Franck Faraci - Hypertension and ageing : Lessons from experimental models

7/29/2019 Franck Faraci - Hypertension and ageing : Lessons from experimental models

1/58

Ayportogsi g ngk Nbigb:

Hoss gs Dr l Oxporilogtnh L kohs

Drngm L. Dnrnfi, UaK

Kopnrtlogts `d Lokifigo ngk Uanrlnf`h`byFnrki`vnsfuhnr Fogtor


2/58

ogk`taohinh kysdugfti`g sl``ta lusfho kysdugfti`g nhtorok ly`bogif t`go ntaor`sfhor`sis

Moy Donturos ngk F`gsoquogfos `d Hnrbo ngkVlnhh Tossoh Kisonso ig Crnig

Hnrbo Nrtory Kisonso

ogk`taohinh kysdugfti`g sl``ta lusfho kysdugfti`g nhtorok ly`bogif t`go igwnrk vnsfuhnr rol`kohigb vog`us ncg`rlnhitios CCC kysdugfti`g

Vlnhh Tossoh Kisonso

ilpnirok vns`kihnti`g rokufok f`hhntornh rosorvo lifr`vnsfuhnr prossuro ncg`rlnhitios ayp`pordusi`g ayporpordusi`g tar`lc`sis lifr`chooks okoln

fohhuhnr igjury waito lnttor igj f`bgitivo kofhig

str`mo fohh konta

F gsoquogfos

nbo

vnsfuhnr bogotifs

Sism Dnft rs


3/58

G@-Lokintok Vibgnhigb ig tao Forocrnh Firfuhnti`g:Kivorso Ilpnft `d G@ H`ss

G@

CA;

NKLN

Fn++

@3-

V@K

KKNA

H-Nrb G@V

sBF

cnsnh pordusi`g vns`kihnti`g

- gour`trngslittors (Nfa, sucstngfo U- saonr d`rfos- lotnc`hif dnft`rs (igsuhig,

tayrìk a`rl`go, nkip`goftig)- taornpoutifs (stntigs, f`rtif`storìks)

gour`vnsfuhnr fùphigb ngbi`bogosis

gour`bogosis igaiciti`g `d phntohots ngk houm`fytos igaiciti`g `d vnsfuhnr br`wta (ayportr`pay) igaiciti`g `d NUU ngk -nlyhìk

fBLU

Fnv->

@G@@-

Oddofts `d G@


4/58

Uhoi`tr`pif Oddofts `d Ngbi`togsig II ig Kisonso

NFO `r Faylns

Ngb >-2 Ngb II

Ngbi`togsig I

N[> N[3

vnsfuhnr t`goigdhnllnti`g`xikntivo strossporloncihitybr`wta

Ngbi`togsig`bogSogig

ayportogsi`g aonrt dnihuro ntaor`sfhor`sis igdhnllnti`g ngourysls

igsuhig rosistngfo kincotos lotnc`hif sygkr`lo trnulntif crnig igjury str`mo Nhzaoilors kisonso shoop kis`rkorok crontaigb aypora`l`fystoigolin fibnrotto sl`migb `cosity nbigb

F`gkiti`gs `r Sism Dnft`rs

lns

NFO3

rofop


5/58

Forocrnh Lifr`vnsfuhnr Kysdugfti`gig n L`koh `d Kiot-Igkufok @cosity

Forocr`vnsfuhnr Kysdugfti`g ig n Bogotif L`koh `dNgbi`togsig II-Igkufok Ayportogsi`g

K

ihnti`g(%lnx)

Lifo Oxprossigb Aulng Sogig ngk AulngNgbi togsig bog (S+N+)

5

;5

15

5

;5

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? ; 1 2 4 1 2 4 ?

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S+N+

S+N+ + UOB-V@K

Nfa (-h`b L) G@G@nto (-h`b L)

* 5

;5

15

5

?5

>55

Toaifho

Ngb II (>.; lb/mb por kny)

Lifo wita Far gif Igdusi g d Ngbi togII

? ; 1 2 4

Nfa (-h`b L) Unpnvori

*


6/58

GD- C

V@K>V@K3BUx>

IH->5

N[>-S

Ngbi`togsig II-Igkufok Tnsfuhnr Kisonso:Lofangisls ngk Ilpnft ig Crnig

Ngb II

IH-4

V[N[6 S@V

igdhnllnti`g

`xikntivo stross

G`x (G`x3, G`x>)

vnsfuhnr t`go ngk rol`kohigb

ayp`pordusi`gf`bgitivo ilpnirlogtstr`mo


7/58

Igaiciti`g `d V[N[6 Nftivnti`g Urovogts Ngb II-Igkufo@xikntivo Vtross ngk Forocr`vnsfuhnr Kysdugfti`g

5

?5

>55

5

?5

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5

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>55

5

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15

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(%lnx)

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NFa (-h`b L) N36>12 (-h`b L) UnpnvorigoF`g Ngb II

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Vupor`xiko(

SH_/sof/lb)

Toaifho

Ngb II

Ngb II + V6I-35>

*

**

# #

>> >5 91 2 4 ? ;


8/58

pinh nrtori`ho

pnrogfaylnhnrtori`ho

Forocrnh F`rtox

Kotorligngts ngk F`gsoquogfos `dIgwnrk Lifr`vnsfuhnr Sol`kohigb

Ayportogsi g

Igwnrk Sol kohigb

VAS/VASVU

S

+

N

+

lifo Ngb II igdusi`g Ossogtinh ayportogsi`

lifr`vnsfuhnr prossurovns`kihnt`r fnpnfity (ligilnh rosistngfo)forocrnh ch``k dh`w


9/58

Ngb II-Kopogkogt Ayportogsi`g Ur`kufosLifr`vnsfuhnr Ayportr`pay ngk Igwnrk Sol`kohigb

S+N+ (Ngb II-kopogkogt)CUA-3 (Ngb II-igkopogkogt)

*

>55

>65

>45

355

;55

455

65

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25

65

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25

(llAb)

(l3)

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(l)

F`g S+N+ F`g CUAF`g Ayport F`g Ayport

** **

*

TnsfuhnrSol kohigb

LongNrtorinh Urossuro Fr ss-softi gnhNron


10/58

Forocr`vnsfuhnr Oddofts `d Ngbi`togsig II:S`ho `d GNKUA @xiknso

SohntivoHovohs

GNKUA @xiknso

?5

>55

>?5

G`x3+/y G`x3-/y

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5

3?

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5

35

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45

5

65

45

95

Kinlotor(%fangbo) Nfotyhfa higo Gitr prussiko

65

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* *

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GNKUA

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(llAb)

Ch k Urossuro

5

>

3

p33pa x lSGN Vupor xiko Iggor Kinlotor

G`x3+/y

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(

l)

Sohntiv

oHovohs


11/58

C`kyRoibat(b)

Nfotyhfa`higo (L)

5

35

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5

35

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5

35

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5

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Lifr`vnsfuhnr Kysdugfti`g Ig Kiot-Igkufok @cosity:F`ll`g _gkorhyigb Lofangisls

Kinlotor(%fangbo)

Uoriro

gnhDnt(b)

Kinlotor(%fangbo)

> >5 > >5

> >5 > >5

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Aiba-Dnt Kiot (ADK) Igku@cosity

F?2Ch/4J `r G`x3-/- lifoF`gtr`h (>5% mfnh dr`l d`r ADK (;?% mfnh dr`l dd`r 1-64 wms.

9 1 2 4 ?

Fnr tik Nrtory

Sohnxnti`g(%)

F`g

ADK

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ADK

Nfa (-h`b L)

N) C)

F)

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* *


12/58

Higms Cotwoog Tnsfuhnr Kisonso:

F`ll`g _gkorhyigb Lofangisls D`r C`ta NbigbNgk Ayportogsi`g


13/58

Nffohorntok Ogk`taohinh Kysdugfti`g Rita Nbigb ig taForocrnh Firfuhnti`g: S`ho `d N[>-Sofopt`r

5

65

45

95 5

65

45

95

5

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>55

5

;5

15

5

;5

15

Kinlotor(%lnx)

N[>-S+/+ N[>-S

-/-

Sohnxnti`g(%)

Nkuht (4> l`)@hk (>1> l`)Tory @hk (36> l`) Nkuht (?> l`)@hk (>9> l`)

Nkuht (?> l`)@hk (36> l`)Tory @hk (73? l`)

N rtn Cnsihnr Nrtory Cnsihnr NrtoryNkuht@hkTory @hk

1 2 4 ? ; 1 2 4 ? ; 1 2 4 9 1 2 4 ? ;

Nfotyhfa`higo (-h`b L) Unpnvorigo Nfotyhfa`higo (-h`b L)

**

*#

#


14/58

Uor`xis`lo Ur`hidornt`r-Nftivntok Sofopt`r- (UUNS

[ainz`hikigoki`gos ([ZKs)

SQS

hipiks oif`sng`iks gitr`-dntty nfiks

UUNS

hibngk

hibngk-kopogkogttrngsnftivnti`g (UUSO) nftivo roprossi`g trngs-roprossi`g `d `taor

trngsfripti`g dnft`rs

fohh lolcrngo

bogo oxprossi`g

nkip`bogosis

bhuf`so uptnmoigsuhig sogsitivity

dhuik rotogti`g

vnsfuhnr strufturo

vnsfuhnr t`go

gournh ngk bhinhdugfti`g

Kivorso Fohhuhnr [nrbot


15/58

Ogk`taohinh Dugfti`g ig Lifo Rita Ngb II-KopogkogtAyportogsi`g is Ilpr`vok cy S`sibhitnz`go

Bogos F gtr hhigb

Tnsfuhnr [`go Ogk`taohiul @xikntivo Vtross

Igdhnllnti`g Tnsfuhnr Sol`kohigb Igtornfti`gs wita tao SNV

U togtinh UUNSTnsfuhnr [nrbots

Sohnxnt`ig(%)

-95

-45

-65

5

Nfotyhfa`higo

g`g-[b S+N+

Toaifho

S`sibhitnz`go

*


16/58

Rant is tao S`ho `d UUNS ig Tnsfuhnr Lusfho0

GF

KGN-cigkigb

k`lnig

Hibngk-cigkigb

k`lnig

Vl``ta lusfho spofidif: sl``ta lusfholy`sig aonvy fanig pr`l`tor (V).Oxprossi`g `d k`ligngt gobntivo d`rls `d

UUNS (V-U;42H) `r wihk-typo UUNS(V-R[) ig vnsfuhnr lusfho.

T395L U;42HUUNS

KG-Lutnti`gs Fohh-Vpofidif Aulngizok L`uso

Anhnci ot nh, Fohh Lotnc`hisl2

g`rlnh c`ky woibat g`rlnh dnt kistricuti`g

g`rlnh phnsln bhuf`so, igsuhig, hoptig l`kost ayportogsi`g

igsuhig rosistngfo kincotos onrhy-`gsot ayportogsi`g proofhnlpsin

Gnturo;53:115Cnrr s ot nh


17/58

Kinlotor(%fang

bo)

g`g-[bV-U;42H [bV-R[ [b

Kinlotor(%`dlnx)

*U8 5.5

* **

5

?5

>55

>?5

Kinlotor(l)

5

?5

>55

5

;5

15

5

;5

15

9 1 2 4

-45

-65

5

Kinlotor(%`dln

x)

5

;5

15

1 2 4 ? ;

MFh Unpnvorigo

Gitr`prussiko (-h`b L) Nfa (-h`b L) Ngb >-2 (-h`b L)

1 2 4 ? ;

g`g-[bV-U;42H [bV-R[ [b

* **

Forocr`vnsfuhnr Sosp`gsos t` Gitrif @xikoNro Ilpnirok ig V-U;42H Lifo


18/58

Kinlotor(%

fangbo)

Igtordorogfo Rita UUNS ig Tnsfuhnr Lusfho IgaicitsLifr`vnsfuhnr Sosp`gsos t` G@ Ig Tiv`

Nfotyhfa`higo (L) Gitr`prussiko (L)

*

5

3?

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5

35

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g`g-[b

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> >5 5.5> 5.> >

F c h Li h K d ti


19/58

K

inlotor(%fangbo)

5

35

;5

5

3?

?5

5

3?

?5

5.> > >5 5.5> 5.> > 5.> > >5

Forocrnh Lifr`vnsfuhnr Kysdugfti`gig n L`koh `d Kiot-Igkufok @cosity

Forocr`vnsfuhnr Kysdugfti`g ig n L`koh `dK@FN-Vnht-Igkufok Ayportogsi`g

F`gtr`h

K@FN-snht

-35

5

35

;5

45

5

3?

?5

2?

>55

Nfotyhfa`higo (L) Gitr`prussiko (L) Gidokipigo (L)

Kihnti`g

(%lnx) F`gtr`h

K@FN-snht

C)

N)

9 1 2 4 ? ;

Nfa (-h`b L) Gitr`prussiko (-h`b L)>5 2 ?9 1 4 ;

K@FN-Vnht IgkufokAyportogsi g

Ko`xyf`rtif`stor`go nfotnF?2Ch/4J lifo (6 wms)

tnp A3@ `r 5.>? l`h/H GnF

Vupprossi`g d poripaornh SNftivnti`g `d fogtrnh SNV

Fogtrnh N[>-S, VGV, NTU, O

Ohovntok nrtorinh prossuroTnsfuhnr kysdugfti`g

* **

*


20/58

Sa` Mignso: Ilpnft `g Tnsfuhnr [`go ngkIgtornfti`gs wita G@-Vibgnhigb

G@

G`x @3- A3@3

V@K

Sa`BOD

oG@V(ignftivo) LHFU-U

LHF LHF-U

Sofopt`r Vogs`r (prossuro)

@taor oddofts

N[>-SO[>-S

BKU ignftivo

Sa`N Sa`NB[U nftivo

Sa Mignso

F gtrnfti g

G@ (sBF/fBMI)

LHFM


21/58

Gitr`prussiko (-h`b L) Ngb >-2 (-h`b L) Ngb >-2 (-h`b L)

Kinlotor(%`dlnx)

*U8 5.5>

g`g-[bg`g-[b + Y32463

* *

**

5

;5

15

5

;5

15

5

?5

>55

5

;5

15

5

;5

15

Ngb >-2 (-h`b L) Ngb >-2 (-h`b L)9 1 2 4 9 1 2 4

Igaiciti`g `d Sa`-Mignso Sost`ros Sosp`gsos t` G@D`hh`wigb UUNS Igtordorogfo ig Tnsfuhnr Lusfho

g`g-[bV-U;42HV-U;42H + [olp`h

g`g-[bV-U;42HV-U;42H + UJ6;

1 2 4 ? ; 9 1 2 4 9 1 2 4

g`g-[bV-U;42HV-U;42H+ Y32463

g`g-[bV-U;42H

V-U;42H+ Y32463

g`g-[bg`g-[b + Y32463

**

*

*

I k L i [ i V hh F c h N i


22/58

5 ?5 >55 >?5 355

5

>5

35

65

;5

-;5

-65

-35

->5

5

*U85.5? vs. g`g-[b

g1->9

-?5

-;5

-65

-35

->5

5

5 ?5 >55 >?5 355

15

95

>55

>>5

>35

>65

Igfronsok Ly`bogif [`go ig Vlnhh Forocrnh NrtoriosDr`l V-U;42H Lifo

`go (2? llAb) MFh (>55 lL)

Kinlotor(%f

angbo)

Kinlotor(%f

angbo

)

N

ftivo[`go

Kinlotor(l)

y`bogif [`go Unssivo Kinlotor

g`g-[bV-U;42H [b

g`g-[bV-U;42H [b

g`g-[b

V-U;42H [bg`g-[b

V-U;42H [b

*U85.5? vs. g`g-[bg


23/58

Lifr`vnsfuhnr Sol`kohigb: Igtordorogfo wita UUNSTnsfuhnr Lusfho Lilifs Oddofts `d Ngb II

KG-UUNS

Ayportogsi g

Igwnrk Sol kohigb

VAS/VASVU S+N+ lifo

Ngb II igdusi`g Ossogtinh ayportogsi`

V-U;42H [b U;4?H mg`fmig (H/+)

lifr`vnsfuhnr prossurovns`kihnt`r fnpnfity (ligilnh rosistngfo)forocrnh ch``k dh`w

Lifr`vnsfuhnr Urossuro(llAb)* U8 5.5?

5 3? ?5

15

;5

5

Kinlotor(l)

*V-U;42H

g`g-[b


24/58

Uhoi`tr`pif Oddofts `d Ngbi`togsig II

NFO `r Faylns

Ngb >-2 Ngb II

Ngbi`togsig I

N[> N[3


Ngbi`togsig`bog

Sogig ayportogsi`g aonrt dnihuro ntaor`sfhor`sis igdhnllnti`g ngourysls igsuhig rosistngfo kincotos lotnc`hif sygkr`lo trnulntif crnig igjury str`mo Nhzaoilors kisonso shoop kis`rkorok crontaigb aypora`l`fystoigolin

fibnrotto sl`migb `cosity nbigb


lns

NFO3

rofop

Nublogtok Sosp`gsos t` Ngbi`togsig I ngk


25/58

-45

-65

5

Kinlotor(%

fangbo)

-;5

-35

5

-;5

-35

5

MFI (?5 lL)

g`g-[bV-U;42H [b

>> >5 9 1 >> >5 9 1 2

g`g-[bV-U;42H [b

g`g-[b

V-U;42H [b

Nublogtok Sosp`gsos t` Ngbi`togsig I ngk

Ngbi`togsig II ig V-U;42H Lifo

-;5

-35

5

-;5

-35

5

Ngb II (-h`b L) Ngb I (-h`b L)

>> >5 9 1 >> >5 9 1

Ngb II (-h`b L) Ngb II (-h`b L)

V-U;42HV-U;42H+ Y32463

V-U;42H [bV-U;42H + h`snrtng

**

*

*

S`ho `d N[ > Sofopt`rs ngk NFO ig Lokintigb


26/58

S`ho `d N[-> Sofopt`rs ngk NFO ig LokintigbSosp`gsos t` Ngbi`togsig I

Kinlotor

(%fangbo)

Ngbi`togsig I (-h`b L)

g`g-[bV-UUNSV-UUNS+ h`snrtng

g`g-[bV-UUNSV-UUNS+ fnpt`prih


27/58

Rant is tao S`ho `d UUNS ig Ogk`taohiul0

G

F

KGN-cigkigb

k`lnig

Hibngk-cigkigbk`lnig

Ogk`taohinh spofidif: vnsfuhnr fnkaorig(ToFnk) pr`l`tor (O-UUNS). Oxprossi`g`d k`ligngt gobntivo (T395L) `r wihk-typoUUNS ig ogk`taohiul.

T395L U;42HUUNS

Lutnti`gs Fohh-Vpofidif L`koh

g`rlnh c`ky woibat g`rlnh dnt kistricuti`g g`rlnh phnsln bhuf`so g`rlnh igsuhig sogsitivity g`rlnh ch``k prossuro

Coyor ot nh, Firf Sos >56:4?;

Nffohorntok Ogk`taohinh Kysdugfti`g ig Rita Nbigb


28/58

Nffohorntok Ogk`taohinh Kysdugfti`g ig Rita Nbigbig O-T395L Lifo

Nfotyhfa`higo (-h`b L) Gitr`prussiko (-h`b L)

* U 8 5.5? vs nkuht

5

?5

>55

5

?5

>55

5

?5

>55

5

?5

>55

Sohnxnti`g(%)

>5

g`g-[b O-T395L [b g`g-[b O-T395L [b

>59 1 2 4 ? 9 1 2 4 ?9 1 2 4 ?9 1 2 4 ?

nkuht`hk

nkuht`hk

nkuht`hk

nkuht`hk

*

**

*

U`togtinh Lofangisls `d Tnsfuhnr Kysdugfti`g


29/58

U`togtinh Lofangisls `d Tnsfuhnr Kysdugfti`gKurigb Nbigb

saonr strossnfotyhfa`higo

G@

CA;

NKLN

Fn++

@3- @3

G`xH-Nrb oG@V

Ilpnirok G@-Vibgnhigb

@G@@- pr`stng`iksis`pr`stngos

UHN3

Igfronsok Tns f gstrifti g

@3-

F@Q>/3

G`x

[U rofopt`rs

@xikntivo Vtross D`rlnti`g `d OKFD

saonr strossnfotyhfa`higo

Fn++

V@K

Ogk`taohinh Kysdugfti`g ig @hk O T395L Lifo is


30/58

Ogk`taohinh Kysdugfti`g ig @hk O-T395L Lifo isLokintok cy Vupor`xiko

Nfotyhfa`higo (-h`b L)

*U 8 5.5? vs nkuht

*

Fyfh``xybognso Vupor`xiko

5

?5

>55

5

?5

>55

5

?5

>55

5

?5

>55

Sohnxnti`g(%)

g`g-[b O-T395L [b g`g-[b O-T395L [b

9 1 2 4 ? 9 1 2 4 ? 9 1 2 4 ? 9 1 2 4 ?

**

nkuht`hknkuht + igk`lotanfig`hk + igk`lotanfig

nkuht`hknkuht + tolp`h`hk + tolp`h

Ogk`taohinh Kysdugfti`g ig @hk O T395L Lifo is


31/58

Ogk`taohinh Kysdugfti`g ig @hk O-T395L Lifo isLokintok cy GNKUA @xiknso


*GNKUA @xiknso

GNKUA

@3

@3-

5

?5

>55

5

?5

>55

g`g-[b O-T395L [b

Sohnxnti`g(%)

9 1 2 4 ? 9 1 2 4 ?

*

*

* *

nkuht`hk`hk + TNV3125

nkuht`hk`hk + TNV3

Ogk`taohinh Kysdugfti`g ig @hk O-T395L Lifo is


32/58

Ogk`taohinh Kysdugfti`g ig @hk O-T395L Lifo isKopogkogt `g Nftivity `d Sa` Mignso


* *

Sa Mignso

5

?5

>55

5

?5

>55

Sohnxnti`g(%)

9 1 2 4 ? 9 1 2 4 ?

g`g-[b O-T395L

nkuht`hk`hk + Y32463

nkuht`hk`hk + Y32463

G@

S@V

oG@V

LHFU-U(ignftivo)

LHF LHF-U

Sa`NB[U nftivo

Sa Mignso

F gtrnfti g

G@

LHFM

Is Ogk`taohinh Kysdugfti`g Rita Nbigb Urovogtok cy


33/58

Is Ogk`taohinh Kysdugfti`g Rita Nbigb Urovogtok cyOgk`taohinh-Vpofidif @voroxprossi`g `d UUNS0

5

65

45

95

5

?5

>55

Kinlotor(%lnx)

Nkuht (4> l`)@hk (>1> l`)Tory @hk (36> l`)Cnsihnr Nrtory

Nkuht@hkTory @hk

1 2 4 ? ;

Nfotyhfa`higo (-h`b L) Unpnvorigo

*#

Tnsfuhnr fnkaorig (ToFnk) pr`l`torwaifa igfronsos oxprossi`g `d wihk-

typoUUNS ig ogk`taohiul (O-R[).

Ogk`taohinh-Vpofidif L`koh

Fohh-Vpofidif Ilpnft `d UUNS ig Sohnti`g t`


34/58

Fohh Vpofidif Ilpnft `d UUNS ig Sohnti`g t`Hnrbo ngk Vlnhh Tossoh Kisonso

UUNSans olorbok ns vory igtorostigb l`hofuho ig rohnti`g t` tao forocrnhfirfuhnti`g. Ig tao ncsogfo `d ox`bog`us panrlnf`h`bifnh nftivnti`g,UUNSoxorts pr`ligogt ngk s`lotilos robi`g-spofidif oddofts witaigforocrnh ch``k vossohs.

Ig vnsfuhnr lusfho, UUNSpr`l`tos G@-lokintok sibgnhigb, robuhntosly`bogif t`go, igaicits S@FM, ngk pr`tofts nbnigst igwnrk rol`kohigb.

Ig ogk`taohiul, UUNS is ossogtinh t` pr`toft nbnigst `xikntivo stross ngk n

ogk`taohinh kysdugfti`g cr`ubat `g ly nbigb.

Bogotif igtordorogfo wita UUNSfng lilif oddofts `d Ngb II ngk lnyigfronso tao d`rlnti`g `d Ngb II.

UUNS, `r spofidif tnrbots, lny phny n moy r`ho ig pr`toftigb nbnigst hnrbongk slnhh vossoh kisonso ig crnig.

N m h k


35/58

Nfmg`whokbologts

Furt Viblugk, UaKBnry Cnulcnfa, LKG`cuy` Lnokn, UaKVtovog Hogtz, LK, UaKK`gnhk Aoistnk, LKVong Kiki`g, UaKV`pa`fhos Fariss`c`his, UaK

Yi Fau, UaKNgkrons Coyor, UaKFnrlog Anhnci LK, UaKUil`grnt Motsnwnts`lmr`g, UaKSifnrk` Uogn-Vihvn, LK, UaKNgkrow Jàgs`g, UaKYigb Hi

Lifanoh Ko Vihvn, UaKJàg Rollio, LK, UaKJustig Br`co, UaKKnvik Ansng, LK

U@>s ngk S@>s

Cubaor Dùgknti`g Nwnrk

[rngsnthngtif Gotw`rm

`d Oxfohhogfo

Hisn L`krifmFygtain HygfaKnho Migzogcnw[`l Bora`hk

Igfronsok Ly`bogif [`go ig V-U;42H Lifo:


36/58

-?5

-;5

-65

-35

->5

5

*

*U85.5? vs. f`gtr`h

g


37/58

Ur`p`sok Lofangisl `d Igfronsok Ly`bogif [`go

ig V-U;42H Lifo

LHFU

LHF-p LHFNftig

Tns`f`gstrifti`g

U;42H

KG-UUNS

LHFM

Sa`N-

B[U

S@FM

Igfronsok igtrnhulignh

prossuro

UUNS

Lofang`sogs`r

F gtricutigb

Lofangisls0

S@V (@3-, A3@3) N[>-S Vpaigb`sigo->-U-3-S Ohovntok prossuro

Kivorso Ilpnft d Ogk taohinh Kysdugfti g

I t d O k ta hi h K d ti i C i


38/58

igfronsok vnsfuhnr t`go

phntohot nbbrobnti`g houm`fyto nkaosi`g vnsfuhnr ayportr`pay ilpnirok ngbi`bogosis igdhnllnti`g ntaor`sfhor`sis h`ss `d CCC igtobrity ngk dugfti`g soizuros ilpnirok gour`gnh sibgnhigb ilpnirok gour`vnsfuhnr f`uphigb ilpnirok gour`bogosis ilpnirok bhinh dugfti`g

igfronsok d`rlnti`g `d NUU str`mo luhtipho sfhor`sis f`bgitivo kofhigo

p y

vnsfuhnrlusfho

ch``k fohhsgour`gs

bhin

Ogk`taohiul

Ilpnft `d Ogk`taohinh Kysdugfti`g ig Crnig

Odd t d Nhk t F c h D ti


39/58

Oddofts `d Nhk`stor`go `g Forocr`vnsfuhnr Dugfti`g

Kincotos 43:6>6

Kinlotor(%lnx)

Nfotyhfa higo Unpnvorigo Vupor xiko

>56f

`ugts/sof/lb

5

;5

15

5

?5

>55

5

;5

15

ToaifhoNhk`stor`go (5.31 lb/mb por kny)

*

*

Uh i t i Odd t d N bi t i II


40/58

Uhoi`tr`pif Oddofts `d Ngbi`togsig II

NFO `r Faylns

Ngb >-2 Ngb II

Ngbi`togsig I

N[> N[3


Ngbi`togsig`bog

Sogig ayportogsi`g aonrt dnihuro ntaor`sfhor`sis igdhnllnti`g ngourysls igsuhig rosistngfo

kincotos lotnc`hif sygkr`lo trnulntif crnig igjury str`mo Nhzaoilors kisonso shoop kis`rkorok crontaigb aypora`l`fystoigolin fibnrotto sl`migb `cosity nbigb


lns

NFO3

rofop

Vox-Igkopogkogt Oddofts `d Igtordorogfo wita UUNS


41/58

p ig Tnsfuhnr Lusfho

Tnsfuhnr Sosp`gsos t` G@ Nro Kopogkogt `g


42/58

Gitr`prussiko (-h`b L)

g`g-[bg`g- [b + @K^V-U;42HV-U;42H + @K^

-3?

5

3?

?5

2?

Kinlotor(%`dlnx)

>5 9 1 2 4 ? ;

*U8 5.5>

*

p pNftivnti`g `d V`hucho Bungyhnto Fyfhnso

K`ligngt Gobntivo Lutnti`gs ig UUNS ig Aulngs


43/58

b Ur`kufo Ayportogsi`g

GF KGN-cigkigb

k`lnig

Hibngk-cigkigbk`lnig

UUNS T395L U;42H

Gnturo;53:115

Lutnti`gs

Ray Vtuky UUNS _sigb Bogotif Nppr`nfaos0


44/58

Ray Vtuky UUNS_sigb Bogotif Nppr`nfaos0

Bogotif kntn higmigb lutnti`gs ig UUNSwita ayportogsi`g.Aulngizok lùso l`kohs.

Nvìk systolif oddofts `d [ZKs `g lotnc`hisl ngk bhuf`so utihiznti`

Nhh`ws fohh-spofidif lngipuhnti`g. [rngsfripti`g dnft`rs `dtog nft ig nfohh-spofidif lnggor.

Nvìk `dd-tnrbot ngk `pp`sigb oddofts `d [ZKs. V`lo cogodifinhoddofts

`d [ZKs nro g`t lokintok cy UUNS. Ur`viko igsibat igt` ilp`rtngfo `d UUNSwaog krivog cy ogk`bog`

hibngks.

Forocrnh Lifr`vnsfuhnturo Ig Tiv`


45/58

Forocrnh Lifr`vnsfuhnturo Ig Tiv`

Kinlo

tor(%fangbo)

R[

L? M@F`g

H-GGN

Nfotyhfa`higo (L)

* * * *

Lifr vnsfuhnr Ogkp igts

Tnsfuhnr t`go Ogk`taohinh dugfti`g

Lifr`vnsfuhnr rol`kohigb Lifr`vnsfuhnr prossuro S@V CCC porloncihity Igtornfti`gs wita ch``k ohologts

Igfronsok Ly`bogif [`go ig V-U;42H Lifo:


46/58

S`ho `d Sa` Mignso

LHFU

LHF-p LHFNftig

Tns`f`gstrifti`g

U;42H

KG-UUNS

LHFM

Sa`N-

B[U

S@FM

Igfronsok igtrnhulignh

prossuroLofang`sogs`r

UUNS

Lifr`vnsfuhnr Kysdugfti`g ig Ko`xyf`rtif`stor`go


47/58

(K@FN)-Vnht Kopogkogt Ayportogsi`g

Kinlotor(%

fangbo)

Nfotyhfa`higo (L) Gitr`prussiko (L) Gidokipigo (L)

5

35

;5

5

3?

?5

5

3?

?5

5.> > >5 5.5> 5.> > 5.> > >5

voaifho

K@FN

Igtornfti`gs Cotwoog UUNS Sa`-Mignso ngk S@V


48/58

Igtornfti`gs Cotwoog UUNS, Sa` Mignso ngk S@V


S@V

G`x

KG-UUNS

Sa` mignsoUUNS

LHF oG@V

UUNS

UUNS

H`ss `d Ogk`taohiul-Korivok Gitrif @xiko Ur`l`tos


49/58

Tnsfuhnr Kisonso

saonr stross

nfotyhfa`higo

G@

CA;

NKLN Fn++

@3- A3@3

V@K

KKNA

H-Nrb oG@V

ayp`pordusi`g

f`bgitivo kofhigstr`mo

vnsfuhnr t`go (f`gtrnftiho pr`toigs, S@FM) tar`lc`sis (phntohot nftivnti`g)

igdhnllnti g (GD- C, houm`fyto rofruitlogt) `xikntivo stross (`xHKH) vnsfuhnr br`wta (pr`hidornti`g, ayportr`pay)

Hnrbo ngk Vlnhh Tossoh Kisonso

Igtornfti`gs Cotwoog Gitrif @xiko ngk S@V:F V


50/58

Ilpnft `g Fohh Vibgnhigb

saonr stross, nfotyhfa`higo

G@

CA; @3-

V@K

H-NrbG`x>/3

A3@3

G`x;

fBLU

@G@@-

sibgnhigb

igjury

sibgnhigb

oG@V

sBF

@A.

Ngbi`togsig II-Igkufok Tnsfuhnr Kisonso:L a i k I i C i


51/58

GD- C

V@K>, V@K3, BUx>

IH->5

N[>-S

Lofangisls ngk Ilpnft ig Crnig

Ngb II

IH-4

V[N[6 S@V

igdhnllnti`g`xikntivo stross

G`x (G`x3, G`x>)



Ngbi`togsig II-Igkufok Tnsfuhnr Kisonso:L a i k I t i C i


52/58

GD- C

V@Ks, BUx>

N[>-S

Lofangisls ngk Ilpnft ig Crnig

Ngb II

IH-4

V[N[6S@V

igdhnllnti`g

`xikntivo stross

G`x



Tnsfuhnr Sol`kohigb:K t i t k I t d T h Vt t


53/58

Kotorligngts ngk Ilpnft `d Tossoh Vtrufturo

forocrnh ch``k dh`wlifr`vnsfuhnr prossuro

Igwnrk @utwnrkSol`kohigb F`gtr`h Sol`kohigb

oG@Vprobgngfyonrhy ntaor`sfhor`sisrohnxigUUNS

Ngb IIKG-UUNS

Igtordorogfo wita UUNSUr`kufos IgwnrkLi h S k hi i C i


54/58

Lifr`vnsfuhnr Sol`kohigb ig Crnig

Lifr`vnsfuhnr Urossuro(llAb)

*

g`g-[b V-U;42H

Forocrnh Nrtori`hos Vlnhh Losogtorif Nrtorios

5 3? ?5 5 >55 355

Urossuro (llAb)

Kinlotor

(l)

3?5

355

>?5

>555

;5

15

V-U;42H

V-U;42H

g`g-[b

g`g-[b

U8 5.5?

*

*

Igaiciti`g `d Sa`-Mignso Sost`ros Sosp`gsos t` G@D`hh`wigb UUNS Igtordorogfo ig Tnsfuhnr Lusfho


55/58

D`hh`wigb UUNS Igtordorogfo ig Tnsfuhnr Lusfho

Gitr`prussiko (-h`b L) Ngb >-2 (-h`b L) Ngb >-2 (-h`b L

*U8 5.5>

5

?5

>55

5

;5

15

5

;5

15

Kinlotor(%

`dlnx)

g`g-[bV-U;42HV-U;42H + Y32463

g`g-[bV-U;42HV-U;42H + Y32463

g`g-[bg`g-[b + Y32463

1 2 4 ? ; 9 1 2 4 9 1 2 4

*

*

@xikntivo Vtross K`os G`t Lokinto IlpnirokSosp`gsos t` G@ D`hh`wigb UUNS Igtordorogfo


56/58

Sosp`gsos t` G@ D`hh`wigb UUNS Igtordorogfo

Kinlotor(%

`dlnx)

*U8 5.5>5

;5

15

5

;5

15

9 1 2 4 9 1 2 4Ngb >-2 (-h`b L) Ngb >-2 (-h`b L)

g`g-[bV-U;42HV-U;42H + [olp`h

g`g-[bV-U;42HV-U;42H + UJ6;

* *

Nffohorntok Ogk`taohinh Kysdugfti`g ig NbokO T395L Lifo


57/58

O-T395L Lifo


* U 8 5.5? vs nkuht

Sohnxnti`g(%)

5

?5

>55

9 1 2 4 ?

nkuht`hkvory `hk

31-39 l`

3;> l`

5

?5

>55

g`g-[b O-T395L [b

9 1 2 4 ?

nkuht`hkvory `hk

Aotor`bogoity ig tao Ilpnft `d UUNS Igtordorogfoig Tnsfuhnr Lusfho


58/58

ig Tnsfuhnr Lusfho

Gitr`prussiko (-h`b L)

**

5

?5

>55

Sohnxnti`g(%)

5

?5

>55

9 1 2 4 ? ;>5 9 1 2 4 ?

Fnr`tik Nrtory Vlnhh Losogtorif Nrtorios

Kinlotor(%

`dlnx)

g`g-[bV-U;42H [b

g`g-[bV-U;42H [b*

*

Documents

Franck Faraci - Hypertension and ageing : Lessons from experimental models