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SYNTHESIS OF PYRAZOLE DERIVATIVES OF
NAPHTHYL
PROPIOPHENONES AS POTENTIAL
CYTOTOXIC AGENTS AND
CHEMICAL INVESTIGATION OF PIPER
ATTENUATUM
GURINDERDEEP SINGH
REGISTRATION NO: 80404446001
B.PHARM
I.S.F. COLLEGE OF PHARMACY
MOGA
THESIS
SUBMITTED IN PARTIAL FULFILMENT OF THE REQUIREMENTS
FOR THE DEGREE OF
MASTER OF PHARMACY IN PHARMACEUTICAL CHEMISTRY
OF THE
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PUNJAB TECHNICAL UNIVERSITY
JALANDHAR
JULY, 2010
DEDICATED
TO MY
BELOVED PARENTS
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CONTENTSPAGE NUMBER
I. Certificate
II. Acknowledgement
III. Abbreviations
Part-1 Synthesis of pyrazole derivatives of naphthyl propiophenones as potential
cytotoxic agents
1.1Introduction.1
1.2 Aim of work...12
1.3 Results andDiscussion.....15
1.4 Experimental Work..31
Part-2
Chemical investigation of Piper Attenuatum
2.1Introduction..34
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2.2 Review of literature....38
2.3 Aim of work...49
2.4 Results andDiscussion..51
2.5Experimental
...53
2.6Bibliography..58
Part 3
3.1Abbreviations
..67
3.2 Generalremarks...68
CERTIFICATE
This is to certify that the work reported in the thesis entitled Synthesis of
pyrazole derivatives of naphthyl propiophenones as potential cytotoxic
agents and Chemical investigation ofPiper Attenuatumhas been carried out
by Mr. Gurinderdeep Singh himself under our supervision at ISF College of
Pharmacy , Moga,Punjab(India)during the academic session 2009-2010. The
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work reported in the thesis has not been submitted for the award of any other
degree.
Supervisor Co-Supervisor
Dr. K. L. Dhar Mr Kunal Nepali
Head of Department Lecturer
Pharmaceutical chemistry ISF College of Pharmacy
ISF College of Pharmacy Moga-142001(INDIA)
Moga-142001(INDIA)
Forwarded by:
Supervisor
Dr. T. R. Bhardwaj Dr. K. L. Dhar
Director, PG Studies Head of Department
ISF College of Pharmacy Pharmaceutical Chemistry
Moga-142001(INDIA) ISF College of Pharmacy
Moga-142001(INDIA)
DECLARATION
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I hereby declare that the work reported in the thesis entitled SYNTHESIS OF
PYRAZOLE DERIVATIVES OF NAPHTHYL PROPIOPHENONES AS
POTENTIAL CYTOTOXICAGENTS AND CHEMICAL INVESTIGATION
OF PIPER ATTENUATUM. has been carried out by me under the joint
supervision of Prof. K.L. Dhar and Mr. Kunal Nepali at I.S.F. College of
Pharmacy, Moga, Punjab (India) during the academic session 2009-2010.The
work reported in the thesis has not been submitted for the award of any other
degree.
Place: Moga Gurinderdeep Singh
Date:
Acknowledgement
A journey is easier when you travel together. Interdependence is
certainly more valuable than independence. It gives me immense
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pleasure to acknowledge with gratitude, the help and guidance
rendered to me by a lot of people.
I feel great pleasure in expressing my profound indebtedness to Mr.
Parveen Garg, Chairman, ISF college of Pharmacy for giving me an
opportunity to work in their esteemed institute.
I wish to express my profound sense of respect and gratitude to my
guide Dr. K. L. Dhar, Scintific advisor, Professor and head of
department of Pharmaceutical chemistry, ISF College of Pharmacy,
Moga, and for his keen interest, invaluable guidance, untiring efforts,
and constant encouragement during the course of present
investigation. Their affection and guidance is something I will cherish
all my life.
I also owe thanks to Dr. O. P. Suri and to my co-guide Mr. kunal
nepali for their affectionate encouragement and untiring efforts to
develop independent thinking in me.
My cordial wishes and thanks to Dr. G. S. Sarma, Dr. Manish
Gupta, Dr. Rajkumar,Dr. Vikramdeep monga,Mr. Mukunda S
Bande andMrs. Shilpi,Mr. Sameer Sapra and Mr. Sunil Yadav
for their time to time help in lab.
I am also thankful to lab technicians and non teaching staff of the
college.
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I Am Also Thankful to All My Classmates for Their Help, Care,
Encouragement and Moral Support during My Training .My feelings
towards my parents and my Sisterare to be felt to be believed. I
extend my heartiest gratitude to them for their constant cooperation
and guidance during this work, because without their sincerity, power
of their blessings and warmth of their love, the completion of this work
would have remained a distant dream.
Gurinderdeep
Singh
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Part-1
SYNTHESIS OF PYRAZOLE DERIVATIVES OF NAPHTHYL
PROPIOPHENONES AS POTENTIAL CYTOTOXIC AGENTS
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1.1Introduction
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1.2 Aim of work
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1.3 Results and
Discussion
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1.4 Experimental
Work
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Part-2
CHEMICAL INVESTIGATION OF PIPER ATTENUATUM
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2.1
Introduction
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2.2 Review of
Literature
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2.3 Aim of work
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2.4 Results and
Discussion
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2.5 ExperimentalWork
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2.6 Bibliography
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Part-3
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3.1 Abbreviations
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3.2 General Remarks
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