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fMRI Setup. slice orientations. sagittal. coronal. axial. SPGR Anatomics (1). resolution in-plane 0.9375 mm 2 through-plane 1.5 mm. SPGR Anatomics (2). SPGR Anatomics (3). Diffusion-Weighted Imaging (1). Diffusion-Weighted Imaging (2). Diffusion-Weighted Imaging (3). Slice Locations. - PowerPoint PPT Presentation
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Auditory versus Visual Sentence Task
Constable, Pugh et al., (NeuroImage 2004)
common print(red) speech(blue)
R - L
An Initial Neurobiological Reading Model
ANTERIORAreas:
inferior frontal gyrus (including Broca’s area)
One Hypothesized Function:Articulatory recoding
OCCIPITOTEMPORAL (VENTRAL)
Areas: occipitotemporal juncture, middle and inferior temporal gyriHypothesized Function: Linguistically structured memory- based fast word identification system (posterior aspect = “word-form” area)
TEMPOROPARIETAL(DORSAL)
Areas:supramarginal, angular, superior temporal (Wernicke’s) gyri
Hypothesized Function:Mapping of orthographic to phonological and semantic representations
(Pugh et al. 2000)
Auditory versus Visual Sentence Task
Constable, Pugh et al., (NeuroImage 2004)
common print(red) speech(blue)
R - L
temporoparietal
occipitotemporal
anterior
Simulated Hemodynamic Response (1)
mean = 5000sd = 100effect size 0-1%, 0-50 pointsGamma function tau=1.08; n=3; delay=3
Linear Deconvolution
Neuronal activity is modeled as a sequence of point events.slide courtesy of Matthew Brown, University of Western Ontario
Functional Connectivity
activations in Shaywitz et al. 2002
older good readers
74 good readers 7-18 yrs70 dyslexic readers 7-18 yrs