GeneSNP500Cancer

SNP IDNucleotide

ChangeCorresponding Amino

Acid ChangeKnown Effects of SNP/ Amino Acid Change

CYP1B1

rs10012 G C gly arg(amino acid #48)

Protective against head and neck cancers in North Indians. (Singh, A., 2008)Alters surface area of protein, impacting interactions with redox partners and metabolic capacity. (Lewis, D., 2003)Decreases metabolic capacity of B[a]P 7,8-diol. (Shimada, T., 2001)

rs1056836 C G leu val(amino acid #432)

Protective against breast cancer in Nigerians. (Okobia, M., 2009)Protective against lung cancer in African Americans, but a risk factor for lung cancer in Caucasians. (Wenzlaff, A., 2005)Alters surface area of protein, impacting interactions with redox partners and metabolic capacity. (Lewis, D., 2003)Decreases metabolic capacity in in vitro reactions, but no change in metabolic capacity in S. typhimurium model. (Shimada, T., 2001; Shimada, T., 1999)

rs1056837 T C asp asp(silent mutation- amino acid #449)

NA

GSTM3 rs7483 G A val ile(amino acid #224)

No conformational change predicted in in silico studies, but increases metabolic capacity in in vitro reactions. (Tetlow, N., 2004)

NQO1 rs689453 G A glu glu(silent mutation- amino acid #24)

NA

Part A

GeneSNP500Cancer

SNP IDNucleotide

ChangeCorresponding

Amino Acid ChangeKnown Effects of SNP/ Amino Acid Change

XRCC1

rs25487 G A arg gln(amino acid #399)

Causes conformational change of protein due to loss of an a-helix. (Monaco, R., 2007)Protective against lung cancer in North Indians. (Pachouri, S., 2007)Risk factor for prostate cancer in Southern Chinese. (Xu, Z., 2007)Protective against high-risk colorectal adenoma in Norwegians. (Skjelbred, C., 2006)Risk factor for breast cancer in pre-menopausal South Indian women. (Chacko, P., 2005)Risk factor for acute lymphoblastic leukemia in South Indian children. (Hong, Y.-C., 2005)Risk factor for colorectal cancer in South Koreans. (Joseph, T., 2005)Increased progression-free survival following treatment of non-small cell lung cancer in South Koreans. (Yoon, S., 2005)Increased resistance to radiation challenge in fibroblasts, but increased micronuclei formation in lymphocytes. (Alsbeih, G., 2007; Godderis, L., 2004)Protective against pancreatic cancer in Northern Californian (Caucasian, African American and Asian) men. (Duell, E., 2004)Risk factor for esophageal squamous cell carcinoma in Chinese. (Yu, H.-P., 2004)Associated with p53 mutations in Taiwanese oral cancer patients. (Hsieh, L.-L., 2003)Protective against bladder cancer in Northern Italians who are heavy smokers.(Shen, M., 2003)Increased sister chromatid exchange in Taiwanese factory workers who were also heavy smokers. (Lei, Y.-C., 2002)Protective against non-melanoma skin cancer in New Hampshirites (Caucasians). (Nelson, H., 2002)Associated with increased B[a]P-DNA adduct formation in male smokers with lung cancer. (Pastorelli, R., 2002)Protective against breast cancer in North Carolinian (African American) women. (Duell, E., 2001)

rs25489 G A arg his(amino acid #280)

Risk factor for high-risk colorectal adenoma in Norwegians. (Skjelbred, C., 2006)Risk factor for dysplastic leukoplakia in South Indians. (Ramachandran, S., 2006)Protective against breast cancer in post-menopausal South Indian women. (Chacko, P., 2005)Associated with increased DNA damage in Belgian industrial plant workers. (Mateuca, R., 2005)Associated with increased DNA strand breaks in healthy cancer-free Hungarians. (Tuimala, J., 2002)Risk factor for lung cancer in Chinese miners. (Ratnasinghe, D., 2001)

Part B