LETI Seminar, 4th October 2012

Human healthcare system using ubiquitous sensors:ubiquitous sensors:

Project P3-G3 in Aichi prefecture

Kazuo SATOProfessor, Aichi Institute of TechnologyEmeritus professor, Nagoya UniversityEmeritus professor, Nagoya University

Project 3: Extremely-Early Stage Diagnostics Technologies for Human Diseases (2011-2015)

Leader: Prof. M. Ohta

Minimally Invasive Continuous Diagnostic Method for Cerebral d C di l Di

G1and Cardiovascular Diseases (K. Sawada, Toyohashi Inst. Tech.)

2-D Ion image sensorMechanical characterization of vascular systemy

Highly Sensitive, Less Invasive, and Reliable Device for the f C

G2Bedside Detection of Early-stage Cancer (Y. Baba, Nagoya U.)

Single cell detection in microfluidics3-D image construction by catheter camera3 D image construction by catheter camera

Non-/Less Invasive Sensing Systems for Biological Information G3(K. Sato, Aichi Inst. Tech.)

Textile-type physical sensing systemBreath/skin gas monitoringBreath/skin gas monitoring

Goal of the G3: Non-/Less Invasive Sensing Systems Detecting Biological Information

Ubi it ( ll d/ di t ib t d)Ubiquitous (small and/or distributed) sensors monitoring individual human health in daily life.

Data Accumulation

Data ScreeningHospital

Medical Doctor

Exercising Eating SleepingWorking

Technologies and output applicationsTechnologies and output applications of our project

Textile type physical sensing systemTechnologies: conductive textile as force/strainTechnologies: conductive textile as force/strain sensorA li ti B d l h t i tApplications: Bedsore alarm sheets, spirometer shirts in real life

Breath/skin gas monitoringBreath/skin gas monitoringTechnologies: selective gas sensing devices (th l S O GC)(thermal, SnO2, GC) Applications: Early stage detection/control of diabetes, diet, cancer, vascular disease

W bl i t b dWearable sensing systems based on functional textiles

Two different approaches toTwo different approaches to wearable systems

Miniaturization of discrete micro devicesMiniaturization of discrete micro devicesEmbedded micro-devices in wearable goods: i.e., h i t t h hi t t h tshoes, wrist watch, shirts, patch tapeMyHeart Project, Wealthy Project y j y j

F ti l t tilFunctional textileClothing is used as a sensing deviceg gAichi Project, BEANS Project

GLOVE TYPE OF WEARABLE TACTILE SENSORPRODUCED BY ARTIFICIAL HOLLOW FIBERPRODUCED BY ARTIFICIAL HOLLOW FIBERY. Hasegawa, M. Shikida, D. Ogura, and K. Sato, Tech. Dig. Transducers-07, vol.2 pp. 1453-1456

Patched type tactile sensor gloveg

Pitch: 2.0 mm

Detection principle of sensor devicex 4.5 mm

Textile becomes sensing elementsTextile becomes sensing elementsFiber elementsFiber elements(1) Metal wire(2) Fiber coated with(2) Fiber coated with

conductive materials(3) Elastic tubular fiber ( )

with conductive materials Sensing functions(1) Pressure ( )(2) Frictional force(3) Humidity, wetting( ) y, g

Wiring functiong

Antenna functionAntenna function

Conductors are woven in warp and weftConductors are woven in warp and weft in a large area of textile

O i T til R h C tOwari Textile Research Center, Aichi Center for Industry and Science Technology )

Sensing textileSensing textileMetal wires are woven.Pressure distribution detected

Owari Textile Research Center, Aichi prefecture

Textile-type physical sensing system:Textile-type physical sensing system: Application-1: Bed sheets

モニタリングBedsore alarm in nursery careSudden infant death syndrome alarmSudden infant death syndrome alarmSleep apnea syndrome analysis

2D image fof pressure

distributionWirelessconnection

Te tile sensor in aTextile sensor in a shape of bed sheets

Prototype Bedsore Alarm Sheets, P3G3S3 2011.11

Pressure sensing matrix（128×64）20002000mmmm

Drive

unit

Y -

2

mm

mm

ve u

nit

Y -

1D

PC for operation

900

900mm

Main

Driv operation

and display

USBUSB

FFCFFC

circuitDrive unitX - 1

Drive unitX - 2

Drive unitX - 3

Drive unitX - 4

AC100VAC100V

Textile-type physical sensing system yp p y g yApplication-2: Breathing capacity

Textile antennaSpirometrymeasurement for COPDfor COPD patient

Wireless connection

sensors

Textile Medical doctorWearable battery and

Textile wiring

circuits

A sensor element detecting stretching motion

Breath/skin gas monitoring

Correlations between body gas species and y g phuman health conditions are reported in literature However the gas concentrationliterature. However, the gas concentration fluctuates by person, by the time, by food, etc.Field test is required for statistic dataField test is required for statistic data acquisition and diagnostic statement.Development of quick and portable gas sensing system for popular use.sensing system for popular use.

Breath/Skin gas monitoring systemBreath/Skin gas monitoring system

Thermoelectric gas sensor f H CO CH d N lfor H2, CO, CH4, and Nonanal

Sensors for other gases SnO2,2Gas Chromatograph

What already reported in literature are;Breath/skin gas components reflects human health conditions.

Acetone : diabetes, excessive diet/exercise ,NO : vascular system (when choked, after

i )exercise)Alcohol: alcoholic, drinkingAlcohol: alcoholic, drinkingAmmonia: chronic hepatitisSick-house chemicals : appears through bodybodyNonanal : cancerGlucose in sweat: diabetes

Acetone in skin gas increases d i iduring exercise G3-S2 Skin gas group

1) Riding a bicycle ergometer2)上腕を洗浄・乾燥、600mlの窒素を入れ、１分間試料採取。3)60watt, 120watt,165wattの強度でそれぞれ５分間、4-5, 9-10, ) , , 強度でそれぞれ 分間、 , ,14-15分間の皮膚ガスを採取。4)60回転/分、一般学生及びワンダーフォーゲルの学生

1012

gas

Cool down165 watt

68

in s

kin

pm) 120 watt

24

ceto

ne (p 60 watt

0rest 60 120 165 After 5 min

Ac

５ 15 10 20 Time (min)

Thermoelectric Hydrogen Sensor (THS)Thermoelectric Hydrogen Sensor (THS)

H2+ O / catalyst ⇒ H2O + heat

ΔT ⇒ Seebeck effect

H

ΔV

H2OO2

H2

A: hot side(QA)

B: cold side(QB)catalyst

Temperature differece

thermoelectric film: SiGe

differeceΔTA-B ⇒ QA - QB

Catalytic combustion

18

Catalytic combustion Thermoelectric conversion (from heat to electric)

Developed gas detector for Acetone/Ethanol in skin gas

Acetone/Ethanol detection

① C d ti d ti f ki① Condensation and separation of skin gasDetection time: 7 min.

Automated condensation of skin gas.（C CO

② Direct detection of Ethanol

（Cryogenic condensation using Liquid CO2,Separation using GC tailored for Acetone/Ethanol ）

②Detection time: 1 min.

Skin gas taken from finger

Ｇ３Ｓ２ 皮膚ガスの病の関連の解明

Members of P3 Medical +Engineering+IndustryMembers of P3

◆ K. SATO (Aichi Inst. Tech.) MEMS

Medical Engineering Industry

◇ W. Shin (Adv. Inst. Sci. Tech.) Gas sensor, Breezing Gas Analysis◇ T. Tsuda (Nagoya Inst. Tech) Human Skin Gas Analysis◇ K Mase (Nagoya University) Human Behavior Analysis◇ K. Mase (Nagoya University) Human Behavior Analysis

T. Kawabe (Nagoya University) Respiratory, Sleep ApneaK. Ohno (Nagoya University) Internal, Tissue systemT. Hida (Aichi Cancer Center) Lung CancerI. Kato (Saitama Medical University) Pediatric, SIDST Murohara (Nagoya University) Cardiovascular MetabolicT. Murohara (Nagoya University) Cardiovascular, MetabolicT. Ikeguchi (Owari Textile Center, AITEC) Functional Textile T. Horiba (Owari Textile Center, AITEC) Functional Textile T. Okuwa (Nagoya Inst. Tech.) Skin Gas Analysis M. Shikida (Nagoya University) MEMS, Soft MEMS SensorsM Sasaki (Toyota Inst Tech ) MEMS Sensor electronicsM. Sasaki (Toyota Inst.Tech.) MEMS, Sensor electronics

IndustryyTsuchiya, Kurabo, Brother, DENSO, INAX, Suzuken, Figaro

SummarySu a yTextile-type physical sensing systemyp p y g y

Textile becomes sensing elements instead of patched micro devicespatched micro-devicesTextile is easily accepted in daily lifeRobustness and noise-reduction required

Breath/skin gas monitoringBreath/skin gas monitoringDevelopment of portable gas sensing system p p g g y(Thermal, SnO2, GC, Sampling method)Easier than blood exam for daily life useEasier than blood exam. for daily life useCorrelation between body gas and health conditions must be clarified by field test

Future work

We are going to start field test including gas sampling from volunteers in fall 2012.Members in Faculty of Nursing Care, Sugiyama Univ. is y g , g ygoing to evaluate the bed sheets.Smart phone as a platform for data communication.Smart phone as a platform for data communication.Medical information service as a business.