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PCB 3233 Practice Exam 4: Chapters 7 and 8 *Please note that these questions are ONLY here to help. They are NOT actual test questions. Some, all, or none of these topics may be on your exam. Professor Weigel did not review this. Do NOT use this as your ONLY study resource, continue to review PowerPoints, recordings, textbook, notes, light board videos, etc*
1. T cell precursors migrate from the bone marrow to the thymus through the lymph canals, and enter the thymus through the afferent lymphatic.
A. True. B. False.
2. DiGeorge’s Syndrome:
A. Involves a deletion in chromosome 22. B. The thymus is not affected at all. C. The affected person is susceptible to a wide range of opportunistic infections
because the thymus failed to develop, also resembles SCID. D. A&C.
3. Which of the following statement/statements is/are true about the thymus?
A. A thymectomy in an adult will not affect T cell immunity in an adult. B. The thymus is most active in older people. C. Because the thymus involves as we grow older, as time passes we gradually have
a lower T cell count in our body. D. A&B
4. Which of the following surface proteins will an uncommitted progenitor cell that just
entered the thymus have? A. CD4 B. CD8 C. CD34 D. L-7 receptor
5. A double negative progenitor T cell:
A. Will never become a double positive Thymocyte B. Does not have CD4 and CD8 on its surface, and does have CD2 and CD5. C. Needs IL-7 and Notch 1 to receive the signals that drive their maturation. D. B&C.
6. When a TCR on a naïve T cell binds to a peptide- MHC complex on a P-APC that does
not express B7 the T cell can still be activated at later time. A. True B. False
Chpt 7 Slide qFlood
Chpt 7Slide14
Chpt 7Slide15
Chpt 7Slide 18
Chpt 7Slide 1819
T cell becomes anergicChpt 8 Slide 50
7. The types of molecules of that carry out effector functions of T Cells are: A. Cytokines B. Cytotoxins C. Antibodies D. A&B
8. Which of the following is NOT a signal that originates from a successful rearrangement of a ! chain and the pre T cell receptor?
A. Stimulates proliferation B. Stimulates expression of either CD4 or CD8 co-receptors. C. Stops any additional TCR ! chain locus rearrangement. D. Signals to become permissive for " chain rearrangement.
9. Once the gene segments of the ! chain are rearranged successfully and the cell has
finished proliferating: A. The RAG genes are turned back on. B. Rearrangement of the " chain locus is induced. C. There is a bigger chance that the rearranging thymocyte will become a #: $ T cell
than a ": ! T cell. D. A&B
10. The pre-T cell receptor is composed of
A. Fully formed TCR (with both " %&' ! chains). B. ! chain and a preT". C. CD3 and ( chains. D. B&C
11. How many tries, per chromosome, does a T cell have to produce a functioning ! chain?
A. 1 B. 2 C. 4 D. 6
12. The " chain locus has only one chance of rearrangement per chromosome.
A. True B. False.
13. The second checkpoint in T cell development:
A. Makes sure that the surrogate " chain can bind to the ! chain. B. Makes sure that the " chain can bind to the ! chain. C. Tests whether the newly formed TCR can bind to self-antigens. D. All the above
Chpt 8 Slide 76
Chpt 7 Slide 22O
Chpt 7 Slide 30
Chpt 7 Slide 22
Chpt 7 Slide 28
Chpt 7 Slide 31
Chpt 7Slide 34
14. Both types of T cells (": ! and #: $) have to go through positive selection before leaving the thymus.
A. True B. False
15. Which of the following statement/statements is/are true about positive selection?
A. Takes place in the medulla of the thymus B. Is mediated by cortical epithelial cells that have self MHC I or MHC II loaded
with exogenous peptides. C. Will determine whether the double positive T cell becomes a CD4 T cell or a CD8
T cell (single positive). D. A thymocyte will die after 30 days if it does not receive a positive signal from the
cortical epithelial cell.
16. What signals are necessary in order for a T cell to be activated? A. Binding of the TCR and co receptor to peptide on MHC B. Binding of CD28 and B7 C. Binding of CTLA 4 to B7 D. A&B
17. Which of the following statement/s is/are true about negative selection?
A. Is mediated only by cortical epithelial cells B. This process occurs in the cortex of the thymus C. Macrophages are involved which are the cells that carry MHC loaded with self-
peptides. D. T cells that bind too strongly to a self-peptide die by apoptosis.
18. A T regulatory cell:
A. Is a type of CD4 T cell. B. Expresses CD25, which is the transcriptional repressor used by T Regulatory
Cells, and is unique to these cells. C. Expresses FoxP3, which is the transcriptional repressor used by T Regulatory
Cells, and is unique to these cells. D. A & C
19. T cells rearrange the ! chain before # $ chains?
A. True B. False
20. Positive selection tests whether the _____ and _____ regions of the TCR can bind to a/an
______. A. CDR 3; CDR 2; Self Antigen B. CDR 3; CDR 1; MHC C. CDR 1; CDR 2; MHC D. CDR 1; CDR 2; Self Antigen
to Chpt 7 Slide 37don't useMHC's to recognize antigen
B iswrong Chpt 7because it usesselfpeptidesnot Slideexogenous 43Chpt7 slide39 41
Chpt 8 Slide31 32
Chpt 7Slide 46
Chpt7Slide 50
aChpt 7 Slide 21
Chpt 7 Slide 37
21. Which of the following statements regarding dendritic cells is/are not true? A. When immature, the dendritic cell is located in a tissue and is performing
endocytosis/phagocytosis. B. A mature dendritic cell is called a Langerhans cell. C. DEC 205 is a protein involved in receptor mediated endocytosis. D. Micropinocytosis is the process in which the dendritic cell engulfs extracellular
fluid.
22. Circulating naïve T cells will: A. Enter the thymus through HEV thanks to the CCL 19 and CCL 21 gradient. B. Enter the secondary lymphoid tissue though HEV thanks to the CCL 19 and CCL
21 gradient. C. Will not be able to pass through the HEV if CCR 10 is not present on the T cell
surface. D. B&C
23. When the T cell is screening the peptide: A. T cell’s LFA-1 binds to ICAM-1 or ICAM-2 on the APC. B. ICAM-3 on the dendritic cell binds on DC-SIGN on an activated t cell. C. SP1 receptors will be suppressed if the T cell is able to bind successfully to a
peptide: MHC complex. D. A&C
24. What cytotoxins do CD8 T cells produce to induce apoptosis in target cells?
A. Perforins B. Granzymes C. Apitoxin D. A&B
25. Which of the following statement/s regarding the costimulatory protein B7 is/are true?
A. CTLA-4 has a twenty-fold binding strength less than CD28 B. B7 (on the surface of the T cell) binds to CD28 (on the surface of the P-APC), and
is the signal that indicates whether the peptide loaded on the MHC II is exogenous.
C. When CTLA-4 binds to B7, the T cell proliferation slows down. D. A&B
26. Expression of which co-stimulatory receptor/molecule distinguishes P-APC from other
cells? A. IL2 B. CXCL8 C. CD25 D. B7
27. Which of the following cells are Professional Antigen Presenting Cells (P-APC)?
A. B Cells
Chpt 8Slide 9
Chpt8Slide 2
Chpt 8 Slide 29
Chpt 8 Slide 89
Chpt 8Slide 34
Chpt 8 Slide 32
Chpt 8 Slide 8
Macropinocytosis
B. Macrophages C. Dendritic Cells D. All of the Above
28. T cell activation is also known as: A. Hypermutation B. RNA splicing C. T cell Priming D. None of the above
29. All leukocytes are lymphocytes
A. True B. False
30. Which of the following is not a cell that can differentiate from a CD4 T cell?
A. TH1 B. TH2 C. TH17 D. T Cytotoxic
31. IL-4 will induce differentiation to which type of T cell?
A. TH1 B. TH2 C. TH17 D. TFH
32. Which of the following cells is mismatched with its function?
A. TH1: reduces inflammation at the site of infection B. TH2: defense against parasites C. TH17: recruits macrophages at the site of infection D. A&C
33. The disease Lepromatous leprosy:
A. Is a low infectivity disease that causes differentiation and a bias for TH1 cells. B. Is a high infectivity disease that causes differentiation and a bias for TH2 cells. C. Will have a higher concentration of IL-4, IL-5 and IL-10. D. B&C
34. What is the purpose of an activated dendritic cells?
A. phagocytic B. destructive C. present antigen D. None of the above
35. An activated CD4 T cell will have on its surface:
A. L selectin
Chpt 8 Slide 4
Chpt 8 Slide 55
Chpt 8 Slide 55
Chpt 8 Slides57158
Chpt 8 Slide 61
Chpt 8 Slide 15
B. VLA-4 C. LFA-1 D. B&C
36. An effector CD8 T still needs B7 to be able to respond to its specific antigen
A. True B. False
37. Which of the following statement/s is/are true regarding cytokine receptors?
A. They have a cytoplasmic tail that are associated with JAK proteins. B. STATs activate JAKs, which in turn will migrate to the nucleus and activate
specific genes. C. JAKs activate STATs, which in turn will migrate to the nucleus and activate
specific genes. D. A&C
38. T Cytotoxic Cells can cause apoptosis of cells that are infected with a viral pathogen.
A. True B. False
39. INF γ plays an important role in fighting viral infections because:
A. It increases the presentation of peptides on MHC I. B. It activates macrophages that will help with disposing of dead cells. C. Inhibits the replication of viruses in the infected cells D. All the above
40. The signal/signals that a macrophage needs to be activated from a T cell is/are?
A. Primary signal: CD40 ligand/CD40 receptor – Secondary: IFN-γ B. Primary signal: IFN-γ – Secondary: CD40 ligand/CD40 receptor C. Primary signal: IFN-γ D. Primary signal: CD40 ligand/CD40 receptor
41. A pathogen that invades the intracellular vesicular system of cells:
A. Reduce the response of TH1 cells. B. Cannot be reached by antibodies, cannot be presented on MHC I molecules that
will activate CD8 T cells C. Will not affect the ability of macrophages to lyse bacteria once in its
phagolysosome. D. A&C
42. CD4 can aid in the activation of CD8 by secreting IL2
A. True B. False
43. Which lymphocyte is specialized in fighting parasitic infections, and has orange staining
when looked in the microscope?
Chpt 8 Slide 71 74
Chpt 8 Slide 67
Chpt 8Slides79 80
Chpt 8 Slide 77
Chpt 8Slide 85
Chpt 8Slide 92
Chpt8Slide94
Chpt 8 Slide 62
A. Eosinophil B. Basophil C. Macrophage D. None of the above.
44. Which of the following cell is responsible for activating naïve T cells within lymphoid
tissues? A. B-Cells B. Neutrophils C. Dendritic Cells D. Macrophages
45. Activated Dendritic cells secrete which chemokine that specifically attracts naïve T cells
towards them once in the lymphoid tissue? A. CCL13 B. CCL18 C. CCL19 D. CCL21
For questions 46-50 match the T cell with the correct cytokine/cytotoxin that they secrete
46. Cytotoxic T Cell A. IL-17 and IL-6 47. TH1 B. TGF-b and IL10 48. TH2 C. Perforin, Granulysin, IL2, INF-g 49. T-Reg D. IL-4, IL5 50. TH17 E. INF-γ, GM-CSF, TNFα, IL-2.
Chpt 8 Slide 5
Chpt 8 Slide 37
characteristic cytokine
chp slide 55175
GOODLUCK