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HUMERA

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Pharmacologic Name

•Adalimumab

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Pharmacologic Class

• BIOLOGIC RESPONSE MODIFIER

• Tumor ecrosis !ac"or #TNF$ %loc&er'

• Tumor ecrosis !ac"ors refer to a groupof cytokines that can cause cell death (apoptosis

• C("o&ies are a broad and loose category of smproteins that are important in cell signalling.

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Formulations

•

soln for SC inj - prelled syringe n prelled pen• !"mg#".$m%&

• $"mg#".'m%&

• '"mg#".'m%&

•

'"mg#".m%

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*ndications

•

rheumatoid arthritis• ju+enile idiopathic arthritis

• psoriatic arthritis

• ankylosing spondylitis

•

pla,ue psoriasis• hidradenitis suppurati+a

• Crohns disease

• ulcerati+e colitis

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echanism of action

•

/soriasis is a chronic& in0ammatory disease# immmediated disease.

• 1he interaction of multiple immune cell types inc 1-cells& macrophages& and dendritic cells inducesabnormally rapid keratinocytic proliferation and

incomplete maturation.• 1hese abnormalities result in thickening and sca

the skin.

•  *ncreased le+els of 12F are found in psoriasis pl

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•

 1he mechanism of action of adalimumab is primlinked to the neutrali3ation of 12F-alpha bioacti+pre+enting the interaction of 12F-alpha 4ith thesurface 12F receptors

• 1hrough this mechanism& adalimumab inhibits s

 12F-alpha-induced e+ents& ie& the release of serucytokines

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si)e e*ec"s

•

injection site reactions• hi+es

• di5culty breathing

• s4elling of your face& lips& tongue& or throat.

•

6ecause adalimumab suppresses 12F& 4hich is pthe immune system& latent infections& suchas tuberculosis& can be reacti+ated& and the immsystem may be unable to ght ne4 infections

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• Abdominal or stomach fullness

• body aches or pain• cough or hoarseness

• ear congestion

• gas 4ith abdominal or stomach pain

• lightheadedness

• loss of +oice

• lo4er back or side pain

• muscle aches and pains

• nasal congestion

• pain or tenderness around the eyes or cheekbones• rapid and sometimes shallo4 breathing

• shi+ering

• sunken eyes

• thirst

• trouble sleeping

• 4armth on the skin

• 4rinkled skin

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Stop drug n report 7 pt educatio

•

fe+er& night s4eats& 4eight loss& tiredness• feeling full after eating only a small amount

• pain in your upper stomach that may spread to yshoulder

•

easy bruising or bleeding& pale skin& feeling...•  8o not gi+e %*9: 9*;