Figure 1. Number of Tuberculosis Cases: California, 1930-2011

1980

1982

1984

1986

1988

1990

1992

1994

1996

1998

2000

2002

2004

2006

2008

2010

0

1,000

2,000

3,000

4,000

5,000

6,000

California Department of Public Health, Tuberculosis Control Branch

Nu

mb

e r o

f Tu

ber

culo

s is

Cas

e s

1930 1940 1950 1960 1970 1980

2,000

4,000

6,000

8,000

10,000

12,000

Year

Figure 2. Number of Tuberculosis Cases and Case Rates: California, 2002-2011

2002 2003 2004 2005 2006 2007 2008 2009 2010 20110

1,000

2,000

3,000

4,000

0

5

10

15

20

Year

*

Cas

e R

ate

per

100

,000

Number of Cases

Case Rate per 100,000 Population

National Case RateCalifornia Department of Public Health, Tuberculosis Control Branch

*Nu

mb

er o

f C

ases

Figure 3. Tuberculosis Cases by Race/Ethnicity: California, 2011

Asian/Pacific Islander1,137 (48.9%)

Hispanic848 (36.5%)

Unknown1 (<0.1%)

Black 137 (5.9%)

American Indian/Alaska Native

5 (0.2%)

White197 (8.5%)

California Department of Public Health, Tuberculosis Control Branch

76

Figure 4. Tuberculosis Case Rates by Race/Ethnicity: California, 2002-2011

2002 2003 2004 2005 2006 2007 2008 2009 2010 20110

5

10

15

20

25

30

35

40Asian/Pacific IslanderBlackHispanicWhiteAmerican Indian/Alaska Na-tive

Year

Cas

es p

er 1

00,0

00

California Department of Public Health, Tuberculosis Control Branch

Figure 5. Tuberculosis Cases in Foreign-born and U.S.-born Persons: California, 2002-2011

2002 2003 2004 2005 2006 2007 2008 2009 2010 20110

500

1,000

1,500

2,000

2,500

3,000

0

20

40

60

80

100

U.S.-born Foreign-born Percent Foreign-born

Nu

mb

er o

f C

ases

Per

cen

t o

f C

ases

California Department of Public Health, Tuberculosis Control Branch

78

Figure 6. Tuberculosis Cases by Country of Origin: California, 2011

U.S.-born511 (21.9%)

Foreign-born1,787 (76.9%)

Unknown27 (1.2%)

Philippines375 (21.0%)

Mexico497 (27.8%)

All OtherCountries

675 (37.8%)

Vietnam240 (13.4%)

California Department of Public Health, Tuberculosis Control Branch

Figure 7. Tuberculosis Cases in Persons 0-4 Years of Age: California, 2002-2011

1 2 3 4 5 6 7 8 9 100

20

40

60

80

100

120

140

0

0.5

1

1.5

2

2.5

3

3.5

4

4.5

Nu

mb

er o

f C

ases

Per

cen

t o

f C

ases

Number of Cases Percent of Cases

California Department of Public Health, Tuberculosis Control Branch

Year

2002 2003 2004 2005 2006 2007 2008 2009 2010 2011

Figure 8. Tuberculosis Cases by Verification Criteria: California, 2011

Provider Diagnosis98 (4.2%)

Positive Culture1,840 (79.1%)

Clinical Case336 (14.5%)

Positive Smear12 (0.5%)

California Department of Public Health, Tuberculosis Control Branch

81

NAAT*39 (1.7%)

*NAAT= Nucleic Acid Amplification Test

Figure 9. Deaths in Persons with Tuberculosis: California, 2000-2009

2000 2001 2002 2003 2004 2005 2006 2007 2008 20090

100

200

300

400

0

2

4

6

8

10

12

Year

Per

cen

t o

f C

ases

Nu

mb

er o

f D

eath

s

California Department of Public Health, Tuberculosis Control Branch

Dead at Diagnosis

Died During Treatment Died Before Starting Treatment

Percent Dying with Tuberculosis

Figure 10. Tuberculosis Cases by HIV/AIDS Diagnosis:* California, 2001-2010

2001 2002 2003 2004 2005 2006 2007 2008 2009 20100

50

100

150

200

250

300

0

2

4

6

8

Year

Nu

mb

er o

f C

ases

wit

h H

IV/A

IDS

Per

cen

t o

f C

ases

wit

h H

I V/A

IDS

* Match found in HIV/AIDS Registry, California Department of Public Health, Office of AIDS

Number of Tuberculosis Cases with HIV/AIDSPercent of Tuberculosis Cases with HIV/AIDS

83

California Department of Public Health, Tuberculosis Control Branch

Figure 11. HIV/AIDS-associated Tuberculosis* by Race/Ethnicity: California, 2001-2010

2001 2002 2003 2004 2005 2006 2007 2008 2009 20100

25

50

75

100

125

150

HispanicBlackWhiteAsian/Pacific IslanderAmerican Indian/Alaska Na-tive

Year

Nu

mb

er o

f C

ases

wit

h H

IV/A

IDS

* Match found in HIV/AIDS Registry, California Department of Public Health, Office of AIDS

California Department of Public Health, Tuberculosis Control Branch

1 2 3 4 5 6 7 8 9 100

5

10

15

20

25

30

35

40

45

50

Figure 12. Tuberculosis Cases with Multidrug Resistance (MDR) on Initial or Final Drug

Susceptibility Testing:* California, 2000-2009N

um

ber

of

MD

R

Tub

ercu

losi

s C

ases

*Cases with resistance to at least isoniazid, and either rifampin, rifabutin or rifapentine reported on the Initial Drug Susceptibility Report (Follow-up 1) or on the Case Completion Report (Follow-up 2)

35

43

34

41

36 37

2832 33

38

2001 20092000 2002 2003 2004 2005 2006 2007 2008

California Department of Public Health, Tuberculosis Control Branch

Initial Susceptibility Test Final Susceptibility Test

Figure 13. Tuberculosis Cases with Initial Multidrug Resistance (MDR):* California, 2007-2011

*Cases with initial drug resistance to at least isoniazid, and either rifampin, rifabutin or rifapentineCalifornia Department of Public Health, Tuberculosis Control Branch

Long Beach

Pasadena

Berkeley

San Francisco

³25 cases

15-24 cases

5-14 cases

1-4 cases

None

Initial MDR Cases:2007-2011

Figure 14. Tuberculosis Cases1 by Outcome of Therapy: California, 2009

Completed Therapy £12 Months1,780 (74.5%)

Completed Therapy >12 Months235 (9.8%)

Moved2

97 (4.1%)

Died180 (7.5%)

Lost3

21 (0.9%) Refused17 (0.7%)

Other31 (1.3%)

1 Patient was alive at diagnosis and started on an initial drug regimen of two or more drugs.2 Patient moved to another jurisdiction with a known forwarding address before treatment was completed;

final outcome not available.3 Patient could not be located prior to the completion of treatment.

NoInformation28 (1.2%)

California Department of Public Health, Tuberculosis Control Branch

Figure 15. Outcome in Tuberculosis Cases for Whom One Year or Less of Treatment was Indicated1:

California, 2009

Completed Therapy £12 Months1,770 (76.2%)

Completed Therapy >12 Months195 (8.4%)

Moved2

91 (3.9%)

Died175 (7.5%)

Lost3

21 (0.9%)

Refused16 (0.7%)

Other29 (1.2%)

NoInformation 25 (1.1%)

1 Excludes cases with rifampin resistant disease, cases with meningeal disease, and cases less than 15 years of age with disseminated tuberculosis disease.2 Patient moved to another jurisdiction with a known forwarding address before treatment was completed; final outcome not available.3 Patient could not be located prior to the completion of treatment.

California Department of Public Health, Tuberculosis Control Branch

Figure 16. Outcome in Tuberculosis Cases for Whom Greater than One Year of Treatment

was Indicated:1 California, 2009

Completed Therapy £12 Months10 (14.9%)

Completed Therapy >12 Months40 (60.0%)

Moved2

6 (9.0%)

Died5 (7.5%)

NoInformation 3 (4.5%)

1 Includes cases with rifampin resistant disease, cases with meningeal disease, and cases less than 15 years of age with disseminated tuberculosis disease.

2 Patient moved to another jurisdiction with a known forwarding address before treatment was completed; final outcome not available.

California Department of Public Health, Tuberculosis Control Branch

Refused1 (2.0%)

Other2 (3.0%)

Figure 17. Completion of Tuberculosis Therapy: California, 2000-2009

2000 2001 2002 2003 2004 2005 2006 2007 2008 20090

20

40

60

80

100

Per

cen

t o

f C

ases

Co

mp

leti

ng

T

her

apy

CompletedCompleted in 1 year or less

Note: Excludes cases with rifampin resistant disease, cases with meningeal disease, cases less than 15 years of age with disseminated tuberculosis disease, and those that died during treatment.

90

California Department of Public Health, Tuberculosis Control Branch