Upload
buinhi
View
227
Download
1
Embed Size (px)
Citation preview
Next-Generation Accelerators
for Proton-Beam Therapy
Shmuel Eisenmann, PhD
Founder, CEO
Sagi Brink-Danan, MSc, MBA
VP, Business Development
Proprietary and Confidential Information
Not to be Reproduced or Distributed without Written Permission
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved.
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved. │ Page 2
Proprietary and Confidential
HIL develops breakthrough nano-tech, laser-based accelerator:
Cost reduction per room (<$12M)
Enables tapping full market potential
Cost limits adoption
~$40M per room <5% of market potential tapped
IN A NUTSHELL Proton therapy (PT) is superior to state of art X-rays
Sources: Hoppe BS et al, Int. J. Rad. Onc. Bio. Phys. 2012, Smith AR Med. Phys. 2009 and more
PT Market potential = $10B per year in US
Cost driven by old accelerator technology
HIL poses no clinical or regulatory risk!
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved. │ Page 3
Proprietary and Confidential
TEAM
Shmuel Eisenmann, PhD Founder, CEO
Prof. Arie Zigler, PhD Co-founder, Chief Scientist
Sagi Brink-Danan, MSc, MBA VP, Business Development
Guy Shinar, PhD, MBA Board Director
Judith Zilberstein, PhD Board Director
Alfred R. Smith, PhD Advisor
Zelig A. Tochner, MD Advisor
Morry Blumenfeld, PhD Advisor
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved. │ Page 4
Proprietary and Confidential
THERE IS A NEED FOR SAFER RADIATION THERAPY
“ Every X-ray beam I use puts most of the dose where I don’t want it. By contrast, proton beams put most of the dose in the tumor. ”
- Jerry Slater, MD - Loma Linda Univ. Medical Center
“ Because of the dose distributional advantages of proton beams, my judgment is that protons will replace photons for radical dose therapy within the next 2-3 decades. ”
- Herman Suit, MD - Massachusetts General Hospital
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved. │ Page 5
Proprietary and Confidential
X rays Protons
PROTONS SAFER THAN STATE-OF-ART X-RAYS
Up to 70% reduction in “dose bath” to healthy tissue
Sources: Hoppe BS et al, Int. J. Rad. Onc. Bio. Phys. 2012, Smith AR Med. Phys. 2009, ProCure site and more
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved. │ Page 6
Proprietary and Confidential
PT MARKET POTENTIAL IS ENORMOUS YET UNFULFILLED
Sources: Cancer Facts & Figures 2012, American Cancer Society
$10B/YR
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved. │ Page 7
Proprietary and Confidential
ONLY 35 PROTON FACILITIES WORLDWIDE
Sources: NAPT, PTCOG website 2012
“If they built one across the street, I wouldn’t worry about it.” James Cox, MD - M D Anderson Cancer Center
Japan 6 US 10
Europe 15
Asia 2
Africa 1
Under Development 31
Canada 1
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved. │ Page 8
Proprietary and Confidential
EXISTING PT IS NOT
COST-EFFECTIVE
Sources: AD Little Market Study (2008), Published industry data
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved. │ Page 9
Proprietary and Confidential
• Weight of equipment > 100 Tons • > 4m Concrete walls • $150-250M to build • $5-10M/year to operate
OLD ACCELERATOR TECH DRIVES PROHIBITIVE SIZE AND COST
Sources: AD Little Market Study (2008), Published industry data
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved. │ Page 10
Proprietary and Confidential
Sources: Personal communications, Published industry data
HIL’S TECH BREAKTHROUGH: ENABLING COST EFFECTIVE PT
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved. │ Page 11
Proprietary and Confidential
LASER ACCELERATOR TECHNOLOGY CAN MAKE A SMALL AND CHEAP PROTON THERAPY SOLUTION
Sources: R.A. Snavely et. al. Phys. Rev. Lett. 85 p.2945 (2000) , AIP Conference Proceedings, Volume 1024, pp. 275-300 (2008).
*Note: Gantry not drawn to scale; likely to be ~5m in diameter
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved. │ Page 12
Proprietary and Confidential
0.1
1
10
100
0.001 0.01 0.1 1 10 100 1000
Pro
ton
max
imal
En
erg
y [M
eV
]
Laser power on target [Twatt]
High Energy Protons
Terawatt Laser
Structured Target
USE OF CURRENTLY AVAILABLE COMMERCIAL LASER SYSTEMS WILL PRODUCE THERAPEUTIC LEVEL PROTON BEAMS
Commercially Available
Lasers
HIL SOLUTION: LASER ACCELERATOR
HIL’s Data PIC Simulation Others
COUPLING LASER TO NANO-TARGET
Copyright © 2010-12 HIL Applied Medical, Ltd. All rights reserved. │ Page 13
Proprietary and Confidential
THANK YOU!
Shmuel Eisenmann, PhD
Founder, CEO
(+)972-52-260-2128
Sagi Brink-Danan, MSc, MBA
VP, Business Development
(+)972-58-781-1808
(+)1-401-489-3009