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Health & Social Care Research Strategy2015- 2020
Delivering Innovation through Research Scottish Government Health and Social Care Research Strategy
http://www.gov.scot/Publications/2015/10/5164
Why should Scotland do clinical research
• The ambition of this strategy is to increase the level of high-quality health research conducted in Scotland, for the health and financial benefits of our population, so that we are recognised globally as a leader in health science.
• Research central to ethos of evidence-based person-centred healthcare system
• Access to clinical trials for Scottish patients
• Inward investment
UK – wide comparison
• Office for National Statistics
• Scotland, 2013:– ~8.3% of UK– ~10% compared to
England
Academic Strengths
• 11.8% of UK health research expenditure in Scotland (UKCRC, 2015)
• Scotland has 8.3% of UK population
Territorial Health Boards
NWTCB3
CSO Annual Budget – approx. £68 m
NHS Research Scotland Support Budget - £44 mmeets the costs to the NHS of hosting and participating in clinical research
• NHS Support Costs• Excess Treatment Costs• Researcher Support Budget• Around 190 wte NHS posts (research nurses, data managers,
radiologists etc)• NRS Fellowship Scheme• Topic-specific research networks and specialty groups
Networks and Specialty Groups
• Supporting recruitment and delivery to studies is the primary goal• All eligible or commercial studies are supported
• Every eligible, commercial, (or NIHR adopted) study is the responsibility of at least one Network or SG
• Together, this ensures national oversight of all eligible studies within each specialty
NRS Performance Manager NRS Performance Manager NRS Performance Manager NRS Performance Manager
SurgeryI&EAnaesthesia
NRS Neurodegenera
tive Disease Network
NRS Diabetes Network
NRS Primary Care Network
NRS Paediatrics Network
NRS Stroke Network
NRS Mental Health Network
NRS Cancer Network
NRS CV Manager
NRS RH & C Manager
NRS MSK Manager
DermatologyLead
RespiratoryLead
HepatologyLead
CardiovascularChampion
Cancer ChampionPaediatricsChampion
StrokeChampion
Primary CareChampion
Mental HealthChampion
DiabetesChampion
MSKChampion
Infec’s D’ses & Microbi’y
Lead
RenalLead
Gastroen’yLead
Metabolic & Endocrine
Lead
Critical CareLead
Age & AgingLead
Oral & DentalLead
N-M haematologyLead
GeneticsLead
OphthalmologyLead
ENTLead
Reprod. H’th & Childbirth Champion
Dementia & ND Champion
NRS West NodeNHS Ayrshire & Arran, NHS Dumfries &
Galloway, NHS Greater Glasgow & Clyde, NHS Lanarkshire, NHS NWTCB
NRS North NodeNHS Grampian, NHS Highland, NHS Orkney,
NHS Shetland, NHS Western Isles,
NRS East NodeNHS Fife, NHS Forth Valley, NHS Tayside
NRS South East NodeNHS Borders, NHS Lothian
NRS Champions
NRS Research leads
NRS Nodal Delivery Infrastructure
Revised Structure
What is SHARE?• A register of people aged 16 or over and
living in Scotland who have said they are interested in helping with medical research.
• They give permission to for the NHS to check their Datasets to see if they may be suitable for research projects.
• 90,000 signed up as of last Wednesday• Extend to NHS staff using NHS patient
records solely to advise GP’s and hospital consultants of studies that may be of interest to their patients?
• Proposed amendments to EU Data Protection Regulations?
Annual Budget – approx. £68 m
UK Research Contribution - £7.7 m
Allows Scottish-based researchers to apply for NIHR research grants
NETSCC programme eligibility
Researchers in Scotland can be principle applicants to NETSCC programmes (*can be co-applicants to all)
Programme Commissioned stream
Researcher-led stream
Themed calls
EME Y Y Y
HTA Y Y Y
PHR Y Y Y
HS&DR N* Y Y
CSO Strategic Priorities
• Maximise Scottish success in NETSCC schemesPositioning of ETM and HSP committees accordingly
• Address Scottish Government policy driven research needs
• Target funding through collaborations and/or specific initiatives
Operational Priorities
• More efficient processes – allow CSO to do more with same resource
Research Funding
Outline of CSO grant schemes
• Catalytic research grants • Response mode research grants• Themed research calls directed to – special initiatives around emerging opportunities– Scottish Government policy priorities
• Clinical research fellowships• Charity co-funding initiatives
Catalytic research grants
Launch 1st February 2016
ObjectiveApplications are strengthened by supporting evidence of feasibility or proof of principle. To support successful applications to other funders, small grants for work to provide supporting evidence / groundwork for applications for health research to other funders.
Characteristics Small (≤ £35k, no FEC) and short (≤ 6 months duration) projectQuick decision based on short application Broad scope (e.g. survey, focus group, consensus-forming meeting, analysis, testing samples, acceptability/feasibility study, audit) but adhering to usual research governance requirements Applicant must demonstrate potential utility to support application to another funder for health research (across CSO committee remit) No deadline – applications submitted at anytime (but may close scheme during year depending on budget) - Usual CSO eligibility requirements
ExcludesStand-alone work with no firm plan for follow on application. Work to support applications to CSO
Catalytic research grants
ProcessShort application (<4 pages): applicant details, context and why work is needed, utility to support grant to other funder, details of funder and scheme, work plan, resource justificationSubmitted through research officeReviewed by CSO +/- external peer-review with decision within 1 month
OutputShort report describing what was done, why and the next steps, financial reconciliation.1 year CSO follow up after completion to establish outcome.
CSO research funding committees
• 2 committees – each 2x per year – up to 4 projects funded per meeting
• Funding limit raised to £300,000 per application (80% full economic cost)
Remit
• Health Services / Public Health
• Translational Medicine
Eligibility
• Scottish-based PI / CI• Research must be of relevance to health / well-being of Scottish population
Response Mode Grants
Translational Clinical Studies Research Committee
• The Committee considers applications for research aimed at improving treatments and / or diagnostic approaches for conditions of clinical importance to the population of Scotland.
• Applications must demonstrate the clinical relevance of the research and its potential for translation into clinical practice. Applications that seek to address questions of clinical importance in small patient groups (e.g. rare diseases) are welcomed.
Health Improvement, Protection and
Services Research Committee
• The Committee considers applications for research aimed at improving or protecting population health or improving the quality, safety and/or effectiveness of healthcare in Scotland.
• Applications must demonstrate the relevance and importance of the research and its potential for significant impact on health in Scotland. A clear pathway for translation of the results into policy and/or practice must be presented.
Process changes
Initial 4 page synopsis – scored against set criteria by committee members
Reject – feedback provided
Proceed to full application – around 12-15 per round
Revised full application form• More clearly defined translational focus• Why CSO and not NETSCC / Research Council /
Medical Research Charity• Emphasis on applicants to identify external reviewers
Response Mode Grants
Common pitfalls
• Proposals that are well written / scientifically sound without addressing an issue of clinical importance unlikely to be funded
• Put together strong team of CoI’s – multidisciplinary / multicentre
• Don’t try and “squeeze” a larger research proposal into the £300K limit - CSO contributes ~ £8 million per year to allow Scottish access to NIHR programmes
• Engage with NHS R&D / University Research Office early
Collaborative funding with medical research charities• Alzheimer’s Research UK – research project
• Prostate Cancer UK – research project
• Action Duchenne / M.D.UK – clinical fellowship
• MND Assoc. / MND Scotland – clinical fellowship
• Scottish Huntington’s Assoc. (with RS Macdonald Trust) – academic fellowship
• Stroke Association – Research Project and Senior Clinical Lectureship
• Breast Cancer Now – research project
• Pancreatic Cancer UK – research project - 2 call now live
• Marie-Curie – research project – up to £450K
• Action Medical Research – 2 x research projects – up to £200K each
• Wellbeing of Women – research project – up to £200K
• British Lung Foundation – research project – up to £300K
• Arthritis Research UK – research project – pre-call
• Progressive Supranuclear Palsy Association – clinical fellowship
Research Fellowships
Clinical Academic Fellowships• Applications through host institution• Typically completed NTN• 3 year duration – PhD• CSO covers salary, PhD fees, £10K per year consumables• 2015 round closed – rolling programme of charity co-funded fellowships
Scottish Senior Clinical Fellowship Scheme• Five years of “protected” time in which to develop an internationally
competitive research programme• Five years of support for a research assistant (@ £35k pa total salary costs),
research consumables (@ £23k pa), and £60k to contribute to the costs of one PhD student over the 5 year period.
• Closing date for next round Feb/Mar 2016
