©2012, Genentech ©2012, Genentech

Green BioPharma: Innovative

Medicines from Sustainable Labs Kristi Budzinski, PhD

Monday, May 19, 2014

©2012, Genentech ©2012, Genentech

Genentech Introduction

Green BioPharma Program

Green Lab Assessments

Findings

Greening the Culture

©2012, Genentech

Genentech Background

Founder of biotechnology industry

Mission: Our goal is to use the power of genetic engineering and advanced

technologies to make medicines that address unmet medical needs, and help millions

of people worldwide. Our commitment to sustainable development respects the

needs of the individual, the society, and the environment.

South San Francisco Headquarters

• 15,000 employees support entire value chain

• Additional manufacturing sites in Vacaville

and Oceanside, CA

Member of Roche Group since 2009

• Robust GNE/Roche clinical development pipeline

• 37 marketed products

• 45 NMEs in clinical trials

• Increased emphasis on corporate

environmental sustainability

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©2012, Genentech

Corporate Sustainability Goals

11% 10% 50%

SSF Site goals by 2014

20 % energy, water,

and waste reductions

in just 2 years

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Governance Structure 5

©2012, Genentech

Mission Statement:

• To increase our colleagues’ knowledge and awareness of sustainability

• To provide a forum to generate, exchange, and evaluate sustainability ideas to improve the environmental performance of Genentech's operations, our communities, and our homes

• And to have fun while leading by example in our industry.

Employee Engagement

Grass roots: 2500 members and growing, formed 2002.

6

More green genes members means more

environmentally-conscious scientists!

©2012, Genentech

Environmental Impact of Labs 7

Square foot allocation by area Energy usage by area Total -20/ULT

Freezers

HEEPI July 2011 Detailed results from S-Lab audits

Category Life

Science Chemistry

Office

space

HVAC-related 46% 60% 3%

Space/water

heating 20% 20% 74%

Equipment/

small power 25% 15% 12%

Lighting 10% 5% 11%

Lower campus 321

FRC I & II 482

B27

Freezer farm 170

South campus 482

©2012, Genentech

Sustainability: From the Office to the Lab

Creation of Green BioPharma Program

‒ Inspired by Green Chemistry

‒ Focuses on our core competencies

‒ Develop tools and metrics to influence behavior and decision-

making

Foundations

‒ Scientifically defensible and data driven

‒ Sustainable business process

‒ Engage employees

‒ Encourage innovation

Cross-functional governance structure

‒ Enable leaders to do what’s best for the company and sustainability

‒ Use metrics to drive implementation and build leadership support

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©2012, Genentech

Definition and Vision

Definition

Green BioPharma is the design, development, and

implementation of biological and chemical products and

processes that reduce or eliminate the use and generation of

substances hazardous to human health and the environment.

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Vision

• Customers, business partners, and the community regard Genentech as

a leader in efforts that reduce its ecological footprint resulting from

its core competencies.

• Employees continuously innovate, evaluate, and implement ways to

reduce the environmental impact of their decisions and operations.

• Wherever possible, the result of green innovations are quantified.

Green BioPharma forges the bridge between patients, people and

the environment.

©2012, Genentech

Green BioPharma @ GNE: a short timeline

~2009 • Roche Technical Working Group on Green Chemistry established

• 1-2 GNE process chemists involved

• Sponsors lectures and annual process chemistry contest

• Limited exposure to rest of company

Fall 2011 • Green Genes lunch and learn talks by Green Chemistry scientists at UCB

• Great response from employees

• Created a Green Genes subteam

• Launched the Green BioPharma Program

• Hired a Green BioPharma Project Manager

• Established Green BioPharma Steering Committee, as part of Sustainability Council

2012 • Steering Committee endorsed 2012 goals and projects

• Green Genes Subteam ~130 volunteers

2013 • Published a video on this effort

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©2012, Genentech

Green BioPharma Steering Committee

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Objectives:

1. Recommend SSF Green

BioPharma projects

2. Provide project guidance

and prioritization

3. Promote employee

innovation in lab and

manufacturing areas

4. Develop and report

performance metrics to

stakeholders

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©2012, Genentech

Strategic Focus Areas 12

Institutionalize Programs

Engage Leadership and Employees

• Behaviors, decision-making

Develop and Deploy Tools/ Metrics

• Educate stakeholders

• Drive performance

Manage Supply Chain and End-of-

Life

• Streamline procurement and waste decisions

Collaborate with Vendors

• Promote innovation

• Drive higher value services

• Greener products

©2012, Genentech

Green Genes Sub-team

Socialize initiatives within labs

Green Chemistry lecture series

Green Product Lunch and Learns

Test greener products, share data

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Green Chemistry Task force

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Raising Impact Awareness

©2012, Genentech

Green Lab Assessments

Purpose:

1. Collect baseline data on the environmental footprint of different types of laboratories at Genentech

i. Examples: chemistry, molecular biology, quality control, DNA sequencing

2. Engage employees to effect personal or behavioral change through data collection and sharing.

Method:

1. Identify candidate laboratories

2. Present process at group meeting i. Establish lab champion as single point-of-contact

3. Perform assessment and collect data

4. Report feedback with follow-up action items

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©2012, Genentech

Lab Assessment: The Approach

Impact categories

• Energy usage

• Cold storage

• Waste streams

• Purchasing

5/19/2014

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Energy Results for Bench-top Equipment

Centrifuges (9/lab)

Cooled centrifuges (2/lab)

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Vortexers (5/lab) Shakers (2/lab)

Thermomixer or heat block (2/lab) Pipet aides (1pp)

VS

EquipmentAverage

power (W)

Typical

usage

(hrs/yr)

Energy

consumption per

unit (kWh/yr)

# units per

lab

Est. total energy

consumed by lab

(kwH/yr)

Estimated Cost

per unit

($/yr)

Estimated Cost

per lab

($/yr)

Water bath @37C5 8760 42 2 84 $11.76 $23.52

CO2 Incubator @ 37C 130 8760 1139 2 2278 $318.86 $637.73

Thermal cycler 120 1500 180 1 180 $25.20 $25.20

Ultracentrifuge (benchtop) 109 8760 955 1 955 $133.68 $133.68

Centrifuge 10 8760 88 9 788 $110.38 $993.38

Cooled centrifuge 30 8760 263 2 526 $73.58 $147.17

Heat block @ 42 10 8760 88 2 175 $24.53 $49.06

Total $697.99 $2,009.73

©2012, Genentech

Bench-top Centrifuge Case study 18

Standby

energy

difference is

0.0024 kWh

0.00014 kWh

0.0026 kWh

Avg power consumption

Week 1: 0.072 kWh/day

Week 2: 0.062 kWh/day

Yearly savings: 3.65 kWh

or 5.7 lbs CO2 per unit!

©2012, Genentech

Cold Storage Metrics for GNE Labs 19

1455+ total freezers on campus

Raising all freezers to -70 would

save the CO2 emissions

equivalent to 39 homes.

Unplugging freezers <10%

full would be equivalent to

taking 74 cars off the road.

©2012, Genentech

Freezer Footprint Reduction Campaign 20

50% have an

online or written

inventory system

for contents

35% conduct a

periodic freezer

clean-out

> 50% plan to

purchase new

freezers within 3

years

Cu

rren

t sta

te

Fu

ture

sta

te

>70% have an

online inventory

system for

contents

Lab

Cleanouts

include a freezer

clean-out

>40% of labs

share freezer

space

New freezers are

energy efficient

Stirling freezers

©2012, Genentech

Non-hazardous Lab Waste Metrics

Compostable 37%

Recyclable lab plastics/PPE

26%

Actual landfill

22%

Mixed paper 9% Cardboard

3%

Bottles/cans

5%

B5 waste forensics data Current collection systems

1 trash can

per person

0.5 recycling bin

per person

Avg 45-50

pairs/ week

(400-450 g)

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Lab Purchasing Habits

Cataloging lab supply stocks guides

greener product recommendations

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Using Data to Change Behavior

©2012, Genentech

Create a Sharing Economy: Surplus Chem Recycling

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Inventory and

storage

Lab

Clean-outs Donate

excess

chemicals

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1. Lower the activation energy for participation!

2. Create system that mimics current business process as closely as possible.

3. Advertise, advertise, advertise.

1 global Roche award!

Inspire Sustainable

Behavior Award

>$10,000

saved!

330

containers

purchased

415

items in

stock

©2012, Genentech

Greener Products: Replacing Ethidium Bromide 25

SyberSafe GNE Testing

©2012, Genentech

Green Chemistry Committee: Better Solvent Selection 26

Resulted in 2014

Dept Goal:

Reduce use of

dichloromethane

(DCM) by 25%.

©2012, Genentech

Reducing Laboratory Landfill Waste 27

Make it easy, available, and applicable

Add additional streams as necessary

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Encouraging Greener Lab Supply Choices

Reuse before buying new!

Reuse, less packaging, and safer

products where appropriate!

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©2012, Genentech

Greener Instrumentation Initiatives

Center for Advanced Light Microscopy (CALM) core microscopy resource for Genentech Research

CALM has found LED systems to be bright, stable and reliable

- Equivalent or lower exposure times

- Intensity stable over time

- Reduced energy usage

Commitment to replace all Hg-based light sources by 2016

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LEDs Eliminate:

• > $7000/year in bulb costs

• Disposal cost and time

• Surprise bulb failures

In partnership with:

©2012, Genentech

Roadmap for Successful Organizational Change 30

Steering Committee sets goals that align with program

mission

Program Manager researches and identifies potential initiatives and

early adopters

Prospective initiatives are tested within scientific

communities

Necessary groups, depts., etc. connected to provide resources --products, staff,

publicity, etc -- for initiative

Steering Committee helps achieve senior management support for

initiative

Track initiative progress, collect data, and communicate results

“Successful” initiative turned over to stakeholders and becomes embedded

in program, process, procedure

©2012, Genentech

Effecting Individual Change 31

Empower labs to

make better choices

Provide data to

support

recommendations

Use early adopters to

gain institutionally

relevant data

Mimic current

business processes

Gain leadership

support Recognize efforts

©2012, Genentech

Acknowledgements

Participating Labs

Jane Grogan

Jacob Corn

Erin Deuber

Media Prep B6, B10,

B48

Ira Mellman Labs

Vishva Dixit

Kathy Kozak

Pamela Chan

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Green BioPharma

Steering Committee

Tina Larson, PTDU

Tse-Sung Wu, EHS

Stefan Koenig, SMPC

Jacob Corn, EDB

Ekta Mahajan, PD Eng

Debbie O’Conner, CCPP

Joe Jerkins, IMP QS

Bonnie Shum, MSAT

Site Services

EHS

Sustainability

Clean Harbors

Facilities

Cool Ops