Human Aging System Diagram 20 20 20 20 20 20 20 30 30 30 30 30 30 30 40 40 40 40 40 40 40 50 50 50 50

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    Age Age

    Heart failure #7

    Fibrosis #9

    Ухудшение питания клеток #13

    Accumulation of glycated proteins #15

    Accumulation of lipid-protein crosslinks #19

    Негомологичная рекомбинация хромосом #21

    Decline in impact of sympathetic nervous system on the heart #23

    Deterioration of toxins removal #25

    Decline in cell functions #27

    Decline in the process of synthesis of collagen and elastin #29

    Atrophy of the lung alveoli #31

    Chronic generalized lingering inflammation #33

    Accumulation of amyloid fibrils (amyloid beta) #37

    Вторичный иммунодефицит #39

    X-syndrome #45

    Начало возрастных изменений в печени #47

    Oncogenesis (malignant and benign tumors) #49

    Hypotrophy of adrenal glands #51

    Loss of the elasticity of lung tissue #53

    Гипотрофия тканей, вызванная ухудшением общего кровообращения #56

    Pneumonia #59

    Incomplete digestion of food #61

    Changes of the physical and chemical properties of the membrane matrix #63

    Decline in protein synthesis #65

    Hypoxia #67

    Accumulation of denatured proteins #71

    Breast Cancer #73

    Spleen atrophy #75

    Decline in physical performance #77

    Accumulation of protein aggregates #85

    Decline in activity of the functional elements of fabrics #87

    Сахарный диабет пожилого возраста #91

    Размножение гладкомышечных клеток #93

    Loss of mobility #95

    Точковые (ядерные) мутации #97

    Decline in number of B-lymphocytes that are responsible for specific reactions #99

    Inhibition of the proteasome #101

    Усиление атрофии мышц #103

    Reducing the speed of reflexes #109

    Reduction of number of T-helper cells #111

    Неусвоение витамина B12 #115

    Increase in activity of parathyroid hormone #117

    Increase in secretion of prolactin #123

    Dysregulation of various systems of the organism #126

    Obesity #130

    Myocardial infarction #131

    Renal insufficiency #133

    Bony spikes #137

    Продуцирование воспалительных цитокинов #139

    Соединение альвеол между собой #141

    Decline in functional activity (of tissues, organs, systems) #143

    Senile infirmity #145

    The accumulation of nonfunctional proteins #147

    Sarcopenia #149

    Decrease in secretion of thyroid hormones #151

    Уменьшение количества серотонина #153

    Стойкое понижение уровня инсулина в крови #155

    Стохастическое повреждение ДНК #157

    Formation of malonic aldehyde #159

    Гипотрофия эндокринной части поджелудочной железы #161

    Reducing the number of functional cells #163

    Damage of the mitochondrial membranes #165

    Increase in the number of collagen fibers (between cells) #169

    Ca leaching from the bones #171

    Prostate cancer #173

    Decline in secretion of IGF-1 (Insulin-like growth factor-1) #175

    Увеличение количества амилоидных бляшек #177

    Weakening of the stem cells pool due to homing disruptions #181

    Chromosomal aberrations #185

    Accumulation of lipofuscin #187

    Formation of foam cells #189

    Lung cancer #191Alzheimerdisease #193

    Decline in estrogen production #195

    Anemia #197

    Crosslinks #201

    Osteochondrosis #203

    Артериальная гипертония #205

    Ухудшение функций миоцитов #207

    Decrease of cell proliferation #209

    Накопление повреждений в миоцитах #217

    Excess activation of proto-oncogenes #223

    Активирование очагов онкологических клеток #225

    Degradation of the extracellular matrix in cartilage #231

    Renal insufficiency #235

    Изменение рецепторной чувствительности клетки #237

    Genomic instability #239

    Decline in norepinephrine secretion #241

    Блокирование реакций клетки на факторы роста, активирующие ее пролиферацию #243

    Formation of signal of double-stranded break of the DNA #245

    Повреждения эндотелия #247

    Decline in the number of myocytes #249

    Decline in the production of TSH (thyroid-stimulating hormone) #251

    Loss of telomere covering proteins (TRF2) #253

    Rheumatism #257

    Various mtDNA damage #259

    Bad homing #266

    Патологическое укорочение теломер #268

    Нарушение структуры хроматина #270

    Replicative aging (permanent cessation of mitosis) #272

    Deterioration of the microcirculation in the pancreas #273

    Уменьшение синтеза С-комплемента #276

    Изменение проницаемости альвеолярной стенки #279

    Inflammatory reactions in the tissues #281

    Уменьшение жизненной емкости легких #283

    Уменьшение скорости физиологической регенерации тканей #288

    Ишемический инсульт #295

    Hypotrophy of epiphysis #301

    Переломы #307

    Уплотнение клеточной мемраны #311

    Increase in the secretion of vasopressin #315

    Infringement of functions of cells #319

    Decrease in the secretion of dehydroepiandrosterone #321

    Compression of the organ #323

    Accumulation of defective collagen #325

    Deterioration of work of ensemble of cells #333

    Hypoxia (of varying degrees) #345

    Hypotrophy of thyroid #347

    Выработка свободных радикалов #353

    Emergence of defective mitochondria #357

    Epigenetic disturbances (cross-linking of DNA-protein, DNA demethylation) #359

    Накопление нефункциональных белков #363

    Arthritis #367

    Транспозиция мобильных элементов генома #373

    Образование 8-оксо-2’деоксигуанозина в промоторных и энхансерных участках ДНК #375

    Osteoporosis #377

    Hypotrophy of gonads #383

    Deterioration of of cognitive abilities of brain #385

    Reduction of the number of intercellular connections #389

    Prostatic hypertrophy #391

    Adverse change in the extracellular matrix #399

    Deterioration of tissue nutrition #401

    Mitotic catastrophe #407

    Подавление секреции паратиреоидного гормона #411

    DNA-DNA crosslinks #427

    Cell volume reduction #431

    Adverse change in the constitutive expression of genes #433

    Parkinson's Disease #437

    Уменьшение количества (и ухудшение качества) адгезивных рецепторов #447

    Decline in the number and quality of the ribosomes #453

    Formation of atherosclerotic plaques #463

    Decreased secretion of sex hormones (testosterone, estradiol, progesterone) #467

    Disruption of metabolite transport across membrane #471

    Decline in production of ACTH (Adrenocorticotropic hormone) #475

    Reduced elasticity of blood vessels #489

    CHD #495

    Нарушение индуцибельной экспрессии генов ДНК #501

    Pulmonary insufficiency #505

    Abnormal daily rhythm of secretion of neuropeptide Y #509

    Integration of retroviruses in DNA #511

    Increase in the number of aldehydes #519

    Decline inf the assimilation of calcium and vitamin D in the intestine #523

    Accumulation of oxidized proteins #525

    Снижение активности ферментов #529

    Decline in secretion of thyroid hormones #531

    Reduced synthesis of calcitriol #535

    Накопление нефункциональных белков, входящих в состав антиоксидантных систем #539

    The death of the organism #543

    Decreased secretion of melatonin #551

    Blocking of the replication forks #553

    Mutations in mtDNA #555

    The accumulation of fatty acids in the blood #557

    Decline in the number of neurons #563

    Появление аутоиммунной реакции #565

    Formation of alkylated bases #575

    Кишечная интоксикация #589

    Повышение активности АФК #593

    Уменьшение образования Т-лимфоцитов #595

    Degradation of the extracellular matrix in tendons #599

    Menopause and Andropause #601

    Suppression of autophagy #603

    Overfilling in lysosomes #607

    Понижение

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