Department of PediatricsDivision of Pediatric NephrologyP.O. Box 016960 (M-714)Miami, Florida 33101

_____________PRST STD

US Postage PAID

Miami, FLPermit No. 438

pedIatrIc nepHrology 41st year semInarMarch 6 - March 9, 2014The Alexander All Suite Ocean Front ResortMiami Beach, Florida

Sponsored by the

Presented by The Division of Pediatric Nephrology, Department of Pediatrics and the Division of Renal Pathology, Department of Pathology

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All SuiTE OcEAn FrOnT rESOrT5225 cOllinS AvEnuE, MiAMi BEAcH, Fl 33140

March 6 - March 9, 2014

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forty firstPediatric NePhrology SemiNar aNd FirSt reNal Pathology coUrSe

For More Information call 305-243-6716visit us at http://pediatrics.med.miami.edu/nephrology/seminar

Wednesday marcH 5, 20146:00-8:00 P.M. Registration

PEDIATRIC RENAL PATHOLOGY COURSE (Pre-Seminar)Director: Laura Barisoni, M.D.co-Directors: surya seshan, M.D. and David B. thomas, M.D.

tHursday marcH 6, 20147:00-8:00 A.M. Registration. Continental Breakfast8:00-8:10 A.M. Introduction. Opening Remarks Gastón e. Zilleruelo, M.D. Laura Barisoni, M.D.

SESSION 1: PROTEINURIC LESSIONS Moderator: Helen Liapis, M.D.8:10-8:50 A.M. Processing and Reporting of Renal Biopsies David B. thomas, M.D.8:50-9:30 A.M. Algorithmic Approach to Renal Diseases Laura Barisoni, M.D. 9:30-10:10 A.M. Podocytopathies (MCD-FSGS) Laura Barisoni, M.D.10:10-10:30 A.M. Break10:30-11:10 A.M. Congenital and Infantile Nephrotic Syndrome Helen Liapis, M.D.11:10-11:30 A.M. IgM-C1Q Nephropathies David B. thomas, M.D.11:30-12:00 P.M. Membranous GN Laura Barisoni, M.D.12:00-1:00 P.M. Lunch

SESSION 2: HEMATURIAS/NEPHRITIC SYNDROMES Moderator: Laura Barisoni, M.D.1:00-1:45 P.M. MPGN/DDD/C3 Nephropathy sanjeev sethi, M.D., Ph.D.1:45-2:30 P.M. Post-Infectious GN sanjeev sethi, M.D., Ph.D.2:30-3:00 P.M. IgA-HSP surya seshan, M.D.3:00-3:20 P.M. Break

SESSION 3: SYSTEMIC DISEASES Moderator: David Thomas, M.D.3:20-4:10 P.M. Lupus Nephritis surya seshan, M.D.4:10-4:40 P.M. Vasculitis David B. thomas, M.D. 4:40-5:10 P.M. Thrombotic Microangiopathy surya seshan, M.D.5:10-5:30 P.M. Discussion

frIday marcH 7, 20147:00-8:00 A.M. Registration. Continental Breakfast.

SESSION 4: GENETIC/METABOLIC DISORDERS Moderator: Helen Liapis, M.D.8:00-8:30 A.M. Collagen type III, IV, Fibronectin Lesions David B. thomas, M.D. 8:30-9:15 A.M. Fabry and Inherited Metabolic Disorders surya seshan, M.D.9:15-9:45 A.M. Mitochondriopathies Laura Barisoni, M.D.9:45-10:30 A.M. Acquired and Inherited Tubulointerstitial Nephritis robert colvin M.D.10:30-10:50 A.M. Break

SESSION 5: TRANSPLANT PATHOLOGY Moderator: Surya Seshan, M.D.10:50-11:40 A.M. Allograft Rejection: Cellular, AMR robert colvin, M.D.11:40-12:20 P.M. Recurrent and De-Novo Glomerular Diseases surya seshan, M.D.12:20-1:00 P.M. Transplant Infections robert colvin, M.D.1:00-2:00 P.M. Lunch PEDIATRIC NEPHROLOGY SEMINAR AND RENAL PATHOLOGY COURSE COMBINED SESSION FRIDAY MARCH 7, 2014 AFTERNOON

seMiNAr Director: Gastón e. Zilleruelo M.D.seMiNAr co-Directors: carolyn L. Abitbol M.D., Michael Freundlich M.D.

SESSION 6: CYSTIC RENAL DISEASES AND CAKUT Moderator: Uri S. Alon, M.D.2:00-2:30 P.M. Clinical Presentation and Diagnostic Imaging Jayanthi chandar, M.D.2:30-3:00 P.M. Genetic Diagnosis olaf Bodamer, M.D., Ph.D.3:00-3:30 P.M. Cystic Diseases: Pathology Helen Liapis, M.D.3:30-4:00 P.M. Break4:00-4:30 P.M. Congenital Anomalies:Clinical Presentations and Genetics olaf Bodamer, M.D., P.hD.4:30-5:00 P.M. CAKUT: Pathology Maria M. rodriguez, M.D.

SESSION 7: CASE PRESENTATIONS (15 min each) Moderator: Jayanthi Chandar, M.D.5:00-6:00 P.M. Child with Nephrotic Syndrome Child with Nephritic Syndrome Child with Inherited Kidney Disease Child with Kidney Cystic Disease6:00-6:30 P.M. Medical Knowledge competence Assessment 6:30-7:30 P.M. WeLcoMe recePtioN

program pedIatrIc nepHrology semInar 2014

program pedIatrIc nepHrology semInar 2014

saturday marcH 8, 20147:30-8:00 A.M. Registration. Continental Breakfast.

SESSION 8: CHRONIC KIDNEY DISEASES AND HYPERTENSION Moderator: Frederick J, Kaskel M.D., Ph.D.8:00-8:20 A.M. Physiological Mechanisms of Nephron Loss in the Progression to ESRD H. William schnaper, M.D.8:20-8:40 A.M. Practical Application of Genetics in Pediatric Nephrology Friedhelm Hildebrandt, M.D.8:40-9:00 A.M. Selecting the Optimal Antihypertensive Agent Guido Filler M.D., Ph.D. 9:00-9:20 A.M. Hypertension and Obesity Melvin Bonilla-Felix, M.D.9:20-9:40 A.M. Nephroprevention in the Child with CKD Guido Filler M.D., Ph.D.9:40-10:10 A.M. chester edelmann Jr. Memorial Lecture: Glomerulonephritis Update 2014 Frederick J. Kaskel, M.D., Ph.D.10:10-10:30 A.M. Panel Discussion10:30-11:00 A.M. Break and Visit Exhibits11:00-11:10 A.M. the José strauss Visiting Professor Award

SESSION 9: RENO-CARDIAC INTERACTIONS Moderator: Michael Freundlich, M.D.11:10-11:40 A.M. Cardio-renal Syndromes in Pediatrics: Definitions, Mechanisms and Causes Michael Freundlich, M.D.11:40-12:00 P.M. Cardiac Geometry Adaptation in CKD Mark Mitsnefes, M.D.,Ms12:00-12:20 P.M. How Does FGF23 Target the Kidneys? Jyothsna Gattineni, M.D.12:20-12:40 P.M. How Does FGF23 Damage the Heart? christian Faul, Ph.D.12:40-1:00 P.M. How Does Vitamin D Protect the Heart? Michael Freundlich, M.D.1:00-1:30 P.M. Panel Discussion1:30-2:30 P.M. Meet the Professors Luncheon

SESSION 10: WORKSHOP ON GROWTH AND NUTRITION IN CKD Moderator: John D. Mahan, M.D.3:00-3:20 P.M. Assessment of Growth and Body Mass in Infants and Children with CKD carolyn L. Abitbol, M.D.3:20-3:40 P.M. Nutritional Assessment and Management of Children with CKD John D. Mahan, M.D.3:40-4:00 P.M. Nephron Mass and the Programming of the Metabolic Syndrome in Infants with CKD carolyn L. Abitbol, M.D.4:00-4:20 P.M. Poor Growth in Children with Hypophosphatemic Disorders Uri s. Alon, M.D.4:20-4:40 P.M. Role of rHu-GH in CKD and Post Renal Transplantation John D. Mahan, M.D.4:40-5:00 P.M. Fluid and Electrolyte Requirements in Children with CKD carolyn L. Abitbol M.D.

5:00-6:00 P.M. Case Studies and Discussion6:00-6:20 P.M. Medical Knowledge competency Assessment

sunday marcH 9, 20147:00-8:00 A.M. Registration. Continental Breakfast.

SESSION 11: RESEARCH AND TRAINING INITIATIVES Moderator: H. William Schnaper, M.D.8:00-8:20 A.M. Advances in Research: Impact of Translational Science William e. smoyer, M.D.8:20-8:40 A.M. Grant Writing: Tips for a Successful Application H. William schnaper, M.D.8:40-9:00 A.M. Keys to Career Development: Coaching and Mentoring Skills John D. Mahan, M.D.

SESSION 12: TRANSPLANT UPDATES 2014 Moderators: Vera Koch, M.D. Nelson Orta, M.D.9:00-9:20 A.M. When to Re-Transplant? Approach to Desensitization Guido Filler, M.D., Ph.D.9:20-9:40 A.M. Role of Eculizumab in Recurrent HUS Howard trachtman, M.D. 9:40-10:00 A.M. Post-Transplant Viral Infections Jayanthi chandar, M.D.10:00-10:20 A.M. Role of SuPAR in CKD Howard trachtman, M.D.10:20-10:40 A.M. Steroid Free Protocols richard N. Fine, M.D. 10:40-11:00 A.M. Panel Discussion11:00-11:20 A.M. Break. Visit exhibits

SESSION 13: DIALYSIS AND CRRT (#) Moderators: Carolyn L. Abitbol, M.D. Wacharee Seeherunvong, M.D.11:20-11:40 A.M. Renal Replacement Therapy: Which Modality? carolyn L. Abitbol M.D.11:40-12:00 P.M. Which is the Ideal PD Prescription? Francisco J. cano, M.D.12:00-12:20 P.M. Vascular access for hemodialysis: from the radio-cephalic av fistula to the axillary-right atrium av graft Marwan tabbara, M.D.12:20-12:40 P.M. Cardiovascular disease in dialysis patients: challenges and opportunities Mark Mitsnefes, M.D., Ms12:40-1:00 P.M. CRRT: Indications, Modalities Patrick Brophy, M.D. 1:00-1:30 P.M. Panel Discussion

ADJOURN

(#) A HANDS-ON WORKSHOP FOR LIVE CRRT WILL TAKE PLACE AT HOLTZ CHILDREN’S HOSPITAL AT THE END OF THE SEMINAR WITH AN ADDITIONAL FEE FOR DETAILS AND INFORMATION E-MAIL: pediatricnephrology@med.miami.edu

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acKnoWledgementsendorsements

Carolyn L. Abitbol, M.D. Professor of Pediatrics Division of Pediatric Nephrology, Medical Director, Pediatric Dialysis Unit, Co-Director Pediatric Nephrology Seminar

Laura Barisoni, M.D.Professor of Pathology, Division Chief, Renal Pathology Service, Department of Pathology, Director Renal Pathology Course

Olaf Bodamer, M.D., Ph.D.Professor of Human Genetics, Biochemistry and Molecular Biology, Division of Clinical and Translational Genetics, Dr. John T Macdonald Foundation, Department of Human Genetics

Jayanthi Chandar, M.D.Associate Professor of Clinical Pediatrics, Division of Pediatric Nephrology

Christian Faul, Ph.D. Assistant Professor of Medicine and Cell Biology. Division of Nephrology and Hypertension

Michael Freundlich, M.D.Professor of Clinical Pediatrics, Division of Pediatric NephrologyCo-Director Pediatric Nephrology Seminar

María M. Rodriguez, M.D. Professor of Pathology, Director of Pediatric PathologyDepartment of Pathology

José Strauss, M.D.Emeritus Professor, Division of Pediatric Nephrology, Former Chairman Pediatric Nephrology Seminars

Marwan Tabbara, M.D. Associate Professor of Surgery. Division of Vascular Surgery

David B. Thomas, M.D.Professor of Pathology, Department of Pathology, Co-Director Renal Pathology Course

Wacharee Seeherunvong, M.D.Assistant Professor of Clinical Pediatrics, Division of Pediatric Nephrology

Gastón E. Zilleruelo, M.D. Professor of Pediatrics, Director, Division of Pediatric Nephrology, Program Director, Pediatric Nephrology Seminar

Uri S. Alon, M.D. Professor of Pediatrics and Director of Research and Education, Section of Nephrology, Children’s Mercy Hospital and Clinics, University of Missouri, Kansas City, MO

Melvin Bonilla-Felix, M.D. Professor and Chair, Department of PediatricsUniversity of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico

Patrick Brophy, M.D. Director of Pediatric Nephrology, Children’s Hospital, Iowa City, IA

Francisco J. Cano, M.D.Profesor Titular, Coordinador Dialisis Peritoneal, Unidad de Nefrologia Infantil, Hospital Luis Calvo Mackenna, Director Revista Chilena de Pediatria, Santiago, Chile

Robert Colvin, M.D.Benjamin Castleman Distinguished Professor of Pathology, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA

Guido Filler, M.D., Ph.D. Professor of Pediatrics, Chair Department of PediatricsChildren’s Hospital, London Health Science Centre University of Western Ontario, Canada

Richard N. Fine, M.D. Professor of Pediatrics , State University of NY at Stony Brook, NY

Jyothsna Gattineni, M.D.Assistant Professor of Pediatrics, Division of Nephrology, UT Southwestern Medical Center, Dallas, Texas

Friedhelm Hildebrandt, M.D.Chief Division of Nephrology, Boston Children’s Hospital, Professor of Pediatrics, Harvard Medical School, Boston, MA

Frederick J. Kaskel M.D., Ph.D.Professor of Pediatrics and Director of Pediatric Nephrology, Department of Pediatrics, Children’s Hospital at Montefiore, NY

Vera Koch, M.D. Professor of Pediatric Nephrology, Instituto da Crianza do Hospital das Clinicas, Universidad of Sao Paulo, School of Medicine, Brazil. Secretary General ALANEPE

Helen Liapis, M.D.Professor of Pathology and Immunology, Department of Pathology and Immunology, Division of Anatomic Pathology, Washington University School of Medicine St Louis, MO

John D. Mahan, M.D.Professor, Department of Pediatrics, Program Director, Pediatric Residency Program, Program Director, Pediatric Nephrology Fellowship Program, Vice Chair for Education, The Ohio State University COM

Mark Mitsnefes, M.D., MS. Professor of Pediatrics, Division of Nephrology and Hypertension, Program Director Clinical Translational Research Center, Cincinnati Children’s Hospital, OH

Nelson R. Orta, M.D.Profesor Titular de Pediatria. Director del Postgrado de Nefrologia Pediatrica, Hospital de Niños, Universidad de Carabobo, Valencia, Venezuela

William E. Smoyer, M.D. Director Center for Clinical and Translational Research. The Research Institute at Nationwide Children’s Hospital, Columbus, OH

H. William Schnaper, M.D.Professor of Pediatrics; Vice Chairman, Children’s Memorial Medical Center, Feinberg School of Medicine, Northwestern University, Chicago, IL Past President, ASPN

Surya Seshan, M.D.Professor of Pathology, Department of Pathology, The New York Hospital-Cornell Med. Ctr, New York, NY Renal Pathology Course Co-Director

Sanjeev Sethi, MD, Ph.D.Professor of Pathology, Department of Laboratory Medicine and Pathology, Mayo ClinicRochester, MN

Howard Trachtman, M.D.Professor of Pediatrics, Division of Nephrology, New York University Langone Medical Center, New York, NY

AlExiOn PHArMAcEuTicAlS

Flanked by the roaring Atlantic Ocean and rippling Intracoastal Waterway, the Alexander

All Suite Ocean Front Resort is located in the heart of Miami Beach. Attendees will enjoy

late-winter in South Florida which is unlike that in any other part of the U.S. thanks to

a subtropical climate and strong Caribbean/Latin American influences. It’s just the right

place for recharging your personal and professional perspectives in the company of friends

and colleagues. You won’t need your coat, boots, or umbrella, but a light jacket may feel

good in Miami’s moonlit evening breezes and super-air conditioned restaurants.

Room Rates: US $299.00 + US $15.00 Resort Fee and 13% tax-Single/Double Occupancy-

European plan (meals not included). Room rates apply three day prior to, during and

three days after the Seminar. Reservations must be received by February 5, 2014, to take

advantage of the above rate. Please use attendee code 3618 when making your reservations.

After this date, reservation requests will be considered on a space available basis.

Advanced Registration Fee:Renal Pathology Course ONLY US $250.00

March 6th and March 7th

Pediatric Nephrology Seminar ONLY US $350.00

March 8th and March 9th

Pediatric Nephrology Seminar ONLY US $295.00

Physicians in Training, Nurses and

Allied Health Professionals

Pediatric Renal Pathology Course and US $500.00

Pediatric Nephrology Seminar

CRRT Workshop on Sunday afternoon US $ 50.00

Physicians in Training will need letter of verification from Chief of service.

Tuition includes admission to scientific sessions, a course flash drive and

continental breakfasts. After February 20, 2014 and (On-Site) US $650.00

for physician in practice and US $330.00 for others.

PLEASE NOTE THAT ONLY US CHECKS AND MONEY ORDERS CAN BE ACCEPTED

FOR ONSITE REGISTRATION. NO CREDIT CARDS CAN BE ACCEPTED ON SITE.

Services for the Disabled:If special arrangements are required for an individual with a disability to

attend this conference, please contact: Gaston Zilleruelo, M.D., (305) 585-6726

and the Alexander All Suite Ocean Front Resort 1-800-327-6121 or

(305) 865-6500 no later than February 8, 2014.

For Additional Information, contact:Department of Pediatrics

Division of Pediatric Nephrology

P.O. Box 016960 (M-714)

Miami, FL 33101

Tel. (305) 585-6726

Email: pediatricnephrology@med.miami.edu

To register online, visit http://pediatrics.med.miami.edu/nephrology/

seminar select conference you are attending and click register and pay.

Registration Cancellation PolicyRefunds will be made only if written notice of cancellation is received prior to February 26, 2014. A US $75.00 fee is charged to all refunds.

After this date, no refunds will be made. In cases where a course is cancelled due to insufficient registrations, a full tuition refund will be made.

Hotel InformatIonTHE AlExAndEr All SuiTE OcEAnFrOnT rESOrT

5225 cOllinS AvEnuE, MiAMi BEAcH, Fl 33140Tel: 1-800-327-6121 or (305) 865-6500

Email: reservations@alexanderhotel.com

pedIatrIc nepHrology semInar XlIregIstratIon InformatIon

objectIves • Identifyrecentdiscoveriesinbasic,translationalandclinicalresearchinselectedareasofpediatricnephrologyandrenalpathology • Assessdiagnostictoolsinthepractitionerapproachtochildrenwithcommonfluidandelectrolytesdisorders • Evaluatepathogenesis,complicationsandmanagementofchildrenwithcysticrenaldiseasesandCongenitalAnomaliesoftheUrinary Tract(CAKUT),nephroticsyndromeandcomplementdeficientglomerulopathies • Assesstheimpactofgrowthandnutritioninchildrenwithchronickidneydiseases(CKD)andtheeffectsofuseofrecombinantgrowth hormonetherapyintheirmanagement • MoreeffectivelymanagechildrenwithCKD,dialysisandtransplantanditscomplications • Evaluatepathogenesis,complicationsandmanagementofchildrenwithhypertensionandreno-cardiacinteractions • Explaintheprocessofhowtosuccessfullyapplyforresearchfunds • Assesstheimportanceofleadershipstylesandstrengthstoobtainsuccessfuloutcomes • Introductiontotheroutinehandling,processingandreportingofkidneybiopsieswithasystematicapproachinthediagnosisofmedical renaldiseases • Assesstheinformationobtainedfromkidneybiopsiesanditsclinicalcorrelation

founded by: José Strauss, M.D.

program dIrector: Gastón Zilleruelo, M.D.

assocIate program dIrectors: Carolyn L. Abitbol, M.D. and Michael Freundlich, M.D.

course descrIptIon

faculty dIsclosure and conflIct of Interest resolutIonAllconflictsofinterestofanyindividual(s)inapositiontocontrolthecontentofthisCMEactivitywillbeidentifiedandresolvedpriortothiseducationalactivitybeingprovided.Disclosureaboutproviderandfacultyrelationships,orthelackthereof,willbeprovidedtolearners.

target audIencePediatricNephrologySeminarXLIandtheRenalPathologyCourseareaninternationalforumforpediatricandadultnephrologists,pediatricians,internists,generalpractitioners,renalpathologists,neonatologists,pediatricurologists,transplantsurgeons,nurses,nutritionistsandalliedhealthprofessionalstoreviewselectedrelevantsubjectsandsharenewscientificmaterials

accredItatIonTheUniversityofMiamiLeonardM.MillerSchoolofMedicine isaccreditedby theAccreditationCouncil forContinuingMedicalEducationtoprovidecontinuingmedicaleducationforphysicians.

credIt desIgnatIonTheUniversityofMiamiLeonardM.MillerSchoolofMedicinedesignatesthisliveactivityforamaximumof26.5AMA PRA Category 1 Credits™.Physiciansshouldclaimonlythecreditcommensuratewiththeextentoftheirparticipationintheactivity.

TheMiamiPediatricNephrologySeminarXLIisanuniqueinternationalgatheringofpediatricandinternalmedicinenephrologists,pediatricians,pediatricurologists,transplantsurgeons,renalpathologists,nurses,nutritionistsandalliedhealthprofessionalsfromallovertheUnitedStatesandtheworld,sponsoredbytheUniversityofMiami,LeonardMillerSchoolofMedicineandHoltzChildren’sHospitalatJacksonMemorialHospital.Thecontentisbasic,theapproachisclinical.Conceptualandpracticalproblemsarefeaturedinabalanceofformalpresentationsfollowedbyinformaldiscussions.Topicscoveredrelatetoresearchadvancestotheunderstandingofmechanismsofrenaldiseasesandclinicaldiagnosisandmanagement.Allregistrantshaveopportunitiestobeinvolvedinadynamicexchangeofinformation,experienceandinsight.Selectionoftopics,facultyandformatarebasedonsuggestionsfrompastSeminarparticipantsandcurrentquestions.Inaddition,wewillhaveanoptionalPre-Seminar First Pediatric Renal Pathology CoursedirectedbytherenownedpathologistLauraBarisoniM.D.Thisisanintensive,twodayscomprehensivecoursecoveringallaspectsofnephropathologystartingwithsampleprocessingandtransitioningtoglomerular,tubular,cysticaswellassystemicandmetabolicdisordersaffectingpediatricandyoungadultpatients.ThisCoursewillstartonMarch6andwillcontinueonFridayMarch7,2014.

ThePediatric Nephrology Seminar XLIwillstartwithacombinedSessiononFridayafternoon.TheSeminarwillhaveanotherexcitingscientificprogramwithatotalof8Sessionscoveringawiderangeoftopics,includingCystic Renal Diseases and CAKUT, Clinico –Pathologic Correlations, Chronic Kidney Diseases and Hypertension, Reno-cardiac Interactions, Nutrition and Growth in CKD (Workshop), Dialysis/CRRT and Transplant ChallengesandasessiondevotedtoFellowship Training Issues and Research Initiatives.AttheendoftheSeminaraworkshopforliveCRRTprocedureswillbeconductedatHoltzChildren’sHospitalforselectedparticipants.TheSeminarwillfeature21distinguishedGuestFacultyincludingthePresidentoftheAmericanSocietyofPediatricNephrology,severalASPNCouncilMembersand,theALANEPEGeneralSecretaryamongothersand12LocalFacultymemberswhowillprovideexpertiseandcordialexchangesincludingseveralpaneldiscussionsandMeettheProfessorLuncheons.Wehopeyouwillenjoyattendingthisnewlystructuredscientificmeeting.Detailsregardingthefullprogram,speakers,registration,grantapplicationsandhotelreservationsareavailableinourWebpageathttp://pediatrics.med.miami.edu/nephrology/seminar.