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7/27/2019 Final Ebc Ct Chapter Pcb Program Master 9-24-14
http://slidepdf.com/reader/full/final-ebc-ct-chapter-pcb-program-master-9-24-14 1/106
Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
EFN Ncooentanut Ndipter Prcgrib
Bioigaog PNF Abpintem Fuakmaog
Biteraiks
7/27/2019 Final Ebc Ct Chapter Pcb Program Master 9-24-14
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Wekncbe
Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
Hcdo Lagurekka
Ndiar
EFN Ncooentanut Ndipter
]eib Keimer
Westco & ^ibpsco
7/27/2019 Final Ebc Ct Chapter Pcb Program Master 9-24-14
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Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
]dioj ycu tc cur dcst8
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Ndipter Ndiar
Hcdo Lagurekka, Westco & ^ibpsco
\ane Ndiar
Vutdiooe L. Nikifrese, Ocrtdeist Utakataes
Keimersdap ]eib
Hco Ifpkioikp, Vescurne Cptacos, Aon.
Lrio Dcey, ]agde & Fcom
Nirk ^tcpper , ]VN Eovarcobeotik Ncrpcritaco
Vyio \esncva, ]BN Eovarcobeotik
Hcdo Wimswcrtd, Frcwo & Vumoanj
Batndekk Wurbfriom, GXI GecEovarcobeotik, Aon.
EFN Ncooentanut Ndipter
Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
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Prcgribs
Inness
Oetwcrjaog
EFN Bebfersdap Feoelats
Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
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• ^ep >08 Cllsdcre Waom Upmite, BI ]ijes tde Keim
• Cnt 98 ^ckir Eoergy Bitndbijaog Lcrub
• Cnt >8 N] Ndipter, ^ckam Wiste Bioigebeot
• Cnt 78 OD Ndipter, Lkccm Pkiao Abpints co Mevekcpbeot• Cnt 18 VA Ndipter, Facrebemaitaco lcr ^ate Vestcritaco
• Cnt 9<8 N] Ndipter, Urfio ^caks
• Cnt >08 N] Ndipter, Mib Bioigebeot - Veg. Upmite
• Ocv 9=8 N] Ndipter, ^tcrbwiter Bgbt. Ncostruntaco ^ates
Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
Upncbaog Prcgribs
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• Preseotitacos wakk fe pcstem tc tde EFN wefsate „ Kaoj tc preseotit acos ao lck kcw -up ebia k
• Hcao Ndipter cr Ncbbattee kastserv
„ Ebiak request tc [email protected]
• Get aovckvem ao EFN Ndipters iom Ncbbattees
• Iumaeone Aotrcmuntaco
Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
Laoik Octes
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Aotrcmuntaco
Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
Lrioj Vannairma
Prcgrib Ndiar & Bcmeritcr
\ane Presameot
Westco & ^ibpsco
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^tiomirm cl Nire lcr PNF-abpintem
Fuakmaog Biteraiks
Vcfert Itwccm, PE, K^P
Presameot
Vescurne Ncotrck Isscnaites
Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
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Aotrc iom Vekeviot Vegukitacos -
PNFs ao Fuakmaog BiteraiksPreseotitaco tc
EFN N] Ndipter^eptebfer 6=, 609=
Lrioj Vannairma, PE, K^PWestco & ^ibpsco
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Preseotitaco Igeomi
• Finjgrcuom tc tde Assue cl PNFs ao FuakmaogBiteraiks
• Vegukitcry requarebeots (]^NI =0 NLV 7<9)
• Vasj Issessbeot Assues
• Pkiooaog lcr i PNF Prcgrib
• Issessbeot iom Vebemaik Beisures
• Meem Vestrantacos iom K] Bcoatcraog
• Yuestacos iom Masnussacos
NKAEO] OIBE DEVE
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Finjgrcuom tc tde Prcfkeb
• PNFs ire ncbbcoky lcuom ao
fuakmaog biteraiks
• PNF regukitacos (]cxan ^ufstione
Ncotrck Int =0 NLV 7<9) oct setup
lcr fuakmaog biteraiks
• ^quire peg ao i rcuom dcke!
• ]de intuik rasj as pccrky uomerstccm
• Vasj ncbbuoanitaco jey
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Ncbbco Uses cl PNFs ao Fuakmaog Biteraiks
• Imdesaves• Ispdikt Vcclaog Biteraiks
• Niukjaog
• Lkucresneot Kagdt Fikkists
• Grcut
• Aosukitaog Ncitaogs Baxem
Watd Isfestcs
• Piaots
• Pkistanazers
• ]ir Piper
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Assues• ]de preseone cl PNFs ao fuakmaog prcmunts it ?/2 50
ppb as regukitem uomer ]^NI.
• Bioulinturem prcmunts ncotiaoaog PNFs dive feeolcuom ao bioy fuakmaogs
• Niukj iom scbe piaot typanikky ncotiaos PNFs it verydagd keveks - %
• ]de PNFs ao tde niukj bagrite tc i kabatem exteot tcsurrcuomaog biteraiks (iar, scak, biscory).
• ]ypanik reocvitaco prcnemures nio aonreise expcsurestc wcrjers iom fuakmaog resameots, aonkumaog ndakmreo.
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PNF Fukj Prcmunt Wiste vs. PNF
Vebemaitaco Wiste
(Lrcb U^ EPI Wefsate)
PNF-ncotiaoaog niukj iom imhineotncotibaoitem fuakmaog sufstrite as
ncosamerem Fukj Prcmunt Wiste (al PNF
nconeotritaco ao niukj as ? 50 ppb. ]dese
biteraiks bust fe rebcvem wdeo
ameotalaem.
Al PNFs dive ncotibaoitem imhineot scak
tdas bemai as ncosamerem PNF rebemaitaco
wiste.
Veneot EPI Veaoterpretitaco cl PNF FukjPrcmunt Wiste vs. PNF Vebemaitaco Wiste
^cak as Vebemaitaco wiste
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Ellent cl tde Veaoterpretitaco
• Oct bund „ fag mum
• ^takk lew kcnik maspcsik linakataes
• ]&M ncstky
• Lakkaog iviakifke kiomlakks watd tcos N&M mefras
• Bummaes tde witers co nkeir guamione lcrissessbeot iom rebemaitaco
• Keives rccb lcr re-re-reaoterpretitaco
• Everycoe mcaog wditever tde leek as hustalaem
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Vasj Assues
• Pccrky uomerstccm• OQ ^ndccks frcugdt assue tc kagdt
• PNF ao fuakmaog biteraiks as uoiutdcrazem
maspcsik iom bust fe rebemaitem uomer ]^NI
• Vasj issessbeot iom ncbbuoanitaco as jey
• Oc nkeir kaoj fetweeo PNFs iom nioner
• Nconero lcr ndakmreo‑s deiktd piribcuot
• Ncostruntaco/reocvitaco rasj „
NDIOGE CVMEV^!
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Aomccr Iar ^nreeoaog Keveks
EPI‑s Vencbbeomem Pufkan Deiktd Keveks cl PNFs ao ^ndcck Aomccr Iar
(og/b>)(www.epi.gcv/pnfsaoniukj/bixnconeotritacos.pml)
Ige 9-;6 Ige 6-;> Ige >-;< Ige <-;96 Ige 96-;95 Ige 95-;91 Ige 91+
70 70 900 >00 =50 <00 =50
EPI‑s Vegacoik ^nreeoaog Keveks (og/b>)
(www.epi.gcv/reg>dwbm/rasj/dubio/rf-nconeotritacoStifke)
Ircnkcr 909< Ircnkcr 965=Vesameotaik 960 =.>
Aomustraik <90 69
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^cbe Vasj Cfservitacos
• Keveks cl PNFs beisurem ao aomccr iar lrcb fuakmaog biteraik
scurnes nio exneem rencbbeomem expcsure keveks
• Intuik rasjs biy fe sufstiotaikky cverestabitem mue tcexpcsure guamekaoes feaog dagdky prctentave
• PNFs lcuom ao aomccr iar ire typanikky tde kess ndkcraoitem, iomgeoerikky kess tcxan, ncogeoers cl tde pireot baxtures
• PNF rasj issessbeot betdcms ire uonertiao, ncukm feabprcvem, iom wakk kajeky evckve
]IJE IWIQ BE^^IGE^ „MCO‑] HUBP AO]C IAV ^IBPKAOG IOMVA^J NCBBUOANI]ACO A^ JEQ!!!!
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Mces by fuakmaog dive PNFs3
Dcw mc A prcneem3
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^c bioy questacos…
Dcw mc PNFs abpint biaoteoione cr pkios lcr reocvitaco3^dcukm A test lcr PNFs33
Dcw mc A prctent resameots lrcb expcsure3
^dcukm A rebcve PNFs cr nio A keive ao pkine3
Ib A meikaog watd abpintem sufstrite biteraik3
Mc A oeem EPI ipprcvik lcr wdit A mc3
Dcw bund wakk at ncst3
Dcw mc A prcnure i ncotrintcr3
Wdit wakk fe tde abpint tc prchent sndemuke3
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Wdit as tde cverikk gcik3
• Perlcrb fuakmaog biaoteoione
• Veocvite/mebckasd i fuakmaog
• Vepkine fuakmaog ncbpcoeots (D\IN)
• Batagite expcsure tc rebiaoaog PNF
biteraiks
• Imdere tc i tagdt sndemuke
• Baoabaze cverikk prchent ncsts
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Pkiooaog lcr PNF Bioigebeot
• Uplrcot pkiooaog „ rencgoaze PNF assue
• Prctent deiktd cl resameots iom wcrjers
• PNF ifitebeot as expeosave8
c Evikuite bioigebeot ao pkine
c Ivcam surprases iom ncstky mekiys muraog reocvitaco prchents
• Estifkasd i Pkio! (e.g. Mebc Pckany, VeocvitacoPckany, Ao-Pkine Bioigebeot Pckany etn.)
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Pkiooaog Ipprcind
• Nckkent fisan fuakmaog aolcrbitaco (ige cl ncostruntaco/reocvitaco)
• \asuikky issess lcr suspent biteraiks (kcnitaco, ncomataco, pcteotaiklcr meteracritaco)
• Aoncrpcrite luture pkios lcr fuakmaogs (biaoteoione, reocvitaco,
mebckataco)
• Mevekcp Menasaco ]rees
• Mevekcp Fest Bioigebeot Printanes lcr aomavamuik fuakmaog
ncbpcoeots
• Ippky ncrrentave intacos8
c Baoabik meteracritaco ↖ regukir aospentaco, eonipsukitaco
c Exteosave meteracritaco ↖ immatacoik issessbeot, ifitebeot
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65
Meem Vestrantacos
• Wakk fe oeemem al PNF fukj prcmunt wiste≥9 ppb as tc rebiao ao pkine, iom8
9. Vebiaoaog PNFs ire eonipsukitem.
6. ]de fuakmaog wakk fe kabatem tc ‛kcw-
cnnupiony‒ use.
• ]ypanikky aovckves i Vasj-Fisem Ipprcind
• ^tite eovarcobeotik meem restrantacos
biy iksc fe usem.
• Vequares kcog-terb bcoatcraog iom
biaoteoione.
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6<
Bcoatcraog iom Biaoteoione Aospentaco
Pkio(BBAP)
• Aospentaco/Bcoatcraog intavataes biy aonkume8 „ \asuik aospentacos lcr aotegraty cl eonipsukiot
„ Ndebanik evikuitaco (a.e., wape sibpkaog, iar sibpkaog)
„ Witer repekkeony testaog
• BBAP sdcukm cutkaoe intaco tdresdckms iom ncrrentave intaco prcnemures• Ncbbuoanitaco cl BBAP aospentaco resukts tc fuakmaog cnnupiots as
rencbbeomem.
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Yuestacos333
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Vcfert N. Itwccm, P.E., K^PPresameot
SSSSSSSSSSSSSSSSSSSSSSSSSSVescurne Ncotrck Isscnaites, Aon.
Qcur ]rustem I mvasc r ̂ aone 914<
Aomustry-wame ^tiomirm cl Nire
MC WE VEIKKQ DI\E COE 3
^]IOMIVM CL NIVE
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^]IOMIVM CL NIVE
• ]de megree cl prumeone iom niutaco requarem cl io
aomavamuik wdc dis i kegik cfkagitaco requaraog imdereone
tc i stiomirm cl reiscoifke nire wdake perlcrbaog ioyint tdit ncukm lcreseeifky dirb ctders
• I stiomirm cl nire as meterbaoem fy tde stiomirm tdit
wcukm fe exernasem fy tde reiscoifky prumeotprclessacoiks ao tdit kaoe cl wcrj
• ]de stiomirm cl nire as abpcrtiot feniuse at meterbaoes
tde kevek cl oegkageone requarem tc estifkasd i vikamniuse cl intaco
OC & DEVE‑^ WDQ
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OC & DEVE‑^ WDQ• ^cbe cwoers wakk oct sibpke, fut tdey wiot io
ifitebeot spen. & ncbpkaione
• ^cbe prchents sibpke - scbe mco‑t
• Wame viraitaco exasts ao ippkanitaco cl8
^AP
Perlcrbione fisem
Vasj fisem
• Wdeo sibpkaog as mcoe8
Lrequeonaes viry
^cbe beet ^uf-pirt O tc tde tee, ctders siy at mces
oct ippky
^cbe sibpke sufstrite - scbe mc oct
• Wdeo ifitebeot as mcoe8 ^cbe use lukk ncotiaobeot
^cbe use ncotrckkem rebcvik
^cbe use octdaog spenaik
LCUV NDIKKEOGE^ WE LINE
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LCUV NDIKKEOGE^ WE LINE
• ]estaog as oct biomitem
• Vegukitacos oct wratteo lcr fuakmaog
biteraiks
• Oc ippkanifke guamione
• Maspcsik cptacos ire kabatem
VE AO]EVPVE]I]ACO
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VE-AO]EVPVE]I]ACO
• Ikkcws rebcvik /maspcsik cl fukj iom
rebemaitaco wiste is fukj
• PNF kelt fedaom 2 rebemaitaco wiste
• Dis oct sabpkalaem cr nkiralaem tde prcness
^c, wdit as tde reik vikue 3
^UGGE^]EM IPPVCIND
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^UGGE^]EM IPPVCIND• Aoveotcry dagd rasj struntures iom/cr biteraiks
• Melaoe8
Ncostruntaco ige Veocvitaco cr mebckataco pkios
Biteraik ncomataco
Cnnupiots & pcteotaik expcsures
• ^ekentave sibpkaog cl suspent biteraiks
• Oc aomccr iar sibpkaog watdcut jocwkemge cl ikk pcssafke
aomccr scurnes cl PNF
• Up-lrcot pkiooaog lcr ncotrckkem rebcvik.
• Nirelukky wratteo ncotrint mcnubeots.
• Ncoservitave cll-sate maspcsik cl abpintem biteraik.
PKIO LAV^] ^IBPKE ^ENCOM
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PKIO LAV^] „ ^IBPKE ^ENCOM
• Nertiao keveks cl PNF „ Fag abpint
co prchent• Wcrjers ragdt-tc-jocw „ Abpcrtiot
• ^dcukm ncotrck ikk expcsures muraog
iom ilter tde wcrj
• Iotanapite maspcsik requarebeotseirky
• Uomerstiom abpints co sndemukes
iom ncsts.
VEOC\I]ACO PCKANQ
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VEOC\I]ACO PCKANQ
• Lcnus co fuakmaogs fuakt / reocvitem pracr tc 9174 (9140)
• Issess ireis tc fe abpintem
• Al suspent PNF-ncotiaoaog biteraiks ire preseot, sibpke lcr
PNFs
• Al PNF ?50 ppb, issess sufstrite & ifite
• Al PNF ?9 & ;50 ppb, sibe is ifcve, uokess exnkumem
„ Octe „ N]‑s guamione nikks lcr eonipsukitaco cr rebcvik
• Ncosamer ikk abpintem mefras maspcsem cl is ? 50 ppb fukj
prcmunt
NI^E ^]UMQ 9 ]de lints
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NI^E ^]UMQ 9 „ ]de lints
• Ekebeotiry sndcck fuakt 91<0
• Lukk eovekcpe weitderazitaco
• Waomcws8 600 „ 96‑x5‑ watd ¿‒ niukjaog 2=65 sl 2 <,400 kl
• Expiosaco hcaots8
6= - =0‑ dagd watd 9‒ niukjaog 2 40 sl 2 1<0 kl
NI^E ^]UMQ 9 Wdit mc we mc 3
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NI^E ^]UMQ 9 „ Wdit mc we mc 3
• Dcw bioy sibpkes 3
Waomcws8
• 9/900 sl 2 5• 9/90 kl 2 <4
• 9/ 65% cl waomcws 2 50
• 9/waomcw 2 600
Hcaots8• 9/900 sl 2 9
• 9/90 kl 2 1<• 9/65% cl keogtd 2 (9/< hcaots) 2 9/6=0 kl 2 =
• 9/65% cl hcaots 2 90
• PNF 2 950,000 ppb - wdere tc stcp
sibpkaog 3
• Mc ycu sibpke sufstrite 3
• Wdit as ycur ifitebeot ipprcind 3
NI^E ^]UMQ 6
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NI^E ^]UMQ 6
• ]de Lints8 „ Pckane firrinjs fuakt 91<5
„ ^ekentave reocvitaco aosame iom cutsame
„ Waomcws8 950 „ <‑x>‑ watd 9/6‒ niukjaog 2996 sl 2 6,700 kl
„ Aoteracr piaot8 Bcst surlines „ >5 rccbs @ 650,000 sl
„ Lkccraog watd bistan
• Wdit mc we mc 3 „ =5 snreeoaog sibpkes ioikyzem
„ Ikk OM exnept 9 piaot sibpke @ 65 ppb
„ Fkmg. fuakt iom piaotem pracr tc 914=
„
• Mc ycu oeem bcre sibpkaog 3
• As tdas piaot exnkumem 3
• Wdit as ycur ifitebeot ipprcind 3
KE]‑^ ]IKJ
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KE] ^ ]IKJ
• ^ibpke lrequeonaes
• Wdit biteraik tc sibpke8
Niukjaog
Piaot
Vccls
Bistan
^ufstrite
• Wdeo tc stcp sibpkaog
• Wdit EPI ipprcind wcrjs fest8
^AP
Perlcrbione
Vasj Fisem
• Uomer wdit narnubstione mc we
octaly EPI versus NcomuntPerlcrbione Fisem
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I^]B ^tiomirm 9567-9> iom
PNFs ao Fuakmaog Biteraiks8
I Mue Makageone Assue3
Vanj \iomeoferg
^eoacr Prchent Bioiger
Westco & ^ibpsco
Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
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I^]B Mue Makageone iom PNFsPreseotitaco
tc
EFN PNF Ncbbattee
^eptebfer 6=, 609=
Vanj \iomeoferg, PG
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Preseotitaco Igeomi• Pdise A E^I ^tiomirm iom PNFs
• Pcteotaik Prcfkebs Isscnaitem watd Exnkumaog PNFs lrcb tde^tiomirm
• Pcteotaik PNF Abpintem Fuakmaog Biteraik ao i Mebckataco Wiste^treib
• Wdit‑s tde Prcfkeb3
• Vegukitcry Vequarebeots
• Vasj Assues
• Prchent Exibpkes
• Nconkusacos
• Yuestacos iom Masnussacos
.
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PNFs iom Nurreot I^]B ^tiomirms
• ]de oew Pdise A E^I ^tiomirm (I^]B E 9567-9>)
wdand as ncosamerem tde ‛Gckm ^tiomirm‒ lcr
eovarcobeotik mue makageone lcr
ncbbernaik/aomustraik prcperty triosintacos mces
oct requare tde ameotalanitaco cl ao-pkine PNFs aofuakmaog biteraiks.
„ ]de ritacoike lcr exnkumaog PNFs as tde sibe is lcr
exnkumaog keim fisem-piaot cr isfestcs ncotiaoaog
biteraiks ao tdit wdake tdese prcmunts ire ao-pkine
tdey mc oct lat tde NEVNKI melaoataco cl i rekeise.
Io Assue watd tde Pdise A E^I ^tiomirm
Dcwever, al PNFs ire lcuom ao wiste lcrb (a.e. niukj
co tde grcuom) tdeo tdey ire tc fe ncosamerem i
VEN uomer tde stiomirm!!
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PNFs iom Nurreot I^]B ^tiomirms
]das as wdit tde stiomirm ^iys co PNFs8
Exnerpt tijeo marentky lrcb I^]B 9567-05
^c dcw mces at get aonkumem iom issessem33
Ioswer8 Is i ‛oco-sncpe ncosameritaco‒
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PNFs iom Nurreot I^]B ^tiomirms
• EPI miti aomanites tdit 1.6% cl ikk PNFs usem
fetweeo 9160 iom tde kite 9170‑s were usem tc
aonreise tde pkistanaty cl fuakmaog prcmunts. ]das
beios tdit rcugdky 995 bakkaco pcuoms cl PNFs ire
cut ao cur ckm fuakmaog stcnj.• Al ncosuktiots ire oct spenalanikky kccjaog lcr PNFs
is i pirt cl eovarcobeotik mue makageone tdey wakk
fe bassem.
Pcteotaik Prcfkeb Isscnaitem watd oct issessaog lcr PNFs
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Cjiy ^c…Wdit‑s tde prcfkeb3
• Nkeioaog up PNFs ao fuakmaog biteraiks nio prcve tc fe bcre
ncstky tdio i kct cl petrckeub iom dizirmcus sufstione VENs!
• Uomerstiomaog tde oiture iom exteot cl PNFs ao fuakmaog
biteraiks sdcukm fe pirt cl every Pdise A E^I wdere tdere ire
fuakmaogs ncostruntem fetweeo 9160 iom 9171 iom wdeotdere as mebckataco/reocvitaco pkiooem.
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]ypes cl Fuakmaog Biteraiks Jocwo tc
Ncotiao PNFs
• Niukjaog• Piaots
• Imdesaves
• Ispdikt Vcclaog Biteraiks
• Lkucresneot Kagdt Fikkists
• Grcut
• Aosukitaog Ncitaogs Baxem
Watd Isfestcs
• Pkistanazer Igeots
• ]ir Piper
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Wdit dippeos al we mco‑t kccj3
• Al tdey ire oct ameotalaem iom abprcperkymaspcsem, tdas wakk keim tc i ]cxan^ufstione Ncotrck Int (]^NI) vackitaco.
• Al ameotalaem iom stakk ao-use, mepeomaog cotde nconeotritaco preseot PNFs bust fe
rebemaitem. PNFs ao fuakmaog biteraik(ifcve 50 ppb) as i ‛prcdafatem use‒
• Deiktd iom silety
„ Intuik deiktd rasjs uonertiao
„ Pufkan cutnry iom perneptaco nio mraveprchents
„ Wcrjer prctentaco
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Wdit dippeos al we mco‑t kccj3
• ]ypanik reocvitaco/mebckataco nio aonreise PNFexpcsures
• Bust ipprcpraiteky maspcse cl PNF biteraiks
• Mribitan aonreise ao mebckataco maspcsik ncsts
• Ndioge Crmers lrcb ncotrintcrs mue tc deagdteoem
iwireoess cl assues
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Vegukitcry Vequarebeots
• Oc cfkagitaco tc test lcr PNFs• Oc requarebeot tc repcrt
• Oc expkanat requarebeot tc rebcve
• Oc spenalan regukitacos immressaog PNF
fuakmaog biteraiks ≥50 ppb ‛ao use‒
• Fut al PNFs ao fuakmaog biteraiks ?50 ppb
exast, cwoer as ao vackitaco cl ]^NI
• Oc jocwo nises cl EPI eolcrnebeot futnertiaoky pcssafke
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Vasj Assues• PNF ao fuakmaog biteraiks as
prcdafatem use iom bust fe maspcsemuomer ]^NI
• Vasj issessbeot iom ncbbuoanitacoas jey
• Oc nkeir kaoj fetweeo PNFs iomnioner ao dubios
• Nconero lcr ndakmreo‑s deiktd
piribcuot• Ncostruntaco/reocvitaco rasj „
NDIOGE CVMEV^!
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5>
ETIBPKE 98 ]ypanik PNF Waomcw Niukj
Ifitebeot
• PNF niukjaog it waomcw lribes
• Perlcrbione-fisem rebcvik
• ^ibpkem franj it <-aond cllset tc veraly oc PNF
abpint
• Nut-cut/rebcvem franj iom waomcw lcr
maspcsik is Fukj Prcmunt Wiste
• ^ibpkaog iom rebemaitaco immem $500,000 tc
tde prchent.
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5=
ETIBPKE 68 PNF Piaot Ifitebeot
• Ckm ^ndcck Fuakmaog ao Biaoe tdit wis
ncovertem tc dcusaog
• PNFs were aonkumem ao cragaoik 6090 Pdise A
E^I iom Issessem muraog Aoataik Pdise AA E^I
• PNFs lcuom ao piaot cver 50 ppb ao fisebeot
iom larst lkccr
• ^ibpkaog iom rebemaitaco immem +/-$=00,000
tc tde prchent, fut tdese ncsts were
iotanapitem.
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Nconkusacos
• ]de issessbeot cl PNFs sdcukm fe aonkumem aoikk Pdise A E^Is co prcpertaes tdit dive
fuakmaogs ncostruntem cr reocvitem fetweeo
9160 iom 9171 iom wdere
mebckataco/reocvitaco as pkiooem.
• Uomerstiom tde assue felcre ycu fuy at!!
•Issessbeot as ndeip „ rebemaitaco as $$$
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Yuestacos333
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]cp ]aps lcr PNF Ioikysas
Hab Cnndaikaoa
\ane Presameot
Ikpdi Ioikytanik
Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
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Bioigaog PNF Abpintem
Fuakmaog Biteraiks]cp ]aps lcr PNF Ioikysas
Ocrtdeist Utakataes
Ferkao, Ncooentanut1/6=/609=
Hab Cnndaikaoa
Ikpdi Ioikytanik
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> >‑
5 <
6
=
6‑
=‑
5‑ <‑
Pcky „ Ndkcraoitem - Fapdeoyks
Nk--
Nk-- --Nk
Wd t PNF 3
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Wdit ire PNFs3
• Pckyndkcraoitem fapdeoyks ndebanik strunture divaogtwc feozeoe raogs ncooentem fy coe fcom iom divaog9 -90 ndkcraoes co tde raog
• 90 pcssafke raog ittindbeot pcaots keims tc 601pcssafke ncbfaoitacos
„ 601 aomavamuik PNF ncbpcuoms „ NCOGEOEV^
• Nio fe grcupem inncrmaog tc tde # cl ndkcraoe itcbs „ Kevek (cr Megree) cl ndkcraoitaco
„ DCBCKCGs (dcbckcgues)
Dcbckcgs
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g
EbparanikLcrbuki
BckenukirWeagdt
# Ascbers
N96 D90 95=.9 9
N96 D1Nk 944.0 > Bcocndkcrcfapdeoyks
N96 D4Nk6 666.0 96 Mandkcrcfapdeoyks
N96 D7Nk> 65<.0 6= ]randkcrcfapdeoyksN96 D<Nk= 641.1 =6 ]etrindkcrcfapdeoyks
N96 D5Nk5 >6>.1 =< Peotindkcrcfapdeoyks
N96 D=Nk< >57.4 =6 Dexindkcrcfapdeoyks
N96
D>Nk
7 >19.4 6=
DeptindkcrcfapdeoyksN96 D6Nk4 =65.4 96 Cntindkcrcfapdeoyks
N96 D9Nk1 =51.7 > Ococndkcrcfapdeoyks
N96 Nk90 =1>.7 9 Menindkcrcfapdeoyk
Ircnkcrs
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Ircnkcrs
]endoanik grime baxtures cl ncogeoers, bime fy fitnd
ndkcraoitaco cl fapdeoyk
Bcosiotc trime oibe
Oaoe Ircnkcrs8
9669, 96>6, 96=6/909<, 96=4,
965=, 96<0, 96<6, 96<4
]ctik 965= Ncbpcsataco
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]ctik 965= Ncbpcsataco
Nk= „ 9<%
Nk5 „ <0%
Nk< - 6=%
]abe
A.^.
Ioikysas cl PNFs
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<=
Ioikysas cl PNFs• Prepiritave betdcms (sckams)
„ Extrintaco
„ ^cxdket, Betdcm >5=0
„ Banrcwive issastem,
Betdcm >5=<
„ Innekeritem sckveot
extrintaco, Betdcm >5=5
^cxdket Extrintaco
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^cxdket Extrintaco
Lrioz vco ^cxdket
^ibpke Extrintaco & Abpint co Vepcrtaog Kabats
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^ibpke Extrintaco & Abpint co Vepcrtaog Kabats
^ibpke Prep• ‛waoocwaog mcwo‒ prcness
• asckite (extrint) & nconeotrite
• expkcat sckufakaty mallereone
• prabiry scurne cl
betdcm seosatavaty
iom…betdcm
perlcrbione prcfkebs
9000 bK
iquecussibpke
>00 bK
crgioan
sckveot
9 bK
crgioan
sckveotextrint
9 bg/K aostrubeot T (9000/9) nconeotritaco lintcr
2 9 ug/K betdcm seosatavaty
extrintaco
nconeotritaco
<<
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<7
• Extrint nkeio ups
„ ^ukluran inam
„ Lkcrasak „ Gek perbeitaco
ndrcbitcgripdy (GPN)
PNF Aostrubeotik Ioikyses - Ircnkcrs
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y
„ Betdcm 4046, GN-ENM
• Pittero rencgoataco & peij ritacs „ Betdcm 4046 ndikkeoges
• Ncbpkex baxtures cl ircnkcrs
„ ‛mcufke ncuotaog‒ pcteotaik
• ‛weitderaog‒ / facmegrimitaco, aoterlereones
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Wdit as ]PD3
<1
Ncogeoers & Dcbckcgs
GN/B^ ioikysas
Kcw resckutaco biss
spentrcbetryBetdcm 4670/<40
Dagd resckutaco biss
spentrcbetry
Betdcm 9<<4
PNF Ioikysas it ]^NI ^ates
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PNF Ioikysas it ]^NI ^ates
• ]^NI ^ufpirt F 7<9.616
„ Extrintaco betdcm >5=0N ^cxdket
„ Extrintaco betdcm >550F ^coanitaco
• EPI Veg 9, NIB & VNP* mc oct ikkcw scoanitaco
• ]^NI ^ufpirt Y 7<9.>60
„ Ikteroitave extrintaco prcnemures/Ncbpirifakaty ^tumy
„ Bitrax-bitndem, a.e. siom, nkiy, kcib, etn.
„ Oct bund cptacos watd fuakmaog biteraiks
„ ^tumy bust fe ipprcvem pracr tc sibpkaog
PNF Ioikysas ao Inncrmione watd N] VNP Guamione
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PNF Ioikysas ao Inncrmione watd N] VNP Guamione
• Lrcb i kifcritcry perspentave, sibe prctcncks ao pkine
is Bissindusetts NIB
• Uktriscoan extrintaco „ Betdcm >550N
„ ‛Ncotibaoitem sckams‒ ‛^coanitaco biy coky fe usem lcr tde extrintaco cl dagdky
ncotibaoitem (lree prcmunt) oco-scak/semabeots
(mefras). Ioy ctder use cl uktriscoan extrintaco as oct
ikkcwem‒
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PNF Ioikysas ao Inncrmione watd N] VNP Guamione
• Ircnkcrs 96<6 & 96<4 oct spenalanikky kastem
„ Kifcritcry tc aonkume al requestem cr al preseot ao
sibpke
• Vequarebeots lcr Ircnkcr versus ‛striy ncogeoers‒ octis spenalanikky melaoem
Ioikysas cl Fuakmaog- Vekitem Biteraiks
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Ioikysas cl Fuakmaog Vekitem Biteraiks
• Niukjaog & piaots
„ Nio fe mallanukt bitrax
„ Pcteotaik lcr dagd nconeotritacos
• Nconrete & franjs
• ^eikers• ^urlines
„ Wape testaog, 900 NB6
• Aomccr iar
„ Aoataik aomanitaco cl i prcfkeb3
„ Betdcms ]C-90 kcw- vck, ]C-= dagd-vck• PUL nirtramges
PNFs ao Iar
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PNFs ao Iar^cbe ncosameritacos8
• \ipcr pdise & pirtanukite fcroe „ ^ibpkaog betdcm aonkumes fctd scurnes
• Kesser ndkcraoitem ncogeoers pcteotaikky cver-represeotem
• ]ctik PNFs usem lcr aodikitaco evikuitaco „ Vequarebeot tc beet regukitcry cr prcgribbitan guamione
• Uktabite metentaco kabat meravem lrcb tde sibpke bemai kif
metentaco kabats iom tde ibcuot cl iar sibpkem (lkcw rite T
sibpkaog muritaco)
„ ^ibpkaog tabes/rites relkent expcsure kabat cr snreeoaog keveks
7=
PNF B td m a Ia
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Aomccr Iar ^ibpkesEPI ]C-90I (I^]B =4<9 sabakir betdcm) PNF Ircnkcrs
EPI ]C-90I Bcm PNF Dcbckcgues fy GN/B^
LKCW VI]E8 9.0 „ 5.0 K/bao
^IBPKEV8 PUL Nirtramge watd PUL Lakter cr PUL TIM• ^ibpke ]abe = tc 6= dcurs
• Iar \ckube 6=0 tc 7600 katers
• Vioge as 0.09 tc 90 bg/b> lcr i =0-K iar sibpke
75
PNF Betdcms ao Iar
Abpcrtiot tc nikafrite/ndenj pubp felcre
iom ilter sibpkaog watd tde bemai ao-kaoedttp8//www.sjnaon.ncb/prcm/797-590.isp
PNF B td m a Ia
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PNF Betdcms ao Iar
7<
Aomccr/Cutmccr Iar ^ibpkes
EPI ]C-=I PNF Ircnkcrs
EPI ]C-=I Bcm PNF Dcbckcgues/Ncogeoers fy
GN/B^
LKCW VI]E8 600 „ 640 K/bao^IBPKEV8 PUL Nirtramge watd PUL Lakter cr PUL TIM
• ^ibpke ]abe = tc 6= dcurs
• Iar \ckube =4 B> tc =0> B>
• Vepcrtaog Kabat ~ 0.009= ug/B> it 6=0 Katers lcr
6=drs
Abpcrtiot8 Lkcw rites lcr ]C-=I ire geoerikky
tcc dagd lcr aomccr Iar ippkanitacos
Dagd \ckube ^ibpker
Laekm ^nreeoaog
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• Abbuocissiy fisem test jats
„ ^W-4=< Betdcm =060
• ]ctik crgioan ndkcraoe / ndkcrame aco test jats
• Laekm GN
• Bcst stumaes fisem co scaks & trioslcrber caks
„ Prchent spenalan betdcm mevekcpbeot suggestem
• Mallanukt bitrax, ircnkcr preseot, ctder aoterlereones
„ Ncrrekitaco watd kif testaog
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www.nku-ao.crg/ncotibaoiotlcnus/meliukt.lcnus/sen/
PckyndkcraoitemSFapdeoyksSPNFs/nit/MetentacoSiomS
^ate Ndirinterazitaco/
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dttp8//pnfwcrjsdcp.crg
Ha C da ka a
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40
Hab Cnndaikaoa [email protected]
(504) >40-4<94
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PNFs ao Fuakmaog Biteraiks „
Vebcvik iom Maspcsik Assues
^teve Nrcss, Deratige Eovarcobeotik
Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
Vcss Dirtbio, HB Eovarcobeotik
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H Be NCVPCVI]ACO
Nertalaem WFE A MFE
Cpeoaog
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Octewcrtdy Ifitebeot Atebs
Fukj Prcmunt Wiste (FPW) Bioigebeot cl PNF Biteraiks
p g
Octewcrtdy Ifitebeot Atebs
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Ndebanik Ippkanitaco iom Eonipsukitaco
Epcxy vs Nkeir Ncit
Nipsur „ Vebcvik nio niuse assues eonipsukitacoellcrt
Octewcrtdy Ifitebeot Atebs
Nkeir ^tite Cl PNFs
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Nkeir ^tite Cl PNFs
FPW
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Wiste meravem lrcb bioulinturem prcmunts
ncotiaoaog PNFs ao i oco-kaquam stite wdere tdenconeotritaco it tde tabe cl mesagoitaco lcr
maspcsik as ? 50 ppb
9. Perlcrbione Fisem „ ]^NI Kiomlakk
6. ^ckam Wiste Kiomlakk
>. Vasj-Fise „ EPI Ipprcvik
Atebs tc Octe
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Perlcrbione iom ^WK mc oct requare EPI ipprcvik
Perlcrbione iom ^WK Maspcsik cptacos
Nio‑t mekaoeite ;50 biteraik -
bust fe exnkumem prcmunt
^cak as oct FPW „ Vebemaitaco Wiste
Iksc ^tite regukitem fisem co nconeotritacos
Atebs tc Octe
FPW Veaoterpretitaco
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FPW Veaoterpretitaco Dis Niuse iom Ellent
Ikkcws lcr scurne iom sufstrite tc fe bioigem is
sibe „ sepiritaco as oct io assue
Inncbbcmite nkeio-up ellcrts iom bioige ncsts lcrmaspcsik
Bcve tc bcre iggressave nkeio-ups
^cuoms Greit…..
p
FPW Prcs
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Prcneem Watdcut EPI Ipprcvik
Expemate ^ndemuke
^ive Ncsts „ Perdips
FPW Ncos
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Pranaog
Kabatem Cutkets
^uppky & Mebiom „ ikkcws prane tc rebiao
dagd
Kcog ]erb Kaifakaty3333
Pcteotaik Assues watd lckkcwaog ^ufpirt C, O & V(peer revaew)
Nkisses nionekem it Estifrccj
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Nkisses nionekem it Estifrccj
^ndcck muraog PNF rebemaitaco ^tumeots it tde Hcsepd Estifrccj ^ndcck ao Kexaogtco wakk oct dive
regukir nkisses lcr tde rest cl tde weej wdake eovarcobeotik ncosuktiots
iom ncotrintcrs ncotaoue wcrj tc remune keveks cl pckyndkcraoitem
fapdeoyks (PNFs) ao tde ekebeotiry sndcck fuakmaog.
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Kexaogtco sndccks sue PNFbijers ao lemerik ncurt
Kiomlakks
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Ndccse waseky fisem co kcog terb assues Nkcsure luoms
Cperitacos & Keindite Nckkentaco
Vequestaog bcre aolcrbitaco tc cftiao ipprcvik8
Vepcrts co issessbeot, ioikytanik iom bips
]NKP co PNF^ iom Keim
Geoeritcr nerts
Piperwcrj FPW
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^tite Mraveo Cversagdt cl Biteraiks ‛Qcga Ferri‒ ^tite cl BI „ BI06
Vequares octalanitaco tc Wiste Fureiu
^tite cl N]
Oc Octalanitaco
^tite cl VA3333
Oco-dizirmcus Wiste bioalest
Ctder ^tites
Laoasdaog Octes
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]de type cl maspcsik cptaco mraves prane Ncst ioikysas co sibpkaog vs maspcsik
Ncosameritaco ifcut bcvaog aotc Vebemaitaco Wiste tc sive
bcoey Al tabe iom fuakmaog ncomatacos wirriot
Vencbbeom i wiste bioigebeot pkio al sufbattaog tc EPI.
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]riospcrtitaco Maspcsik
Cl
PNF Fukj Prcmunt Wiste
Iom
PNF Vebemaitaco Wiste
Deratige Eovarcobeotik ^ervanes
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• Deratige „ Cwoersdap „ Libaky ]rust„ ]DG „ 6>+ Ncbpioaes
„ Aoteroitacoik - ?$5F ioouikky
• VNVI ^uftatke N Kiomlakk
„ Ncostruntem lcr Deratige„ Eirky 40‑s „ 9,000 Inres
„ Uoat 6 cpeoem Likk 6007
„ Iutdcrazem lcr NEVNKI wistes
• Vcindmike, AO
Deratige Kiomlakk AMEB Perbat Bcmalanitaco)
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• AMEB (Iutdcrazem uomer >00< cl VNVI)
• Bcmalaem AMEB perbat tc innept • K. PCKQNDKCVAOI]EM FAPDEOQK WI^]E
„ 9. ]de Perbattee biy reneave iom maspcse cl
pckyndkcraoitem fapdeoyk (PNF) Vebemaitaco Wiste lrcb
sekl-abpkebeotaog co-sate nkeioups is melaoem it =0 NLV7<9.<9(i).
„ 6. ]de Perbattee biy reneave iom maspcse cl PNF
Vebemaitaco Wiste wdand dis reneavem rasj-fisem maspcsik
ipprcvik lrcb U.^. EPI is ikkcwem fy =0 NLV 7<9.<9(n).„ >. ]de Perbattee biy reneave iom maspcse cl PNF Fukj
Prcmunt Wiste ao inncrmione watd =0 NLV 7<9.<6(i)(>).
PNF Fukj Prcmunt
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• =0 NLV 7<9.<6(i)(>)
„ Ao i dizirmcus wiste kiomlakk perbattem fy EPI uomer sentaco >00= clVNVI, cr fy i ^tite iutdcrazem uomer sentaco >00< cl VNVI.
• Wiste Ipprcvik
„ As at iksc i VNVI wiste3
„ ]NKP Betiks ifsckute requarebeot
„ ^ibpkes requarem fy Deratige lcr Ipprcvik
„ Ncpy cl Wcrj Pkio
„ VNVI „ Vepreseotitave sibpke cl tde wiste
=0 NLV 6<4.90
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• Vepreseotitave sibpke beios i sibpke cl i
uoaverse cr wdcke (e.g., wiste pake, kigcco, grcuomwiter) wdand nio fe expentem tc exdafat tde iverige
prcpertaes cl tde uoaverse cr wdcke.
Fukj Prcmunt Wiste ]riospcrtitaco
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• ]ypanikky oct Dagd \ckube 2 Vckk-clls
• Vckk-clls 2 ETPEO^A\E !
• Dagd \ckube „ Viak Cptaco
PNF Vebemaitaco Wiste
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• Ipprcvik Prcness
„ Ncpy cl Wcrj Pkio„ Ncpy cl EPI Ipprcvik cl Wcrj Pkio
„ VNVI ]estaog „ Lukk Ndirinterazitaco
„ Aovestagitcry Ioikytanik
„ Deratige Ipprcvik ^ibpkes
• Wcrj Pkio Assues lcr ≥ 50 ppb PNFs „ ]^NI perbattem linakaty
versus
„ =0 NLV 7<9.<9(i)(5)(a)(F)(6)(aaa )
]^NI Kiomlakks
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PNF Vebemaitaco Wiste - ]riospcrtitaco
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• Viak as Greeo Vebemaitaco
I Vcuomtifke Masnussaco watd
• Jab ]asi ]^NI Imbaoastritcr EPI Vegaco 9
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Bcmeritcr8 Lrioj Vannairma, Westco & ^ibpsco
Pioekasts8
• Vanj \iomeoferg, Westco & ^ibpsco
• Vcss Dirtbio, HB Eovarcobeotik• Vcfert Itwccm, Presameot, Vescurne Ncotrck Isscnaites
• ^teve Nrcss, Deratige Eovarcobeotik
• Hab Cnndaikaoa, Ikpdi Ioikytanik
• Jab ]asi ]^NI Imbaoastritcr, EPI Vegaco 9
Eovarcobeotik Fusaoess Ncuonak cl Oew Eogkiom
Eoergy Eovarcobeot Encocby
EFN Ncooentanut Ndipter Prcgrib
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EFN Ncooentanut Ndipter Prcgrib
Bioigaog PNF Abpintem
Fuakmaog Biteraiks
]dioj ycu lcr itteomaog.