Ferro Y, et al.

www.e-enm.org Copyright © 2020 Korean Endocrine Society

Supplemental Table S1. Servings of Various Food Categories Consumed Daily or Weekly during the Study According with the Dietary Treatment

Food categories MedDiet (n=24)

MedDiet+SEY (n=24)

P-MedDiet (n=24)

Whole-grain products, serving/day

4–5 4–5 4–5a

Fruit/vegetables, serving/day

8–10 8–10 8–10

Nuts, serving/day 1–2 1–2 -

Legumes, serving/wk 2–3 2–3 2–3

Cheese and yogurt, serving/wk

2 2b 2b

Poultry, serving/wk <3 <3 <3

Red meat, serving/wk <2 <2 <2

Fish, serving/wk 3–4 3–4 3–4

Extravirgin olive oil, g/wk >200 >200 >200

Chitosan, times/day - - 1

Green tea, cups/day - - 2–3

MedDiet, Mediterranean Diet; SEY, sterol-enriched yogurt; P-MedDiet, Portfolio-Mediterranean Diet.a2 serving/day of oats or barley; b1 serving/day of sterol-enriched yogurt.

Portfolio-Mediterranean Diet

Copyright © 2020 Korean Endocrine Society www.e-enm.org

40

20

0

−20

−40

−60

−80

−100

40

20

0

−20

−40

−60

−80

−100

40

20

0

−20

−40

−60

−80

−100

(mg/

dL)

MedDiet (n=24) MedDiet+SEY (n=24)

Individual LDL-C reduction according to the dietary treatment

P-MedDiet (n=24)

Supplemental Fig. S1. Individual low density lipoprotein cholesterol (LDL-C) reduction according to the dietary treatment. (A) Mediterra-nean Diet (MedDiet). (B) Sterol-enriched yogurt (SEY). (C) Portfolio-Mediterranean Diet (P-MedDiet).

A B C

Ferro Y, et al.

www.e-enm.org Copyright © 2020 Korean Endocrine Society

−110

−115

−120

−125

−130

−135

−140

−1

−3

−5

−7

−9

−11

−13

−15

−1

−3

−5

−7

−9

−11

−13

−15

0

−2

−4

−6

−8

−10

−12

0

−10

−20

−30

−40

−50

−60

−70

21.5

10.5

0−0.5

−1−1.5

−2

∆ Ca

lorie

s int

ake (

Kca

l)∆

Satu

rate

d fa

t (g)

∆ Fa

ts (g

)∆

Mon

ouns

atur

ated

fatty

acid

s (g)

∆ Ch

oles

tero

l (g)

∆ Po

lyun

satu

rate

d fa

ts (g

)

MedDiet

MedDiet

P=0.29

P<0.001

P<0.001

P=0.001

P<0.001

P=0.12

MedDiet

MedDiet

MedDiet

MedDiet

MedDiet+SEY

MedDiet+SEY

P=0.011

P=0.04

P=0.10

P=0.12

P=0.014

P=0.033

MedDiet+SEY

MedDiet+SEY

MedDiet+SEY

MedDiet+SEY

P-MedDiet

P-MedDiet

P=0.34

P=0.004

P=0.006

P=0.004

P=0.003

P=0.012

P=0.002

P-MedDiet

P-MedDiet

P-MedDiet

P-MedDiet

Supplemental Fig. S2. Nutrients intake changes during the dietary treatment. (A) Calories intake change, (B) fats change, (C) cholesterol change, (D) saturated fat change, € monounsaturated fatty acids change, and (F) polyunsaturated fats change. MedDiet, Mediterranean Diet; SEY, sterol-enriched yogurt; P-MedDiet, Portfolio-Mediterranean Diet.

A

D

B

E

C

F