Hormel Institute, University of Minnesota

MEMORANDUM OF AGREEMENTESTABLISHING

THE HORMEL INSTITUTEAUSTIN, MINNESOTA

AS A

UNIT OFTHE GRADUATE SCHOOL

UNIVERSITY OF MINNESOTA

CERTIFICATE OF INCORPORATIONAND BY LAWS OF

THE HORMEL FOUNDATIONAUSTIN MINNESOTA

NOVEMBER 30, 1942

MEMORANDUM OF AGREEMENTESTABLISHING

THE HORMEL INSTITUTEAUSTIN, MINNESOTA

AS A

UNIT OFTHE GRADUATE SCHOOL

UNIVERSITY OF MINNESOTA

CERTIFICATE OF INCORPORATIONAND BY LAWS OF

THE HORMEL FOUNDATIONAUSTIN MINNESOTA

NOVEMBER 30, 1942

Legacy of Legacy of George A. Hormel George A. Hormel

and and Jay C. HormelJay C. Hormel

Jay C. Hormel resolved that the Jay C. Hormel resolved that the major portion of the Hormel major portion of the Hormel Foundation income should Foundation income should benefit scientific research benefit scientific research

“ “Good research means training, Good research means training, talent, facilities, and hard work.”talent, facilities, and hard work.”

Early Projects and Emphasis

preservation of foods preservation of foods Development of a miniature pig for Development of a miniature pig for

use in studying human diseaseuse in studying human disease the nation’s leading center of the nation’s leading center of

scientific research in the field of scientific research in the field of lipidslipids

Discovery of (and coining of the terms) omega 3 and omega 6 fatty acids and their relevance to health

Dr. Zigang DongDr. Zigang DongDr. Ralph T.HolmanDr. Ralph T.Holman

Employs some of the world's leading scientists working on cutting edge research.

Many collaborative research partners University of Minnesota Cancer Center Mayo Clinic• Rutgers University the University of Arizona

Access to hundreds of natural compounds for testing in the prevention and treatment of cancer.

Unique Features of The Hormel Institute

Hormel Institute Scientists: Hormel Institute Scientists:

1) Use the tools of molecular and cellular biology 1) Use the tools of molecular and cellular biology a) to evaluate changes in cancer cells a) to evaluate changes in cancer cells b) to determine the role of mutant cancer genes b) to determine the role of mutant cancer genes in producing changes in cell function. in producing changes in cell function.

2) Attempt to understand the changes seen in 2) Attempt to understand the changes seen in cancer cells compared with normal cells. cancer cells compared with normal cells.

3) A major focus of the researchers is the 3) A major focus of the researchers is the development of novel “natural” compounds that are development of novel “natural” compounds that are non-toxic to normal tissues and cells but highly non-toxic to normal tissues and cells but highly effective in preventing and/or treating various types effective in preventing and/or treating various types of cancers. of cancers.

To win the war against cancer:To win the war against cancer:

• We must know the enemy--We must know the enemy--understand carcinogenesis.understand carcinogenesis.

• Prevent or treat cancer by Prevent or treat cancer by targeting specific cancer targeting specific cancer genes and/or proteins.genes and/or proteins.

RasRas

RafRaf

MEK1/2MEK1/2

EGFR

TAKTAK

MKKMKK3/63/6

Rac,Rac,RhoRho

MKKMKK4/74/7

MKKMKK1-51-5

TCFTCFElk1Elk1

c-fosc-fos

TCFTCFElk1Elk1 ATF2ATF2

FosFos

PPPP

target genestarget genes

JunJunPPPP

JunJun AP-1AP-1c-junc-jun

JunJunPPPP

FosFos

ApoptosisTumor

AP-1AP-1

PP PP

JunJun

Erk1/2P

P

p38 kinaseP PP

JNKs

PKC

Biophysics

Cancer Biology

Cellular & Developmental Biology

Cellular & Molecular Biology

Membrane Biochemistry

Nutrition & Metabolism

Strategic Assets of the Hormel Institute, University of Minnesota

A statement of our strategic assets in light of the criteria outlined in Advancing the Public Good: Securing the University’s Leadership Position in the 21st Century

1. Centrality to Mission• The Hormel Institute has achieved excellence

in basic research

• In the past year we were published 23 times including twice in Nature.

• In the past year 43% of our submitted grant applications were funded.

• Each faculty member has at least one R01 grant and in several cases more than one.

POST-TRANSLATIONALMODIFICATION OF P53 IN TUMORIGENESISAnn M. Bode and Zigang Dong

ResveratrolEGCGCaffeineTheaflavins

Resveratrol or caffeine induce p53 Ser 15 phosphorylation

ResveratrolEGCGCaffeineTheaflavins

POST-TRANSLATIONALMODIFICATION OF P53 IN TUMORIGENESISAnn M. Bode and Zigang Dong

2. Quality, Productivity, Impact

• The Hormel Institute has experienced rapid recent growth in the past three years.

• Since 2002 the Hormel Institute has grown from 50 staff to over 90 staff.

• National Institutes of Health (NIH) funding has tripled.

• This rapid growth continues as additional faculty are being recruited.

3. Uniqueness & Comparative Advantage

• The Hormel Institute has focused research on the most deadly disease; cancer.

• The potential of Hormel Institute research is non-toxic, natural alternatives to chemotherapy and novel approaches to cancer prevention.

• Our published and widely known research on green tea and ginger are only two examples of many more compounds that will help people prevent and treat cancer without the toxicity of chemotherapy.

4. Enhancement of Academic Synergies

• The Hormel Institute has a growing portfolio of impressive collaborators:– Mayo Clinic– University of Minnesota Cancer Center– University of Arizona– Rutgers University

• Our jointly sponsored symposia with the Mayo Clinic Cancer Center; Dietary Factors and Cancer Prevention and Targeting Carcinogenesis continue to inform the field of chemoprevention

Agricultural Biotechnology on Natural Compounds as Anti-Cancer Agents;

together we are initiating and coordinating systematic testing of

hundreds of dietary factors isolated from natural agricultural sources.

5. Demand and Resources

• Each additional staff position created at the Hormel Institute brings a high paying job to rural Minnesota.

• The commercialization of Hormel Institute discoveries will create additional economic development and improve the quality of life for Minnesotans and the quality of health for people throughout the world.

• Local economic development entities (Southern Minnesota Initiative Foundation, City of Austin and Development Corporation of Austin) understand our value and enthusiastically support the Hormel Institute.

Matt Kramer, Commissioner of Department of Employment and Economic Development

“I was amazed when I went down there what a jewel that facility is,” he said, “All along, the state’s bioscience initiative has focused on promoting Minnesota’s strengths. One of our strongest industries has been food manufacturing. What the Hormel Institute can do is show through their research that food compounds can play a critical role in disease management.”

Gene Goddard, bioscience industry specialist with the Minnesota Department of Employment and Economic Development

“What impresses me today is the open-mindedness of the researchers here.”

Congressman Gil Gutknecht

Senator Norm Coleman views cancer research at the Hormel Institute as “valuable and important

work” and sees the jobs created here as an example of his “Rural Renaissance.”

6. Efficiency & Effectiveness

There is a large return in the form of publications, grants, and intellectual property resulting from investments made in the Hormel Institute, University of Minnesota.

7. Development & Leveraging of Resources

• The Hormel Institute is the legacy of Jay C. Hormel, who intended that Hormel Institute conduct research in the biomedical sciences.

• The Hormel Foundation has faithfully supported the Hormel Institute since 1942.

• The Hormel Foundation is the majority shareholder of the Hormel Foods Company.

• The Hormel Foundation will become one of the world’s largest foundations supporting medical research in the coming decades.

Hormel Institute, University of Minnesota Outreach to Southern Minnesota

• Summer Undergraduate Research Experience Program (S.U.R.E.)

• Southern Minnesota Internet Group internet service provider to over 5,000 greater Minnesota customers. SMIG is endeavoring to provide wireless internet coverage for all of Austin. Wireless Austin would make Austin one of the few cities in the nation with city wide wireless access.

Keys to the Future The Hormel Institute’s aim is to build bridges

that effectively span the gap between basic laboratory research and clinical application.

Next Steps

–Meeting the needs created by our rapid expansion

–Achieving “critical mass” for our faculty and sections

“Jay Hormel would be very proud of the Institute if he were

alive today”

Mr. Richard KnowltonChairman, Hormel Foundation

On the occasion of the Hormel Institute’s

60th Anniversary Celebration

Questions and Answers

Zigang Dong, M.D., Dr.P.H.Executive Director

and Hormel-Knowlton ProfessorHormel Institute, University of Minnesota

801 16th Ave NEAustin, MN 55912

507-437-9600zgdong@hi.umn.edu

www.hi.umn.edu