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Global FMD Surveillance Laboratory Network
Samia Metwally, FAO Juan Lubroth, FAO
Vincent Martin, FAO
Jemi Domenech, OIE
Pillars of the Global FMD Control Strategy
• Strategy combines and integrates FAO and OIE tools:
PCP and regional roadmaps
PVS competencies for each PCP stage
• Strengthens:
Laboratories
Epidemiology
Vaccines
Supports at advanced FMD-PCP stages: Emergency responses
Identification of farms and animals
Biosecurity
Public private partnerships
Advocates for continued research in particular in the field of diagnostics, strain
characterization, vaccines, vaccine quality control and epidemiology
2
Pattern of Countries per PCP Stage (2012)
• Majority of countries (34) at PCP stage 0 are within Africa
• Majority of countries (12) at PCP
stages 1 and 2 are within Eurasia
• More emphasis for capacity on virus pools 3, 4, 5 & 6
0
5
10
15
20
25
30
35
40
Initial PCP 0 Initial PCP 1 Initial PCP 2 Initial PCP 3
Africa
East andSoutheast Asia
Eurasia
South America
South Asia
Africa
East and
Southeast
Asia Eurasia
South
America South Asia Total
Initial PCP 0 34 1 4 0 0 39
Initial PCP 1 4 2 12 0 5 23
Initial PCP 2 4 3 8 2 0 17
Initial PCP 3 4 1 2 0 1 8
Total 46 7 26 2 6 87*
Laboratory Network- One Tool of the Global Strategy
1. Develop, maintain and strengthen an integrated international, regional and national networks of laboratories that can respond quickly to needs for rapid and accurate testing, and timely notification
I. Gain more intelligence on FMD virus strains circulating in regions
II. Improve vaccine selection – supporting both endemic and free countries and essential to progressive control
III. Enhance diagnostic capability for other priority diseases in the region
Lab Network- at Global Level
• Training for regional and reference labs/centers
• Support to proficiency testing
• Supply of diagnostic kits
• Virus characterization on pre-screened samples
• Personnel for the management and technical support of the global laboratory network
Personnel 29%
Support Missions
5%
Global
Coordination 11%
International Conferences
9%
Laboratory network
28%
Epidemiology Network
2%
Database 16%
$3m
$1.75m $3.05m
5-year cost at global level 10.7 of 819 M USD
Source; cost estimate of global strategy by Emiko Fukase, world bank
OIE/FAO FMD Ref Lab Network FMD Seven Regional Virus Pools
WRL- FMD Reference lab/centers
Number of samples received at WRLFMD and FAO/OIE Ref centres (FORC)
Data obtained from the annual reports of OIE-FAO FMD reference laboratory network
a Testing performed in FORC located outside of the virus pool
Virus pool 2010 2011 2012
WRL FORC WRL FORC WRL FORC
1
Eastern Asia 108 132 183 216 78 133
2
Southern Asia 303 244 428 409 88 790
3
Eurasia 323 15a 332 41a 417 15a
4
Eastern Africa 354 0 70 0 151 127
5
Western Africa 83 0 0 0 0 0
6
Southern Africa 20 666 33 588 30 123
7
South America 9 37 1 8 0 1
Total 1,200 1,094 1,047 1,262 764 1,189
Proposal: Global Laboratory Network;
Diagnostics for Global FMD Control Strategy
Overall Objective:
This project is aimed to strengthen and expand the global FMD laboratory network to better coordinate, harmonize and enhance the quality of the global diagnostics that is pivotal in the implementation of the global FMD control strategy
Global coordinating lab (GCL)
FAO and OIE reference labs/centers (FORC)
Fostering regional laboratories in virus pools 3,4 & 5
Link diagnostics with epidemiology, risk-based surveillance and other streams of the global agenda
• Output 1:
Coordination of the global laboratory network
• 1.1 establishment of procedures for the harmonization of the communication
and data sharing between all laboratories within the network, FAO and OIE;
• 1.2 organization of the annual OIE/FAO reference laboratory network
meeting including all additional laboratories of the global network and
support of regional leading lab participation;
• 1.3 annual report on the global FMD status based on information sharing
within the global laboratory network .
Project Outputs & Activities
• Output 2: Advanced global capability to provide information and confirmation on the status of circulating FMD virus for effective control measures
and selection of appropriate vaccine strains
• 2.1 diagnostic analysis of samples by GCL and FORC from regional leading laboratories and countries in regions Antigen detection and serotyping P1 sequencing, vaccine matching Timely reporting to submitting countries, FAO and OIE
• 2.2 supply of diagnostic kits to the regional leading laboratories (max. 6)
ELISAs, PCR reagents and pen-side tests – pre-screening
• 2.3 support to sample shipment from the regional leading laboratories in virus pools 3, 4 and 5
Project Outputs & Activities
• Output 3:
Improvement and harmonization of FMD diagnostics within the global laboratory network
coordinated by the GCL in collaboration with experts from FORC.
• 3.1 classroom and bench training to all regional leading laboratories (max. 6) virus isolation, FMD antigen and antibody ELISAs, molecular assays (PCR)
• 3.2 classroom and bench training to FORC (max. 12)
vaccine matching, P1 sequencing, phylogenetic analysis
• 3.3 training to FORC and leading laboratories on the preparation of proficiency test panels and inter-laboratory comparison tests
• 3.4 in-country training at all regional leading laboratories
• 3.5 supply an annual inter-laboratory proficiency test panels all laboratories and implementation of relevant follow-up activities to improve performance of laboratories that could not strive to pass the proficiency tests
Project Outputs & Broad Activities
Output 4: Project monitoring and link with technical and policy
related activities for the implementation of the global strategy
• 4.1 Monitoring and evaluation by an advisory group; yearly meetings for progress evaluation and feedback on the project implementation.
• 4.2 GF TADs FMD WG inputs to the global laboratory network activities providing the necessary feedback from the other streams of implementation of the global strategy.
Project Outputs & Activities
Expected Outcomes
• Strengthening and expand the global FMD laboratory network, as proposed in the FAO/OIE global control strategy, that will have a close and continuous link with the the global control agenda
• Increasing the knowledge on the circulating FMD virus world-wide, and improve vaccine selection for effective and immediate response to outbreaks
• Building capabilities for FMD diagnosis in regional virus pools 3, 4 and 5 through establishing regional
leading laboratories (future FORC)