Furanyl FentanylThe Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

Latest Revision: 6/15/2016 Page 1 of 5SWGDRUG.org/monographs.htm

1. GENERAL INFORMATION

IUPAC Name: N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]furan-2-carboxamide

CAS#: 101345-66-8

Synonyms: 2-Furanyl fentanyl

Source: DEA Reference Material Collection

Appearance: White powder

UVmax(nm): Not determined

2. CHEMICAL AND PHYSICAL DATA

2.1 CHEMICAL DATA

Form Chemical Formula Molecular Weight Melting Point (oC)

Base C24H26N2O2 374 Not Determined

HCl C24H26N2O2 HCl 411 232.7

N

N

O

O

Furanyl FentanylThe Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

Latest Revision: 6/15/2016 Page 2 of 5SWGDRUG.org/monographs.htm

3. QUALITATIVE DATA

3.1 NUCLEAR MAGNETIC RESONANCE

Sample Preparation: Dilute analyte to ~12 mg/mL in DMSO-d6 containing TMS for 0 ppm reference anddimethylfumarate as quantitative internal standard.

Instrument: 400 MHz NMR spectrometerParameters: Spectral width: at least containing -3 ppm through 13 ppm

Pulse angle: 90o

Delay between pulses: 45 seconds

1HNMR: Furanyl fentanyl HCl; Lot# ALB-288-12; 400MHz

dimethylfumarate

H2ODMSO

TMSimpurity

10.5 10.3

1

7.50 7.25

3431

6.350

1

5.45

1

4.90 4.80

1

3.60

2

2.1 2.0 1.9 1.8

22

10 9 8 7 6 5 4 3 2 1 0

2224211134311

3.2 3.1 3.0

24

NH+

Furanyl FentanylThe Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

50

Latest Revision: 6/15/2016 Page 3 of 5SWGDRUG.org/monographs.htm

3.2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY

Sample Preparation: Dilute analyte ~3 mg/mL in CHCl3

Instrument: Agilent gas chromatograph operated in split mode with MS detectorColumn: DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 µmCarrier Gas: Helium at 1.5 mL/minTemperatures: Injector: 280oC MSD transfer line: 280oC

MS Source: 230oC MS Quad: 150oCOven program:

1) 100oC initial temperature for 1.0 min2) Ramp to 280oC at 12 oC/min3) Hold final temperature for 9.0 min

Injection Parameters: Split Ratio = 23:1, 1 µL injectedMS Parameters: Mass scan range: 30-550 amu Threshold: 150

Tune file: stune.u Acquisition mode: scanRetention Time: 20.634 min

EI Mass Spectrum: Furanyl fentanyl HCl; Lot# ALB-288-12

m/z35030025020015010050

[x 1

06 ]In

tens

ity

0.5

42424242424242424242424242424242424242424242

51515151515151515151515151515151515151515151

77777777777777777777777777777777777777777777

95959595959595959595959595959595959595959595

130130130130130130130130130130130130130130130130130130130130130130158158158158158158158158158158158158158158158158158158158158158158

170170170170170170170170170170170170170170170170170170170170170170186186186186186186186186186186186186186186186186186186186186186186

198198198198198198198198198198198198198198198198198198198198198198212212212212212212212212212212212212212212212212212212212212212212

240240240240240240240240240240240240240240240240240240240240240240

253253253253253253253253253253253253253253253253253253253253253253

283283283283283283283283283283283283283283283283283283283283283283

327327327327327327327327327327327327327327327327327327327327327327 341341341341341341341341341341341341341341341341341341341341341341 372372372372372372372372372372372372372372372372372372372372372372

m/z350300250200150100

[x 1

05 ]In

tens

ity

0.5

1.0

1.5

42424242424242424242424242424242424242424242

51515151515151515151515151515151515151515151

77777777777777777777777777777777777777777777

95959595959595959595959595959595959595959595

130130130130130130130130130130130130130130130130130130130130130130

158158158158158158158158158158158158158158158158158158158158158158

170170170170170170170170170170170170170170170170170170170170170170

186186186186186186186186186186186186186186186186186186186186186186

198198198198198198198198198198198198198198198198198198198198198198

212212212212212212212212212212212212212212212212212212212212212212

240240240240240240240240240240240240240240240240240240240240240240

253253253253253253253253253253253253253253253253253253253253253253

283283283283283283283283283283283283283283283283283283283283283283

327327327327327327327327327327327327327327327327327327327327327327 341341341341341341341341341341341341341341341341341341341341341341 372372372372372372372372372372372372372372372372372372372372372372

Furanyl FentanylThe Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

Page 4 of 5Latest Revision: 6/15/2016 SWGDRUG.org/monographs.htm

3.3 INFRARED SPECTROSCOPY (FTIR)

Instrument: FTIR with diamond ATR attachment (1 bounce)Scan Parameters: Number of scans: 32

Number of background scans: 32Resolution: 4 cm-1

Sample gain: 4Aperture: 80

FTIR ATR (Diamond 1 Bounce): Furanyl fentanyl HCl; Lot# ALB-288-12

Wavenumber (cm-1)3500 3000 2500 2000 1500 1000

%Tr

ansm

ittan

ce

32

40

48

56

64

72

442442442442442442442442442442442442442442442442442442442442442442

600600600600600600600600600600600600600600600600600600600600600600

713713713713713713713713713713713713713713713713713713713713713713

772772772772772772772772772772772772772772772772772772772772772772

885885885885885885885885885885885885885885885885885885885885885885

947947947947947947947947947947947947947947947947947947947947947947

1031103110311031103110311031103110311031103110311031103110311031103110311031103110311031

1134113411341134113411341134113411341134113411341134113411341134113411341134113411341134

1238123812381238123812381238123812381238123812381238123812381238123812381238123812381238

133813381338133813381338133813381338133813381338133813381338133813381338133813381338133814071407140714071407140714071407140714071407140714071407140714071407140714071407140714071471

147114711471147114711471147114711471147114711471147114711471147114711471147114711471

1629162916291629162916291629162916291629162916291629162916291629162916291629162916291629

2376237623762376237623762376237623762376237623762376237623762376237623762376237623762376

2443244324432443244324432443244324432443244324432443244324432443244324432443244324432443

2501250125012501250125012501250125012501250125012501250125012501250125012501250125012501

2625262526252625262526252625262526252625262526252625262526252625262526252625262526252625

2930293029302930293029302930293029302930293029302930293029302930293029302930293029302930

3086308630863086308630863086308630863086308630863086308630863086308630863086308630863086

3417341734173417341734173417341734173417341734173417341734173417341734173417341734173417

Wavenumber (cm-1)1760 1680 1600 1520 1440 1360 1280 1200 1120 1040 960 880 800 720 640

%Tr

ansm

ittan

ce

32

40

48

56

64

72

418418418418418418418418418418418418418418418418418418418418418418

442442442442442442442442442442442442442442442442442442442442442442

482482482482482482482482482482482482482482482482482482482482482482

516516516516516516516516516516516516516516516516516516516516516516

552552552552552552552552552552552552552552552552552552552552552552

600600600600600600600600600600600600600600600600600600600600600600

607607607607607607607607607607607607607607607607607607607607607607

623623623623623623623623623623623623623623623623623623623623623623

661661661661661661661661661661661661661661661661661661661661661661

713713713713713713713713713713713713713713713713713713713713713713

738738738738738738738738738738738738738738738738738738738738738738

751751751751751751751751751751751751751751751751751751751751751751

772772772772772772772772772772772772772772772772772772772772772772

787787787787787787787787787787787787787787787787787787787787787787

847847847847847847847847847847847847847847847847847847847847847847

885885885885885885885885885885885885885885885885885885885885885885

920920920920920920920920920920920920920920920920920920920920920920

947947947947947947947947947947947947947947947947947947947947947947

9729729729729729729729729729729729729729729729729729729729729729721001

100110011001100110011001100110011001100110011001100110011001100110011001100110011001

1031103110311031103110311031103110311031103110311031103110311031103110311031103110311031

1046104610461046104610461046104610461046104610461046104610461046104610461046104610461046

1089108910891089108910891089108910891089108910891089108910891089108910891089108910891089

1134113411341134113411341134113411341134113411341134113411341134113411341134113411341134

1158115811581158115811581158115811581158115811581158115811581158115811581158115811581158

1189118911891189118911891189118911891189118911891189118911891189118911891189118911891189

1238123812381238123812381238123812381238123812381238123812381238123812381238123812381238

1281128112811281128112811281128112811281128112811281128112811281128112811281128112811281

13021302130213021302130213021302130213021302130213021302130213021302130213021302130213021324

1324132413241324132413241324132413241324132413241324132413241324132413241324132413241338

133813381338133813381338133813381338133813381338133813381338133813381338133813381338

1357135713571357135713571357135713571357135713571357135713571357135713571357135713571357

1388138813881388138813881388138813881388138813881388138813881388138813881388138813881388

14071407140714071407140714071407140714071407140714071407140714071407140714071407140714071463

146314631463146314631463146314631463146314631463146314631463146314631463146314631463

1471147114711471147114711471147114711471147114711471147114711471147114711471147114711471

1493149314931493149314931493149314931493149314931493149314931493149314931493149314931493

15591559155915591559155915591559155915591559155915591559155915591559155915591559155915591594

159415941594159415941594159415941594159415941594159415941594159415941594159415941594

1629162916291629162916291629162916291629162916291629162916291629162916291629162916291629

Furanyl FentanylThe Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

Latest Revision: 6/15/2016 Page 5 of 5SWGDRUG.org/monographs.htm

https://en.wikipedia.org/wiki/Furanylfentanyl

4. ADDITIONAL RESOURCES

Wikipedia