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Hormones CHO metabolism Protein metabolism Lipidmetabolism

Other functions

1.GrowthHormone

HYPERGLYCEMIC-Diminish uptakeglucose by cell

-Decrease numberof insulin receptor-Decreaseutilization glucose-Increase glucagondeposition

ANABOLIC-Increase transportamino acid into

cells-Increase proteinsynthesis by cell-Stimulatetranscription RNA-Decrease proteincatabolism

LIPOLYTIC-Increaseutilization of fat

release fattyacid-Enhance FA

Acetyl coA(energy)

-indirectly in thebone and skeleton

-Stimulateerythropoiesis

-Increase GITabsorption of Ca &Phosphate

-Decreaseexcretion of Na&K

2.Thyroid

hormones (T3,T4)

HYPERGLYCEMIC

-Increaseabsorption fromGIT

-Enhancegluconeogenesis

BOTH

-LOW dose :increase formation

-HIGH dose :excess cabolism

Increase all

aspect of lipidmetabolism

Lipolytic>lipogenic

-^BMR >60-100%

-^ synthesis manyintracellularenzymes

-^Na K ATPaseMito : ^ size, no&activity

-Carotene vit A

-Growth of skmuscle and NS

-CVS: ^affinity tocatecholamine &increasebloodflow

-^respiration

-GIT: ^secretion &motility

-Sexual : normalmenstruation &fertility^milk secretion

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3.Catecholamine HYPERGLYCEMICStimulateglycogenolysis(liver)

_ Mobilize FFAfrom adiposetissue

-^metabolic rate

-^HR & forcecontraction & vc

-Spleniccontraction

-vc of renal bv decrease urine

-^rate & depthresp

-Potentiate sk mcontraction & vd of

sk muscle bv

-Excite NS alert

-^visual field

4.Glucocorticcoid HYPERGLYCEMIC-Stimulategluconeogenesis(liver)-^mobilization

amino acid to liver-Decrease glucoseutilization by cell

CATABOLIC excliver-Reduce cellularprotein EXC liver:*Decrease

synthesis*Increasecatabolism

-^liver protein &plasma protein(liver)

-Diminish transportamino acid intoextrahepatic cells

LIPOLYTIC-Increaselipolysis

-Increase its

utilization ofenergy

-Circulatorysystem

-Skeletal muscle

-NS

-Blood cells &immunity

-Ca metabolism &bone

-Anti inflamm. &anti allergic effects

5.Insulin HYPOGLYCEMIC-Facilitate entryglucose into cells

-Facilitateglycogenesis (liver)

ANABOLIC-Active transportamino acid intocells

-Direct effect onribososme forming

LIPOGENESIS-Decreaseutilization of fat

-Promotelipogenesis

-Synergistic withGH

-^ activity Na KATPase K entercells

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-Inhibitgluconeogenesis

new proteins-Inhibit catabolismof protein

-Conserve amino

acid in proteinstores

6.Glucagon HYPERGLYCEMIC-Glycogenolysis(liver)

-Gluconeogenesis

-Increase hepaticdeamination ofamino acid

LIPOLYTIC-Activatehormonesensitive lipase

-^ketone bodyformation

-Stimulatesecretion of GH,insulin andpancreas SS