GMXB Your Global Equipment and Processing Solution

FREUND-VECTOR CORPORATION 675 44th Street, Marion, IA 52302-3800 Phone: 319-377-8263 Fax: 319-377-5574 Email: sales@freund-vector.com www.freund-vector.com

GMP-Compliant Design

Production and Laboratory Sizes Available

316 Stainless Steel Enclosure from Floor to Bowl Level

Easy Access to Internal Components for Maintenance,

Calibration and Inspection

Processing Flexibility

User-Defined Mixer and Chopper Speeds

Aqueous and Solvent Processing

Jacketed Bowl for Product Temperature Control (Opt.)

Vacuum Drying for One-Pot Processing (Opt.)

Designed for Granulation Suites

Full Range of Product Charge and Discharge Systems

Integrated Process Controls and Cleaning (Opt.)

Engineered Scalability

Consistent Bowl and Blade Geometries

User-Defined Blade Tip Speeds Via Variable

Frequency Drive

Precise Liquid Addition Control

Validatable, Operator-Friendly Control System

Compu 4™ Control System Available for Additional Data Management

and Integration with Fluid Bed Dryers and Auxiliary Equipment

Automatic (Recipe Driven) and Manual Operational Modes

Multiple End-Point Detection Parameters - Power Curve Profile,

Wet Massing Time, and Product Temperature Change (Opt.)

Production Granumeist™ Systems For Wet Granulation and Mixing Processes

The GMXB Granumeist™ High Shear Granulator/Mixer is designed for efficient and homogenous wet granulation of powders to form a medium to high density granule. Its GMP-compliant design allows for easy cleaning and maintenance, faster processing times, and total user safety. Every GMXB Granumeist™ is backed by Freund-Vector’s comprehensive range of services, including product and process development, process scale-up and transfer, calibration and maintenance programs, and proactive project management. Engineered with the end-user in mind, the GMXB Granumeist™ family is the ideal solution for your wet granulation and mixing needs.

GMXB-600 Granumeist™ High Shear Granulator/Mixer

FREUND-VECTOR CORPORATION 675 44th Street, Marion, IA 52302-3800 Phone: 319-377-8263 Fax: 319-377-5574 Email: sales@freund-vector.com Your Global Equipment and Processing Solution

www.freund-vector.com 1/2012

GMXB

GMXB MODEL BRIM VOLUME WORKING CAPACITY GMXB-LAB Micro 1, 2, 4, and 6 L 300 mL – 4.2 L

GMXB-LAB Mini 4, 6, and 10 L 1.2 – 9 L

GMXB-Pilot 10, 25, and 65 L 3 – 58 L

GMXB-100 100 L 10 - 90 L

GMXB-150 150 L 15 - 135 L

GMXB-300 300 L 30 - 270 L

GMXB-400 400 L 40 - 360 L

GMXB-600 600 L 60 - 540 L

GMXB-900 900 L 90 - 810 L

GMXB-1200 1200 L 120 - 1080 L

GMXB-1500 1500 L 150 – 1350 L

GMXB-1800 1800 L 180 – 1620 L

Providing equipment and processing solutions around the world since 1972, Freund-Vector is a subsidiary of Freund Corporation located in Tokyo, Japan. Globally, Freund-Vector has thousands of system installations in the pharmaceutical, healthcare, chemical, agricultural, and food industries.

1. Machine Frame

2. Bowl 3. Bowl Cover

4. View Window 5. Chopper Motor

6. Maintenance Panel 7. Mixer Motor

8. Maintenance Door 9. Product Charge Port

10. Product Discharge Valve 11. Bowl Filter

12. Solution Addition Port 13. WIP Port (Optional)

14. Product Temperature Probe 15. Bowl Light 16. Emergency Stop

Note: Drawing above for GMXB-100 Granumeist™ models and larger.