3
Legend Suppl Fig.1- Risk of COPD according to plasma levels of C-reactive protein (CRP) among never smokers (A) and ever smokers (B). Multiple adjustment was for age, sex, smoking, body mass index, physical activity, asthma medication, and ischemic heart disease; models for hospitalisation due to COPD were also adjusted for FEV1 % predicted. Overall p-values are test for trend of risk estimates (odds ratios or hazard ratios) where CRP groups with increasing level of plasma CRP has been coded 1, 2 and 3.

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Page 1: Figure 131193

Legend Suppl Fig.1- Risk of COPD according to plasma levels of C-reactive protein (CRP) among never smokers (A) and ever smokers (B). Multiple adjustment was for age, sex, smoking, body mass index, physical activity, asthma medication, and ischemic heart disease; models for hospitalisation due to COPD were also adjusted for FEV1 % predicted. Overall p-values are test for trend of risk estimates (odds ratios or hazard ratios) where CRP groups with increasing level of plasma CRP has been coded 1, 2 and 3.

Page 2: Figure 131193

0.5 1.0 2.0 4.0 0.5 1.0 2.0 4.0

Copenhagen General Population Study COPD CRP, mg/L Participants Events

<1 4012 141 <0.001 <0.001 1-3 10529 514 0.52 0.003 >3 3409 253 0.001 <0.001

Odds ratio (95% CI) Odds ratio (95% CI) COPD hospitalisation CRP, mg/L Participants Events

<1 3867 20 <0.001 0.06 1-3 9688 123 0.37 0.06 >3 3158 87 <0.001 0.05

Odds ratio (95% CI) Odds ratio (95% CI)

0.5 1.0 2.0 4.0 0.5 1.0 2.0 4.0

Suppl. Fig.1A Age, sex, and smoking adjusted p risk p trend Multiple adjusted p risk p trend

Copenhagen City Heart Study COPD CRP, mg/L Participants Events

<1 193 20 0.45 0.62 1-3 1268 117 0.048 0.18 >3 319 40 0.18 0.42

Odds ratio (95% CI) Odds ratio (95% CI)

COPD hospitalisation CRP, mg/L Participants Events

<1 179 0 0.92 0.31 1-3 1204 33 >3 301 9 0.92 0.31

Hazard ratio (95% CI) Hazard ratio (95% CI)

0.5 1.0 2.0 4.0 0.5 1.0 2.0 4.0

0.5 1.0 2.0 4.0 0.5 1.0 2.0 4.0

Page 3: Figure 131193

0.5 1.0 2.0 4.0 0.5 1.0 2.0 4.0

Copenhagen General Population Study COPD CRP, mg/L Participants Events

<1 4900 434 <0.001 <0.001 1-3 7281 877 0.09 <0.001 >3 4479 872 <0.001 <0.001

Odds ratio (95% CI) Odds ratio (95% CI) COPD hospitalisation CRP, mg/L Participants Events

<1 4504 168 <0.001 <0.001 1-3 6451 392 0.009 0.005 >3 3750 444 <0.001 <0.001

Odds ratio (95% CI) Odds ratio (95% CI)

0.5 1.0 2.0 4.0 0.5 1.0 2.0 4.0

Suppl. Fig.1B Age, sex, and smoking adjusted p risk p trend Multiple adjusted p risk p trend

Copenhagen City Heart Study COPD CRP, mg/L Participants Events

<1 423 59 <0.001 <0.001 1-3 3730 736 0.08 0.006 >3 1402 372 0.001 <0.001

Odds ratio (95% CI) Odds ratio (95% CI)

COPD hospitalisation CRP, mg/L Participants Events

<1 387 27 <0.001 <0.001 1-3 3191 438 0.10 0.36 >3 1112 293 <0.001 0.026

Hazard ratio (95% CI) Hazard ratio (95% CI)

0.5 1.0 2.0 4.0 0.5 1.0 2.0 4.0

0.5 1.0 2.0 4.0 0.5 1.0 2.0 4.0


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