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HYPERSENSITIVITY IoriO
NORMAL immune Nhs DONTHURTthe host o o o o o oit EXCESSIVE ANTIGENS o
diseasecausing a p p p p p a
normal immuneresponse sensitized BugsEnvironment
excessive response hypersensitive self
PROCESS x i RXN TYPESimmuneresponse triggered maintained inappropriately type l ALLERGYhardtoeliminatestimulus immediatehardtoSTOPoncestarting antigenbindsto IgEantibodiSO hypersensitivity diseases Chronic onmastcell
DebilitatingHardtotreat STEPS releasemediator
allergeninhaledleatent RESULTadtyfpI ANTIBODIES injected dilation
antibodiesbindtoantigens allergenSlims 112prod SMcontractiononcellsurface THIsecretecytokines inflam persists
STEPS macrophageseat mastcellbindsIgEAbbindtocell complementactivated allergenbridgesIgEonmastcellsurfaceantigens inflamoccurs mastcelldegranulatesThesehappen RESULT cellsdieinflamharmsopsonizationlphagoc t
ShytREtAgfEainme
contentsORinflammation histamine
OR chemotacticfactorcellular dysfunction gyrqnyile.fi temnetmsjL.mem.bprPoYfIhgf'ainiadmmetabolites
phosphmetabolites leukotrienes
jtijp 3 im OMPfxE.actonBrs.sm cytokinesAbbindtoAg complexes WBCs PT RESPONSE4 complexescirca te immediateresponseminTWOTYPES egetstuck vasodibrasleak LOCAL7
SMspasm skin it.ch hivesSystemic IC inflammation granulecontentsprostag Gl diarrheadisease necrotizingvasculitis leukotrienes lung bronohoconst
complexesformedinciro laterXh hrs ANAPHYLAXIS7depositedin inserieralorgans inflamltissuedestruct itchhives redEX scrumsickness I Inoffeeisgernupnffeiinniect cytokines bronchoconstwheezin
Abmade AbAgcomplex laryngealedemalocal1C listAll complexeslodgeinkidneyjointssmallvessels Manthecomplexesformedantigeninjectsite inflamfeverpainproteinuria vomitcrampsdiarrhe
P g I l t i l iprecipitated injectionsite shockEXArthusNn ji i i localizedareaofskinNECROSIS DEATH
from1Cvasculitis
oinfoiiiin reiminaman
mn i.IEIt.i.ainEicomplexesprecipitate RELEASEcytokines macroph
INFLAMMATION inflameedemahemhurrageulceration useful ORagainst1C adorganisms kill directly
1CactivatecomplementattractIactivateneutrophilslmonocytes UpHERE inflamcelldestrucleakyvessels granulomaform
neutrophilstmonocytesreleasebadstuff TWOTYPES1CactivateclottingOUTCOMES vasoulitis glomerulonephritisarthritis Delayed Hypersensitivity TBtest
µ 1ft secretecytokines macrophagecome killE DirectcytotoxicityII Exposure atupgresainftfetfenfiD4afeInffl D8 kill targetcells
effector THImemorycellsto
fdExposure TAIcells toAgexposure CD8tcellsseeAgoncellsurf
releasecytokines activate Tcellsdiff cytotoxicTeemacrophages inflammation whichkill things like
RESULT macrophageseatAg organtransplantcellYAYNAYlotsof inflamedamage pancreaticisletcells