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Hyper-Accelerating Commercialization and Economic Growth by Catalyzing the Start-up Ecosystem Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission POWERING GROWTH:

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Page 1: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Hyper-Accelerating Commercialization and Economic Growth by

Catalyzing the Start-up Ecosystem Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission

POWERING GROWTH:

Page 2: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Team Capability: • 20 years + experience in commercializing inventions;

evaluated 75K+ inventions• Advisors: Serial Entrepreneurs, Industry, Foundations• Core Team: ~20 people. 90% PhDs, MBAs• 120+ high profile, strategy engagements:$21B profit

Unique Challenge-Accelerator given IP & Talent Access:• Derisked IP: 21 agreements across NASA, NIH, NCI,

CDC, etc• Talent: 85+ Serial Entrepreneurs, Industry, etc.

Evolution:• Derisked IP: More Federal Labs• Disrupting the Venture architecture norms

CAI’s Approach

Commercialization Strategy Startups & Industry

Due Diligence – Selecting Investments & Technologies

Select the Best Federally Funded Inventions

Maximize Commercial PotentialOperators & Management Talent

Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission

Center  for  Advancing  Innovation—Overview  

Page 3: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

New Model for Venture Philanthropy with outsized returns

Spun out 33 Companies from NIH; 1200+ Jobs Created; 19 Agreements with NIH and NASA

Prestigious Awards & Recognition HHS, NASA, White House, Wired, Nature, Huffington Post, CBS etc.

Challenge  AcceleratorsSince  2012

Page 4: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

-­‐

500  

1,000  

1,500  

2,000  

2,500  

3,000  

3,500  2009

2011

2013

2015

2017

2019

2021

2023

2025

2027

2029

2031

RE  ($

Billion

s,  PPP

1)

CAGR  Forecast  of  GERDII  Expenditure  (based  on  UNESCO  1996-­‐2009)

BrazilCanadaChinaIndiaJapanRussiaS.  KoreaSingaporeUSEU

4

In  addition,  R&D  forecasts  show  China  will  surpass  the  US  by  2019

2019

Sources:  CAI  Analysis  Model,  UNESCO  Institute  for  Statistics1PPP:  purchasing  power  parity  (PPP)  asks  how  much  money  would  be  needed  to  purchase  the  same  goods  and  services  in  two  

different  countries  II  Gross  Expenditure  on  R&D

2009  RE  Top  5:

1. US2. EU

3. Japan4. China5. S.  Korea 2031  RE  Top  5:

1. China2. US3. EU

4. Japan5. S.  Korea

China

USEU

Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission

Global  Expenditure  on  R&D  (GERD)

Page 5: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Global  forecasts  predict  similar  trends:  lost  leadership  position  in  2014

Sources:  CAI  Analysis  Model,  WIPO

CAGR  Forecast  Patents  Issued(based  on  1996-­‐2009)

CAGR  Forecast  Patent  Applications(based  on  1996-­‐2009)

0

200000

400000

600000

800000

1000000

1200000

1400000

1600000

2009 2016 2021 2026 2031

Patent  App

lications

EU India Japan S.  Korea US

0

100000

200000

300000

400000

500000

600000

700000

800000

900000

1000000

2009 2016 2021 2026 2031

Patent  Grants

EU India Japan S.  Korea US

US

US

0

10

20

30

2009 2031

Millions  Paten

t  Ap

ps

0

10

20

30

2009 2031

Millions  Paten

t  Gran

tsChina  (surpassed  the  US  in  2014)

China  (surpassed  the  US  in  2014)

Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission

Global  PATENTS

Page 6: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Globally,  return  on  innovation  is  declining;  the  US  is  not  declining  as  fast!  

Sources:  CAI  Analysis  Model,  UNESCO  Institute  for  Statistics,  World  Bank  GDP  

Estimates

0

10

20

30

40

50

60

70

80

90

2009

2010

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

2031

GDP  /  RE

CAGR  Real  GDP  (Applied  to  Nominal)  Forecast  /  CAGR  GERD  Forecast  

(based  on  1996-­‐2009  World  Bank,  UNESCO)

Brazil

Canada

China

India

Japan

Russia

S.  Korea

Singapore

US

EU

US China

Country CAGR  ‘02-­‐’09

CAGR  ‘04-­‐’09

India 2.6% 6.5%

Russia 2.6% 9.4%

Canada 2.1% 6.2%

US 1.3% 0.04%

EU 1.0% 0.93%

Brazil -­‐0.9% 11.3%

Japan -­‐2.1% -­‐1.5%

S.  Korea -­‐2.8% -­‐4.0%

China -­‐2.9% 6.9%

Singapore -­‐4.3% 2.6%

CAI  Proprietary  and    Confidential.  Do  not  distribute  outside  of  CAI    without  written  permission

GERD  CAGR

Global  RETURN  on  Innovation

Page 7: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

$0

$5,000

$10,000

$15,000

$20,000

$25,000

$30,000

$35,000

$40,0002009

2012

2015

2018

2021

2024

2027

2030

GDP  (Billions)

CAGR  Real  GDP  Forecast  Applied  to  Nominal  GDP

(based  on  1996-­‐2009  World  Bank)

SingaporeUnited  StatesJapanSouth  KoreaCanadaRussiaBrazilIndiaEUChina

GDP  Growth  Rate

US  =  2.32% China  =  9.25%2024

Sources:  CAI  Analysis  Model,  UNESCO  Institute  for  Statistics,  World  Bank  GDP  Estimates

Innovation  Arms  Race

Page 8: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

LicensedMove to translational researchMore funding in lab; science continuesNo funding in lab to continueWithdrawn/terminated licenseTerminated by inventor

Federally  Funded  Research

Invention  Disclosed  and  Potentially  Patented

Product

Translational  Research,<0.1%

Inability  to  Find  and  Fund  Promising  Inventions

Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission

Problem:  Identifying  the  Best  Inventionsand  Furthering  R&D

Page 9: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

915

122

2619

132

458

804

1150

31%27%

55%

12%

96%

42%

79%

0%

20%

40%

60%

80%

100%

120%

0

500

1000

1500

2000

2500

3000

Federal2Labs Top2Hospitals Top2Med2Schools Top2Universities Bottom2 Hospitals Bottom2Med2Schools

Bottom2Universities

%"of"D

isclosures"R

emov

ed"from

"She

lf

Additio

nal"D

isclosures"R

emov

ed"from

"Shelf

Yearly"Additional"Disclosures"Removed"from"Shelf"by"Segment"–Best=in=Class"Performance(%"Removed"from"Shelf)

Segment Federal2Labs Top2Hospitals Top2Med2Schools Top2Universities Bottom2 Hospitals Bottom2Med2Schools

Bottom2Universities

#2of2Institutions 8 5 35 3 16 41 45

114/Federal2Lab

12K742Additional2Inventions

7K252Additional2Inventions

Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission

150,000  inventions  from  the  top  145  institutions

Page 10: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Potential

CurrentState

Key$InsightUS.universities.can.still.improve.by.at.least.25%,.while.federal.labs.have.>80%.potential.growth.in.

every.stage.of.commercialization

0%10%20%30%40%50%60%70%80%90%100%

Licenses.&.Options.+.

Startups

Invention.Disclosures.

Patents.Issued.

Patent.Applications.

License.Income.

Current$Universities$Potentialvs.$Average

(AUTM$2002<2009)

0%10%20%30%40%50%60%70%80%90%

100%

Licenses.&.

Options.+.…

Invention.

Disclosures.

Patents.Issued.

Patent.

Applications.

License.Income.

Current$Federal$Labs$Potentialvs.$Average

(NSF/NIST$2002<2009)

Sources:.The.Center.for.Advancing.Innovation.Analysis.Model,.NIST,.NSF,.AUTM.Survey.2002V2009

Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission

Average State

Average  Performance  Opportunity

Page 11: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Potential

CurrentState

Key$InsightUS.universities.and.federal.labs.

have.>500%.potential.growth.in.at.every.stage.of.commercialization

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Licenses.&.Options.+.

Startups

Invention.Disclosures.

Patents.Issued.

Patent.Applications.

License.Income.

Current$Universities$vs.$BIC$Potential (AUTM$2002=2009)

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Licenses.&.Options.+.

Startups

Invention.Disclosures.

Patents.Issued.

Patent.Applications.

License.Income.

Current$Federal$Labs$vs.$BIC(NSF/NIST$ 2002=2009)

Sources:.CAI.Analysis.Model,.NIST,.NSF,.AUTM.Survey.2002U2009

Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission

Best-­‐‑in-­‐‑Class  Performance  Opportunity

Page 12: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Dimension Current  State  (2009) Opportunity %  DifferenceGDP $49,068,748,297 $864,230,818,581 1661%#  Licenses 3922 43885 1019%

Current  Universities  Potential

Dimension Current  State  (2009) Opportunity %  DifferenceGDP $4,056,551,354 $623,614,223,359 15273%#  Licenses 1462 31667 2066%

Current  Federal  Laboratories  Potential

Dimension Current  State  (2009) Opportunity %  DifferenceGDP $53,125,299,651 $1,487,845,041,940 2701%#Licenses 5384 75551 1303%

Cumulative  Potential

3-­‐6%  Inventions  x  

80-­‐90%  failure  rate$500  billion  to  $1.5  trillion

The  $1.5  Trillion  Opportunity

Page 13: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

What is it? A business plan and start-up challenge featuring inventions conceived and developed by scientists at NASA

Challenge Goal: Drive economic growth and create/ amplify entrepreneurial platforms by commercializing NASA inventions

Challenge End Point: New startups launched with seed funding

Space  Race  Overview

Page 14: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Step 1: Create PIA Agreement

Step 2: Received Invention Database Info

Inventions  ~50,000

Step 3: Perform Due Diligence on Portfolio

MarketAttractiveness

TechQuality

Operational Feasibility

Other Categories§ Patent life§ Capital efficiency§ Progress vs. promise

Step 4: Recommend Disposition

Commercialize

Reward

Kill

Restructure

Step 5: Determine CommercializationPath

Startup License

Large Co License

CRADA

Other Business

Model

Phase I: Due Diligence

Phase 2: Startup Challenge

Select Inventions Crowdsource TeamsEvaluate Elevator

SpeechesEvaluate Business

PlansLaunch Startups

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The  Model

Page 15: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Phase  0:  

Enter  ChallengeJan.  19th2015–May  1st  2016

• Teams  submit  proposed  team  and  accept  CDA.    Rolling  entry  into  challenge

• Jan.  19th:  Open  challenge  for  entries,  rolling  acceptance  

st

Phase  1:  

Elevator  

Speech

May  2nd

2016  –Jun.  15th2016

• Teams  develop  a  2  minute  elevator  speech  video  and  also  a  350  word  executive  summary

• Jun.  5th:  Due  date  for  elevator  speech  and  executive  summar

Phase  2:  

Business  PlanJun.  16th

2016  –Sep.  9th2016

• Teams  develop  a  10  page  business  plan  accompanied  by  a  10-­‐20  minute  live  pitch

• Aug.  21st:  Due  date  for  business  plans

• Aug.  22nd –Aug.  26th:  Live  

Phase  3:  

Start-­‐up

Sept.  9th

2016  –TBD

• Teams  launch  their  startup;  raise  capital  and  apply  for  a  license

• Bi-­‐weekly  milestones  for  teams  –schedule  to  be  outlined

• TBD:  Announce  startup  

Space  Race  Challenge  Timeline

Page 16: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Select SPACE RACE Challenge Topic and Engage Stakeholders

Planning

Startup teams paired with world-class, seasoned exec level industry experts

Mentorship

Invention Selection

Tailored Training

Curriculum

Business Plan and Live Pitch

Multi-Disciplinary Teams Enter

2 minute video with executive summary

Elevator SpeechWinners and Finalists Selected

Identify 5-10 commercially viable inventions

Form Team and Select Invention

Letter of Intent - robust teams enter with world class mentors

Elevator speech - 5 teams per invention evaluated & down-selected

Business Plan - Teams pitch to world class panel of judges

Winning teams become founders of startup, negotiate license & raise seed funding

12 Month Intensive & Disciplined Accelerator Training

500-1000 people combine to form multi-disciplinary teams

PartnershipAnd Licensing Agreements

LAUNCHSTARTUPS

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Space  Race  Overview  and  Accelerator  Training

Page 17: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

NA

SA

Inve

ntio

nsTe

ams

For

med

wit

h in

vent

ions

Star

t-up

s F

orm

edP

oten

tial

Exi

ts

Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 1 Team 1

Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2 Team 2

Team 3 Team 3 Team 3

Team 4 Team 10 Team 12 Team 4 Team 10 Team 8 Team 15 Team 10 Team 9

Invention #1 Invention #2 Invention #3 Invention #4 Invention #5 Invention #6 Invention #7 Invention #8 Invention #9 Invention #10

Startup #1

Startup #2

Startup #3

Startup #4.A

Startup #5

Startup #6

Startup #7

Startup #8.A

Startup #9

Startup #10

Startup # 4.B

Startup #8.B

Year 1 Startups Year 2 Startups

Exit #4.B

Exit #7

Confidential & Proprietary – Center for Advancing Innovation and Gazelle Futures LLC

- Do Not Distribute

Space  Race—Crowdsourcing  Top  Global  Talent

Page 18: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Overview:Self-monitoring electronics that can detect and diagnosewirefaults, determine fault location,

A Device For Wire Fault Detection and Rerouting

Electrical and Electronics

and autonomously transfer electrical power or data connectivity to an alternate wire path

Inventions –Electrical and Aeronautics

Overview: A ceramic composite (CMC) acoustic liner for aircraft engines that offers increased noise reduction with a lighter, more compact, and heat resistant design

Light Weight Acoustic Liner to Reduce Noise in Aircraft Engines

Aeronautics

Page 19: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Overview: A Lightweight UAV sensing and control system able to be fitted for drones and nano-drones reaching one pound or less and/or <6-inch wingspans,

Light Weight UAV Sensing and Control System

allowing for long flight segments due to its power-saving capabilities

Inventions –Robotics

Overview:Rugged, lightweight, small autonomous robot excavator

RASSOR Robotic Excavator

used in inaccessible sites such as high-risk mining, search and rescue as well as disaster response applications

Page 20: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Inventions –Optics

Overview:A 3D imaging laser system that uses a simple lens system to simultaneously generate a

High-resolution, real-time three-dimensional imaging

one-dimensional or two-dimensional array of optical (light) spots to illuminate an object, surface or image to generate a topographic profile.

Overview:Cost effective method for high precision polishing to shape optical surfaces by employing an

Electrochemically Enhanced Mechanical Polishing (EEMP)

electrochemical and mechanical shaping / polishing method

Page 21: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Inventions –Energy

Overview:Airborne Wind Energy (AWE) vehicles use the wind to generate power at higher altitudes;

Kite-like Wind Power Generation Control System

this invention maximizes and optimizes AWE power generation

Overview: A solid oxide fuel cell capable of power densities 5X of a normal power cell due to a unique fabrication

High-Power Density Solid Oxide Fuel Cell and Fabrication Process

process utilizing a freeze-tape casting method

Page 22: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Inventions –Materials and Coatings

Overview:Novel use of laser surface pattering and chemical film coatings to create surfaces resistant

Surface Particle Contamination Mitigation Methods

to water, dust, organic growth, and other surface contaminants

Overview:Liquid and micro-particle powder coating applied on the surface of reinforced concrete for

Liquid Coating for Corrosion Prevention in Rebar

corrosion prevention and structural integrity in steel rebars

Page 23: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Unique  Inventions,  Incredible  Deal  Flow  Example NASA Robotics Invention

Overview:Rugged, lightweight, small, autonomous robot excavator used in sites such as

RASSOR Robotic Excavator

high-risk or inaccessible mining, search and rescue, as well as disaster response applications

Only invention to exploit $25 quadrillion extraplanetary mining industry; $200B to $1T of value in just one asteroid

TRL 9, space-flight tested, $35.8M taxpayer dollars invested in R&D

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11 more late-stage inventions: • Focused on space technologies, precision

medicine, clean energy, and others • Selected from NASA portfolio of 24K+

inventions: 100+ commercially viable space inventions; 300+ precision medicine

Expanding portfolio: patents and inventions from DoD, DoE, DARPA, Navy and other government-funded agencies

Low deal flow: currently only ~90 VC-backed space companies from 2000-2015

Opportunity: develop world-changing technologies, create new industries and ecosystems, drive outsized growth and returns

Page 24: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission

Startup Challenge Evolution to Fund

Page 25: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Early investors end up <20% minority interest, often without

enough power to kill the “walking dead” & redeploy

Investors attempt to short list the best out of the

noise through quality of team, traction and solid

plan

Investors often deal with unsophisticated founders

who don’t understand governance or valuation

Early Stage investors often receive 100’s if not 1000’s of pitch decks, emails or via

fast pitch events for dealfow

Invest(1-5)

Term Sheet(5-10)

Diligence(10-25)

Pitch(100’s)

Diligence(1000’s)

Invest(2-5)

SourceBPs &

Teams/Tech(5-10)

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Solving  Early  Stage  Investing  Problems

Page 26: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Quality Strategic Deal FlowStruggles to find worthy opportunities

matched to strategic needs

Capital EfficiencyMost IP is capital & time intensive. Cost

reduction levers are key, e.g., startup nimbleness and regional advantages

Skilled Startup TeamsSeasoned entrepreneurs seeded in teams

prevent rooky mistakes

Accelerated ResultsTeams require funding and go around the

US to raise it for 6-12 months

Commercialization RisksInventions require de-risking –

lead to high failure rates

Favorable TermsLicensing agreements often have onerous

deal terms and are quick to negotiate

R&D$Productivity

Size$of$R&D$Organization

Large&Pharma&Co’s

Optimal&Size

89%

92%

65%

21%

52%

34% VALUE&OPPORTUNITY&ANALYSISYOUR&PRODUCT

adventureindependance

securitysensualityconfidence

power

comfortsafety

ease3of3use

visualauditorytactile

olfactorytaste

point3in3timesense3of3place

personality

socialenvironmental

reliableenabling

craftmanshipdurability

LOW MED HIGH

Emotion

Ergonomics

Aesthetics

Identity

Impact

Core4Tech.

Quality

Profit4 ImpactBrand4ImpactExtendable

COMPETITION&(OR&NEXT&PRODUCT)adventure

independancesecurity

sensualtiyconfidence

power

comfortsafety

ease3of3use

visualauditorytactile

olfactorytaste

point3in3timesense3of3place

personality

socialenvironmental

reliableenabling

craftmanshipdurability

LOW MED HIGH

Emotion

Ergonomics

Aesthetics

Identity

Impact

Core4Tech.

Quality

Profit4 ImpactBrand4ImpactExtendable

Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission

Gazelle  Solves  Pipeline  Challenges

Page 27: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

An early stage venture capital fund that leverages exclusive, low-cost access to a large

portfolio of risk mitigated inventions combined with a proven and award winning “Startup

Challenge Accelerator” to rapidly launch new capital efficient companies and grow jobs.

Gazelle Futures Mission

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Page 28: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Financial Impact

$90MEndowment

20Companies

56%+Fund IRR

Investing + “venture philanthropy” of LP’s 50% split carry creates a sustainable source of future funding

Proven, award winning accelerator matches inventions to region’s strengths & significantly increases new startups

Securing the majority of equity at the early stage captures all value creation, resulting in strong for all investors

Even with highly conservative assumption of 90% failure failure rate, startups jobs generate a large commerce impact in area

$600M

Social Impact

$180MInvestor Returns

Limited Partners that invest capital are positioned to realize strong exit return multiples over the 10 yr life

GDP Impact

82%Employment

Challenge graduates have attractive entrepreneurial skills that lead to high job placement success in market

2500Trained

Over 500+ people per year x 5 years receive advanced STEM training during the 12 month accelerator process

18KTotal Jobs

Growing Life Science oriented startups creates a large multiplier effect, leading to job growth throughout the local ecosystem

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Measurable  Impact  with  $20MM  FundTarget  Case

Page 29: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Gazelle Futures Fund Overview

9 yr | 4 yr InvestingFund Horizon

Match to Region Strengths

Market Focus

Seed to Series AStage Focus

$20MM Segments ($100MM Total)

Total Fund

Under-valued RegionsGeographic Focus

Performance BasedGP Carry Interest

5x + Exit TargetsOutsize Returns

$200K - $1.2MMInvestment Size

10-20 Seed | Series AInvestments

Substantial 100%Equity Positions

Gazelle Futures | 9508 Burning Tree Road; Bethesda, MD 20817 [email protected] | (202) 438-2208 | www.gazellefutures.com

Fund MissionDe-risked, Capital Efficient

§ Builds on successful startup model§ Breast Cancer Startup Challenge, Neuro

Startup Challenge§ Kaufmann Foundation proprietary

research§ STEM and entrepreneurship education

DifferentiationUnique Deal/Team Access§ Unprecedented no/low-cost

licensing access § De-risked portfolio of 24,000 NIH

& NASA inventions§ Crowd source global talent

Investment Strategy“Lead Seed”-Founder Friendly

§ Up to $1MM+ seed investments § Founder friendly support from

industry experts§ lowest cost/% ownership and

maintaining substantial positions through future dilutive rounds

Social Impact Financials100% Performance Based

§ Performance based IRR goals§ Creation of regional endowment§ 2.5% mgmt fee for Challenge

Accelerator.

Confidential & Proprietary | DO NOT DISTRIBUTE

Experienced Investment Team

Rosemarie H. TrumanManaging Partner

- CEO, Center for Advancing Innovation- Launched 33 Award Winning NIH Startups- 22 Yrs & $210B+ F500 Growth Strategy- IBM, Goldman, JP Morgan, E&Y, Oracle

Nick DonafrioBoard Chairman

- IBM VP of Global Innovation and Technology for 35 years (IBM Watson)

- Industry and thought leader- MITRE, Liberty Mutual, Wigix, others

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BENEFITS

Disruptive  Investors

§ Outsized  returns  and  IRRs§ Diverse  invention  

portfolio:  energy,  personalized  medicine,  adv.  manufacturing

§ Performance  driven  fund§ Proven,  efficient,  data  

driven,  award-­‐winning,  investment  model

§ Impact  investing  with  multiplier  effect  

§ Network  expansion  –AUTM,  BIO,  White  House,  etc.

Government  andTech  Transfer:

§ Multiplier  effect  in  impacting  public  health,  energy,  medicine,  other  sectors

§ Supports  the  Presidential  Memorandum  and  Startup  America

§ New  paradigm  of  commercializing  inventions

§ Expanded  private  funding  for  R&D

§ New  platform  to  train  the  next  generation  of  scientists

§ Support  STEM  education

Powering  Growth:

§ Train  1000s new  STEM  entrepreneurs§ Create  100s  startups§ Create  millions  of  new  jobs§ Support  regional  sustainability§ Contribute  to  GDP  through  new  products

CAI  and  Gazelle  Futures:

§ Drive  and  accelerate  high  growth  business§ Increase  the  volume  of  commercialization§ Accelerate  ground  breaking  innovations

Key  Takeaways  for  Stakeholders

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Rosemarie Truman: (202) 438-2208

twitter.com/centerinnovate

www.thecenterforadvancinginnovation.org

https://www.linkedin.com/company/the-center-for-advancing-innovation-inc-?trk=biz-companies-cym

Contact

9508 Burning Tree Road, Bethesda, MD 20817

The Center for Advancing Innovation, INC

Gazelle Futures, INC

Rosemarie H. Truman | Founder and CEO Sourav Sinha | Entrepreneur in Residence

[email protected]

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Key Takeaways

Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission

§ YOU can do this too! We’ve built a nice platform AND have lessons learned

§ Join the SPACE RACE; build a team; be a judge; advise the challenge; mentor a team

§ GAZELLE is seeking strategic partnerships & advisors; please connect with us if interested

THANK YOU

ROSEMARIE TRUMAN, FOUNDER AND CEOSOURAV SINHA, ENTREPRENEUR IN RESIDENCE

THE CENTER FOR ADVANCING [email protected]

TEXT: 202 438 2208

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Healthy Cell Cancer Cell

No Effect Azonafide Kills Cell

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§ Winner of Breast Cancer Startup Challenge by the National Cancer Institute (NCI)

§ Awarded grants from Avon Foundation for Women, NASA/Center for the Advancement of Science in Space (CASIS), and the Horizon 2020 Program (UK)

§ Winner of MassChallenge & MassBio 2014 Startup Accelerators§ Winner of the Rice Business Plan Competition§ Raised seed financing, currently raising a bridge round§ Partnered with 14 pharma partners all over the world§ Partnered with 6 academic labs all over the world§ Offices in Boston and London § Closed Startup Exclusive Option License Agreement with the NCI§ Showcases: TEDMED, World ADC Summit, Engage Forum Tokyo,

Protein & Antibody Engineering Summit (Shanghai & Boston ’15)

Team Progress

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Startup Challenge Evolution to FundCAI$performsdue$diligence

on$exclusive$access$invention$portfolio

CAI$runs$challenge/accelerator,$crowd;sourcing$ startup$teams.$Teams$apply$for$SBIR$funds

CAI$selects$winning$business$plans$and$teamsC$CAI$facilitates$licensing$agreement

Gazelle$exclusive$$deal$with$CAI$to$perform$due$diligence

Gazelle$creates$company$vehicle$ for$inventions$– and$owns$100%

Gazelle$funds$startup$leadership$and$provides$first$tranche$fundingC$owns$55%$equity

Space&Race

Gazelle$performs$ongoing$governance$and$has$strict$go/no;go$milestones

Gazelle$puts$in$Series$A$fundingC$funding$ is$matched.$Valuations$double

Liquidity$Event$

Gazelle$pays$out$to$LPs

Prepared for LES- Confidential & Proprietary the Center for Advancing Innovation and Gazelle Futures - Do Not Distribute without Permission

Page 36: FINAL PLENARY SPACE RACE SHORT apr 23 2016 (3)

Who Can Join the SPACE RACE?Recruiting Multi-Disciplinary Teams

Team Design:

Mandatory Requirements

Challenge  TEAM Business

Legal

Invention Specific  Technical  

Seasoned  Entrepreneur

Typical Participation

Students:• Graduate and undergraduate students• Post-docs as well as those in residency

Others - match skill sets of mentors to invention and team:• Business Development Leaders from Large Companies

• Key Opinion Leaders• FDA/Regulatory• Venture Capitalists

• Clinical Research Outsourcer (CRO)

• Over  18  years  old*• At  least  three  students  on  the  team

*and younger with parent’s permission as long as the rest of the team meets requirementsConfidential & Proprietary to The Center for Advancing Innovation. Do Not Distribute