3
Maturitas 78 (2014) 8–10 Contents lists available at ScienceDirect Maturitas jou rn al hom ep age: www.elsevier.com/locate/maturitas Review Health benefits of encore careers for baby boomers Anya Topiwala, Shivani Patel, Klaus P. Ebmeier Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK a r t i c l e i n f o Article history: Received 6 February 2014 Accepted 10 February 2014 Keywords: Retirement Pension Dementia Depression a b s t r a c t Baby boomers now represent an aging population group at risk of the diseases of older age. Their relatively high education, amongst other attributes, means that they can make a significant contribution to the work force beyond the statutory retirement age. On an individual level, potential health benefits may motivate them to pursue encore careers. We review some of the evidence supporting such a trend. © 2014 Elsevier Ireland Ltd. All rights reserved. Contents 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. Health benefits of occupation on psychiatric morbidity and mortality . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.1. Depression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.2. Cognitive impairment and dementia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. Mortality . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 4. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Competing interest . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Funding . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Provenance and peer review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 1. Introduction The great population bulge of the 50–68 year olds (the “baby boomers”), has caused some anxiety to policy makers, as the pension-paying younger generations are getting smaller and smaller, and already need to be supplemented in many West- ern countries by younger overseas immigrants and their children. UK projections estimate that baby boomers will live on average another 15.8–20.9 years [1]. They will thus represent a substan- tial section of the population (26% in the US) [2]. Yet in the UK, median retirement age is 64.6 for men, and 62.3 years for women, respectively [3]. Public health focus has been on the risk of illnesses common after retirement, such as depression (point prevalence of Corresponding author. Tel.: +44 1865 226469; fax: +44 1865 793101. E-mail address: [email protected] (K.P. Ebmeier). 4.6–9.3% in >75 year olds) [4] and dementia (5.9–7.0% of >65 year olds) [5]. While pension ages are being increased to catch up grad- ually with the projected budget deficits, the question arises, if this may not confer benefits on this generation, rather than just repre- senting an economic sacrifice to be made. Certainly, baby boomers are well placed to work on a paid or voluntary basis into older age. US statistics show that as a group they are better educated (28.8% have at least a bachelor’s degree), are more likely to be employed (74.1%) and wealthier (only 8.9% in poverty) than are any other age strata of the population [2]. 2. Health benefits of occupation on psychiatric morbidity and mortality 2.1. Depression Prolonged unemployment accounts for a proportion of depres- sion across adult age groups [6–8]. Unemployed, but also part-time http://dx.doi.org/10.1016/j.maturitas.2014.02.005 0378-5122/© 2014 Elsevier Ireland Ltd. All rights reserved.

Health benefits of encore careers for baby boomers

  • Upload
    klaus-p

  • View
    212

  • Download
    0

Embed Size (px)

Citation preview

R

H

AD

a

ARA

KRPDD

C

1

“tseUatmrc

h0

Maturitas 78 (2014) 8–10

Contents lists available at ScienceDirect

Maturitas

jou rn al hom ep age: www.elsev ier .com/ locate /matur i tas

eview

ealth benefits of encore careers for baby boomers

nya Topiwala, Shivani Patel, Klaus P. Ebmeier ∗

epartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK

r t i c l e i n f o

rticle history:eceived 6 February 2014

a b s t r a c t

Baby boomers now represent an aging population group at risk of the diseases of older age. Their relativelyhigh education, amongst other attributes, means that they can make a significant contribution to the work

ccepted 10 February 2014

eywords:etirementensionementiaepression

force beyond the statutory retirement age. On an individual level, potential health benefits may motivatethem to pursue encore careers. We review some of the evidence supporting such a trend.

© 2014 Elsevier Ireland Ltd. All rights reserved.

ontents

1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82. Health benefits of occupation on psychiatric morbidity and mortality . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

2.1. Depression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82.2. Cognitive impairment and dementia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

3. Mortality . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9Competing interest . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

Funding . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9Provenance and peer review. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

. Introduction

The great population bulge of the 50–68 year olds (thebaby boomers”), has caused some anxiety to policy makers, ashe pension-paying younger generations are getting smaller andmaller, and already need to be supplemented in many West-rn countries by younger overseas immigrants and their children.K projections estimate that baby boomers will live on averagenother 15.8–20.9 years [1]. They will thus represent a substan-

4.6–9.3% in >75 year olds) [4] and dementia (5.9–7.0% of >65 yearolds) [5]. While pension ages are being increased to catch up grad-ually with the projected budget deficits, the question arises, if thismay not confer benefits on this generation, rather than just repre-senting an economic sacrifice to be made. Certainly, baby boomersare well placed to work on a paid or voluntary basis into older age.US statistics show that as a group they are better educated (28.8%have at least a bachelor’s degree), are more likely to be employed(74.1%) and wealthier (only 8.9% in poverty) than are any other agestrata of the population [2].

ial section of the population (26% in the US) [2]. Yet in the UK,

edian retirement age is 64.6 for men, and 62.3 years for women,espectively [3]. Public health focus has been on the risk of illnessesommon after retirement, such as depression (point prevalence of

∗ Corresponding author. Tel.: +44 1865 226469; fax: +44 1865 793101.E-mail address: [email protected] (K.P. Ebmeier).

ttp://dx.doi.org/10.1016/j.maturitas.2014.02.005378-5122/© 2014 Elsevier Ireland Ltd. All rights reserved.

2. Health benefits of occupation on psychiatric morbidityand mortality

2.1. Depression

Prolonged unemployment accounts for a proportion of depres-sion across adult age groups [6–8]. Unemployed, but also part-time

aturi

ailstardSsaawrcaamapwicgmw

2

trdth[

lewmhd

aac[td

iida

wlp

3

m4

A. Topiwala et al. / M

nd retired workers are more likely to be depressed than thosen full-time work [6]. In many cases it may be difficult to estab-ish whether unemployment led to depression or vice versa, butome studies have claimed that unemployment is causally relatedo depression [9,10]. Loss of regular income has been identified as

critical factor contributing toward depressive symptoms. Men atetirement age, who were working for pay, were less likely to beepressed than men who were not being paid for their work [11].imilarly, the low-income unemployed suffer most with depres-ion, further supporting the idea that loss of financial security is

critical factor [12]. Regularity of work has also been identifieds important in reducing reported depressive symptoms. Full-timeorkers, compared with ‘non-standard’ or temporary workers,

eported fewer depressive symptoms, even after adjusting for edu-ation, occupational class and income [13]. This suggests that inddition to providing a livelihood, paid employment gives workers

sense of purpose and self-worth that is removed with retire-ent. Social isolation (particularly the size of the social network

nd subjective social support) has been identified as important inredicting depression in the elderly retired population [14]. Thoseho engage in fewer social activities have a significantly higher

ncidence of depression [15]. Social support appears relevant tohronicity of major depressive illness more than its severity [16]. Asoing to work is the main form of social interaction for many, retire-ent may thus predispose older individuals toward depression,hich would be mitigated by an encore career.

.2. Cognitive impairment and dementia

A number of studies have demonstrated a link between high life-ime occupational attainment (i.e. non-manual/white collar) and aeduced incidence of all cause [17], vascular [18], and Parkinson’sisease dementia [19]. Duration of employment may determinehe strength of such associations [18]. Additionally, one study hasinted at a negative impact of retirement upon cognitive function20].

No study has to date examined the association between laterife careers and dementia risk. However, it seems reasonable toxtrapolate from studies of mental activity and social interaction,hich would be components of the majority of encore careers. Aeta-analysis in 2004 concluded that social and mental activities

ave a beneficial effect on cognition and a protective effect againstementia [21].

Longitudinal studies associate cognitively stimulating leisurectivities (one can argue for a similarity with mental work) with

decreased risk of dementia [22], Alzheimer’s disease [23], vas-ular dementia [24], as well as with a later age of dementia onset25]. Similarly, the majority of studies have shown reduced cogni-ive decline with increasing leisure activity [26]. Such activities areiverse and include computer use [22], odd jobs and knitting [27].

The majority (10/12) of longitudinal studies have shown thatncreased social interaction is associated with reduced dementiancidence [28] or later onset [25]. Similarly, 17 of 18 studies haveemonstrated a significant correlation between increased socialctivity and reduced cognitive decline [29].

Of course, one must make causal interpretations in such studiesith care. The vast majority of participants were >65 years at base-

ine, hence decreased mental or social activity may be the result ofre-existing subtle cognitive impairments.

. Mortality

There is a substantial evidence base suggesting that unemploy-ent in middle age increases mortality. In one prospective study of

0–59 year olds, those unemployed in the five years after screening

tas 78 (2014) 8–10 9

had approximately double the risk of dying (from cardiovasculardisease or cancer) compared with those continuously employed,even after adjustment for multiple confounders [30]. However, therelationship between employment and mortality is likely to becomplicated, and one cannot necessarily extrapolate that encorecareers would decrease mortality. Temporary (rather than per-manent) employment may actually increase mortality [31] – therelationship between total working hours and mortality may actu-ally be u-shaped [32].

Correspondingly, several studies have found mortality is higheramongst those retiring early (<65 years) [33], although this asso-ciation may be confounded by those retiring early on grounds ofill health. Following adjustment for this, early retirees spent fewerdays in hospital in the preceding two years and had no change inmortality [34].

One can make a compelling argument that encore careers maydecrease suicides in baby boomers. Unemployment [35], retire-ment [36], and a restricted social network [37] are all risk factors forelderly suicide. A meta-analysis found that having a hobby or activeparticipation in an organization decreased the risk of suicide in >65year olds (although this was not significant following adjustmentfor life events, psychosocial variables and mental health) [38].

4. Conclusions

Baby boomers now represent an aging population and are atrisk from debilitating diseases of older age. Their relatively higheducation, amongst other attributes, means that they could makea significant contribution to the work force beyond the statutoryretirement age. On an individual level, potential health benefitsmay motivate them to pursue encore careers. Mental and socialactivities seem to decrease the risk of dementia; employment,income and social contact decrease the risk of depression; and mor-tality (particularly from suicide) is decreased by employment andsocial contact. Depression, dementia or lethal morbidity may ofcourse result in early retirement rather than vice versa. However,physical and mental activity seems to improve mood and cognitiveperformance supporting the argument that employment confers abeneficial impact on health [39,40].

Contributors

All authors were involved in the first draft (part) and full revisionof the manuscript.

Competing interest

Anya Topiwala and Shivani Patel both declared no competinginterest and Klaus P. Ebmeier reports consultation fees receivedfrom Lily in relation to Amyvid TM.

Funding

Anya Topiwala – UK Medical Research Council (G1001354) –Clinical Lecturer.

Shivani Patel – North East Thames Foundation School.Klaus P. Ebmeier – UK Medical Research Council (G1001354),

the Gordon Edward Small’s Charitable Trust (SC008962), and theHDH Wills 1965 Charitable Trust.

Provenance and peer review

Commissioned and externally peer reviewed.

1 aturi

R

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

[

0 A. Topiwala et al. / M

eferences

[1] Office for National Statistics. Life expectancy at birth and at age 65 for local areasin England and Wales, 2010–2012; 2013. Available from: http://www.ons.gov.uk/ons/rel/subnational-health4/life-expectancy-at-birth-and-at-age-65-by-local-areas-in-england-and-wales/2010-12/stb-life-expectancy-at-birth-2010-12.html

[2] United States Census Bureau. American Community Survey Fact Finder. Amer-ican Community Survey [Internet]; 2006. Available from: http://factfinder2.census.gov/

[3] Office for National Statistics. Pension trends; 2012 [chapters 2–4] Availablefrom: www.ons.gov.uk/ons/about-ons/our-statistics/publications/pension-trends/index.html

[4] Meeks TW, Vahia IV, Lavretsky H, Kulkarni G, Jeste DV. A tune in a minor“can b major”: a review of epidemiology, illness course, and public healthimplications of subthreshold depression in older adults. J Affect Disord2011;129(1–3):126–42.

[5] Matthews FE, Arthur A, Barnes LE, et al. A two-decade comparison of prevalenceof dementia in individuals aged 65 years and older from three geographicalareas of England: results of the Cognitive Function and Ageing Study I and II.Lancet 2013;382(9902):1405–12.

[6] Mirowsky J, Ross CE. Age and depression. J Health Soc Behav1992;33(3):187–205, discussion 6-12.

[7] Christ SL, Lee DJ, Fleming LE, et al. Employment and occupation effects ondepressive symptoms in older Americans: does working past age 65 protectagainst depression? J Gerontol B: Psychol Sci Soc Sci 2007;62(6):S399–403.

[8] Villamil E, Huppert FA, Melzer D. Low prevalence of depression and anxiety islinked to statutory retirement ages rather than personal work exit: a nationalsurvey. Psychol Med 2006;36(7):999–1009.

[9] Montgomery SM, Cook DG, Bartley MJ, Wadsworth ME. Unemployment pre-dates symptoms of depression and anxiety resulting in medical consultation inyoung men. Int J Epidemiol 1999;28(1):95–100.

10] Dooley D, Catalano R, Wilson G. Depression and unemployment: panel find-ings from the Epidemiologic Catchment Area study. Am J Community Psychol1994;22(6):745–65.

11] Butterworth P, Gill SC, Rodgers B, Anstey KJ, Villamil E, Melzer D. Retirementand mental health: analysis of the Australian national survey of mental healthand well-being. Soc Sci Med 2006;62(5):1179–91.

12] D’Arcy C, Siddique CM. Unemployment and health: an analysis of “CanadaHealth Survey” data. Int J Health Serv 1985;15(4):609–35.

13] Kim IH, Muntaner C, Khang YH, Paek D, Cho SI. The relationship between non-standard working and mental health in a representative sample of the SouthKorean population. Soc Sci Med 2006;63(3):566–74.

14] George LK, Blazer DG, Hughes DC, Fowler N. Social support and the outcome ofmajor depression. Br J Psychiatry 1989;154:478–85.

15] Yamashita K, Kobayashi S, Yamaguchi S, et al. Feelings of well-being and depres-sion in relation to social activity in normal elderly people. Nihon Ronen IgakkaiZasshi 1993;30(8):693–7.

16] Hays JC, Krishnan KR, George LK, Pieper CF, Flint EP, Blazer DG. Psychoso-cial and physical correlates of chronic depression. Psychiatry Res 1997;72(3):149–59.

17] Stern Y, Gurland B, Tatemichi TK, Tang MX, Wilder D, Mayeux R. Influence of

education and occupation on the incidence of Alzheimer’s disease. J Am MedAssoc 1994;271(13):1004–10.

18] Kroger E, Andel R, Lindsay J, Benounissa Z, Verreault R, Laurin D. Is complexityof work associated with risk of dementia? The Canadian Study of Health AndAging. Am J Epidemiol 2008;167(7):820–30.

[

[

tas 78 (2014) 8–10

19] Helmer C, Letenneur L, Rouch I, et al. Occupation during life and risk of demen-tia in French elderly community residents. J Neurol Neurosurg Psychiatry2001;71(3):303–9.

20] Roberts BA, Fuhrer R, Marmot M, Richards M. Does retirement influence cog-nitive performance? The Whitehall II Study. J Epidemiol Community Health2011;65(11):958–63.

21] Fratiglioni L, Paillard-Borg S, Winblad B. An active and socially inte-grated lifestyle in late life might protect against dementia. Lancet Neurol2004;3(6):343–53.

22] Almeida OP, Yeap BB, Alfonso H, Hankey GJ, Flicker L, Norman PE. Older menwho use computers have lower risk of dementia. PLoS ONE 2012;7(8):e44239.

23] Akbaraly TN, Portet F, Fustinoni S, et al. Leisure activities and the riskof dementia in the elderly: results from the Three-City Study. Neurology2009;73(11):854–61.

24] Verghese J, Cuiling W, Katz MJ, Sanders A, Lipton RB. Leisure activities and riskof vascular cognitive impairment in older adults. J Geriatr Psychiatry Neurol2009;22(2):110–8.

25] Paillard-Borg S, Fratiglioni L, Xu W, Winblad B, Wang HX. An active lifestylepostpones dementia onset by more than one year in very old adults. JAlzheimers Dis 2012;31(4):835–42.

26] Wang HX, Jin Y, Hendrie HC, et al. Late life leisure activities and risk of cognitivedecline. J Gerontol A: Biol Sci Med Sci 2013;68(2):205–13.

27] Fabrigoule C, Letenneur L, Dartigues JF, Zarrouk M, Commenges D, Barberger-Gateau P. Social and leisure activities and risk of dementia: a prospectivelongitudinal study. J Am Geriatr Soc 1995;43(5):485–90.

28] Crooks VC, Lubben J, Petitti DB, Little D, Chiu V. Social network, cognitivefunction, and dementia incidence among elderly women. Am J Public Health2008;98(7):1221–7.

29] James BD, Wilson RS, Barnes LL, Bennett DA. Late-life social activity and cogni-tive decline in old age. J Int Neuropsychol Soc 2011;17(6):998–1005.

30] Morris JK, Cook DG, Shaper AG. Loss of employment and mortality. Br Med J1994;308(6937):1135–9.

31] Kivimaki M, Vahtera J, Virtanen M, Elovainio M, Pentti J, Ferrie JE. Temporaryemployment and risk of overall and cause-specific mortality. Am J Epidemiol2003;158(7):663–8.

32] Sokejima S, Kagamimori S. Working hours as a risk factor for acute myocardialinfarction in Japan: case–control study. Br Med J 1998;317(7161):775–80.

33] Tsai SP, Wendt JK, Donnelly RP, de Jong G, Ahmed FS. Age at retirement and longterm survival of an industrial population: prospective cohort study. Br Med J2005;331(7523):995.

34] Brockmann H, Muller R, Helmert U. Time to retire–time to die? A prospectivecohort study of the effects of early retirement on long-term survival. Soc SciMed 2009;69(2):160–4.

35] Voss M, Nylen L, Floderus B, Diderichsen F, Terry PD. Unemployment and earlycause-specific mortality: a study based on the Swedish twin registry. Am JPublic Health 2004;94(12):2155–61.

36] Qin P, Agerbo E, Westergard-Nielsen N, Eriksson T, Mortensen PB. Gender differ-ences in risk factors for suicide in Denmark. Br J Psychiatry 2000;177:546–50.

37] Beautrais AL. A case control study of suicide and attempted suicide in olderadults. Suicide Life Threat Behav 2002;32(1):1–9.

38] Rubenowitz E, Waern M, Wilhelmson K, Allebeck P. Life events and psy-chosocial factors in elderly suicides—a case–control study. Psychol Med

2001;31(7):1193–202.

39] Valkanova V, Eguia Rodriguez R, Ebmeier KP. Mind over matter – what do weknow about neuroplasticity in adults? Int Psychogeriatr 2014:1–19.

40] Behrman S, Ebmeier KP. Can exercise prevent cognitive decline? Practitioner2014;258(1767):17–21.