e r e not !reed 01 marrow be-

\ ' ; '~-ce assumed Lo have sanw ~d contect xi muscle.

("Value for blood taken at 30 day point, Fig 3.

iarc analysis.

O C O I 9 8 b L - -

.. , . - . .

_I . -i

t . . ::I

.

_ . , . a

TABm 6

. "

' 1

- 9 - , J. .

i ! F !

. . I

, ..

. .

. .

I -

_ _

Ikys aft;or In joction

"

1

x5-4 . ZCS ' I

' 0,152 0,167

--

; Yi&mo vrr,

i Y . '

!

- ..

. . . - . . . . . . ' . . . . . , . . _ . .

I-

. . I . . e .

. . . . . _ . . . .

' _ . _ I _ . . . . . . . . . .

. . . . . .

.- .. . . . . J :

. . '. . ._ . -. ' .- . . . - . ,

b . -, . .

. .

- - . . - - . * .

. . . I

. . . . - . . . . . _. I . . , . I I 1 I . ' I. 1. I 1 .. . .

. * . _ . . . . . . . . , . . .

. r e . : . '- . . . '.. . . . . , . . e

. . . . . . .

s. . - . . .* . . -. ' .

.: . . . . . . . - . N .- . . .

- . , .'. . - . .:_ . . . _ . . - , .

,. . -. . ., .

. . _, . - . - . * ..... . - . . . , . .. , - I - . . , . . :-.- - * , . - . -. .y . . _ . : - . . _ - -

.. .. -. 8 . G.

. . . . , . - . . .1 . .

~. . .

. - .

. I \::. ' . I .

. I - . ' . r , _,

.: I < , . - : : , C ' . . . . . . . . . i - ,.. . . . . . . . . . . , ,, , . . * .*.:. ,.;.. . L . . . . . . . . . . . .." . ..- . . . . . . . . -- . _ . . _..

I . . . . . . . . . . . , .. . . .

a - '. 5

v) elf\ 1

, I I . .

i . . m

0 -4

Bcretion of plutonium in the urine fouolring t h e injection oh 94.9 micmgrams of plutonium citrate.

- 00-0 I991 ' . ' L --

I \ i !

- t c

.-

I

t --

. -. 0 <

2. 0 .

. - -

-. ! i

, . - . .

c I I

cyrv

0 0 ts 0 0

g c 4- cy

Q Q3

1.-

* in

QD

Or( $ 9 4-

d 8

K

0 ' * K n

_ _ . - . . . . - .

0 0 0 1 $ 9 2 --

I

- 1 2 -

: . h _ . _ Psblo X o

. a i

' Total. Count&

* . . . . . . .

1833 . :

I

i o , 22

0.90 0.70 ' 0,29-

i r

T i n t t h e cnount of plutonium injected in theso ad jec ta p m d d no approc&bh

Co3-pzrisoc of Dase kve1-s

. .

. .

*

,

. .

urino . Tot&

O O G I995

- .. - -

. I I

. . . I ,

. .

O O G \ 99b

- ?

.i. . . . . i d

... - . . .. I

.: - -

. _

..

. ' -

:It*if3 8

. . - 17 a

Ih general tho relntive amount of plutoniun ?or pan of tissm k i d s to be hi$xz in C a m I1 thm i n Case I. tive In& of fa t ty t i s sue *In Cam I1 GO t h a t the or- and tis3w3 atudiod tcrd t o have a groator proportion of plutonim thnn F ~ J O not& in Cmo I. Tho total fit is Wficul t to e s t a t e fron thc &to at hnnd rind triorefom tho t o t a l a u n t of plu- t o n i m a b s o r k d fn thn fat.

m a t e r in C a m I than in Caao If.

It i s possiblo that tim eq'lnnntion Uos in the conpcnr-

In s p i t e of tho M e r unit c o w n t m t i o n in the fat in Cam f , it my b~ tllat tho proportional anount of plutonium in tlm t o t a l fit UUI

.-

D O 0 I 9 4 8 c

t L . .

4

--

. . . _

. .

I ! ,

t i ' ! !

h

'. .

. . i

. . -.

h -

5 - .

c; t !

i

.. - _ . . . . . . . .. - . - .

. . . . . .. . . - .

. . . . , . .,

.; _. . . , < . . : . .. f . . ~!. ;-

a - - .'. ** :,. ' ...... . . . . . . . . . . . ~ . -.,. - . -

% - . . - *t*' - . - . . . . . . . . . . . . .: . . 9

. .

i

..

0 6-0 2 0 0 0

. . . . . . . . . . . .

I

t --

. .

_-

a

-