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The authors present their own research which was in press atthe time of print. They performed cannulated IOP measure-ments in 125 patients before cataract surgery, and confirmthe findings that CCT influences IOP measurements. Thefifth chapter describes how electrophysiology can be usefulin glaucoma diagnosis. Chapter 6 summarizes the issues ofadherence and persistence (previously labelled compliance).

Chapter 7 describes the impact and management of glau-coma in developing nations. It focuses mostly on angle-closure glaucoma, defining it in a logical manner, and givinga valuable summary of the management options. The eighthchapter discusses Health Economics, with some interestingpapers discussed.

Chapter 9 covers future possibilities for IOP-loweringmedications and their mechanisms, forms of drug deliveryand a brief section on continuous in vivo IOP monitoring.Chapter 10 explains bleb findings with Confocal Laser Tech-nology (Rostock Cornea Module) and the possibility ofgaining more in vivo knowledge of bleb development aftertrabeculectomy surgery. Finally, chapter 11 gives a valuablesummary of Tube Shunt management. Freedman does usethis chapter to describe his technique for supra-Tenon’splacement.

Overall, I found this an extremely valuable read, and Ilook forward to the future 2-yearly publications.

Joanna Koppens FRANZCOGreenlane Clinical Centre, Auckland, New Zealand

Immune Response and the Eye

Jerry Y Niederkorn and Henry J Kaplan (eds)

Basel: Karger, 2007.336 pp. US$296.50. ISBN: 978-3-8055-8187-5.

This 336-page hardcover book is an outstanding update onthe rapidly advancing field of ocular immunology, inflamma-tion and infection. It represents the 92nd volume of ChemicalImmunology and Allergy, a series previously published under thetitles of Progress in Allergy and Chemical Immunology. The book ispresented in 30 short chapters, each of which is a worthytribute to the achievements of J. Wayne Streilein, MD, thescientist to whom the work is dedicated. Dr Streilein iswidely recognized as the father of ocular immune privilege.He edited the first edition of this text in 1999 and, at the timeof his death, was working on the second edition. The 51contributing authors are members of established ocularimmunology laboratories around the world; the majority ofthese individuals undertook training with Dr Streilein duringtheir research careers.

The book introduces its reader to many new immunologi-cal concepts related to the eye, reflecting the high level of

research activity in this field during the past 8 years. Somenotable examples include: the generation and activity ofocular regulatory T cells; involvement of Toll-like receptorsin various ocular diseases; and corneal lymphangiogenesis. Inaddition, the readers’ understanding of many other immuno-logical phenomena specific to the eye is considerablyextended. For example, the book includes very currentdescriptions of: the role of the complement system withinthe eye; the development of anterior chamber-associatedimmune deviation or ACAID; and the regulation of ocularapoptosis by FasL and TNF-related apoptosis-inducingligand. Although chapters are devoted to selected infectionsof the eye – notably, herpetic keratitis, acute retinal necrosis,Pseudomonas aeruginosa keratitis, ocular onchocerciasis andendophthalmitis – the primary focus of the book is on ocularimmunological mechanisms and non-infectious inflam-matory diseases. Increasingly, we are recognizing that theimmune system plays important roles in the pathogenesisof diseases which are not traditionally classified asimmunological. Consequently, it is fitting that sections onglaucoma and age-related macular degeneration are includedin this edition. Because of continuing intense activity in thefield, it is likely that a third edition will be needed beforeanother 8 years are passed. Since completion of this volume,a new class of T helper cells, Th17 cells, has been identifiedas critical to the development of certain inflammatory dis-eases both in the eye and elsewhere.

Some clinical information is presented in certain chapters,but most discussion of disease in this book focuses on patho-genic mechanisms. A background in basic immunology isnecessary to ensure that the reader gains the maximum fromthe text. As such, the book is not directed at the generalophthalmologist. It will be a valuable resource for immunolo-gists who want to understand the specific features of ocularimmunology, and for established or budding basic and trans-lational ophthalmic scientists who are seeking a comprehen-sive review of the field. The book will be a welcome additionto the library of any ophthalmology or immunologydepartment.

Justine R Smith PhD FRANZCOCasey Eye Institute, Oregon Health & Science University, Portland,

Oregon, USA

Graves’ Orbitopathy:A Multidisciplinary Approach

Wilmar M Wiersinga and George J Kahaly (eds)

Basel: Karger, 2007.260 pp. USD151.00. ISBN: 978-3-8055-8342-8.

This concise and beautifully illustrated book is the first text-book from the European Group on Graves’ Orbitopathy

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(EUGOGO) and it has certainly been worth the wait. Thebook, a softcover, mid-sized text, is divided into threesections: diagnosis and pathogenesis, management and mis-cellaneous issues. It knits together expertise from the 13EUGOGO centres across eight European countries to sum-marize current thinking on Graves’ orbitopathy (GO). Theemphasis throughout on the multidisciplinary approach tomanaging this disfiguring and disabling condition reflects thephilosophy of the EUGOGO: care is delivered to patientsvia clinics staffed by ophthalmologists and endocrinologists.These combined thyroid-eye clinics in which a patient isseen simultaneously by specialists from both disciplines are arequirement of EUGOGO membership.

The book is well-organized, logically presented andexceptionally well-referenced. It is a multi-author text; eachchapter is the work of endocrinologists, ophthalmologistsand scientists who have each contributed extensive originalresearch in their respective areas of expertise. The questionand answer format is designed to help clinicians caring forpatients with GO to efficiently locate the information theyneed. This format also helps to maintain a cohesive stylethroughout the book. High-quality images illustrate many ofthe chapters, notably in the excellent opening treatise onclinical manifestations by Jane Dickinson and in the laterchapters on imaging and surgical techniques.

Key elements of our current understanding of GO,including the concepts of disease severity and activity andthe complex relationship between autoimmune thyroiddisease and orbitopathy are covered with detailed references.Several themes recur throughout the book, such as theimportance of smoking cessation in primary prevention and

prompt restoration of euthyroid status after radioiodinetreatment to prevent progression of GO. Rather than appear-ing repetitious, these ideas are included in the context ofeach chapter, reinforcing their importance in patientmanagement.

The closing chapter by Salvi and Baldeschi on futuredevelopments includes up-to-the-minute information on therole of monoclonal antibodies directed at specific immunepathways which may permit more targeted immunosuppres-sive treatment of GO in future. Antioxidant therapy, whichhas shown promise in recent studies as a potential treatmentfor inactive disease could perhaps have been included forcompleteness but it is mentioned in Salvi and Curró’s earlierchapter on management of mild GO.

Although primarily of interest to endocrinologists andophthalmologists with a subspecialty interest in orbitaldisease, the book would be a helpful and contemporaryreference for general ophthalmologists, neurosurgeons,otorhinolaryngologists and maxillofacial surgeons, generalphysicians and radiologists. It integrates well-establishedconcepts with the significant contributions made by thevarious EUGOGO members since the formation of thisgroup less than a decade ago. This book would be a valuableaddition to the reference libraries of physicians, surgeons andfacilities involved in the care of patients with Graves’ disease.

Richard Hart FRANZCODepartment of Ophthalmology, University of Auckland, and

Ophthalmology Department, Greenlane Clinical Centre and City EyeSpecialists, Auckland, New Zealand

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© 2008 The AuthorJournal compilation © 2008 Royal Australian and New Zealand College of Ophthalmologists