20
20 20 20 20 20
20
30
30 30 30 30 30
30
40
40 40 40 40 40
40
50
50 50 50 50 50
50
60
60 60 60 60 60
60
70
70 70 70 70 70
70
80
80 80 80 80 80
80
Age Age
Heart failure #7
Fibrosis #9
Ухудшение
питания клеток #13
Accumulation of
glycated
proteins #15
Accumulation of
lipid-protein
crosslinks #19
Негомологичная
рекомбинация
хромосом #21
Decline in
impact of
sympathetic
nervous system on
the heart #23
Deterioration of
toxins
removal #25
Decline in cell
functions #27
Decline in the
process of
synthesis of
collagen and
elastin #29
Atrophy of the
lung alveoli #31
Chronic
generalized
lingering
inflammation #33
Accumulation of
amyloid
fibrils
(amyloid beta) #37
Вторичный
иммунодефицит #39
X-syndrome #45
Начало
возрастных
изменений в
печени #47
Oncogenesis
(malignant and
benign
tumors) #49
Hypotrophy of
adrenal glands #51
Loss of the
elasticity of
lung tissue #53
Гипотрофия
тканей,
вызванная
ухудшением
общего
кровообращения
#56
Pneumonia #59
Incomplete
digestion of food
#61
Changes of the
physical and
chemical
properties of the
membrane
matrix #63
Decline in
protein
synthesis #65
Hypoxia #67
Accumulation of
denatured
proteins #71
Breast Cancer #73
Spleen
atrophy #75
Decline in
physical
performance #77
Accumulation of
protein
aggregates #85
Decline in
activity of the
functional
elements of
fabrics #87
Сахарный
диабет
пожилого
возраста #91
Размножение
гладкомышечных
клеток #93
Loss of
mobility #95
Точковые
(ядерные)
мутации #97
Decline in
number of
B-lymphocytes
that are
responsible for
specific
reactions #99
Inhibition of the
proteasome #101
Усиление
атрофии мышц #103
Reducing the
speed of
reflexes #109
Reduction of
number of
T-helper cells
#111
Неусвоение
витамина B12 #115
Increase in
activity of
parathyroid
hormone #117
Increase in
secretion of
prolactin #123
Dysregulation of
various
systems of the
organism #126
Obesity #130
Myocardial
infarction #131
Renal
insufficiency
#133
Bony spikes #137
Продуцирование
воспалительных
цитокинов #139
Соединение
альвеол между
собой #141
Decline in
functional
activity (of
tissues,
organs,
systems) #143
Senile
infirmity #145
The
accumulation of
nonfunctional
proteins #147
Sarcopenia #149
Decrease in
secretion of
thyroid
hormones #151
Уменьшение
количества
серотонина #153
Стойкое
понижение
уровня
инсулина в крови
#155
Стохастическое
повреждение ДНК
#157
Formation of
malonic
aldehyde #159
Гипотрофия
эндокринной
части
поджелудочной
железы #161
Reducing the
number of
functional
cells #163
Damage of the
mitochondrial
membranes #165
Increase in the
number of
collagen
fibers
(between
cells) #169
Ca leaching from
the bones #171
Prostate
cancer #173
Decline in
secretion of
IGF-1
(Insulin-like
growth
factor-1) #175
Увеличение
количества
амилоидных
бляшек #177
Weakening of the
stem cells pool due
to homing
disruptions #181
Chromosomal
aberrations #185
Accumulation of
lipofuscin #187
Formation of foam
cells #189
Lung cancer #191Alzheimerdisease #193
Decline in
estrogen
production #195
Anemia #197
Crosslinks #201
Osteochondrosis
#203
Артериальная
гипертония #205
Ухудшение
функций
миоцитов #207
Decrease of cell
proliferation
#209
Накопление
повреждений в
миоцитах #217
Excess
activation of
proto-oncogenes
#223
Активирование
очагов
онкологических
клеток #225
Degradation of the
extracellular
matrix in
cartilage #231
Renal
insufficiency
#235
Изменение
рецепторной
чувствительности
клетки #237
Genomic
instability #239
Decline in
norepinephrine
secretion #241
Блокирование
реакций клетки на
факторы роста,
активирующие ее
пролиферацию
#243
Formation of
signal of
double-stranded
break of the DNA
#245
Повреждения
эндотелия #247
Decline in the
number of
myocytes #249
Decline in the
production of TSH
(thyroid-stimulating
hormone) #251
Loss of
telomere
covering
proteins
(TRF2) #253
Rheumatism #257
Various mtDNA
damage #259
Bad homing #266
Патологическое
укорочение
теломер #268
Нарушение
структуры
хроматина #270
Replicative
aging
(permanent
cessation of
mitosis) #272
Deterioration of
the
microcirculation
in the
pancreas #273
Уменьшение
синтеза
С-комплемента
#276
Изменение
проницаемости
альвеолярной
стенки #279
Inflammatory
reactions in the
tissues #281
Уменьшение
жизненной
емкости легких
#283
Уменьшение
скорости
физиологической
регенерации
тканей #288
Ишемический
инсульт #295
Hypotrophy of
epiphysis #301
Переломы #307
Уплотнение
клеточной
мемраны #311
Increase in the
secretion of
vasopressin #315
Infringement of
functions of
cells #319
Decrease in the
secretion of
dehydroepiandrosterone
#321
Compression of the
organ #323
Accumulation of
defective
collagen #325
Deterioration of
work of
ensemble of
cells #333
Hypoxia (of
varying
degrees) #345
Hypotrophy of
thyroid #347
Выработка
свободных
радикалов #353
Emergence of
defective
mitochondria
#357
Epigenetic
disturbances
(cross-linking of
DNA-protein, DNA
demethylation)
#359
Накопление
нефункциональных
белков #363
Arthritis #367
Транспозиция
мобильных
элементов
генома #373
Образование
8-оксо-2’деоксигуанозина
в
промоторных и
энхансерных
участках ДНК #375
Osteoporosis
#377
Hypotrophy of
gonads #383
Deterioration of of
cognitive
abilities of
brain #385
Reduction of the
number of
intercellular
connections #389
Prostatic
hypertrophy #391
Adverse change in
the
extracellular
matrix #399
Deterioration of
tissue
nutrition #401
Mitotic
catastrophe #407
Подавление
секреции
паратиреоидного
гормона #411
DNA-DNA
crosslinks #427
Cell volume
reduction #431
Adverse change in
the
constitutive
expression of
genes #433
Parkinson's
Disease #437
Уменьшение
количества (и
ухудшение
качества)
адгезивных
рецепторов #447
Decline in the
number and
quality of the
ribosomes #453
Formation of
atherosclerotic
plaques #463
Decreased
secretion of sex
hormones
(testosterone,
estradiol,
progesterone)
#467
Disruption of
metabolite
transport
across
membrane #471
Decline in
production of
ACTH
(Adrenocorticotropic
hormone) #475
Reduced
elasticity of
blood vessels
#489
CHD #495
Нарушение
индуцибельной
экспрессии
генов ДНК #501
Pulmonary
insufficiency
#505
Abnormal daily
rhythm of
secretion of
neuropeptide Y
#509
Integration of
retroviruses in
DNA #511
Increase in the
number of
aldehydes #519
Decline inf the
assimilation of
calcium and
vitamin D in the
intestine #523
Accumulation of
oxidized
proteins #525
Снижение
активности
ферментов #529
Decline in
secretion of
thyroid
hormones #531
Reduced
synthesis of
calcitriol #535
Накопление
нефункциональных
белков,
входящих в
состав
антиоксидантных
систем #539
The death of the
organism #543
Decreased
secretion of
melatonin #551
Blocking of the
replication
forks #553
Mutations in
mtDNA #555
The
accumulation of
fatty acids in the
blood #557
Decline in the
number of
neurons #563
Появление
аутоиммунной
реакции #565
Formation of
alkylated bases
#575
Кишечная
интоксикация
#589
Повышение
активности АФК
#593
Уменьшение
образования
Т-лимфоцитов
#595
Degradation of the
extracellular
matrix in
tendons #599
Menopause and
Andropause #601
Suppression of
autophagy #603
Overfilling in
lysosomes #607
Понижение
