Biochelllist.p I

HLSHemolymphatic Systems

Title. Hemoglobin J

'-.CQono,tooEo,Q-0,(I)V1V1

no3

~1"lr.~~':I.~~'])&fICIE NCy 'b"

. l~c""-h'."'. ( ~k... j<-~

-Gteo:ro..r~c.. 'P~v~[rAV\u..1 G6f>1l1~f.·tAtjKiclJ(e bCl.~fTroriC.J "r....ic..~cf- Ac;.i ~

'?o.rh 1MeJ; \-ev.•..a.~all\.

- 12c.le. 1> G b Pb ,;....R~Jg(uoJ (.~f(~

, ':> NAbPH. h'\-i-O'X.-iJo..",l-

t-Ie\>\"Z.. 1~>q~Q x.r......P ~b~llt\L f"'6k~->

~ re.,jid Cf- /1Ol\ekforn.t>.b(<<..

~~.,..

"if'b ~,.

f

3J.

---

II

SH SH SH@®-S-S@®-SH

,SH~®S_S~®~ SH' ~S Y', S

SH @c(3).SHS@®-SHSH@@-s-S-<1PC&S_S$®SH~® SH ~ SH

SH SHCross-linked hemoglobin

in Heinz bodies

'171II ':Severe

~,;'-f,;,III".r, \.~~{~oderate.'IV , None

<\~.',,:t;~~~'th;-:'/" ,

2- be",li-nA. ~ ~r~~.~brGt~ 1) Qdoi"'~

ed\ Bje f- ~k.. - cO - •• ••

~ 4 ~ Although the activity of the normal~(O" ('J"IM."""'"" enzyme declines <:isred cells age,

even the oldest cells have asufficient level of activity toprovide protection againstoxidative damage and hemolysis.

C~'4"1'< n•••.•~·.c)'-i.::A-'-_-I-:'::~:!.--4;..c1 ~ ht~"Jnc.an4.Mi" CJ{SH

0.eJ. \/ltricl"l;> C:J A -'(fI/'; <•• )

By contrast, very few G5PDMediterranean red cells havesufficient enzyme activity toprevent ox/dative damage, whereasa substantial fraction of youngG6PD A- red cells are ableto provide prOtection.

>

·-

HemoglDbin

~. Tren.I~lIonby rlbo.omet,elc.

--ElI __ -~-

~~~Individuals ·Silent"carrier

,.."Ii ~jO.1 $ ~A~~ ~~~.~ 1/ i.-.J(j 1,.-.4." •.•••.fr J-.J I.6:. <'"•.••:...

-----t.::_-~-

1-I4.J~.J$~#1Y/1".,;.••~(prj

-r- -- r___ ~f"--

P·-Pe.Ji$S~'':tmy" (,'.I

lif'

rvt'yYlClYj C~ .-cC - 1-It alb 5 S -e /nt'<:t --J~ o/deh'dV/

(3- f /Laid S5e/Y11 'q .4 -

_ ~~f- muialic3I1 e,;.. f.k. PO,.,.,'" lar_ mui-al:it)n ~ #.L /-,rt:rns!a!,'an ~~'h'd-r'OJ1 ~dt:rY1 .

_ Pf)wl- mtdabd>l ~ ~ P~-tJ.de.nY!lJliOI1*S!J114

. _ /YIulcdio>?s ~ 6!f,"C-'!!J nbmr'J'TUx//tL;,.lb t;~-If.$

_flbEf3 I, slr-tleflAt"J tJtM.d CflldnhiJ d(inorr71~7" 60/0 ~ '-:J/oPt# t4 mad£.

f!eT'ecf,'1C1:! p~rSi5;/dllaz.t/~/d 1fI(IfPF;j_;:;. CtflJ /,,,,14 f.Jn~K~ 116re-o: nd'utI--? ge.iJh