Name: Joshua Alex Cornforth

Reg No. : 130150408

Title: What role does the actin cytoskeleton play in cancer metastasis?

Supervisor: Jason King

Epithelial Cells

(Regimented, tightly bound collective

of cells that are anchored in place) Mesenchymal Cells

(non-polarised, motile cells that have

dedifferentiated and lost interactions

with surrounding cells )

EMT

Local Break Down

of blood vessel wall

Primary Site of Tumour

(initial invasion of blood stream)

Secondary Site

(Metastasis)

Formation of “Podia”

(lamellipodia, pseudopodia, invadopodia etc)