Singh Lokendra Pal et al. / JPBMS, 2011, 5 (11) 1 Journal of Pharmaceutical and Biomedical Sciences (JPBMS), Vol. 05, Issue 05 Available online at www.jpbms.info JPBMS JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL SCIENCES Floating Effervescent Tablet : A Review *Lokendra Pal Singh 1 , Dr. Rajesh K.S 1 , Deepak.G.Umalkar 1 , VijayKumar Chauhan 1 , Viralkumar Rana 1 , Kamini S. Vasava 1 . 1 Department of Pharmaceutics, Parul institute of Pharmacy, Limda, Vadodara, Gujarat-391760, India. Abstract: In recent years scientific and technological advancements have been made in the research and development of oral drug delivery system. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. Oral sustained drug delivery system is complicated by limited gastric residence times (GRTs). To overcome these limitations, various approaches have been proposed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract which includes floating drug dosage systems (FDDS) , effervescent and non effervescent system, swelling or expanding systems, mucoadhesive systems magnetic systems, modified-shape systems, high density system and other delayed gastric emptying devices. Among these systems, FDDS have been most commonly used. Effervescent FDDS are the most advantageous approach to gastric retention effervescent agent produce CO2 When come to contact with G.I fluid and support to float dosage form. Keywords: Gastro retentive systems; Floating systems; buoyant delivery Systems; Swelling system. Introduction: Oral drug delivery has been known for decades as the most widely utilized route of administered among all the routes that have been employed for the systemic delivery of drug via various pharmaceutical products of different dosage forms. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. [1] Oral sustained drug delivery system is complicated by limited gastric residence times (GRTs).Rapid GI transit can prevent complete drug release in the absorption zone and reduce the efficacy of the administered dose since the majority of drugs are Figure 1: Floating dosage form absorbed in stomach or the upper part of small intestine [2, 3] . To overcome these limitations, various approaches have been proposed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract includes floating drug dosage systems (FDDS) [4-8] swelling or expanding systems [9] , mucoadhesive systems [10,11] , modified-shape systems [12], high-density system [13] , and other delayed gastric emptying devices. Among these systems, FDDS have been most commonly used. Floating drug delivery system (FDDS) has less density (<1.004 gm/cm 3 ) than gastric fluid so they buoyant in fluid and show sustained release. Advantages of Floating Drug Delivery [24-27] • Enhanced bioavailability • Enhanced first-pass biotransformation *Corresponding Author Mr.Lokendra Pal Singh,M.Pharm, Department of Pharmaceutics, Parul Institute of Pharmacy Limda,Vadodara,Gujarat ,India. • Sustained drug delivery/reduced frequency of dosing • Targeted therapy for local ailments in the upper GIT • Reduced fluctuations of drug concentration • Improved receptor activation selectivity • Reduced counter-activity of the body • Extended time over critical (effective) concentration • Minimized adverse activity at the colon • Site specific drug delivery ISSN NO- 2230 - 7885 Review Article
