Diane Kozwich, PhD

FDA Disclaimer

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The Basics - Genes

• Segments of DNA that encode instructions to our cells

• Nucleotides link the two strands of our DNA

• These bases are the alphabet of our genetic code

The Basics - SNPs

• Single nucleotide polymorphism• Result of cell division • Occur in at least 1% of

the population

Understanding the Impact

A T

C G

G T

A T

C G

A T SNP

Gene sends message to encode protein

Protein is created based on message from gene

Parent Child

Areas of Health

• Detoxification• Inflammation• Heart Health• Alcohol Metabolism• Bone Health• Insulin Resistance• Fitness/Weight Management

Detoxification

Gene Impact

CYP1A1 Genotoxic intermediates

CYP1A2 Genotoxic intermediates

GSTM1 Phase II detoxification

GSTP1 Enzyme activity

MnSOD Mitochondrial antioxidant protection

CuZnSOD/SOD3 Antioxidant protection

Inflammation

Gene Impact

CBS Homocysteine

GSTT1 Oxygen radicals

IL-6 Immune cells

TNF-alpha Immune cells

Heart HealthGene ImpactACE Blood pressure and triglyceridesAGT Blood pressure

APOC3 Cholesterol and triglycerides

CETP Cholesterol and triglyceridesLIPC Hepatic lipaseLPL LDL and blood pressure

MTHFR Homocysteine

MTR HomocysteineMTRR General

ENOS/NOS3 Nitric oxide production

PON1 LDL oxidation

Alcohol Metabolism

Gene Impact

ADH1B Conversion of alcohol to acetaldehyde

ADH1C Conversion of alcohol to acetaldehyde

ALDH2 Activity of aldehyde dehydrogenase 2

Bone Health

Gene Impact

COL1A1 Collagen ratio in bones

VDR Bone density

Insulin Sensitivity

Gene Impact

ACE Insulin sensitivity

CRP Insulin sensitivity

LIPC Glucose disposal and oxidation

PPARY2 Insulin sensitivity

PPARGC1A Insulin sensitivity

VDR Fasting glucose and insulin sensitivity

Fitness and Weight Management

Gene Impact

ACE Muscle mass, use and retention

ADRB2 VO2 Max

CRP VO2 Max

IL-6 Muscle recovery

ENOS Nitric oxide production

PPARGC1A VO2 Max

TNF-Alpha Muscle recovery

Gene SNP™ Health Action Plan

• Diet• Lifestyle• Exercise• Supplementation

Gene SNP™ and Transitions™

• Gene SNP dietary recommendations linked to Transitions Lifestyle System®

• Dietary needs based on your genes linked to low GI solutions

Gene SNP™ Dietary Recommendations

• Eating for optimal heart health– Dietary fat intake– B vitamins

• Eating for optimal bone health– Caffeine– Vitamin D and calcium

• Preventing nutrient deficiencies– Antioxidants– Vitamins and minerals

Gene SNP™ and Supplements

• Isotonix OPC-3®• Advanced Level 90 ®• Isotonix® Isochrome• Heart Health™

Advanced Lipitrim Ultra• Isotonix Calcium Plus• Curcumin Extreme• Isotonix Vision

• Isotonix Resveratrol• Isotonix Advanced B-

Complex• Heart Health Essential

Omega III• Isotonix Multivitamin• Isotonix Vitamin D with

K2

Gene SNP™ Health Action Plan

Gene SNP™ Health Action Plan

Gene SNP™ Health Action Plan

Gene SNP™ Health Action Plan

Competition

*Based on information available online as of 2/1/2010

What Gene SNP™ Offers

• Secure online customer profile which can be updated at any time

• Affordable and comprehensive kit evaluates SNPs associated with numerous aspects of health

• Comprehensive online health action plan that offers solutions related to diet, exercise, lifestyle changes and supplementation

• Provides ongoing personal support from a customer manager

• BV!!

Gene SNP™

• Suggested Retail: $395

Getting Started

Purchase your Gene SNP Kit

Obtain DNA sample from cheek swab and mail swab and consent forms to lab

Complete your secure online customer profile

When your results are ready, view your complete Gene SNP Health Action Plan online

Get results! Achieve optimal health by following recommendations based on your genetic profile. Continuously update your customer profile to monitor your progress!