8/20/2019 Hematology Disease in Geriatric (25!01!2016)

http://slidepdf.com/reader/full/hematology-disease-in-geriatric-25012016 1/1

Basic concept aging :

a. Genetic processb. Somatic mutation error in transcription & translation processc. Immune system defect

d. Free radical

 cell destruction

Hematotogreal Disorder in Geriatric Patients :

1. Iron defe anemia2. Megaloblastic anemia3. !ronic lymp!ocytic leu"emia#. Multiple myeloma$. Myelodysplastic syndrome

Aging in Hematopetic system :

% Bone marro : dynamic elements% 'roduction & replication continuously% (ld age : in)olution of BM decrease of BM reser)e% ause : micro%en)eronmental

1. Iron Defe anemiaause : c!ronic blood%loss *mostly+

G , tract : ulcer- )arices- colorectal- malign.  rug */S/- 0S/I+

ects : decrease of or"ing capacity'redisposition to infection

2. Megaloblastic Anemiaa.  B12 defe & folat defe :

*gastrectomy- malabsorption- di)erticel- cro!nic disease-

lymp!oma- drugs etc.+

3. Le!emia

% /M, : 45 adult ageMedian age : $$ y.o

% Increase of incidens 6 age% 'roblem : % 'oor prognosis

 ,o remission rate*lo tolerance to c!emot7- infection etc+

#. "#ronic Lymp#ocytic Le!emia% ,, : most often found leu"emia in 8S/

$. Myelodysplastic $yndrome

% MS : abnormal proliferation of single clone in bon%marro% efects : maturation & proliferation% BM' : usually !ypercellular% 'erip!eral blood smear : cytopenia% linc : anemia- infection- bleeding% MS may progresses to acute ,eu"emia

%. Mltiple Myeloma% MM : malignant grot! of plasma cell% Median age : 92 y.o% /bnormal plasma cell secreting monoclonal