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Global Rare Fungal Infection Registry since 2003
Report October 2011
Working group of the
Under the auspices of
Supported by unrestricted grants from Astellas Pharma, Gilead Sciences, Merck and Pfizer
Study Co-ordinators ................................................................................... 3
Introduction .............................................................................................. 6
Current Results .......................................................................................... 9
Achievements and Goals ........................................................................... 16
Presentations 2010 and 2011 ................................................................. 16
Publications .......................................................................................... 18
Awards ................................................................................................ 18
2011 and 2012 Goals ............................................................................. 19
Long-term Goals ................................................................................... 19
Contact Information ................................................................................. 20
Participating Institutions ........................................................................... 21
Report October 2011 Page 3 of 33
Study Co-ordinators
Clinical ID Microbiology Molecular Biology Pharmacology Pathology
Austria
Elisabeth Presterl, MD Allgemeines Krankenhaus -Universitätskliniken Wien Währinger Gürtel 18-20 1090 Wien T +43-1-40400-4440 F +43-1-4400-4418 elisabeth.presterl@meduni wien.ac.at
Cornelia Lass-Flörl, MD Institute of Hygiene, Microbiology and Social Medicine Universität Innsbruck Fritz-Pregl-Str. 3 6020 Innsbruck T +43-512-9003-70725 F +43-512-9003-73700 [email protected]
Walter Buzina, MD Institut für Hygiene Medizinische Universität Universitätsplatz 4 8010 Graz T +43-316-380-7719 F +43-316-380-9648
Ulrich Strasser. MD Institut für Pathologie Medizinische Universität Innsbruck Müllerstr. 44 A-6020 Innsbruck T +43-512-9003-71304 F +43-512-582-088 [email protected]
Brazil
Marcio Nucci, MD Hospital Universitário Universidade Federal do Rio de Janeiro Av. Brigadeiro Trompovsky S/N 21941-590 Rio de Janeiro T +55-21-2562-2463 F +55-21-2562-2460 [email protected]
Czech Republic
Zdeněk Ráčil, MD Dept. of Internal Medicine Hemato-Oncology University Hospital Brno Jihlavska 20 62500 Brno T +420-53223-2830/3642 F +420-53223-3603 [email protected]
Iva Kocmanova, MD Dept. of Microbiology University Hospital Brno, Jihlavska 20 62500 Brno T +420 53223 2974 [email protected]
Martina Lengerova, MD Dept. of Internal Medicine Hemato-Oncology University Hospital Brno Jihlavska 20 62500 Brno T +420 53223 3642 [email protected]
Mojmir Moulis, MD Dept. of Pathology University Hospital Brno Jihlavska 20 62500 Brno T +420 53223 1111 [email protected]
Ludmila Malaskova, MD Dept. of Biochemistery University Hospital Brno Jihlavska 20 62500 Brno T. +420 53223 3073 [email protected]
Report October 2011 Page 4 of 33
Clinical ID Microbiology Molecular Biology Pharmacology Pathology
Germany
Oliver A. Cornely, MD, FIDSA, FACP Klinikum der Universität Klinik I für Innere Medizin 50924 Köln T +49-221-478-6494 F +49-221-478-3611 [email protected]
Guido Fischer, MS, PhD Landesgesundheitsamt Baden-Württemberg Referat 96 - Arbeitsmedizin, umweltbezogener Gesundheitsschutz Nordbahnhofstraße 135 70191 Stuttgart T +49-711-904-39620 F +49-711-904-37105 [email protected]
Ralf Bialek, MD MVZ Labor Dr. Krause Steenbeker Weg 25 24106 Kiel T +49-431-388-252 [email protected]
Carsten Müller, MD Klinikum der Universität Institut für Pharmakologie 50924 Köln T +49-221-478-5066 F +49 221 478 7184 [email protected]
Axel Hamprecht, MD Klinikum der Universität Institut f. Mikrobiologie, Immunologie u. Hygiene Goldenfelsstr. 19-2 D-50935 Köln T +49-221-478 32023 F +49-(0)221-478-32134
India
Anupma Jyoti Kindo, MD Dept. of Microbiology Sri Ramachandra Medical College/Research Institute No.1, Ramachandra Nagar Porur, Chennai, 600 116 T +91-944-523-9196 F +91 44 2476 5608
Report October 2011 Page 5 of 33
Clinical ID Microbiology Molecular Biology Pharmacology Pathology
Israel
Morad Wattad, MD Rabin Medical Center Infectious Diseases Unit 39 Jabotinski St. 49100 Petah Tikva T +972-3-937-7377 F +972-3-937-6365 [email protected]
Italy
Livio Pagano, MD Dipartimento di Ematologia Universita Cattolica del Sacro Cuore (Roma) Largo Francesco Vito 1 00168 Roma T +39-6-355-03953 F +39-630-51343 [email protected]
Maurizio Sanguinetti, MD Istituto di Microbiologia (Roma) Università Cattolica del Sacro Cuore Largo Francesco Vito 1 00168 Roma T +39-06-3015-4964 F +39-06-3051-152 [email protected]
Annamaria Tortorano, MD Dip. Sanità Pubblica-Microbiologia-Virologia Milano Università di Milano Via Pascal, 36/38 20133 Milano T +39-2-503-15145 F +39-2-503-15146 [email protected]
Andrea Novelli, MD Dipartimento di Farmacologia Università degli Studi di Firenze Viale Pieraccini, 6 50139 Firenze T +39-055-4271-286 F +39-055-4271-280 [email protected]
Gianluigi Vago, MD Department of Clinical Sciences Luigi Sacco Hospital University of Milan Via Pascal, 36/38 20133 Milano T +39 0285994869 F +39 0285994800 [email protected]
Turkey
Sevtap Arikan, MD Mycology Laboratory (Ankara) Hacettepe University 06100 Ankara F +90 (312) 3115250 [email protected]
Report October 2011 Page 6 of 33
Introduction The incidence of invasive fungal infections (IFI) is increasing in all parts of the world.
The etiology for this ongoing epidemiological development is not completely
understood. However, major contributing factors are the increasing number of
transplantation procedures undertaken around the world (estimated at 500,000 per
year), a widening of the indications for intensive chemotherapy, and the growing
number of other clinical conditions requiring immunosuppressive treatment.
Therapeutic standards have been developed for the most frequent IFI, i.e.
candidiasis, aspergillosis and cryptococcosis. But, the so called “rare fungi” are also a
reason for the increased number of IFIs. Thus clinicians are now facing infections
due to a variety of different fungi without any reliable treatment recommendations
and therapeutic decision making is not evidence based. Prevalence of “rare fungi” is
virtually unknown and there is an additional knowledge gap in pathogen biology,
since isolates have not been collected systematically.
In order to overcome the lack of knowledge on epidemiology, clinical course, biology
and pathomechanism and finally to develop an evidence based diagnostic-
therapeutic integrated approach of IFI caused by “rare fungi”, A Global Rare Fungal
Infection Registry – Fungiscope™ has been created.
Fungiscope™ uses a web-based electronic case form accessible via
www.fungiscope.net. For inclusion into the registry patients require cultural,
histopathological, serological or molecular evidence of IFI and the associated clinical
symptoms and signs. The clinical data on underlying disorder and IFI will be
collected and stored in an internet-based database. Additionally, the pathogen
strains and samples of infected tissue are collected, examined and stored in a bio-
bank – the Fungithek. The clinical and biological data are subsequently evaluated
and analysed. Figure 1 presents the data / sample flow and overall project structure.
The clinical database and the bio-bank are connected and accessable to the public
via a web-based search engine - FungiQuest (figure 2).
In the following report we introduce the most current results and achievements. We
also discuss future goals and ongoing developments of the project.
Report October 2011 Page 9 of 33
Current Results Until now, 257 evaluable cases have been documented. The most frequently
registered pathogens were Zygomycetes (n=97; 38%), yeasts (n=41; 16%),
Fusarium spp. (n=41; 16%), and Dematiaceae (n=31; 12%) followed by
Scedosporium spp. (n=15; 6%) and Penicillinum spp. / Paecilomyces spp. (n=9;
3.5%) (figure 3). The majority of patients were Caucasian followed by Asian and
North/South American Indian origins (figure 4). The contribution of cases by
country is shown in figure 5.
Sites of infection differ among pathogens, see figure 6. In patients with invasive
zygomycosis, the lungs were the most commonly involved organs with an
incidence of approximately 50%. Other involved sites were the paranasal sinuses,
the gastrointestinal tract, the central nervous system and deep soft tissues with
an equal distribution of approximately 10%. Fusarium spp. infections frequently
presented as disseminated infections (35%). Commonly involved organs were the
lungs, deep soft tissues and eyes. Infections with Dematiaceae mostly involved
the paranasal sinuses, deep soft tissues, lungs and eyes (range from 14% -
20%). By contrast, yeasts were mostly diagnosed from blood cultures
(approximately 45%) and presented as disseminated infections.
The evaluation of risk factors for the development of IFI revealed differences
between individual pathogens shown in figure 7. The most common risk factors
for developing an infection with Zygomycetes and Fusarium spp. were
chemotherapy or haematopoetic stem cell transplantation (HSCT) (approximately
60%) followed by stay at an intensive care unit and diabetes mellitus, with a
much lower frequency of approximately 20%. Hospitalization in an intensive care
unit and chemotherapy or HSCT remained the most common risk factors for a
yeasts infection, however, they were present with a frequency of only 30%.
Further risk factors were chronic renal or pulmonal diseases and diabetes mellitus.
By contrast, in patients with Dematiaceae infection, the most common risk factor
was diabetes mellitus (approximately 40%) followed by chemotherapy or HSCT
and chronic renal disease, both equaling approximately 15%.
Report October 2011 Page 10 of 33
Mortality, attributable mortality and IFI outcome differed among individual
pathogens and are shown in figure 8. The highest overall mortality was observed
in patients with zygomycosis infection, followed by patients with Fusarium spp.
and yeast infections. By contrast, the lowest overall mortality was revealed in
patients with Dematiaceae, equaling only 9%. The attributable mortality
correlated with overall mortality. The highest rates of complete and partial
remissions were observed in patients with IFI caused by Dematiaceae. Patients
with a yeats infection displayed the lowest rate of response to treatment.
In conclusion, the clinical relevance of invasive fungal infections by rare fungi is
increasing. In a short time, actual cases from several countries world-wide could
be documented and showed a broad spectrum of pathogens. Further investigators
and coordinators are encouraged to contribute to the success of Fungiscope™.
Figure 3: Distribution of 257 pathogens by major groups
Report October 2011 Page 16 of 33
Achievements and Goals Presentations 2010 and 2011
April 10-13, 2010 20th European Congress of Clinical Microbiology
and Infectious Diseases (ECCMID), Vienna, Austria
May 7-8, 2010 Paul-Ehrlich-Gesellschaft für Chemotherapie e.V.,
Spring Meeting of the “Sektion Antimykotische
Chemotherapie”, Bonn, Germany
June 18-19, 2010 MSD Workshop „Infektionen in der Hämatologie“,
Munich, Germany
June 23-26, 2010 10th Congress of Infectious Diseases and Tropical
Medicine, Cologne, Germany
September 9-11, 2010 44th Congress of the German Society for Mycology
(DMykG e.V.), Vienna, Austria
September 12-15, 2010 50th Interscience Conference on Antimicrobial
Agents and Chemotherapy (ICAAC), MA, Boston,
USA
October 1-5, 2010 Annual Congress of the German Society for
Hematology and Oncology (DGHO), Berlin,
Germany
March 31-April 2, 2011 Annual Congress of the German Society for
Infectious Diseases (DGI), Leipzig, Germany
May 7-10, 2011 21st ECCMID/27th ICC, Joint Congress of the
European Society of Clinical Microbiology and
Infectious Diseases and the International Society of
Chemotherapy20th, Milan, Italy
September 1-3, 2011 45th Congress of the German Society for Mycology
(DMykG e.V.), Kiel, Germany
Report October 2011 Page 17 of 33
October 2-5, 2011 5th Trends in Medical Mycology (TIMM), Valencia,
Spain
September 17-21, 2011 51th Interscience Conference on Antimicrobial
Agents and Chemotherapy (ICAAC), Chicago, USA
September 30-October 4, 2011 Annual Congress of the German Society for
Hematology and Oncology (DGHO), Basel,
Switzerland
Report October 2011 Page 18 of 33
Publications
December 2009 M.J.G.T. Rüping, W.J. Heinz, A.J. Kindo, V.
Rickerts, C. Lass-Flörl, C. Beisel, R. Herbrecht, Y.
Roth, G. Silling, A.J. Ullmann, K. Borchert, G.
Egerer, J. Maertens, G. Maschmeyer, A. Simon, M.
Wattad, G. Fischer, J.J. Vehreschild, O.A. Cornely
Forty-one Recent Cases of Invasive Zygomycosis
from a Global Clinical Registry
J Antimicrob Chemother. 2010 Feb;65(2):296-302
July 2008 Rüping M.J.G.T., Albermann N., Ebinger F.,
Burckhard I., Beisel C., Müller C., Vehreschild J.J.,
Kochanek M., Fätkenheuer G., Bangard C., Ullmann
A.J., Herr W., Kolbe K., Hallek M., Cornely O.A.
Posaconazole concentrations in the central nervous
system.
J Antimicrob Chemother 2008 Dec;62 (6):1468-70
Awards
Young Investigator Award 2010 (Nachwuchsförderpreis) of the German Society for Mycology (DMykG e.V.) awarded to Dr. M.J.G.T. Vehreschild for her work on Fungiscope
Report October 2011 Page 19 of 33
2011 and 2012 Goals
Completion of molecular genetic analyses by Prof. Sybren de Hoog from the
CBS Fungal Biodiversity Center
Initiation of an epidemiological online survey to monitor trends
Publication of a subset analysis on rare yeasts, including resistance patterns
Publication of a comparison between sequencing and morphological results
for the first 100 Fungiscope isolates
Publication of a joint analysis on Fusarium spp. in cooperation with the
Brazilian Fusarium spp. Group, chaired by Prof. Nucci.
Extending the FungiQuest™ platform (online since April 2010):
o Faster inclusion of new cases
o Inclusion of FungiThek / isolate information
o Improved search-engine
Long-term Goals Susceptibility testing of all isolates
Comprehensive collection of clinical cases and corresponding isolates from
all continents
Open access structure offering data and isolates to research groups
Basic research
Microbiological studies
Diagnostic studies
Clinical trials
Report October 2011 Page 20 of 33
Contact Information
Chair:
Oliver A. Cornely, MD, FIDSA, FACP [email protected]
Coordinating Physicians:
Maria J.G.T. Vehreschild (née Rüping), MD [email protected]
Technical advisor, site operator clinicalsurveys.net:
Jörg J. Vehreschild, MD [email protected]
Uniklinik Köln
Infectious Diseases – Clinical Trials Unit II
BH E15 R64
Kerpener Strasse 62
50937 Köln
Germany
T +49-221-478-6494
F +49-221-478-3611 www.fungiscope.net
Report October 2011 Page 21 of 33
Participating Institutions Argentina
Infectologia, Fundaleu, Departamento Medico, Buenos Aires, Argentina Maria Cecilia Dignani
Instituto Nacional de Enfermedades Infecciosas "Dr. C. G. Malbrán", Buenos Aires, Argentina
Susana Cordoba
Centro de Referencia de Micología Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina Marisa Biasoli
Australia
Department of Microbiology & Infectious Diseases, Royal Perth Hospital, Perth, Australia
Christopher Heath
Austria
Abt. f. Anästhesie und Intensivmedizin, Wilhelminenspital Wien, Wien, Austria Peter Wimmer
Anästhesiologie und Intensivmedizin, Landesklinikum Thermenregion Baden, Baden, Austria
Franz Schwameis
Infektionen und Tropenmedizin, Universitätsklinik I für Innere Medizin, Medizinische Universität Wien, Wien, Austria
Christina Kratzer, Elisabeth Presterl
Institut für Anästhesie und Intensivmedizin, Landeskrankenhaus Steyr, Steyr, Austria
Achim von Goedecke
Institut für Hygiene, klinische Bakteriologie und Mykologie, Medizinische Universität Graz, Graz, Austria Walter Buzina
Institut für Hygiene, Mikrobiologie und Sozialmedizin, Medizinische Universität Innsbruck, Innsbruck, Austria
Cornelia Lass-Flörl, Isabella Schalk, Anna Huppert
Institut für Pathologie, Medizinische Universität Innsbruck, Innsbruck, Austria Ulrich Strasser
Kinder- Herzzentrum Linz, AKh Linz, Linz, Austria Werner Moosbauer
Klinik für Anästhesiologie, Wagner-Jauregg Nervenklinik, Linz, Austria Udo Illievich
Report October 2011 Page 22 of 33
Klinik für Pneumologie, Inselspital, Universitätsspital Bern, Bern, Austria Sebastian Ott
Krankenhaushygiene, Landeskrankenhaus Klagenfurt, Klagenfurt, Austria Ulrich Zerlauth
Section of Infectious Diseases, Department of Medicine, Medical University of Graz, Austria Martin Hoenigl
Universitätsinstitut für Medizinische Mikrobiologie, Hygiene und Infektiologie - SALK Labor GmbH, Salzberger Universitätsklinikum, Salzberg, Austria
Markus Hell
Universitätsklinik für Dermatologie, Medizinische Universität Wien, Wien, Austria
Katharina Pfistershammer
Belgium
University Hospital Gasthuisberg , Leuven, Belgium
Johan Maertens, Isabel Spriet, Katrien Lagrou
Brazil
Hematology and Mycology Laboratory, Hospital Universitário Clementino Fraga, UFRJ, Rio de Janeiro, Brazil Marcio Nucci
Infection Control Dept., Santa Casa Complexo Hospitalar, Universidade Federal do Rio Grande do Sul, Brazil
Alessandro Pasqualotto
Laboratory of Mycology, Hospital das Clinicas, Federal University of Paraná, Curitiba, Brazil
Flávio de Queiroz Telles
Serviço de Oncohematologia / TMO, Hospital Univ. Prof. Edgard Santos - UFBA, Salvador, Bahia, Brazil
Marco Aurélio Salvino, Monica Botura
Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil Denise Pereira
Canada
Department of Medicine, Peter Lougheed Center, Calgary, Canada Andrew Johnson
Departments of Medicine & Microbiology and Immunology, McGill University, Montreal, Canada Don Sheppard
Microbiology and Infectious Diseases, SMBD - Jewish General Hospital, Montreal, Canada Mark Miller
Service de Maladies Infectieuses, Département de Pédiatrie, McGill University, Montreal, Canada
Philipe Ovetchkine
Report October 2011 Page 23 of 33
Chile
Facultad de Medicina, Universidad de Valparaíso, Chile Thomas Weitzel
Unidad de Infectología, Clínica Alemana, Santiago de Chile, Chile Luis Thompson
China
Changhai Hospital, Department of Hematology, Shanghai P.R., China Yang, Jian-Min
Institute of Hematology, Peking University People's Hospital, Beijing, China Feng-Rong Wang
Department of Hematology, Guangdong General Hospital, Guangdong, China Xin Du
Zhejiang University, School of Medicine, The First Affiliated Hospital, Bone Marrow Transplant Center, Hangzhou Zeijiang, China Huang, He
Columbia
Conjunto Residencial Montevideo, Medellin, Columbia Angela Restrepo, Angela Tobón
Cuba
Instituto de Hematologia e Inmunologia, Habana, Cuba Alberto Arencibia Núñez
Czech Republic
Dept. of Internal Medicine, Hematooncology, Faculty Hospital Brno, Brno, Czech Republic Zdenek Racil
Denmark
Dept. of Hematology, Copenhagen University Hospital, Copenhagen, Denmark
Jannik Helweg-Larsen, Emil Hermansen
France
Hospital Saint-Louis, Paris, France Emmanuel Raffoux, Patricia Ribaud
Hematology and Oncology, University Hospital of Strasbourg Hautepierre Hospital, Strasbourg, France
Raoul Herbrecht
Report October 2011 Page 24 of 33
Germany
Abteilung für Hämatologie, Onkologie und Rheumatologie, Universitätsklinikum Heidelberg, Heidelberg, Germany
Johann Wilhelm Schier
Abteilung für Innere Medizin, Hämatologie u.Onkologie, Klinikum Frankfurt, Germany Michael Kiehl
Abteilung für Kinder- und Jugendmedizin, Marienhospital Witten, Witten, Germany
Bahman Gharavi
Department of Infectious Diseases and Tropical Medicine, Ludwig-Maximilians-Universität München, Muenchen, Germany
Thomas Loescher
Dermatologie, Krankenhaus Dresden-Friedrichstadt, Dresden, Germany Gesina Hansel
Division of Clinical Infectious Diseases, Medical Clinic, Research Center Borstel, Borstel, Germany
Christoph Lange
Gastroenterologie & Infektiologie DGI, St. Josef Hospital, Klinikum der Ruhr-Universität Bochum, Bochum, Germany
Renate Schlottmann
Georg-August-Universität, Goettingen, Germany Silke Neumann
Hämatologie / Internist. Onkologie, Uniklinik Erlangen, Erlangen, Germany Wolf Rösler
Hämatologie und Onkologie, Klinikum Ernst von Bergmann, Potsdam, Germany
Angelika Gerhardt, Georg Maschmeyer
Hämatologie und Onkologie, Medizinische Klinik I, Kliniken Sindelfingen, Sindelfingen, Germany
Stefan Neuburger
Hämatologie und Onkologie, Universitätsklinikum Freiburg, Freiburg, Germany
Hrtmut Bertz, Werner C. Neubauer
Hämatologie/Onkologie/Immunologie/Rheumatologie, Klinikum Schwäbisch Gmünd / Stauferklinik, Mutlangen, Germany Holger Hebart
HNO-Klinik, Universitätsklinikum Düsseldorf, Duesseldorf, Germany Kathrin Scheckenbach
II. Medizinische Klinik, Einheit für Stammzelltransplantation, Klinikum Augsburg, Augsburg
Christoph Schmid
III. Medizinische Klinik und Poliklinik, Johannes Gutenberg Universität Mainz, Mainz, Germany
Andrew Ullmann
Infektiologikum Frankfurt, Frankfurt, Deutschland Gaby Knecht
Report October 2011 Page 25 of 33
Institut für Infektiologie, Asklepios Klinik St. Georg, Hamburg, Germany M. Sabranski
Institut für Medizinische Mikrobiologie und Hygiene, Universität Lübeck, Luebeck, Germany Jan Rupp
Institut für Medizinische Mikrobiologie, Universitätskliniken Göttingen, Göttingen, Deutschland Uwe Groß
Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Germany Claudia Wickenhauser
Institut für Tropenmedizin, Universitätsklinikum Düsseldorf, Düsseldorf, Germany Stefan Reuter
Kinderkardiologie und Pädiatrische Intensivmedizin, Klinikum der Universität München-Großhadern, München, Germany Markus Loeff
Klinik f. Hämato-Onkologie, Klinikum Harlaching, Städtisches Klinikum München GmbH, München, Germany Xavier Schiel
Klinik für Anaesthesiologie und Operative Intensivmedizin, Klinikum Konstanz, Konstanz, Germany
Wolfgang Krüger
Klinik für Dermatologie, University of Tübingen, Tübingen, Germany Sybille Schmidt, Martin Schaller
Klinik für Hals-, Nasen- und Ohrenheilkunde, Klinikum der Universität München-Großhadern, München, Germany
Robert Guerkov
Klinik für Hämatologie und Onkologie, Vivantes Krankenhaus, Berlin, Germany
Jörg Beyer, Markus Müller
Klinik für Hämatologie, Onkologie & Palliativmedizin, Städt. Kliniken Bielefeld gem.GmbH, Bielefeld, Germany Martin Görner
Klinik für Hämatologie, Onkologie und Klin. Immunologie, Universitätsklinikum Düsseldorf, Düsseldorf, Germany
Thomas Schröder
Klinik für Hämatologie/Internistische Onkologie und Stammzelltransplantation, Kliniken Essen Süd, Essen, Germany
Mohammed Wattad
Klinik für Infektiologie und Tropenmedizin, LMU, München, Germany Thomas Loescher
Klinik für Innere Medizin IV, Onkologie und Hämatologie, Martin-Luther-University Halle-Wittenberg, Halle, Germany
Maximilian Christopeit, Hans-Heinrich Wolf
Klinik für Knochenmarktransplantation, Universitätsklinikum Essen, Essen, Rudolf
Report October 2011 Page 26 of 33
Germany Trenschel
Klinik für Neonatologie, Universität zu Bonn, Bonn, Germany Cornelia Graef
Klinik für Nephrologie, Universitätsklinikum Essen, Essen, Germany Oliver Witzke
Klinik für Neurochirurgie, Charité-Universitätsmedizin Berlin, Berlin, Germany Olaf Süss
Klinik für Neurologie, Helios-Klinikum Berlin-Buch, Berlin, Germany Franz-Josef Dieste
Klinik für Pneumologie, Hannover Medical School, Hannover, Germany Matthias Pletz
Klinik I für Innere Medizin, Uniklinik Köln, Köln, Germany
Oliver Cornely, Maria Vehreschild, Jörg Janne Vehreschild, Fedja Farowski
Klinik und Poliklinik für Innere Medizin C, Hämatologie und Onkologie - Transplantationszentrum Universitätsklinikum der Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany
William Krüger
Klinik und Poliklinik für Innere Medizin, Abteilung für Hämatologie und Onkologie, Universitätsklinikum Rostock, Rostock, Germany
Kersten Borchert, Lena Diestel, Michael Schmitt
Klinik und Poliklinik für Orthopädie, Uniklinik Köln, Köln, Germany Rolf Sobottke
Klinik und Poliklinik für Kinderheilkunde, Universitätsklinikum Münster, Münster, Germany Jörg Ritter
Klinikum der Johann Wolfgang Goethe-Universität, Mainz, Germany Sabine Mousset
Klinikum Dortmund Nord, Abteilung Pneumologie/Infektiologie, Germany Stefanie Später
Klinikum Mannheim , Mannheim, Germany Anne Dietz
Klinikum Neuperlach, Müuenchen, Germany Meinolf Karthaus
Medizinische Klinik 5 – Hämatologie und Internistische Onkologie, Uniklinik Erlangen, Erlangen, Germany
Stefan Kallert, Stefan Krause
Medizinische Klinik 5 – Hämatologie und Internistische Onkologie, University of Witten/Herdecke, Köln, Germany
Stefan Sauerland
Medizinische Klinik A, KMT-Zentrum, Uniklinik Münster, Münster, Germany Gerda Silling, Andreas Groll
Report October 2011 Page 27 of 33
Medizinische Klinik I, Klinikum Bremen-Mitte, Bremen, Germany Henrike Thomssen
Medizinische Klinik III, Klinikum der Universität München-Großhadern, München, Germany
Helmut Ostermann, Lisa Peterson
Medizinische Klinik und Poliklinik I, Uniklinik Dresden, Dresden, Germany Ulrich Schuler
Medizinische Klinik und Poliklinik II, Charité-Universitätsmedizin Berlin, Berlin, Germany Markus Ruhnke
Medizinische Klinik und Poliklinik II, Universität Würzburg, Würzburg, Germany
Werner Heinz, Jürgen Löffler, Hartwig Klinker, Bhanu Sinha
Medizinische Klinik und Poliklinik II, Universitätsklinikum Schleswig-Holstein, Kiel, Germany Heinz-A. Horst
Medizinische Klinik und Poliklinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany Gerlinde Egerer
Medizinische Poliklinik, Klinikum der Universität München-Großhadern, Müuenchen, Germany
Johannes Bogner
MVZ Labor Dr. Krause und Kollegen, Kiel, Germany Ralf Bialek
Mykologisches Labor, Krankenhaus Dresden-Friedrichstadt, Dresden, Germany
Irina Vennewald
Onkologikum Frankfurt, Frankfurt, Germany Angelika Böhme
Pädiatrische Hämatologie und Onkologie Infektiologie, Zentrum der Kinderheilkunde, Universität zu Bonn, Bonn, Germany Arne Simon
Rheumatologische Ambulanz, Sana Rheumazentrum Rheinland-Pfalz AG, Bad Kreuznach, Deutschland Eckhard Weber
Uniklinik Frankfurt, Frankfurt, Germany Volker Rickerts
Uniklinik Ulm, Ulm, Germany Georg Härter
Universitätsklinikum Freiburg, Freiburg, Germany Helmut Lang
Zentrum für Infektiologie und Reisemedizin, Universitätsklinikum Freiburg, Freiburg, Germany Dirk Wagner
Greece
Report October 2011 Page 28 of 33
1st Department of Propaedeutic Medicine, Athens University, Athens, Greece Anna Skiada
Cystic Fibrosis Department, Aghia Sophia Children´s Hospital, Athens, Greece
Stavros Doudounakis
Infectious Diseases and Antimicrobial Chemotherapy Research Laboratory, Athens University, Athens, Greece
George L. Petrikkos
Laboratory for Clinical Microbiology, Attikon University General Hospital, Athens, Greece
Joseph Meletiadis
India
Department of Medical Microbiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Arunaloke Chakrabarti
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India Ritesh Agarwal
Dept. of Microbiology, Centre for Basic Sciences, Kasturba Medical College, Manipal University, Manipal, India
Prakash Yegneswaran
Indonesia
Department of Internal Medicine University of Indonesia, Faculty of Medicine University of Indonesia, Mangunkusumo Hospital, Jakarta, Indonesia
Erni J Nelwan
Ireland
Dept. of Bacteriology, Belfast City Hospital, Belfast, Ireland John E. Moore
Trinity College, Dublin Saint James Hospital, Dublin, Ireland Thomas Rogers
Israel
Department of Otolaryngology – Head & Neck Surgery, Edith Wolfson Medical Center, Holon, Israel Yehudah Roth
Hadassah University Medical Center, Jerusalem, Israel Maya Korem
Infectious Diseases Unit, Rabin Medical Center, Petah Tikva, Israel Morad Wattad
Sheba Medical Center Israel, Tel Aviv, Israel Nathan Keller
Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Ronen Ben-Ami
Italy
Department of Biomedical Science and Human Oncology — Hygiene Maria Teresa
Report October 2011 Page 29 of 33
Section, University of Bari, Bari, Italy Montagna
Dipartimento di Ematologia, Universita Cattolica del Sacro Cuore, Rome, Italy Livio Pagano
Dipartimento di Farmacologia, Università degli Studi di Firenze, Firenze, Italy Andrea Novelli
Divisione di Ematologia e Trapianto di Midollo Osseo, Ospedale San Martino, Genova, Italy
Andrea Bacigalupo
Hematology Unit, San Camillo-Forlanini Hospital, Rome, Italy Mariagrazia Garzia
Istituto di Microbiologia, Universita Cattolica del Sacro Cuore, Rome, Italy Maurizio Sanguinetti
Laboratorio di Micologia Medica, Sezione Sanità Pubblica, University of Milan, Milan, Italy
Annamaria Tortorano
Oncoematologia Pediatrica, Policlinico G.B. Rossi, Verona, ItalyClinica di Oncoematologia Pediatrica, Azienda Ospedaliera Padova, Padova, Italy Simone Cesaro
Pathology Unit, Luigi Sacco Hospital, University of Milan, Milan, Italy Gianluigi Vago
Japan
Division of Control and Treatment of Infectious Diseases, Chiba University Hospital, Chiba, Japan
Akira Watanabe, Katsuhiko Kamei
Nagasaki University Hospital, Nagasaki, Japan Shigeru Kohno
Seirei Hamamatsu General Hospital, Shizuoka, Japan Shinichiro Morioka
Korea
Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, Korea
Joon Seong Park
Hematology-Oncology Clinic, Hematopoietic Stem Cell Transplantation Center, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Korea
HyeonSeok Eom
Kuwait
Microbiology Department, Health Sciences Center, Kuwait, Kuwait Eiman Mokaddas
Lebanon
Report October 2011 Page 30 of 33
American University of Beirut Medical Center, Beirut, Lebanon Souha kanj-Sharara
Lithuania
Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania Marius Miglinas
Mexico
Hospital Civil de Guadalajara, Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico,
Eduardo Rodriguez-Noriega
Hospital General de Culiacán, Sinaloa, Mexico Ramón Rivas Llamas
Netherlands
Canisius-Wilhelmina Hospital , Nijmegen, Netherlands Jacques Meis
University Medical Center Groningen, Groningen, the Netherlands Jan P. Arends
Peru
Hematology/ BMT Department, Rebagliati National Hospital, Lima, Peru Eduardo Fernandez-Vertiz
Portugal
Coimbra University Hospital, Coimbra, Portugal Tome, Rui
Romania
Department of Mycology-Mycotoxicology, Universitatea Petre Andrei, Iasi, Romania Mihai Mares
Russia
Department of Clinical Mycology, Allergology and Immunology, St. Petersburg Medical Academy of Postgraduate Education, St. Petersburg, Russia
Klimko, Nikolay
Singapore
Infectious Diseases Care, 03-01 Mount Elizabeth Medical Centre, 228510 Singapore Kurup, Asok
National University Health System, University Medicine Center, Division of Infectious Diseases, NUHS Tower Block, Level 10, 119228 Singapore
Louis Yin Ann, Chai
Report October 2011 Page 31 of 33
National University Health System, University Children\'s Medical Institute, Department of Pediatrics, 119228 Singapore, Singapore Chan, Si Min
Slovakia
National Cancer Institute, Bratislava, Slovakia Lubos Drgona
South Africa
Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa Robert Dunn
Nelson R. Mandela School of Medicine, Pretoria, South Africa Teke Apalata
Spain
Hospital de la Princesa, Madrid, Spain Rafael de la Cámara
Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen del Rocío, Sevilla, Spain
Martin-Pena Almudena
Sweden
Clinical Micrbiological Laboratory, Sunderby Hospital, Luleå, Luleå, Sweden Peter Cettner
Switzerland
Abt. für Spitalhygiene und Spitalepidemiologie, Universitätsspital Basel, Basel, Switzerland
Andreas Widmer
Division of Infectious Dieseases & Hospital Epidemiology, Universitätsspital Basel, Basel, Switzerland U. Flueckiger
Medizin I Abteilung für Hämatologie, Universitätsspital Basel, Basel, Switzerland Alois Gratwohl
Institut für Infektionskrankheiten, Bern, Switzerland Stefan Zimmerli
Universitätsklinik für Pneumologie, Inselspital, Universitätsspital Bern, Bern, Switzerland Sebastian Ott
Taiwan
Far Eastern Memorial Hospital, Taipei, Taiwan Chiaying Liu
Tai-Chen Stem Cell Therapy Center, National Taiwan University, Taipeh, Taiwan Jih-Luh Tang
Division of Infectious Diseases, Department of Internal Medicine, Center For Infection Control, National Taiwan University Hospital, Taipei, Taiwan Yee-Chun Chen
Report October 2011 Page 32 of 33
Thailand
Division of Infectious Diseases and Tropical Medicine, Khon Kaen University, Khon Kaen, Thailand
Ploenchan Chetchotisakd
Turkey
Akdeniz University Medical Faculty, Department of Clinical Microbiology, Antalya, Turkey Dilara Ogunc
Department of Medicine, Section of Infectious Diseases, Hacettepe University Medical School, Ankara, Turkey
Murat Akova, Sevtap Arikan, Omrun Uzun
Beyoglu Eye Training and Research Hospital, Istanbul, Turkey Serhat Imamoglu
United Kingdom
Department of Infection, St George's University of London, London, United Kingdom Jon Lambourne
NPHS Microbiology ABM (Swansea and Bridgend), Wales, United Kingdom Nidhika Berry
USA
Department of Infectious Diseases, Section of Transplant Infectious Diseases, Medicine Institute and Transplant Center, Cleveland Clinic Lerner College of Medicine of Case Western University, Cleveland, Ohio, USA
Sherif Beniameen Mossad
Department of Pathology, University of Colorado, Denver, USA Diane Hutchinson
University of Alabama at Birmingham, Birmingham, USA John Baddley
University of Texas Southwestern Medical Center at Dallas, Dallas, USA Sanjay Revankar
Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA, USA Linda Boyken
MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana, USA
Patricia Connolly
Division of Medical Microbiology, Department of Pathology The Johns Hopkins University School of Medicine, Baltimore, MD, USA Sean Zhang