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www.elsevier.com/locate/pnmrs
Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198
Forty years of Progress in Nuclear Magnetic Resonance Spectroscopy
J.W. Emsley a, J. Feeney b,*
a Chemistry Department, University of Southampton, Southampton SO17 1BJ, UKb Molecular Structure Division , MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Received 6 January 2007Available online 17 January 2007
Keywords: NMR history; Progress in NMR Spectroscopy; NMR Milestones
Contents
1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1792. Milestones in NMR spectroscopy covered by Progress in NMR Spectroscopy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1803. The editors of Progress in NMR Spectroscopy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 184
Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 184Appendix A. Contents of Volumes 1–50 of Progress in NMR Spectroscopy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196
1. Introduction
This issue completes the 50th volume of Progress inNMR Spectroscopy, edited since its initiation 40 yearsago by Jim Emsley, Jim Feeney and Les Sutcliffe (Fig. 1).The journal was founded in 1966 shortly after the publica-tion of their comprehensive (at the time) NMR text-book[1]. This was written when the authors were at LiverpoolUniversity during a period when NMR was expanding atan astonishing rate. After its publication it was realisedthat it would be virtually impossible for such a comprehen-sive text to be kept up-to-date by simply publishing furthereditions. For this reason Les Sutcliffe approached our pub-lisher with the proposal to set up a review series based oninvited articles from carefully chosen NMR experts to pro-vide updated coverage of selected areas across a broadfront of the subject. His proposal was readily acceptedand Progress in NMR Spectroscopy was born. The journalhas continued to grow and flourish initially with Pergamon
0079-6565/$ - see front matter � 2007 Elsevier B.V. All rights reserved.
doi:10.1016/j.pnmrs.2007.01.002
* Corresponding author. Tel.: +44 208 959 3666x2023; fax: +44 208 9064477.
E-mail address: [email protected] (J. Feeney).
Press and latterly (since 1991) with Elsevier. We encourageour selected authors to write thorough, detailed andauthoritative review articles that will be seen by theNMR community as being the primary source for learningabout a topic. The extent to which this has been successfulcan be judged by an examination of the contents of the first50 volumes given in Appendix A. The electronic versions ofany of these articles can be accessed via Science Direct.From the diversity of the review titles in Appendix A itcan be seen that our aim to cover all aspects of NMRand its wide application in chemistry, biology and medicineis being met.
Progress in NMR Spectroscopy is now published simulta-neously on the Internet as part of Science Direct, as well as inthe traditional print form. Making articles available on theInternet, not only for our own journal, but generally for mostscientific publications, has been a very significant advanceand is revolutionizing how we gain access to properly refer-eed material. It is very encouraging how the publishers, both‘‘commercial’’, such as Elsevier, and ‘‘academic’’, such as theLearned Societies, have risen to the challenge posed by such amomentous change in how the results of research can bemade available. Writing papers describing original research
Fig. 1. The editors of Progress in NMR Spectroscopy, Jim Emsley, Jim Feeney and Les Sutcliffe (July 2001).
180 J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198
in primary journals is regarded as an essential part of doingresearch, and needs no encouragement, whereas writing areview is an extra, and competing task, that requires anexceptional effort. Writing a review is an opportunity to chal-lenge one’s understanding of a subject in a more general waythan is done in writing a research paper, and in our view ben-efits not only the individual authors but also the researchcommunity in general.
2. Milestones in NMR spectroscopy covered by Progress in
NMR Spectroscopy
In an earlier historical article [2] we charted the mile-stones in NMR advances up till 1994: we have now updatedthis list to include more recent advances covering theperiod 1995–2006 (see Table 1). Over the last 40 yearsProgress in NMR Spectroscopy has covered most of theareas mentioned here with articles exploring each of thenew emerging areas.
When PNMRS first appeared in 1966 the great advanceswhich were to revolutionize experimental NMR had alreadybeen initiated. In 1958 magic angle spinning (MAS) of solidsamples to provide higher resolution spectra had been dem-onstrated, and Andrew described these experiments in anarticle in Volume 8. In this same volume, Mansfielddescribed some of the pulse methods used for line-narrowingof spectra in solid state NMR, developed by himself and alsoby Waugh and his colleagues. These two techniques, whencombined with methods for polarization transfer, wouldeventually lead to the wonderful array of experiments whichnow make solid-state NMR such a powerful method ofstudying materials including, recently, microcrystalline andfibrous proteins. When PNMRS was first published in1966 it was just one year after Ernst and Anderson had intro-duced the pulse Fourier transform experiment, which wouldeventually revolutionize the whole of NMR. However, mostNMR experiments on liquids and solutions in 1966 still
involved only one dimensional NMR obtained in the contin-uous wave mode at relatively low magnetic fields (100 MHz1H instruments had just become commercially available). Atthis time solution studies mainly used 1H NMR and were pri-marily involved in determinations of molecular structuresand quantitative analysis of complex mixtures. The potentialof the technique for providing dynamic information fromline-width studies and structural information from NOEmeasurements was already well known. When commercialFT spectrometers became available in the late 1960s the dra-matic increase in sensitivity resulted in 13C NMR studies atnatural abundance becoming routine.
The early volumes of JPNMRS were mainly concernedwith reviewing the developments in the basics of NMR: thusarticles appeared on the theory and calculation of chemicalshifts, coupling constants, and how molecular dynamicscan be studied via relaxation rates. Methods of analyzingspectra were described, and detailed descriptions of someof the exciting new techniques of double and multiple reso-nance were provided. Articles appeared in these early vol-umes on MAS and multi-pulse line narrowing, and oneother emerging NMR method was described, namely thatof using liquid crystalline solvents to obtain partially-aver-aged quantities such as chemical shift anisotropies and resid-ual dipolar couplings.
A little later, in 1973, Lauterbur and independently Mans-field and Grannell published the papers which introducedMRI, and which soon led to the now familiar medical imagingtechniques. MRI continued to develop at a rapid rate with firstreports of studies of limbs, organs and then of whole bodiesbeing reported [82]. The quality of the images improvedgreatly following implementation of new techniques such asecho planar imaging [83] and spin-warp imaging [91] togetherwith 3D projection reconstruction methods [94].
The early 1970s also saw the development of a completelynew area of NMR application when Moon and Richards[23] and Hoult and co-workers [24] demonstrated for the
Table 1Milestones in the development of nuclear magnetic resonance spectroscopya
1924–1939 Early work characterizing nuclear magnetic moments and using beam methods [3–5]1936 First attempt (unsuccessful) to detect NMR in solids [45,46]1938 First NMR experiment using molecular beam method [5]1945 Detection of NMR signals in bulk materials [6,7]1948 Bloembergen, Purcell and Pound (BPP) paper on relaxation [8]1948 Van Vleck expression for second and fourth moments [63]1949 Knight shift in metals [9]1949–1950 Discovery of chemical shift [9–11]
Discovery of spin–spin coupling [12–14]1950 Hahn spin echoes [16]1950 Discovery of nuclear quadrupolar resonance [31]1951 Discovery of 1H chemical shifts [30]1952 First commercial NMR spectrometer (Varian 30 MHz)1952 Bloch [6] and Purcell [7] receive Nobel Prize for NMR1953 Bloch equations for NMR relaxation [6,32]1953 Overhauser effect [18]1953 Theory for effects of exchange on NMR spectra [33,34]1954 Carr-Purcell spin echoes [35]1955 Solomon equations for NMR relaxation [36]1955 Relaxation in the rotating frame [37]1956 Early NMR studies on body fluids and tissues [120,121]1953–1958 Sample-spinning used for resolution improvement [32]
Field gradient shimming with electric currents [38]Magnetic flux stabilization (Varian)Spin-decoupling [39]Variable temperature operation ([40] and Varian)
1957 Redfield theory of relaxation [41]1957 Analysis of second-order spectra [42,43,92,93]1957 NMR spectrum shown to be Fourier transform (FT) of Free Induction Decay (FID) [44]1958 Magic angle spinning used for high resolution studies of solids [19,20]1959 Blood flow measurements in vivo [47]1959 Vicinal coupling constant dependence on dihedral angle [48]1961 First 60 MHz field/frequency locked NMR spectrometer (Varian A60)1962 First superconducting magnet NMR spectrometer (Varian 220 MHz)1962 Indirect detection of nuclei heteronuclear double resonance (INDOR) [49]1963 Liquid crystal solvents used [54]1964 Spectrum accumulation for signal averaging [52]1965 Nuclear Overhauser enhancements (NOE) used in conformational studies [50]1965 Pulsed field gradients used for transport and diffusion studies [122,123]1965 Deuterium spectrum of a liquid crystal [51]1965 Fourier transform (FT) techniques introduced [17,52]1967 Spin multiplets detected in solids [53]1969 Nuclear ferromagnetism [56]1969 First commercial FT NMR spectrometer (Bruker 90 MHz)1969 Computer controlled pulse programmers1969 Lanthanide paramagnetic shift reagents [57]1970–1975 13C studies at natural abundance become routine1970 Rotating frame T1 relaxation used for chemical exchange studies [15]1970 First commercial FT spectrometer with superconducting magnet (Bruker 270 MHz)1971 Pulse sequences for solvent signal suppression [58]1971 T1 relaxation measurements in FT mode [60]1971 Two-dimensional (2D) NMR concept suggested [61]1971 Photo CIDNP (chemically induced dynamic nuclear polarization) [64,65]1972 13C studies of cellular metabolism [62]1972 Transferred NOE [21] and its use in studies of bound ligand conformations [29]1973 31P detection of intracellular phosphates [23]1973 NMR analysis of body fluids [23] and tissues [24]1973 Spin-imaging methods proposed [27,28,119]1973 NMR diffraction used for NMR imaging [28]1973 Zeugmatography: first two-dimensional NMR image [27]1973 360 MHz superconducting NMR spectrometer (Bruker)1974 Sensitive point imaging method [66]1974 2D-NMR techniques developed [67]1975 Slice selection in imaging by selective excitation [68–70]
(continued on next page)
J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198 181
Table 1 (continued)
1975 Fourier zeugmatography [71]1976–1979 31P studies of muscle metabolism [72–80]1976 Cross polarization/magic angle spinning for solids [81]1976 Cryogenic probes [124,125]1977 First 600 MHz spectrometer (non-persistent) (Mellon Institute)1977–1980 Spin-imaging of human limbs and organs [82]1977 Echo-planar imaging [83]1977–1978 Whole-body scanning1979 Detection of insensitive nuclei enhanced by polarization transfer (INEPT) [84]1979 Detection of heteronuclear multiple quantum coherence (HMQC) [55,85]1979 500 MHz superconducting spectrometer (Bruker)1979 Chemical shift imaging [86–89]1980 Surface coils used for in vivo NMR [90]1980 Spin warp-imaging [91]1980 3D-projection reconstruction [94]1980 Pulse field gradients used for coherence selection [115]1981 Composite pulse decoupling [98,109]1981 NMR used to diagnose a medical condition [95]1981–1983 Perfusion methods used for NMR studies of cell metabolism [96,97]1982 Full assignments for small protein [99]1983 First 3D structures of proteins from NMR data [22,100]1983 Whole body imaging at 1.5 T [101]1984–1987 Gradient methods used for spatial localization [102–104]1984 Combined imaging and spectroscopy (human brain) [105]1985 FLASH imaging [106]1985 MR Angiographic images [107]1986 NMR microscopy imaging on live cell [108]1987 600 MHz superconducting spectrometer (Bruker; Varian; Oxford Instruments)1987 Para-hydrogen and synthesis used to provide enhanced nuclear alignment [126]1987 Echo-planar imaging at 2 T [110]1987 RARE imaging [127,128]1988 2D-NMR combined with isotopically labelled proteins for full assignments [111]1988 Whole body imaging and spectroscopy at 4T [112]1988 Averaging 2nd order effects in solid state NMR using a double rotor (DOR) [129]1988 Solid state MAS re-coupling experiments [153–156,200]1989 17O NMR in solids by dynamic-angle spinning and double rotation (DAS) [130]1989 3D-NMR on isotopically labelled proteins [113]1990 4D-NMR on isotopically labelled proteins – assignment and conformation [114]1990 Pulse field gradients routinely incorporated into pulse sequences [115,116]1991 Functional MR-detection of cognitive responses [25,26]1991 Richard Ernst receives Nobel Prize for contributions to the development of NMR methodology1992 750 MHz spectrometers (Bruker; Varian; Oxford Instruments)1992 Diffusion-ordered spectroscopy DOSY [131,144]1993 NMR microscopy using superconducting receiver coil [117]1994 NMR force detection [118]1995–1997 Residual dipolar coupling use for protein structure determination [132–134]1995 Microcoil 1H detection in nanolitre volumes [135]1995 Determinations of chirality using NMR of solutions in liquid crystalline solvents [136]1996 Structure activity relationships (SAR) by NMR [137]1996–1999 Automated protein assignments [138,139,206,207]1994–1997 Sensitivity increase in NMR and MRI using hyperpolarized inert gases [140–143]1997–1999 TROSY [145], CRINEPT [146] and CRIPT [147] sequences for structural studies of large proteins >100 kDa1997 Measurement of angles between bond vectors using dipole–dipole cross-correlated relaxation [148]1998 Scalar couplings across hydrogen bonds measured in liquids [149,199]1998 Assignment of MAS spectra via scalar couplings [150,151]1993 Commercial cryoprobe and preamplifiers for increasing sensitivity (Bruker)1998 Whole body 8T MRI for patient scanning [152]1999 NMR structural genomics programs initiated [157–159,201]1999 Sensitivity-Encoded Magnetic Resonance Imaging [160]2000 Targeted contrast reagents [161]2000 Fast spinning for narrowing 1H solid state signals [162]2001 Symmetry based re-coupling schemes for MAS [163]2001 High resolution protein NMR spectroscopy inside living cells [164]2002 Protein structures from solid state NMR studies [165]2002 Kurt Wuthrich awarded Nobel Prize for NMR protein structure determination2002 Automated protein structure determination [166,167]
(continued on next page)
182 J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198
Table 1 (continued)
2002 Scalar couplings across hydrogen bonds measured in solids [168]2002 Single scan 2D spectrum [202]2002 Solid state NMR of amyloid protein structures [169]2002–2005 Fast multidimensional NMR experiments [170–172,203,204]2003 New methods for DNP [173,174]2003 Peter Mansfield and Paul Lauterbur awarded Nobel Prize for MRI2003 High resolution spectra from disordered solids [175]2003 MQ-MAS experiment for 1/2 integer quadrupolar nuclei [176]2003 3D structures of membrane proteins in micelles [177,178]2004 ‘Open’ and ‘Short-bore’ magnets used for MRI2006 Molecular imaging using a targeted hyperpolarized biosensor [179]2006 950 MHz actively shielded magnets used for NMR (Bruker)
a Most of the earlier milestones (1926–1994) were taken from Emsley and Feeney [2], and Feeney [59].
J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198 183
first time that high resolution NMR 31P spectra could beobtained on cells and tissues. These so called MRS (mag-netic resonance spectroscopy) methods were initially usedto examine human muscle metabolism and later extendedto include diagnostic studies of solid tumours and cancercells [180]. In 1974, the spectacular developments in multidi-mensional NMR spectroscopy by Ernst and co-workers [67]triggered acceleration in NMR activity with new possibilitiesbeing further opened up by an avalanche of novel ideas frommany laboratories. The manufacturers also played a majorrole by providing the pulse programmers and probe hard-ware that allowed everyone to join in the fun. New tech-niques were developed in the late 1970s that were torevolutionize multidimensional NMR (most notably INEPT[84] and HMQC [55,85] and the use of pulsed field gradientsfor coherences selection [115,116]). By 1982 application ofthis methodology had led to full structural assignments forsmall proteins and soon after to the first 3D structure deter-mination of a protein in solution using only NMR data[22,100] (part of the work that earned Kurt Wuthrich theNobel Prize for Chemistry in 2002). The late 1980s saw fur-ther improvements in technology with the availability ofhigh field instruments (up to 750 MHz) and the developmentof 2D, 3D and 4D novel pulse sequences for use with isoto-pically (13C/15N) labelled molecules: these were applied withgreat success to assign signals from proteins and other com-plex biological molecules [111,113,114,181,205]. Deutera-tion became commonly used for diluting protons (givingsharper lines for detected nuclei) at 50–80% deuteration lev-els [182,183]. Later >95% deuteration was used to capitalizedon TROSY experiments on large proteins.
Over the last 10 years important advances have alsobeen made in metabolomics studies where the power ofNMR in the analysis of complex mixtures is demonstratedperfectly by providing detailed profiles of the metabolitesin body fluids and tissues under various physiological con-ditions and toxicological challenges [184–186]. Highthroughput screening of potential drugs binding to targetproteins achieved using NMR is another application mak-ing valuable contributions to the drug discovery process inthe pharmaceutical industries [187–190]. Applications ofNMR to fundamental studies in materials such as polymers
have also resulted from the improved NMR technology[191–195]. The determinations of the structures of largeproteins dissolved in aqueous solution have been greatlyfacilitated by the development of new techniques. Forexample, by exploiting dipole-CSA (chemical shift anisotro-py) cross-correlation (instead of ignoring it) TROSY [145]and CRINEPT [146] pulse sequences for detecting the nar-row components of multidimensional signals have vastlyextended the molecular weight range (to >100 kDa) of largemacromolecules that can be successfully studied by NMR.Likewise the clever application of various alignment meth-ods for extracting residual dipolar coupling constants isleading to determinations of improved protein structures[196–198].
Improvements in NMR technology and techniques haveoften stimulated renewed and profitable activity in existingwell-established research areas. For example, paramagneticprobes are now being increasingly used to obtain longrange distance information in proteins. Likewise the appli-cation of dynamic nuclear polarization to enhance sensitiv-ity in studies of biological samples and metabolic processeshas enjoyed a renaissance [173,174]. The availability ofincreased sensitivity afforded by modern spectrometersequipped with cryoprobes now allows routine applicationof the elegant pulse sequence INADEQUATE used fordetecting nuclei involved in 13C–13C spin coupling [208–210]. The full potential of this method can now be realisedparticularly in monitoring the fate of 13C labels in biosyn-thetic pathway studies.
In the last 40 years there have been many clever innova-tions in NMR and MRI, with the major developmentsbeing undoubtedly in the spectrometers and imaging sys-tems. The three elements which go to producing a spec-trometer or imaging system namely the magnet, theradiofrequency generation and detection system, and theintegral computer used to control the data acquisitionand processing required to produce the spectrum or image,have all changed beyond the wildest dreams of the scien-tists in 1966. NMR has also benefited enormously fromthe advances in computing, which in 2007 makes it possibleto calculate chemical shifts, spin–spin coupling constantsand electric field gradients to a precision undreamt of
184 J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198
40 years ago. Such computations, and those used to con-vert NMR data into molecular structures, or spatial imag-es, are at the heart of modern uses of NMR.
Magnet technology has brought us to the threshold ofthe stable, high-resolution, gigahertz spectrometer, andsome whole body MRI systems are now operating at 8 T.This is a far cry from the unstable, power-hungry electro-magnets of 1966, which were the state-of-the-art for mostlaboratories at that time.
Other essential features of the NMR spectrometer havealso seen great progress. Thus, for liquid samples it is nowroutine to select coherences using digital phase shifting, orwith field gradients. The development of gradient-selectionpulse sequences also led to the revitalization of pulse fieldgradient spin-echo experiments, both to measure self-diffu-sion, and to separate spectra of components in a mixtureon the basis of their masses [123]. For solid samples themodern NMR spectrometer is even more dramatically dif-ferent from the systems used by the early pioneers. Magicangle spinning at speeds up to �60 kHz is now available(by using small rotors), and together with many adroitmanipulations of the nuclear spins enable high resolutionspectra of carbons to be obtained on medium sized mole-cules that rival those obtained on the same sample dis-solved in a solvent. Solid state equivalents of 2Dexperiments such as COSY and INADEQUATE have beendemonstrated, and it has even proved possible using protonMAS to determine the structure of a protein in the solidstate [165]. This development circumvents the limitationof molecular weight, which applies in solution state inves-tigations of macromolecular structure. Solid state methods,particularly re-coupling experiments, now make it possibleto obtain structural information for biological materials,such as membrane proteins, which are difficult to studyby diffraction methods.
Both NMR and MRI/MRS continue to develop, and tofind new applications, and the amount of published materialincreases every year showing the continuing need for reviewarticles to summarize, and to critically evaluate the mass ofinformation being produced. We intend that Progress inNMR Spectroscopy will fulfil this need, but to achieve thisgoal requires our fellow NMR spectroscopists to continueto rise to the challenge of writing review articles.
3. The editors of Progress in NMR Spectroscopy
J.W. Emsley (Ph.D., F.R.S.C.): Jim Emsley graduatedwith a degree in Chemistry from the University of Leeds in1956 and then studied in the Department of Inorganic andStructural Chemistry at that University from 1956 to 1960for a Ph.D. on solid state nuclear magnetic resonance. Hewas an ICI Research Fellow from 1960 to 1962 in the Univer-sity of Liverpool. He was a Lecturer in Chemistry in the Uni-versity of Durham from 1962 to 1967 before moving toSouthampton University where he has been a Professor since1995. His main research interests are in NMR studies ofliquid crystalline samples.
J. Feeney (Ph.D., D.Sc., F.R.S.C.): Jim Feeney gradu-ated with a degree in Chemistry from the University of Liv-erpool in 1958 and completed his Ph.D.on NMR solutionstudies in 1960 at the same University. From 1960 to1964 he was a Lecturer in the Chemistry Department atLiverpool University before joining Varian Associates(1964–1969) where he was appointed Director of EuropeanLaboratories in 1967. He joined the Medical ResearchCouncil first in Cambridge (Molecular Pharmacology)1969–1972 and afterwards at the National Institute forMedical Research, Mill Hill, London 1972–2007 where hebecame Centre Controller, MRC Biomedical NMR Centreand Head, Molecular Structure Division. He has been aVisiting Professor at the Universities of Essex and Surrey.His main research interests are in the use of NMR to studyprotein structures and protein ligand interactions.
L.H. Sutcliffe (Ph.D., M.R.S.C.): Les Sutcliffe receivedhis B.Sc. for Chemistry in London and his doctorate forPhysical Chemistry from Leeds University. He was onthe staff in the Inorganic and Physical Chemistry Depart-ment at the University of Liverpool from 1958 to 1985,being appointed Reader in 1971. He moved to the Chemis-try Department at Royal Holloway and Bedford New Col-lege in 1985, becoming Honorary Professor andsubsequently to the University of Surrey in 1990 as VisitingProfessor. In 1995 he moved to the Institute of FoodResearch in Norwich. His special research interests includethe study of molecular dynamics using nuclear and electronmagnetic resonance techniques as applied to the under-standing and development of functional fluids and the rhe-ology of foods.
Acknowledgements
In addition to thanking the 665 authors who have con-tributed to articles in the 50 volumes of Progress in NMRSpectroscopy we would also like to gratefully acknowledgethe tremendous support and professional help we have re-ceived from the Elsevier publishing and production teamsover the years. We have been fortunate in having had excel-lent Publishing Editors who have been active in developingthe journal (most recently Karel Nederveen, Rob vanDaalen, Egbert van Wezenbeek, Michiel Thijssen, AndyGent and Swan Go) and dedicated production teams (mostrecently Rebecca Monahan, Mary Murphy and OwenHynes). Finally we would particularly like to acknowledgethe contributions of their colleagues Cecilia Hughes,Angelique Janssen and April Nishimura who have had amajor impact on the smooth running of the journal byproviding the editors with the vital day-to-day helpfulcontact with Elsevier. We would also like to thank BerryBirdsall, Lyndon Emsley, Geoff Kelly, Malcolm Levitt,Andrew Lane and Peter Morris for their helpful commentson the review, particularly on the list of Milestones.However we have used our own judgement in decidingwhich contributions to include and apologise if we haveoverlooked any important references.
J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198 185
Appendix A. Contents of Volumes 1–50 of Progress in NMR
Spectroscopy
Volume 50
Valentina Domenici, Marco Geppi andCarlo Alberto Veracini
NMR in chiral and achiral smectic phases:structure, orientational order and dynamics
1–50M.L. Johns and K.G. Hollingsworth
Characterization of emulsion systems usingNMR and MRI 51–70Gil Goobes, Patrick S. Stayton and Gary P. Drobny
Solid state NMR studies of molecularrecognition at protein–mineral interfaces 71–85R. Bohmer, K.R. Jeffrey and M. Vogel
Solid-state Li NMR with applications to thetranslational dynamics in ion conductors 87–174Rob van Daalen
Publisher’s note 175Sture Forsen
Congratulations 177J.W. Emsley and J. Feeney
Forty years of Progress in Nuclear MagneticResonance Spectroscopy 179–198Steven P. Brown
Probing proton–proton proximities in the solidstate 199–251Volume 49
N. Rama Krishna and V. Jayalakshmi
Complete relaxation and conformationalexchange matrix analysis of STD-NMRspectra of ligand–receptor complexes 1–25Maya Dadiani, Edna Furman-Haran andHadassa Degani
The application of NMR in tumorangiogenesis research
27–44Lothar Helm
Relaxivity in paramagnetic systems: theoryand mechanisms 45–64Susan J. Berners-Price, Luca Ronconi and PeterJ. Sadler
Insights into the mechanism of action ofplatinum anticancer drugs from multinuclearNMR spectroscopy
65–98Peter B. Barker and Doris D.M. Lin
In vivo proton MR spectroscopy of the humanbrain 99–1283–235
Carole Gardiennet-Doucet, Bernard Henry andPiotr TekelyProbing the ionisation state of functionalgroups by chemical shift tensor fingerprints
129–149Glenn H. Penner and Xiaolong Liu
Silver NMR spectroscopy 151–167R.M. Claramunt, C. Lopez, M.D. Santa Marıa,D. Sanz and J. Elguero
The use of NMR spectroscopy to studytautomerism
169–206R.A. Wind and J.Z. Hu
In vivo and ex vivo high-resolution 1H NMR inbiological systems using low-speed magic anglespinning207–259
Paul S. Pregosin
Ion pairing using PGSE diffusion methods 261–288Volume 48
John Battiste and Richard A. Newmark
Applications of 19F multidimensional NMR 1–23Wolfgang Bermel, Ivano Bertini,Isabella C. Felli, Mario Piccioli andRoberta Pierattelli
13C-detected protonless NMRspectroscopy of proteins in solution
25–45Charles D. Schwieters, John J. Kuszewskiand G. Marius Clore
Using Xplor-NIH for NMR molecularstructure determination
47–62Mark S. Conradi, Brian T. Saam,Dmitriy A. Yablonskiy and Jason C. Woods
Hyperpolarized 3He and perfluorocarbongas diffusion MRI of lungs
63–83Sergey V. Dvinskikh, Dick Sandstrom,Herbert Zimmermann and Arnold Maliniak
Carbon-13 NMR spectroscopy applied tocolumnar liquid crystals 8
5–107Jinyuan Zhou and Peter C.M. van Zijl
Chemical exchange saturation transferimaging and spectroscopy 10 9–136Jeremy Flinders and Thorsten Dieckmann
NMR spectroscopy of ribonucleic acids 13 7–159J. Mitchell, P. Blomler and P.J. McDonald
Spatially resolved nuclear magneticresonance studies of planar samples 16 1–181Wenyi Zhang, Takeshi Sato andSteven O. Smith
18
NMR spectroscopy of basic/aromaticamino acid clusters in membrane proteins
Lukas K. Tamm and Binyong Liang
3–199NMR of membrane proteins in solution 20
1–210 Maggy Hologne, Veniamin Chevelkovand Bernd ReifDeuterated peptides and proteins inMAS solid-state NMR 21
1–232Stephen J. Kadlecek, Kiarash Emami,Martin C. Fischer, Masaru Ishii, Jiangsheng Yu,John M. Woodburn, Mehdi NikKhah,Vahid Vahdat, David A. Lipson,James E. Baumgardner and Rahim R. Rizi
Corrigendum to Imaging physiologicalparameters with hyperpolarized gas MRI 23
Volume 47
Alexey Krushelnitsky and Detlef Reichert
Solid-state NMR and protein dynamics 1–25Christopher A. Hunter,Martin J. Packer and Cristiano Zonta
From structure to chemical shift and vice-versa
27–39186 J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198
Alessandro Bagno, Federico Rastrelliand Giacomo Saielli
NMR techniques for the investigationof solvation phenomena and non-covalentinteractions
41–93Clement R. Yonker and John C. Linehan
The use of supercritical fluids as solventsfor NMR spectroscopy 95–109S. Ramaprasad
1 Magnetic resonance spectroscopicimaging studies of lithium
111–121 Terry Gullion and Alexander J. VegaMeasuring heteronuclear dipolar couplingsfor I = 1/2, S > 1/2 spin pairs byREDOR and REAPDOR NMR
123–136Eduardo Ribeiro deAzevedo, Tito JoseBonagamba and Detlef Reicher
Molecular dynamics in solid polymers
137–164 Tracy L. Whitehead andThomas Kieber-EmmonsApplying in vitro NMR spectroscopy and1H NMR metabonomics to breast cancercharacterization and detection
165–174Mikko I. Kettunen and Kevin M. Brindle
Apoptosis detection using magneticresonance imaging and spectroscopy 175–185Stephen J. Kadlecek, Kiarash Emami,Martin C. Fischer, Masaru Ishii, JiangshengYu, John M. Woodburn, Mehdi NikKhah,Vahid Vahdat, David A. Lipson,James E. Baumgardner and Rahim R. Rizi
Imaging physiological parameters withhyperpolarized gas MRI
187–212Volume 46
Anne S. Ulrich
Solid state 19F NMR methods for studyingbiomembranes 1–21Martin Blackledge
Recent progress in the study of biomolecularstructure and dynamics in solution fromresidual dipolar couplings 23–61Alexej Jerschow
From nuclear structure to the quadrupolar NMRinteraction and high-resolution spectroscopy 63–78Daniel Huster
Investigations of the structure and dynamics ofmembrane-associated peptides by magic anglespinning NMR 7 9–107Daniel Malmodin and Martin Billeter
High-throughput analysis of protein NMRspectra 10 9–129Helena Kovacs, Detlef Moskau andManfred Spraul
Cryogenically cooled probes – a leap in NMRtechnology 13
1–155Book review. M.H. Levitt: Melinda J. Duer,Editor, ‘‘Introduction to Solid-State NMRSpectroscopy’’, Blackwell
Science (2004) 15 7–158 Torsten Brand, Eurico J. Cabrita and Stefan BergerIntermolecular interaction as investigated byNOE and diffusion studies 15
9–196Paul Hodgkinson
Heteronuclear decoupling in the NMR of solids97–222
Volume 45
T. Dziembowska, P.E. Hansen andZ. Rozwadowski
Studies based on deuterium isotope effect on13C chemical shifts
1–29Peter F. Flynn
Multidimensional multinuclear solution NMRstudies of encapsulated macromolecules 31–51Sharon E. Ashbrook and Stephen Wimperis
High-resolution NMR of quadrupolar nucleiin solids: the satellite-transition magic anglespinning (STMAS) experiment 53–108John C. Lindon, Elaine Holmes andJeremy K. Nicholson
Toxicological applications of magneticresonance
109–143Ingo Schnell
Dipolar recoupling in fast-MAS solid-stateNMR spectroscopy 145–207L.A. Cardoza, A.K. Korir, W.H. Otto,C.J. Wurrey and C.K. Larive
Applications of NMR spectroscopy inenvironmental science
209–238A. Suter
The magnetic resonance force microscope 239–274Stephan Grzesiek, Florence Cordier,Victor Jaravine and Michael Barfield
Insights into biomolecular hydrogenbonds from hydrogen bond scalarcouplings
275–300Colan E. Hughes
Spin counting 301–313Chris A.E.M. Spronk, Sander B. Nabuurs,Elmar Krieger, Gert Vriend andGeerten W. Vuister
Validation of protein structures derived byNMR spectroscopy
315–337Volume 44
J. Frahm, P. Dechent, J. Baudewig andK. D. Merboldt
Advances in functional MRI of the humanbrain
1–32
J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198 187
Wolfram Gronwald and Hans Robert Kalbitzer
Automated structure determination ofproteins by NMR spectroscopy 33–96Perttu Permi and Arto Annila
Coherence transfer in proteins 97–137R.K. Harris: book review. ‘‘Annual Reports onNMR Spectroscopy’’, Volume 49, ed. G.A.Webb: Academic Press (Elsevier Science),Oxford, England
ISBN 0-12-505449-1, ISSN 0066-4103 (2003) 139R. Andrew Atkinson and Bruno Kieffer
The role of protein motions in molecularrecognition: insights from heteronuclear NMRrelaxation measurements 141–187David Fushman, Ranjani Varadan,Michael Assfalg and Olivier Walker
Determining domain orientation inmacromolecules by using spin-relaxation andresidual dipolar coupling measurements
189–214Pellegrino Conte, Riccardo Spaccini andAlessandro Piccolo
State of the art of CPMAS 13C NMRspectroscopy applied to natural organic matter
215–223Jeffrey W. Peng, Jonathan Mooreand Norzehan Abdul-Manan
NMR experiments for lead generation in drugdiscovery
225–256Rainer Kimmich and Esteban Anoardo
Field-cycling NMR relaxometry 257–320Volume 43
M.D. Mantle and A.J. Sederman
Dynamic MRI in chemical process and reactionengineering 3– 60Andres Ramos
Book Review: Protein NMR for the Millennium,Vol. 20 of the Biological Magnetic ResonanceBook Series, N.Rama Krishna, Lawrence J.Berliner (Eds.); Kluwer Academic/PlenumPublishers, New York, 2002 61– 62Alex D. Bain
Chemical exchange in NMR 63–1 03Peter Guntert
Automated NMR protein structurecalculation 105–1 25Volume 42
Andrea Cherubini and Angelo Bifone
Hyperpolarized xenon in biology 1–30G. Klein and M.E. Ries
The dynamics and physical structure of polymersabove the glass transition–transverse relaxationstudies of linear chains, star polymers andnetworks 31–52Robert Tycko
Applications of solid state NMR to the structuralcharacterization of amyloid fibrils: methods andresults 53–68Luisa Ciobanu, Andrew G. Webb andCharles H. Pennington
Magnetic resonance imaging of biological cells
69–93 Eriks Kupce, Toshiaki Nishida and Ray FreemanHadamard NMR spectroscopy 9
5–122Volume 41
Marc Baldus
Correlation experiments for assignment andstructure elucidation of immobilizedpolypeptides under magic angle spinning 1–47R. Blinc and T. Apih
NMR in multidimensionally modulatedincommensurate and CDW systems 49–82Zeev Luz, Piotr Tekely and Detlef Reichert
Slow exchange involving equivalent sites insolids by one-dimensional MAS NMRtechniques83–113
Ronald Y. Dong
Relaxation and the dynamics of molecules inthe liquid crystalline phases 115–151Cecil Dybowski and Guenther Neue
Solid state 207Pb NMR spectroscopy 153–170B.M. Fung
13C NMR studies of liquid crystals 171–186Brian J. Stockman and Claudio Dalvit
NMR screening techniques in drug discoveryand drug design 187–231Juha Vaara, Jukka Jokisaari, Roderick E.Wasylishen and David L. Bryce
Spin–spin coupling tensors as determined byexperiment and computational chemistry
233–304Dominique Frueh
Internal motions in proteins and interferenceeffects in nuclear magnetic resonance 305–324Volume 40
Ian C.P. Smith and Laura C. Stewart
Magnetic resonance spectroscopy in medicine:clinical impact 1–34T.N. Huckerby
The keratan sulphates: structuralinvestigations using NMR spectroscopy 35–110M.P. Augustine
Transient properties of radiation damping 111–150S.L. Maunu
NMR studies of wood and wood products 151–174Eva de Alba and Nico Tjandra
NMR dipolar couplings for the structuredetermination of biopolymers in solution 175–197188 J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198
Peter Luginbuhl and Kurt Wuthrich
Semi-classical nuclear spin relaxation theoryrevisited for use with biological macromolecules 199–247Ivano Bertini, Claudio Luchinat and GiacomoParigi
Magnetic susceptibility in paramagnetic NMR
249–273 E.T. Ahrens, P.T. Narasimhan, T. Nakada andR.E. JacobsSmall animal neuroimaging using magneticresonance microscopy
275–306C. Mayer
Nuclear magnetic resonance on dispersednanoparticles 307–366Volume 39
J.C. Lindon, E. Holmes and J.K. Nicholson
Pattern recognition methods and applicationsin biomedical magnetic resonance 1–40Maria L. Garcia-Martin, Paloma Ballesteros andSebastian Cerdan
The metabolism of water in cells and tissues asdetected by NMR methods
41–77Isao Ando, Shigeki Kuroki, Hiromichi Kurosuand Takeshi Yamanobe
NMR chemical shift calculations andstructural characterizations of polymers
79–133Christopher E. Dempsey
Hydrogen exchange in peptides and proteinsusing NMR spectroscopy 135–170Lu-Yun Lian and David A. Middleton
Labelling approaches for protein structuralstudies by solution-state and solid-state NMR 171–190R. Bohmer, G. Diezemann, G. Hinzeand E. Rossler
Dynamics of supercooled liquids and glassysolids
191–267R. George Ratcliffe, Albrecht Roscherand Yair Shachar-Hill
Plant NMR spectroscopy
267–300 Chenhua Zhao and Tetsuo AsakuraStructure of Silk studied with NMR
301–352Volume 38
N. Nestle, A. Schaff and W.S. Veeman
Mechanically detected NMR, an evaluation ofthe applicability for chemical investigations 1–35E.C. Reynhardt and G.L. High
Nuclear magnetic resonance studies ofdiamond37–81
N. Jamin and F. Toma
NMR studies of protein-DNA interactions 83–114R. Sharp, L. Lohr and J. Miller
Paramagnetic NMR relaxation enhancement:recent advances in theory 115–158V.A. Mandelshtam
FDM: the filter diagonalization method fordata processing in NMR experiments 159–196D.M. Korzhnev, M. Billeter, A.S. Arseniev andV.Y. Orekhov
NMR studies of Brownian tumbling andinternal motions in proteins
197–266M. Pons and O. Millet
Dynamic NMR studies of supramolecularcomplexes 267–324J.A. Jones
NMR quantum computation 325–360Volume 37
F.C. Oliveira, M.J.P. Ferreira, C.V. Nunez,G.V. Rodriguez and V.P. Emerenciano
13C NMR spectroscopy of eudesmanesesquiterpenes
1–45L. Ernst
NMR studies of cyclophanes 4 7–190Anil Kumar, R. Christy Rani Graceand P.K. Madhu
Cross-correlations in NMR 19
1–319 R.H. Contreras and J.E. PeraltaAngular dependence of spin–spin couplingconstants 32
1–425Volume 36
P. Lazzeretti
Ring currents 1–88J.J. van der Klink and H.B. Brom
NMR in metals, metal particles and metalcluster compounds 89–201P. Hodgkinson and L. Emsley
Numerical simulation of solid-state NMRexperiments 201–239D. Grucker
Oxymetry by magnetic resonance: applicationsto animal biology and medicine 241–270J.C. Martins, M. Biesemans and R. Willem
Tin NMR based methodologies and their usein structural tin chemistry 271–322Alexander L. Breeze
Isotope-filtered NMR methods for the studyof biomolecular structure and interactions 323–372Volume 35
J.H. Davis and M. Auger
Static and magic angle spinning NMR ofmembrane peptides and proteins 1–84Raymond J. Abraham
A model for the calculation of protonchemical shifts in non-conjugated organiccompounds 85–152J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198 189
M.J. Shapiro and J.S. Gounarides
NMR methods utilized in combinatorialchemistry research 153–200S. Williams
Book Review: In vivo NMR spectroscopy:principles and techniques, R.A. de Graaf,Wiley, Chichester, 1998201
O.N. Antzutkin
Sideband manipulation in magic-angle-spinning nuclear magnetic resonance 203–266H. Fukui
Theory and calculation of nuclear spin–spincoupling constants 267–294H. Desvaux and P. Berthault
Study of dynamic processes in liquids usingoff-resonance rf irradiation 295–340G. Vlahov
Application of NMR to the study of olive oils 341–357J. Horsewill
Quantum tunnelling aspects of methyl grouprotation studied by NMR 359–389Volume 34
J.H. Kristensen, H. Bildsoe, H.J. Jakobsen andN.C. Nielsen
Application of Lie algebra to NMRspectroscopy
1–69Simon B. Duckett and Christopher J. Sleigh
Applications of the parahydrogenphenomenon: a chemical perspective 71–92Michael Sattler, Jurgen Schleucher and ChristianGriesinger
Heteronuclear multidimensional NMRexperiments for the structure determination ofproteins in solution employing pulsed fieldgradients
93–158M.E. Smith and E.R.H. van Eck
Recent advances in experimental solid stateNMR methodology for half-integer spinquadrupolar nuclei 159–201C.S. Johnson, Jr
Diffusion ordered nuclear magnetic resonancespectroscopy: principles and applications 203–256P. Koehl
Linear prediction spectral analysis of NMRdata 257–299S. Williams
Cerebral amino acids studied by nuclearmagnetic resonance spectroscopy in vivo 301–326G.W. Buchanan
Nuclear magnetic resonance studies of crownethers 327–377Volume 33
Peter Bachert
Pharmacokinetics using fluorine NMR in vivo 1–56M. Luhmer and J. Reisse
Quadrupole NMR relaxation of the noblegases dissolved in simple liquids and solutions:a critical review of experimental data in thelight of computer simulation results 57–76Aaron Sodickson and David G. Cory
A generalized k-space formalism for treatingthe spatial aspects of a variety of NMRexperiments 77–108Brian J. Stockman
NMR spectroscopy as a tool forstructure-based drug design 109–151M.J.P. Ferreira, V.P. Emerenciano,G.A.R. Linia, P. Romoff, P.A. T. Macariand G.V. Rodrigues
13C NMR spectroscopy of monoterpenoids
153–206 Mark W.F. Fischer, Ananya Majumdar and ErikR.P. ZuiderwegProtein NMR relaxation: theory, applicationsand outlook
207–272J.B. Miller
NMR imaging of materials 273–308Volume 32
R. Bruschweiler
Dipolar averaging in NMR Spectroscopy:from polarization transfer to crossrelaxation 1–19Eike Brunner and Ulrich Sternberg
Solid-state NMR investigations on the natureof hydrogen bonds 21–57Ray Freeman
Shaped radiofrequency pulses in highresolution NMR 59–106Michael Nilges and Sean I. O’Donoghue
Ambiguous NOEs and automated NOEassignment 107–139P.M. Kentgens
Off-resonance nutation nuclear magneticresonance spectroscopy of half-integerquadrupolar nuclei 141–164Doree Sitkoff and David A. Case
Theories of chemical shift anisotropies inproteins and nucleic acids 165–190Gottfried Otting
Erratum to ‘‘NMR studies of water bound tobiological molecules: Progr. NMR Spectrosc.,31 (1997) 259–285 191Gerhard Wider
Technical aspects of NMR spectroscopy withbiological macromolecules and studies ofhydration in solution 193–275Cheryl H. Arrowsmith and Yu-Sung Wu
NMR of large (s > 25 kDa) proteins andprotein complexes 277–286190 J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198
Sybren S. Wijmenga and Bernd N.M. van Buuren
The use of NMR methods for conformationalstudies of nucleic acids 287–387Volume 31
Andrew G. Webb
Radiofrequency microcoils in magneticresonance 1–42John A. Chudek and Geoffrey Hunter
Magnetic resonance imaging of plants 43–62Vladimir A. Daragan and Kevin H. Mayo
Motional model analyses of protein andpeptide dynamics using NMR relaxation 63–105Barry J. Hardy, Stephen W. Doughty,Martin F. Parretti, Jenifer Tennison,Bryan E. Finn and Kevin Gardner
Internet conferences in NMRspectroscopy
107–117Clifford B. LeMaster
Nuclear magnetic resonance spectroscopy ofmolecules in the gas phase 119–154R. Kreis
Quantitative localized 1H MR spectroscopyfor clinical use 155–195Gareth A. Morris, Herve Barjat andTimothy J. Horne
Reference deconvolution methods
197–257 Gottfried OttingNMR studies of water bound to biologicalmolecules
259–285Richard Kemp-Harper, Steven P. Brown, ColanE. Hughes, Peter Styles and Stephen Wimperis
Erratum to ‘‘23Na NMR methods for selectiveobservation of sodium ions in orderedenvironments’’: Progr. NMR Spectrosc.,30 (1997) 157–181’’
287Andrew N. Lane
Book review: NMR spectroscopy and itsapplications to biomedical research:Susanta K. Sarkar (ed.) 289–291Johannes Natterer and Joachim Bargon
Parahydrogen induced polarization 293–315H. Fukui
Theory and calculation of nuclear shieldingconstants 317–342Ted Watson and C.T. Philip Chang
Characterizing porous media with NMRmethods 343–386Volume 30
Huaping Mo and Thomas C. Pochapsky
Intermolecular interactions characterized bynuclear Overhauser effects 1–38Reginald Waldeck, Philip W. Kuchel,Alison J. Lennon and Bogdan E. Chapman
NMR diffusion measurements to characterizemembrane transport and solute binding
39–68P.J. McDonald
Stray field magnetic resonance imaging 69–99Daniel Canet
Radiofrequency field gradient experiments 101–135Stefan Berger
NMR techniques employing selectiveradiofrequency pulses in combination withpulsed field gradients 137–156Richard Kemp-Harper, Steven P. Brown, ColanE. Hughes, Peter Styles and Stephen Wimperis
NMR methods for selective observation ofsodium ions in ordered environments
157–181W.A. Thomas
Unravelling molecular structure andconformation—the modern role ofcoupling constants 183–207Jerome W. Rathke, Robert J. Klingler,Rex E. Gerald II, Kurt W. Kramarzand Klaus Woelk
Toroids in NMR spectroscopy
209–253Volume 29
John C. Lindon, Jeremy K. Nicholsonand Ian D. Wilson
Direct coupling of chromatographicseparations to NMR spectroscopy
1–49Gabriele Varani, Fareed Aboul-ela andFriedric H.-T. Allain
NMR investigation of RNA structure
51–127 Dan Farcasiu and Anca GhenciuDetermination of acidity functions and acidstrengths by 13C NMR
129–168Fritz Schick
Bone marrow NMR in vivo 169–227Angel C. de Dios
Ab initio calculations of the NMR chemicalshift 229–278Volume 28
J.W. Emsley and J. Feeney
Milestones in the first fifty years of NMR 1–9E.R. Andrew and E. Szczesniak
A historical account of NMR in the solid state 11–36James N. Shoolery
The development of experimental andanalytical high resolution NMR 37–52Jack S. Cohen, Jerzy W. Jaroszewski, OferKaplan, Jesus Ruiz-Cabelloand Steven W. Collier
A history of biological applications of NMRspectroscopy
53–85J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198 191
Felix W. Wehrli
From NMR diffraction and zeugmatographyto modern imaging and beyond 87–135Bertil Halle
Spin dynamics of exchanging quadrupolarnuclei in locally anisotropic systems 137–159Teresa W.-M. Fan
Metabolite profiling by one- andtwo-dimensional NMR analysis ofcomplex mixtures161–219
Kunisuke Asayama, Yoshio Kitaoka, Guo-qingZheng and Kenji Ishida
NMR studies of high Tc superconductors
221–253 Jack M. MillerFluorine-19 magic-angle spinningNMR
255–281J.A. Peters, J. Huskens and D.J. Raber
Lanthanide induced shifts and relaxation rateenhancements 283–350Volume 27
Helmut Duddeck
Selenium-77 nuclear magnetic resonancespectroscopy 1–323Laszlo Szilogyi
Chemical shifts in proteins come of age 325–430Elizabeth F. Hounsell
1H NMR in the structural and conformationalanalysis of oligosaccharides andglycoconjugates 445–474Mika Ala-Korpela
1H NMR spectroscopy of human bloodplasma 475–554Photis Dais and Apostolos Spyros
13C Nuclear magnetic relaxation and localdynamics of synthetic polymers in dilutesolution and in the bulk state 555–633Martin Billeter
Hydration water molecules seen by NMR andby X-ray crystallography 635–645Paul Jonsen
2H zero field NMR spectroscopy 647–727Volume 26
Jukka Jokisaari
NMR of noble gases dissolved in isotropic andanisotropic liquids 1–26Rafael Bruschweiler and David A. Case
Characterization of biomolecular structureand dynamics by NMR cross relaxation 27–58Alex D. Bain, Ian W. Burton andWilliam F. Reynolds
Artifacts in two-dimensional NMR 59–89Ivano Bertini, Claudio Luchinatand Mario Piccioli
Copper-zinc superoxide dismutase: aparamagnetic protein that provides a uniqueframe for the NMR investigation
91–139J. Courtieu, J.P. Bayle and B.M. Fung
Variable angle sample spinning NMR in liquidcrystals 141–169Ioannis P. Gerothanassis
Multinuclear and multidimensional NMRmethodology for studying individualwater molecules bound to peptides andproteins in solution: principles andapplications 171–237Ioannis P. Gerothanassis
17O NMR studies of hemoproteins andsynthetic model compounds in the solutionand solid states 239–292J.T. Gerig
Fluorine NMR of proteins 293–370David M. LeMaster
Isotope labelling in solution proteinassignment and structural analysis 371–419Charles R. Sanders, II , Brian J. Hare,Kathleen P. Howard and James H.Prestegard
Magnetically-oriented phospholipid micellesas a tool for the study of membrane-associatedmolecules
421–444Olle Soderman and Peter Stilbs
NMR studies of complex surfactant systems 445–482Goran Lindblom and Greger Oredd
NMR Studies of translational diffusion inlyotropic liquid crystals and lipidmembranes 483–515Feng Ni
Recent developments in transferred NOEmethods 517–606Volume 25
J.P. Cohen Addad
NMR and fractal properties of polymericliquids and gels 1–316Giovanna Barbarella
Sulfur-33 NMR 317–343P.J. Hore and R.W. Broadhurst
Photo-CIDNP of biopolymers 345–402Mark S. Searle
NMR Studies of Drug–DNA interactions 403–480Andrew N. Lane
NMR studies of dynamics in nucleic acids 481–505E.W. Lang and H.-D. Ludemann
Density dependence of rotational andtranslational molecular dynamics in liquidsstudied by high pressure NMR 507–633192 J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198
Volume 24
Pawan K. Agrawal and Dharam C. Jain
13C NMR spectroscopy of oleananetriterpenoids1–90
Patrick J. Barrie and Jacek Klinowski
129Xe NMR As a probe for the study ofmicroporous solids: a critical review 91–108Majumdar and R.V. Hosur
Simulation of 2D NMR spectra fordetermination of solution conformations ofnucleic acids 109–158Hellmut Eckert
Structural characterization of noncrystallinesolids and glasses using solid state NMR 159–293Timothy J. Norwood
Multiple-quantum NMR methods 295–375T.E. Bull
Relaxation in the rotating frame in liquids 377–410Susan J. Kohler and Nancy H. Kolodny
Sodium magnetic resonance imaging andchemical shift imaging 411–433Robin K. Harris and Alejandro C. Olivieri
Quadrupolar effects transferred to spin 1/2magic-angle spinning spectra of solids 435–456O.B. Lapina, V.M. Mastikhin, A.A. Shubin,V.N. Krasilnikov and K.I. Zamaraev
51V Solid state NMR studies of vanadia basedcatalysts
457–525Detlef Brinkmann
NMR studies of superionic conductors 527–552Volume 23
P. Jezzard, J.J. Attard, T.A. Carpenterand L. D. Hall
Nuclear magnetic resonance imaging in thesolid state
1–41G. Marius Clore and Angela M. Gronenborn
Applications of three- and four-dimensionalheteronuclear NMR spectroscopy to proteinstructure determination 43–92Robert Turner and Paul Keller
Angiography and perfusion measurements byNMR 93–133Maurice Gueron, Pierre Plateauand Michel Decorps
Solvent signal suppression in NMR
135–209 Roy E. Hoffman and George C. LevyModern methods of NMR data processingand data evaluation
211–258V.M. Mastikhin, I.L. Mudrakovskyand A.V. Nosov
1H NMR magic angle spinning (MAS) studiesof heterogeneous catalysis
259–299Leonid B. Krivdin and Ernest W. Della
Spin–spin coupling constants between carbonsseparated by more than one bond 301–610Volume 22
R.V. Hosur
Scaling in one and two dimensional NMRspectroscopy in liquids 1–53S.W. Homans
Oligosaccharide conformations: application ofNMR and energy calculations 55–81Brandan A. Borgias, Miriam Gochin, DeborahJ. Kerwood and Thomas L. James
Relaxation matrix analysis of 2D NMR data
83–100 Gerhard WagnerNMR investigations of protein structure
101–139 Keith G. Orrell, Vladimir Sik and DavidStephensonQuantitative investigations of molecularstereodynamics by 1D and 2D NMR methods
141–208Bernd Wrackmeyer and Klaus Horchler
NMR parameters of alkynes 209–253Henrik Gesmar, Jens J. Led and FritsAbildgaard
Improved methods for quantitative spectralanalysis of NMR data
255–288Jan Schraml
29Si N M R spectroscopy of trimethylsilyl tags 289–348Isao Ando, Takeshi Yamanobe and TetsuoAsakura
Primary and secondary structures of syntheticpolymer systems as studied by 13C N M Rspectroscopy
349–400J.-Ph. Ansermet, C.P. Slichter and J.H. Sinfelt
Solid state NMR techniques for the study ofsurface phenomena 401–421Philip H. Bolton
A primer on isotopic labelling in NMRinvestigations of biopolymers 423–452Oliver W. Howarth
Vanadium-51 NMR 453–485Seymour H. Koenig and Rodney D. Brown III
Field-cycling relaxometry of protein solutionsand tissue: implications for MRI 487–567Ajoy K. Roy and Paul T. Inglefield
Solid state NMR studies of local motions inpolymers 569–603Volume 21
J.W. Akitt
Multinuclear studies of aluminium compounds 1–149Robin L. Armstrong
Displacive order-disorder crossover inperovskite and antifluorite crystals undergoingrotational phase transitions 151–173Andreas Dolle and Thorsten Bluhm
Orientation of the rotational diffusionprincipal axis system determined by nuclearrelaxation data 175–201J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198 193
K. Ott, M.A. Haghani, C.A. Paulick and D.Quitmann
Quadrupolar relaxation and thermodynamicalprocesses in liquid metallic alloys
203–235D. Canet
Construction, evolution and detection ofmagnetization modes designed for treatinglongitudinal relaxation of weakly coupled spin1/2 systems with magnetic equivalence 237–291Leonid B. Krivdin and Gennady A. Kalabin
Structural applications of one-bond carbon–carbon spin–spin coupling constants 293–448Jeremy K. Nicholson and Ian D. Wilson
High resolution proton magnetic resonancespectroscopy of biological fluids 449–501Ole Winneche Sorensen
Polarization transfer experiments inhigh-resolution NMR spectroscopy 503–569Volume 20
Rudolph Willem
2D NMR applied to dynamic stereochemicalproblems 1–94O.N. Chupakhin, V.N. Charushin andA.I. Chernyshev
Application of 1H, 13C and 15N NMRin the chemistry of 1,4-diazines
95–206Poul Erik Hansen
Isotope effects in nuclear shielding 207–255Kevin M. Brindle
NMR methods for measuring enzymekinetics in vivo 257–293Alex D. Bain
The superspin formalism for pulse NMR 295–314George H. Weiss and James A. Ferretti
Optimal design of relaxation time experiments 317–335Robert E. London
13C labelling in studies of metabolic regulation 337–383R. Kimmich, G. Schnur and M. Kopf
The tube concept of macromolecular liquids inthe light of NMR experiments 385–421J.F. Hinton, K.R. Metz and R.W. Briggs
Thallium NMR spectroscopy 423–513David S. Stephenson
Linear prediction and maximum entropymethods in NMR spectroscopy 515–626Volume 19
Peter Stilbs
Fourier transform pulsed-gradient spin-echostudies of molecular diffusion 1–45J. Shaka and James Keeler
Broadband spin decoupling inisotropic-liquids 47–129Wolfgang Robien, Brigitte Kopp,Diana Schabl and Herbert Schwarz
Carbon-13 NMR spectroscopy of cardenolidesand bufadienolides
131–181C. Chachaty
Applications of NMR methods to the physicalchemistry of micellar solutions 183–222Katalin E. Kover and Gyula Batta
Theoretical and practical aspects of one- andtwo-dimensional heteronuclear Overhauserexperiments and selective 13C T1-determinations of heteronuclear distances 223–266P. Gerothanassis
Methods of avoiding the effects of acousticringing in pulsed fourier transform nuclearmagnetic resonance spectroscopy 267–329B. Blumich
White noise nonlinear system analysis innuclear magnetic resonance spectroscopy 331–417Volume 18
J.P.G. Malthouse
13C NMR of enzymes 1–59Malcolm H. Levitt
Composite pulses 61–122Paul Rosch
NMR-studies of phosphoryl transferringenzymes 123–169F. Noack
NMR field-cycling spectroscopy: principlesand applications 171–276Vladimir Mlynarik
Measurement of spin coupling constants toquadrupolar nuclei via relaxation studies 277–305K. Dill and R.D. Carter
13C NMR spectral studies of the N-terminalportion of glycophorins 307–326Manfred Holz
New developments in NMR of simpleelectrolyte solutions 327–403Volume 17
Angela M. Gronenborn and G. Marius Clore
Investigation of the solution structures ofshort nucleic acid fragments by means ofnuclear Overhauser enhancementmeasurements 1–32R.A. Wind, M.J. Duijvestijn, C. van der Lugt, A.Manenschijn and J. Vriend
Applications of dynamic nuclear polarizationin 13C NMR in solids
33–67A. Schwenk
Steady-state techniques for low sensitivity andslowly relaxing nuclei 69–140194 J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198
Jozef Kowalewski, Lars Nordenskiold, NikolasBenetis and Per-Olof Westlund
Theory of nuclear spin relaxation inparamagnetic systems in solution
141–185Janez Stepisnik
Measuring and imaging of flow by NMR 187–209K. Muller, P. Meier and G. Kothe
Multipulse dynamic NMR of liquid crystalpolymers 211–239P.S. Belton and R.G. Ratcliffe
NMR and compartmentation in biologicaltissues 241–279David L. Turner
Basic two-dimensional NMR 281–358Volume 16
David G. Gorenstein
Non-biological aspects of phosphorus-31NMR spectroscopy 1–98J.P. Bloxsidge and J.A. Elvidge
Practical aspects of tritium magnetic resonance 99–114H.G. Hertz
The problem of intramolecular rotation inliquids and nuclear magnetic relaxation 115–162O.W. Sorensen, G.W. Eich, M.H. Levitt, G.Bodenhausen and R.R. Ernst
Product operator formalism for thedescription of NMR pulse experiments
163–192W.S. Veeman
Carbon-13 chemical shift anisotropy 193–235J. Klinowski
Nuclear magnetic resonance studies of zeolites 237–309Christopher J. Turner
Multipulse NMR in liquids 311–370Volume 15
R.E. Gordon, P.E. Hanley and D. Shaw
Topical magnetic resonance 1–47R.A. Iles, A.N. Stevens and J.R. Griffiths
NMR Studies of metabolites in living tissue 49–200N.A.B. Gray
Computer assisted analysis of carbon-13NMR spectral data 201–248J. Lounila and J. Jokisaari
Anisotropies in spin–spin coupling constantsand chemical shifts as determined from theNMR spectra of molecules oriented by liquidcrystal solvents 249–290Peter L. Rinaldi
The determination of absolute configurationusing nuclear magnetic resonance techniques 291–352Jeremy K.M. Sanders and John D. Mersh
Nuclear magnetic double resonance; the use ofdifference spectroscopy 353–400Volume 14
Poul Erik Hansen
Carbon–hydrogen spin–spin couplingconstants 175–295J. Tabony
Nuclear magnetic resonance studies ofmolecules physisorbed on homogeneoussurfaces 1–26J.C. Lindon and A.G. Ferrige
Digitisation and data processing in Fouriertransform NMR 27–66Fuyuhiko Inagaki and Tatsuo Miyazawa
NMR analyses of molecular conformationsand conformational equilibria with thelanthanide probe method 67–111Russell E. Jacobs and Eric Oldfield
NMR of membranes 113–136Geoffrey Bodenhausen
Multiple-quantum NMR 137–173Volume 13
Dennis R. Burton, Sture Forsen, GunnarKarlstrom and Raymond A. Dwek
Proton relaxation enhancement (PRE) inbiochemistry: a critical survey
1–45F. Heatley
Nuclear magnetic relaxation of syntheticpolymers in dilute solution 47–85Lee J. Todd Allen R. Siedle
NMR studies of boranes, carboranes andhetero-atom boranes 87–176Victor Wray
Carbon–carbon coupling constants: acompilation of data and a practicalguide 177–256Pierre Laszlo
Fast kinetics studied by NMR 257–270R. Lenk
Thermodynamics of nuclear spins 271–302C.W. Haigh R.B. Mallion
Ring current theories in nuclear magneticresonance 303–344Volume 12
Oliver W. Howarth David M.J. Lilley
Carbon-13-NMR of peptides and proteins 1–40D.I. Hoult
The NMR receiver: a description and analysisof design 41–77Robert L. Vold and Regitze R. Vold
Nuclear magnetic relaxation in coupled spinsystems 79–133David B. Davies
Conformations of nucleosides and nucleotides 135–225J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198 195
Bernd Wrackmeyer
Carbon-13 NMR spectroscopy of boroncompounds 227–259R.N. Young
NMR spectroscopy of carbanions andcarbocations 261–286Volume 11
Jozef Kowalewski
Calculations of nuclear spin–spin couplingconstants 1–78J.N. Shoolery
Some quantitative applications of 13C NMRspectroscopy 79–93Brian E. Mann
Dynamic 13C NMR spectroscopy 95–114V.S. Petrosyan
NMR Spectra and structures of organotincompounds 115–148K.A.K. Ebraheem and G.A. Webb
Semi-empirical calculations of the chemicalshifts of nuclei other than protons 149–181S. Aime and L. Milone
Dynamic 13C NMR spectroscopy of metalcarbonyls 183–210Henry H. Mantsch, Hazime Saito andIan C.P. Smith
Deuterium magnetic resonance, applicationsin chemistry, physics and biology
211–272Volume 10
P.D. Buckley, K.W. Jolley and D.N. Pinder
Application of density matrix theory to NMRline-shape calculations 1–26J. Hilton and L.H. Sutcliffe
The ‘‘through-space’’ mechanism in spin–spincoupling 27–39V.F. Bystrov
Spin–spin coupling and the conformationalstates of peptide systems 41–82J.W. Emsley, L. Phillips and V. Wray
Flourine coupling constants 83–752Volume 9
J. Reuben
Paramagnetic lanthanide shift reagents inNMR spectroscopy: principles, methodologyand applications 3–70N.M. Sergeyev
Nuclear magnetic resonance spectroscopy ofcyclopentadienyl compounds 71–144Ronald G. Lawler
Chemically induced dynamic nuclearpolarization 147–210Volume 8
E.R. Andrew
The narrowing of NMR spectra of solids byhigh-speed specimen rotation and theresolution of chemical shift and spin multipletstructures for solids 1–39P. Mansfield
Pulsed NMR in solids 43–101J.H. Goldstein, V.S. Watts and L.S. Rattet
13CH Satellite NMR Spectra 104–162G.J. Martin and M.L. Martin
The stereochemistry of double bonds 166–259Volume 7
J.W. Emsley, L. Phillips
Fluorine chemical shifts 1–520Volume 6
J.N. Murrell
The theory of nuclear spin–spin coupling inhigh resolution NMR spectroscopy 1–60E.G. Finer and R.K. Harris
Spin–spin coupling between phosphorusnuclei 61–118E.W. Randall and D.G. Gillies
Nitrogen nuclear magneticresonance 119–174Volume 5
V.J. Kowalewski
The indor technique in high-resolution nuclearmagnetic resonance 1–31T.H. Siddall and W.E. Stewart
Magnetic non-equivalence related tosymmetry considerations and restrictedmolecular motion 33–147Harold Booth
Applications of 1H nuclear magneticresonance spectroscopy to theconformational analysis of cycliccompounds 149–381Volume 4
Roy Foster and Colin A. Fyfe
Nuclear magnetic resonance of organiccharge-transfer complexes 1–89Norman S. Ham, T. Mole
The application of NMR to organometallicexchange reactions 91–192196 J.W. Emsley, J. Feeney / Progress in Nuclear Magnetic Resonance Spectroscopy 50 (2007) 179–198
L.W. Reeves
The study of water in hydrate crystals bynuclear magnetic resonance 193–233C. Deverell
Nuclear magnetic resonance studies ofelectrolyte solutions 235–334Monisha Bose
Nuclear magnetic resonance in magneticmaterials 335–444Volume 3
P. Diehl, R.K. Harris and R.G. Jones
Sub-spectral analysis 1–61H. Batiz-Hernandez and R.A. Bernheim
The isotope shift 63–85K.J. Packer
Nuclear spin relaxation studies of moleculesadsorbed on surfaces 87–128E.L. Mackor and C. Maclean
Relaxation processes in systems of two non-identical spins 129–157H.G. Hertz
Microdynamic behaviour of liquids as studiedby NMR relaxation times 159–230Pierre Laszlo
Solvent effects and nuclear magnetic resonance 231–402Volume 2
D.E. O’Reilly
Chemical shift calculations 1–61A.D. Buckingham, K.A. McLauchlan
High resolution nuclear magnetic resonance inpartially oriented molecules 63–109E. De Boer and H. Van Willigen
Nuclear magnetic resonance of paramagneticsystems 111–161Ruth M. Lynden-Bell
The calculation of line shapes by densitymatrix methods 163–204R.F. Zurcher
The cause and calculation of proton chemicalshifts in non-conjugated organic compounds 205–257Volume 1
R.E. Richards
Foreword xixO. Haworth and R.E. Richards
The use of modulation in magnetic resonance 1–14Ragnar A. Hoffman and Sture Forsen
High resolution nuclear magnetic double andmultiple resonance 15–204J.D. Swalen
Computer techniques in the analysis of NMRspectra 205–250G. Mavel
Studies of phosphorus compounds using themagnetic resonance spectra of nuclei otherthan phosphorus-31 251–373References
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