Fall 2008 LISTSERV LIST UPCOMING CU-BOULDER NEUROSCIENCE SEMINAR Directions to the Seminar Room are at the end of this email ___________________________________________________________ Upcoming Neuroscience seminars here and elsewhere: (If you don't see your group's neuroscience-related talks listed here - please email me your semester seminar schedule!! Thanks!!)

PLEASE NOTE: Seminars are subject to change and/or

cancellation in the event of inclement weather. For additional information, please use the contact following the seminar listing

Seminar/Talk Calendar

Wednesday, August 27th CSU-Fort Collins Anatomy/Zoology Building Room NB793 4 PM Organizational Meeting (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, August 28th CU-Boulder – Dept. of Computer Science Engineering Center ECCR 200 3:30 PM Scott A. Brandt, University of California, Santa Cruz Managing the Performance of Large, Distributed Storage Systems (For additional information, please contact: Elizabeth Jessup at Elizabeth.Jessup@Colorado.EDU) Wednesday, September 3rd CSU-Fort Collins Anatomy/Zoology Building Room W1 4 PM Christian Rosenmund, Associate Professor, Depts. of Molecular and Human Genetics and Neuroscience, Baylor College of Medicine Vesicular Glutamate Transporters: Roles Beyond Neurotransmitter Filling (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, September 4th CU-Boulder – Dept. of Computer Science Engineering Center ECCR 265

3:30 PM Mark Maybee, Sun Microsystem, Inc. ZFS – the Last Word in File Systems (For additional information, please contact: Elizabeth Jessup at Elizabeth.Jessup@Colorado.EDU) Thursday, September 4th UCHSC-Denver RC1 - North, 6th Floor Room P18-6107 4 PM Amy Kayal Molecular Mechanisms of GABA(A) Receptor Subunit Gene Regulation in Epilepsy: Potential New Targets For Therapy (For additional information, please contact: Mellodee Phillips at mellodee.phillips@ucdenver.edu) Thursday, September 4th CU-Boulder – Dept. of Integrative Physiology Ramaley C250 4 PM Jerry Stitzel, Assistant Professor, Dept. of Integrative Physiology and Institute for Behavioral Genetics, University of Colorado Neurobiological Consequences of Genetic Variability in Mouse Chrna7: Implications for Mental Health (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Friday, September 5th CU-Boulder – Institute of Cognitive Science NCAR Room 12 pm ICS Membership Meeting (For additional information, please contact: Donna Caccamise at Donna.Caccamise@Colorado.EDU) Wednesday, September 10th CU-Boulder – Dept. of Chemistry and Biochemistry Cristol Chemistry Building Room 142 4 PM Ray Stevens, Scripps Research Institute Crystal Structures of GPCRʼs and Exciting Pharmacological Insights (For additional information, please contact: Linda Pharris at Linda.Pharris@Colorado.EDU) Wednesday, September 10th CSU-Fort Collins Anatomy/Zoology Room W1

4 PM Jonathan Doorn, Assistant Professor, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, Univ. of Iowa Catabolism and Reactive Intermediates: Implications for Parkinson Disease (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, September 11th CU-Boulder – Dept. of Computer Science Engineering Center ECCR 265 3:30 PM Gerard Fischer, Dept. of Computer Science, University of Colorado, Boulder The Center for Lifelong Learning and Design (L3D) at CU Boulder (For additional information, please contact: Elizabeth Jessup at Elizabeth.Jessup@Colorado.EDU) Thursday, September 11th CU-Boulder – Dept. of Integrative Physiology Ramaley C250 4 PM Monika Fleshner, Associate Professor, Dept. of Integrative Physiology Endogenous HSP72: Cellular Sources and Releasing Signals (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Friday, September 12th CU-Boulder – Institute of Cognitive Science Muenzinger Psychology Room 12:00 PM Matt Jones, Dept. of Psychology, University of Colorado at Boulder Implications of Sequential Effects for Knowledge Representation and Generalization (For additional information, please contact: Donna Caccasmise at Donna.Caccamise@Colorado.EDU) Friday, September 12th CU-Boulder – Institute for Behavioral Genetics Institute for Behavioral Genetics Room 120 4 PM Katerina Kechris, University of Colorado, Denver Integrating Bioinformatics, Genomics and Genetics (For additional information, please contact: Kathy Huckfeldt at Kathy.Huckfeldt@Colorado.EDU) Tuesday, September 16th CU-Boulder – Interdepartmental Neuroscience Seminar Series Muenzinger Psychology Building

Room E-214 4 PM David Morilak, Dept. of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio The good, the bad and the ugly: Brain norepinephrine and stress Norepinephrine (NE) exerts a widespread modulatory influence in the brain, altering the operating characteristics of many primary response circuits innervated by noradrenergic afferents. NE has long been implicated in acute stress, and in the behavioral state of arousal, but it has not been clear how its cellular modulatory effect might define a role in either stress or arousal. NE has also been implicated in depression and anxiety, and is a target of many drugs that are effective in the treatment of these disorders, but again with no clear idea how or why. Our research addresses these three questions: What does NE do in the context of acute stress? How is the acute modulatory function of NE dysregulated by chronic stress, contributing to the cognitive, emotional, behavioral, and physiologic symptoms of depression and anxiety disorders? How is NE function also altered by chronic treatment with NE reuptake blockers that are effective in the treatment of these disorders, contributing to their beneficial clinical effects? Our studies indicate that phasic activation of NE release in hypothalamic and limbic forebrain regions facilitates acute neuroendocrine and behavioral responses mediated in those regions and evoked by acute stress, thus enhancing stress adaptation and coping. On the other hand, elevating tonic noradrenergic transmission in medial prefrontal cortex facilitates cognitive performance on a behavioral test that assesses cognitive flexibility and attentional set shifting, executive functions mediated in mPFC and compromised in depression. Chronic stress sensitizes acute noradrenergic facilitation of behavioral and neuroendocrine stress reactivity, but paradoxically, chronic stress also induces a cognitive deficit indicating reduced noradrenergic tone in mPFC. By contrast, chronic treatment with desipramine, a selective NE reuptake blocker and effective antidepressant, attenuates acute stress reactivity and enhances cognitive performance. Thus, we hypothesize that by “clamping” noradrenergic activity at a tonically elevated, but less phasically excitable level, chronic NE reuptake blockade can alleviate both the “inhibitory” symptoms of depression related to loss of arousal and cognitive deficit, and also the more “activated” symptoms related to anxiety, thereby restoring emotional homeostasis. (For additional information, please contact: Linda Watkins at Linda.Watkins@Colorado.EDU) Wednesday, September 17th CU-Boulder – Dept. of Chemistry and Biochemistry Cristol Chemistry Building Room 142 4 PM Jeff Gordon, Washington University The Human Gut Microbiome: Terra Incognita Is Becoming More ʻCognita (For additional information, please contact: Linda Pharris at Linda.Pharris@Colorado.EDU)

Wednesday, September 17th CSU-Fort Collins Anatomy/Zoology Building Room W1 4 PM Joseph Sisneros, Assistant Professor of Psychology and Biology, Dept. of Psychology, Univ. of Washington Adaptive Sensory Plasticity for Social Communication (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, September 18th CU-Boulder – Dept. of Computer Science Engineering Center ECCR 265 3:30 PM William Schuler, University of Minnesota Spoken Language Understanding Using an Interactive Model (For additional information, please contact: Elizabeth Jessup at Elizabeth.Jessup@Colorado.EDU) Thursday, September 18th CU-Boulder – Dept. of Integrative Physiology Ramaley Biology Room C250 4 PM Kenneth Wright, Jr., Assistant Professor, Dept. of Integrative Physiology, University of Colorado Influence of Sleepiness and Sleep Medication on Cognition and Fall Risk in Young and Old Adults (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Thursday, September 18th UCHSC-Denver RC1 - North, 6th Floor Room P18-6107 4 PM Audrey Yee, Neurologist, The Childrenʼs Hospital What Does the Hippocampal CA3 In-vitro Slice Preparation Tell Us About Epilepsy? (For additional information, please contact: Mellodee Phillips at mellodee.phillips@ucdenver.edu) Wednesday, September 24th CU-Boulder – Bioinformatics Supergroup Ekeley Sciences Building Room W165/W166 4 PM Multiple Speakers

Eric Nawrocki, Howard Hughes Medical Institute at Janelia Farms Brief Updates Rapid Structural SSU rRNA Alignment for Phylogenetic Analyses (For additional information, please contact: Rob Knight at Rob.Knight@Colorado.EDU) Wednesday, September 24th CSU-Fort Collins Anatomy/Zoology Building Room W1 4 PM Jeffrey Martens, Assistant Professor, Dept. of Pharmacology, Univ. of Michigan Ciliary Trafficking of Olfactory Signaling Proteins: Linking Sensory Function and Disease (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, September 25th CU-Boulder – Dept. of Computer Science Engineering Center ECCR 265 3:30 PM Peter Messmer, Tech-X Corporation Challenges Faced on Petascale Architectures (For additional information, please contact: Elizabeth Jessup at Elizabeth.Jessup@Colorado.EDU) Thursday, September 25th CU-Boulder – Dept. of Integrative Physiology Ramaley Biology Room C250 4 PM Christopher Lowry, Assistant Professor, Dept. of Integrative Physiology Does That Warm Fuzzy Feeling Activate Brain Serotonin Neurons? Temperature and Serotonin Systems (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Friday, September 26th CU-Boulder – Institute of Cognitive Science Muenzinger Psychology Room D430 12 PM Jim Alexander Pragmatic Issues in Developing Digital Television Products and Software: Where Can HCI Be Useful?

(For additional information, please contact: Donna Caccamise at Donna.Caccamise@Colorado.EDU) Tuesday, September 30th

CU-Boulder – Interdepartmental Neuroscience Seminar Series Muenzinger Psychology Building Room E-214 4 PM Stephen Davies, Associate Professor, Dept. of Neurosurgery, University of Colorado, Denver

Making Gains without Pain: New Technologies for Repairing Spinal Cord Injuries

The traumatically injured spinal cord often reacts to inflammation and the loss of glia at sites of injury by rapidly forming a meshwork of dense, fibrous scar tissue containing a variety of molecules that are actively inhibitory to axon growth. Although white matter pathways beyond sites of injury are also thought to present an inhibitory environment to axon growth, our research has clearly demonstrated that scar tissue presents the greatest impediment to axon regeneration in the injured adult CNS. My research team is therefore developing two complementary approaches to promoting axon regeneration and functional recovery after spinal cord injury. One line of research is focused on promoting axon regeneration by overcoming scar tissue and the multiple axon growth inhibitors within the environment of the injured spinal cord with a naturally occurring molecule called Decorin. Our other line of research is focused on generating the right kinds of astrocytes from embryonic glial restricted precursors (GRPs) for “bridging” spinal cord injuries and promoting functional recovery. In addition to their effects on spinal repair, I will be discussing some of the unexpected new insights our work with GRP-derived astrocytes (GDAs) has given on the cell biology of allodynia after spinal cord injury. (For additional information, please contact: Linda Watkins at Linda.Watkins@Colorado.EDU) Wednesday, October 1st CU-Boulder – Dept. of Chemistry and Biochemistry Cristol Chemistry Building Room 142 4 PM Robert Tjian, University of California, Berkeley Transcriptional Mechanisms Driving Differentiation and Stem Cell Pluripotency (For additional information, please contact: Linda Pharris at Linda.Pharris@Colorado.EDU) Wednesday, October 1st CSU-Fort Collins Anatomy/Zoology Building Room W1 4 PM David Krizaj, Associate Professor, Ophthalmology, Univ. of Utah School of Medicine Calcium Regulation in Vertebrate Photoreceptors (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, October 2nd CU-Boulder – Dept. of Integrative Physiology Ramaley Biology Room C250 4 PM

Christopher Link, Dept. of Integrative Physiology and Institute of Behavioral Genetics What Are the Molecular and Cellular Processes Underlying Alzheimerʼs Disease? (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Thursday, October 2nd CU-Boulder – Dept. of Computer Science Engineering Center ECCR 265 3:30 PM Amer Diwan, Dept. of Computer Science We Have It Easy. But Do We Have It Right? (For additional information, please contact: Elizabeth Jessup at Elizabeth.Jessup@Colorado.EDU) Thursday, October 2nd UCHSC-Denver RC1 - North, 6th Floor Room P18-6107 4 PM Chris McBain, NIH mGluR7: A fulcrum for state-dependent plasticity of feedforward inhibitory circuits (For additional information, please contact: Mellodee Phillips at mellodee.phillips@ucdenver.edu) Friday, October 3rd CU-Boulder – Institute of Cognitive Science Muenzinger Psychology Room D430 12 pm Elena Paducheva, Research scientist at All-Russian Institute of Scientific Study, Russian Academy of Science, Moscow Verb Taxonomy and Decompositional Semantics of the Lexicon (For additional information, please contact: Donna Caccamise at Donna.Caccamise@Colorado.EDU) Friday, October 3rd CU-Boulder – Institute for Behavioral Genetics Institute for Behavioral Genetics Room 120 4 PM Benjamin F. Voight, Research Fellow, Daly Lab, Broad Institute, MIT Population-Based Homogenized Mapping Using Whole-Genome Association Data (For additional information, please contact: Kathy Huckfeldt at Kathy.Huckfeldt@Colorado.EDU) Saturday, October 4th CU-Boulder – Institute of Cognitive Science Muenzinger Psychology Room D430 Time

DEFD/IBSC Open House (For additional information, please contact: Donna Caccamise at Donna.Caccamise@Colorado.EDU) Wednesday, October 8th CU-Boulder – Dept. of Chemistry and Biochemistry Cristol Chemistry Building Room 142 4 PM Art Johnson, Texas A&M Fluorescence-Detected Nascent Membrane Protein Folding and Biogenesis (For additional information, please contact: Linda Pharris at Linda.Pharris@Colorado.EDU) Wednesday, October 8th CSU-Fort Collins Anatomy/Zoology Building Room W1 4 PM Michael Marletta, Aldo DeBenedictis Distinguished Professor of Chemistry, Dept. of Chemistry; Professor of Biochemistry and Molecular Biology, Dept. of Molecular Biology, Univ. of California, Berkeley Sensing Gases (NO vs. O2) Selectively in Biology: Chemistry to the Rescue (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, October 9th CU-Boulder – Dept. of Computer Science Engineering Center ECCR 265 3:30 PM Leah Buechley, Massachusetts Institute of Technology Media Lab High-Low Tech: Rethinking Cultural and Material Contexts for Computation (For additional information, please contact: Elizabeth Jessup at Elizabeth.Jessup@Colorado.EDU) Thursday, October 9th CU-Boulder – Dept. of Integrative Physiology Ramaley Biology Room C250 4 PM Pei-San Tsai, Associate Professor, Dept. of Integrative Physiology Reproduction and Olfactory Morphogeneis Are Obliterated By Hypomorphy in a Single Gene (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Friday, October 10th CU-Boulder – Institute of Cognitive Science Muenzinger Psychology Room D430

12 PM 1. Tammy Sumner, Alice Healy, and Jim Martin 2. Hiromi Sumiya, Eliana Colunga, Bhuvana Narasimhan Group 1: Supporting Science Understanding through a customized learning service for concept knowledge: A generalization pilot study Group 2: Patterns of generalization in childrenʼs production of Japanese numeral classifiers: The role of semantics and input frequency (For additional information, please contact: Donna Caccamise at Donna.Caccamise@Colorado.EDU) Tuesday, October 14th CU-Boulder – Interdepartmental Neuroscience Seminar Series Muenzinger Room E-214 4 PM Hubert Yin, Assistant Professor, Department of Chemistry and Biochemistry, University of Colorado at Boulder Chemical Biology Studies of Protein-Protein Interactions in Membranes

Protein transmembrane domains regulate many pivotal biological processes in the cell. But molecular recognition in the cellular membrane is little understood due to the lack of available probes with high affinity and specificity. Conventional tools such as antibodies are unable to bind to the transmembrane regions of membrane proteins in intact cells. Exogenous agents that specifically target transmembrane domains are needed to complements the antibody-based probing techniques restricted to water-soluble regions. Previous thought has that transmembrane regions do not provide enough distinguishable features for recognition by small-molecule or peptide agents. Recent findings suggested that we can use naturally-occurring protein complex structures as a seed to design such transmembrane domain probing peptides. We have successfully developed Computed Anti-Helical Membrane Protein (CHAMP), the first computational method to design de novo peptide antagonists of protein-protein interactions in the membrane. This is potentially a generally applicable tool to provide agents that can specifically recognize a target transmembrane sequence and study protein-protein interactions in the membrane. (For additional information, please contact: Linda Watkins at Linda.Watkins@Colorado.EDU) Wednesday, October 15th CU-Boulder – Bioinformatics Supergroup Ekeley Sciences Building Room W165/W166 4 PM 1. Anis Karimpour-Fard, UCDHSC, Hunter and Gill Labs 2. Mike Lynch, OPX Biotechnologies Speaker 1: Investigation of Factors Affecting Prediction of Protein-Protein Interaction Networks by Phylogenetic Profiling Speaker 2: Functional Genomics and Evolutionary Bioinformatics: A Synergistic Team

(For additional information, please contact: Rob Knight at Rob.Knight@Colorado.EDU) Wednesday, October 15th CU-Boulder – Dept. of Chemistry and Biochemistry Cristol Chemistry Building Room 142 4 PM Sheng Ding, Scripps Research Institute A Chemical Approach to Stem Cell Biology (For additional information, please contact: Linda Pharris at Linda.Pharris@Colorado.EDU) Wednesday, October 15th CSU-Fort Collins Anatomy/Zoology Building Room W1 4 PM Suzanne Craft, Professor of Psychiatry and Behavioral Sciences, Univ. of Washington School of Medicine The Role of Impaired Insulin Signaling in Brain Aging and Dementia (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, October 16th CU-Boulder – Dept. of Computer Science Engineering Center ECCR 265 3:30 PM Mary Cummings, Massachusetts Institute of Technology Modeling Single Operator Supervisory Control of Multiple Heterogeneous Unmanned Aerial Vehicles (For additional information, please contact: Elizabeth Jessup at Elizabeth.Jessup@Colorado.EDU) Thursday, October 16th CU-Boulder – Dept. of Integrative Physiology Ramaley Biology Room C250 4 PM Gary F. Mitchell, President, Cardiovascular Engineering, Inc. Aortic Stiffness, Peripheral Microvascular Function, and End-Organ Damage (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Friday, October 17th CU-Boulder – Institute of Cognitive Science Muenzinger Psychology Room D430 12 PM 1. Al Kim, Martha Palmer, and Greg Grudic 2. Ronald LeBel, Anu Sharma, and Eliana Colunga

Group 1: Machine learning methods and psycholinguistic models of word category knowledge Group 2: The role of action-related words on the mirror neuron system (MNS) in children with cochlear implants (For additional information, please contact; Donna Caccamise at Donna.Caccamise) Wednesday, October 22nd CU-Boulder – Dept. of Chemistry and Biochemistry Cristol Chemistry Building Room 142 4 PM Roy Parker, University of Arizona Life, Death, and Mid-Life Crises of Eukaryotic mRNAʼs (For additional information, please contact: Linda Pharris at Linda.Pharris@Colorado.EDU) Wednesday, October 22nd CSU-Fort Collins Anatomy/Zoology Building Room W1 4 PM John Williams, Senior Scientist, Vollum Institute, Oregon Health and Science University Dopamine Mediated Synaptic Transmission (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, October 23rd CU-Boulder – Dept. of Computer Science Engineering Center ECCR 265 3:30 PM Richard Loft, National Center for Atmospheric Research An Inconvenient Question: Are We Going to Get the Algorithms and Computing Technology We Need to Make Critical Climate Predictions in Time? (For additional information, please contact: Elizabeth Jessup at Elizabeth.Jessup@Colorado.EDU) Thursday, October 23rd CU-Boulder – Dept. of Computer Science Engineering Center ECCR 245 5PM Todd Vernon & Walter Knapp, Lijit Networks, Inc. Entrepreneurs Unplugged: Todd Vernon and Walter Knapp (For additional information, please contact: Elizabeth Jessup at Elizabeth.Jessup@Colorado.EDU) Thursday, October 23rd CU-Boulder – Dept. of Integrative Physiology

Ramaley Biology Room C250 4 PM Ruth Wood, Professor, Dept. of Cell and Neurobiology, Keck School of Medicine, University of Southern California Anabolic Steroid Addiction: Insights From Animal Studies (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Monday, October 27th CU-Boulder – Institute of Cognitive Science Muenzinger Psychology Room D430 3 PM Anthony Wagner, Associate Professor of Psychology and Neuroscience, Stanford University Resolving Uncertainty: Priming as a Window onto the Prefrontal Executive System (For additional information, please contact: Donna Caccamise at Donna.Caccamise@Colorado.EDU) Tuesday, October 28th CU-Boulder – Interdepartmental Neuroscience Seminar Series Muenzinger Psychology Building Room E-214 4 PM Anthony Wagner The Cognitive Neuroscience of Remembering Declarative memory permits an organism to bridge the past with the present, providing information from the past that serves to inform present decisions and action. Declarative memory critically depends on the medial temporal lobe (MTL) –– the hippocampal formation and surrounding entorhinal, perirhinal, and parahippocampal cortices –– as well as on interactions between the MTL and other cortical and subcortical structures. In this talk, I will discuss functional neuroimaging data that advance understanding of how the MTL subserves declarative memory. These data support four central conclusions. First, item recognition and event recollection both vary in a continuous manner. Second, a functional gradient exists within the MTL circuit, wherein variability in memory for items and for item-context conjunctions differentially correlates with activation in perirhinal cortex and hippocampus, respectively. Third, the hippocampus interacts with midbrain structures to encode across-event conjunctions, enabling the building of an integrated episodic history that supports generalization. Fourth, such integrative encoding emerges from the circuitry of the hippocampus, which enables it to detect conjunctive prediction errors the have feedback consequences for learning. Collectively, these data indicate that the MTL supports multiple forms of declarative learning, with MTL mechanisms not only empowering us to learn from the past to predict the present, but also to differentially learn from the present when our predictions are violated. Regarding readings for the graduate seminar, I would suggest the following review chapter and the attached empirical paper: Preston, A. R., & Wagner, A. D. (2007). The medial temporal lobe and memory. In R. P. Kesner & J. L. Martinez (Eds.). Neurobiology of Learning and Memory (2nd ed.), pp.

305-337. Elsevier, Inc. Gonsalves, B. D., Kahn, I., Curran, T., Norman, K. A., & Wagner, A. D. (2005). Memory strength and repetition suppression: Multimodal imaging of medial temporal cortical contributions to recognition. Neuron, 47, 751-761. (For additional information, please contact: Linda Watkins at Linda.Watkins@Colorado.EDU) Wednesday, October 29th CU-Boulder – Dept. of Chemistry and Biochemistry Cristol Chemistry Building Room 142 4 PM Lan Huang, University of California, Irvine Deciphering the Ubiquitin-Proteasome Dependent Degradation Pathway Using Proteomic Approaches (For additional information, please contact: Linda Pharris at Linda.Pharris@Colorado.EDU) Wednesday, October, 29th CSU-Fort Collins Anatomy/Zoology Building Room W1 4 PM Anthony Wagner, Associate Professor of Psychology and Neuroscience, Stanford University Title (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, October 30th CU-Boulder – Dept. of Integrative Physiology Ramaley Biology Room C250 4 PM David Allen, Assistant Professor, Dept. of Integrative Physiology, University of Colorado Mechanisms Regulating Myostatin Expression in Skeletal Muscle and Adipose Are Altered by Changes in Energy Balance (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Thursday, October 30th UCHSC-Denver RC1 - North, 6th Floor Room P18-6107 4 PM Wei Chen, Yale University Title (For additional information, please contact: Mellodee Phillips at mellodee.phillips@ucdenver.edu) Wednesday, November 5th

CU-Boulder – Bioinformatics Supergroup Ekeley Sciences Building Room W165/W166 4 PM Maribeth Oscamou, Dept. of Applied Math, Lladser Lab, University of Colorado at Boulder Dave Clark, Dept. of Chemical and Biological Engineering, University of Colorado at Boulder Speaker 1: The Use of Global Optimization Algorithms for Parameters Estimation In Cell Signaling Models Speaker 2: Experimental Strategies for Estimating Parameters In Cell Signaling Models (For additional information, please contact: Rob Knight at Rob.Knight@Colorado.EDU) Wednesday, November 5th CU-Boulder – Dept. of Chemistry and Biochemistry Cristol Chemistry Building Room 142 4 PM Christine Payne, Georgia Tech Intracellular Delivery of Quantum Dots for Live Cell Imaging (For additional information, please contact: Linda Pharris at Linda.Pharris@Colorado.EDU) Wednesday, November 5th CSU-Fort Collins Anatomy/Zoology Building Room W1 4 PM John Rash, Professor, Dept. of Biomedical Sciences – Neuroscience Div., Colorado State University Title (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, November 6th CU-Boulder – Dept. of Integrative Physiology Ramaley Biology Room C250 4 PM LaDora Thompson, Associate Professor, Program in Physical Therapy, University of Minnesota Age-Related Muscle Dysfunction: the Role of Protein Modifications (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Thursday, November 6th UCHSC-Denver RC1 - North, 6th Floor

Room P18-6107 4 PM Mary Bartlett Bunge, University of Miami Title (For additional information, please contact: Mellodee Phillips at mellodee.phillips@ucdenver.edu) Friday, November 7th CU-Boulder – Institute of Cognitive Science Muenzinger Psychology Room D430 12 PM Ned Block, Silver Professor Depts. of Philosophy and Psychology New York University Title (For additional information, please contact: Donna Caccamise at Donna.Caccamise@Colorado.EDU) Tuesday, November 11th CU-Boulder – Interdepartmental Neuroscience Seminar Series Muenzinger Psychology Building Room E-214 4 PM Rock Levinson, Professor of Physiology, University of Colorado School of Medicine, Denver. Changes in Sodium Channel Expression In Chronic Pain Nearly every human will experience severe chronic pain at some point in their lives. Current medications and treatments for this condition have limited effectiveness, and thus chronic pain severely impacts the lives of a substantial number of patients. While the subject of pain is highly complex, our group focuses on the initial mechanisms by which pain is detected and transmitted from the site of injury in the peripheral nervous system (“nociception”). In particular, we study the role that sodium channels play in generating electrical impulses that encode pain. My talk will focus on two major findings, namely that only certain kinds of sodium channels (known as “isoforms”) are specifically involved in normal nociception, and that the expression of these isoforms changes in the peripheral nervous system in chronic pain states. I will describe our studies in both animal models and in human disease. (For additional information, please contact: Linda Watkins at Linda.Watkins@Colorado.EDU) Wednesday, November 12th CU-Boulder – Dept. of Chemistry and Biochemistry Cristol Chemistry Building Room 142 4 PM Tobias Meyer, Stanford University Exploring Cell Signaling Systems by Fluorescence Microscopy (For additional information, please contact: Linda Pharris at Linda.Pharris@Colorado.EDU) Wednesday, November 12th CSU-Fort Collins

Anatomy/Zoology Building Room W1 4 PM Donald Welsh, Senior Scholar, Alberta Heritage Foundation for Medical Research; Associate Professor, Dept. of Physiology and Biophysics Title (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Wednesday, November 12th, and Thursday, November 13th UCHSC-Denver RC1 - North, 6th Floor Room P18-6107 4 PM Post-Rotation Talks (For additional information, please contact: Mellodee Phillips at mellodee.phillips@ucdenver.edu) Thursday, November 13th CU-Boulder – Dept. of Integrative Physiology Ramaley Biology Room C250 4 PM Vaughn Macefield, Professor of Integrative Physiology, School of Medicine, University of Western Australia Group III-IV Muscle Afferents and the Motor Cortex: An fMRI Study (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Friday, November 14th CU-Boulder – Institute of Cognitive Science Muenzinger Psychology Room D430 12 PM Michael Spivey Title (For additional information, please contact: Donna Caccamise at Donna.Caccamise@Colorado.EDU) Friday, November 14th CU-Boulder – Institute for Behavioral Genetics Institute for Behavioral Genetics Room 120 4 PM Isabel Schlaepfer, Graduate Student, Institute for Behavioral Genetics, and Dept. of Integrative Physiology, University of Colorado, Boulder Supporting the Genetic Etiology of Behavioral Disinhibition: Statistical and Biological Evidence from Common Variations in the CHRNA5/A3/B4 Gene Cluster (For additional information, please contact: Kathy Huckfeldt at Kathy.Huckfeldt@Colorado.EDU)

Wednesday, November 19th CU-Boulder – Dept. of Chemistry and Biochemistry Cristol Chemistry Building Room 142 4 PM Jackie Barton. Caltech DNA-mediated Protein Signaling in Damage and Repair (For additional information, please contact: Linda Pharris at Linda.Pharris@Colorado.EDU) Thursday, November 20th CU-Boulder – Dept. of Integrative Physiology Ramaley Biology Room C250 4 PM Cindy Carey, Professor, Dept. of Integrative Physiology, University of Colorado Itʼs War! A 250M Year-Old Immune System vs. a Newly Emerged, Novel Pathogen. Which Will Win? (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Wednesday, December 3rd CU-Boulder – Bioinformatics Supergroup Ekeley Sciences Building Room W165/W166 4 PM Rob Knight, Dept. of Chemistry, University of Colorado at Boulder Phoenix Kwan, ThermoFisher Scientific, Inc. Speaker 1: GO-Getter: Using the Gene Ontology for Functional Profiling Speaker 2: the High-Throughput RNAi Screening Data Analysis Workflow (For additional information, please contact: Rob Knight at Rob.Knight@Colorado.EDU) Wednesday, December 3rd CSU-Fort Collins Anatomy/Zoology Building Room W1 4 PM Christopher Link, University of Colorado Title (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, December 4th CU-Boulder – Dept. of Computer Science Engineering Center ECCR 265 3:30 PM Michael Eisenberg

Title (For additional information, please contact: Elizabeth Jessup at Elizabeth.Jessup@Colorado.EDU) Thursday, December 4th CU-Boulder – Dept. of Integrative Physiology Ramaley Biology Room C250 4 PM Leonard Hayflick, Professor of Anatomy, University of California at San Francisco Aging Is No Longer an Unsolved Problem in Biology (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) Monday, December 8th CU-Boulder – Institute of Cognitive Science Muenzinger Psychology Building Room D430 3 PM Sharon Thompson-Schill Title (For additional information, please contact: Donna Caccamise at Donna.Caccamise@Colorado.EDU) Tuesday, December 9th CU-Boulder – Interdepartmental Neuroscience Seminar Series Muenzinger Psychology Building Room E-214 4 PM Sharon Thompson-Schill Tuning the Language Organ: A New Perspective on the Role of Brocaʼs Area in Language Processing.

For over a century, the relationship between left prefrontal cortex and language processing has been accepted, yet the precise characterization of this link remains elusive. Recent advances in both the psycholinguistic study of language processing and the neuroscientific study of frontal lobe function have converged on an intriguing possibility: The demands to resolve competition between incompatible characterizations of a linguistic stimulus may recruit top-down cognitive control processes mediated by prefrontal cortex. Under this account, the brain region traditionally known as “Brocaʼs area” – one of the principle language centers in classical models of language dysfunction – may be better described in attentional than linguistic terms. This hypothesis draws on a large body of research into the function of prefrontal cortex, and contrasts with other more domain-specific accounts of the function of Brocaʼs area. I will present both functional neuroimaging data from young, healthy volunteers and lesion-deficit analyses of patients with focal brain damage that jointly provide support for the regulatory hypothesis of left prefrontal cortex involvement in language processing. I will emphasize studies of single word production, but I will also discuss parallel findings beyond the domain of speech. Evidence of shared regulatory mechanisms across domains has implications for the psychological and neural architecture of language and may broadly inform the study of both linguistic and nonlinguistic cognitive processes. For reprints and more information, see http://www.psych.upenn.edu/stslab.

(For additional information, please contact: Linda Watkins at Linda.Watkins@Colorado.EDU) Wednesday, December 10th CSU-Fort Collins Anatomy/Zoology Building Room W1 4 PM Front Range Neurosciences Group Meeting (For additional information, please contact: Nancy Graham at nancy.graham@colostate.edu) Thursday, December 11th UCHSC-Denver RC1 - North, 6th Floor Room P18-6107 4 PM Ricardo Dolmetsch, Stanford University Title (For additional information, please contact: Mellodee Phillips at mellodee.phillips@ucdenver.edu) Thursday, December 11th CU-Boulder – Dept. of Computer Science Engineering Center ECCR 265 3:30 PM Dirk Grunwald, Dept. of Computer Science Title (For additional information, please contact: Elizabeth Jessup at Elizabeth.Jessup@Colorado.EDU) Thursday, December 11th CU-Boulder – Dept. of Integrative Physiology Ramaley Biology Room C250 4 PM Thomas Johnson, Professor, Dept. of Integrative Physiology and Institute of Behavioral Genetics, University of Colorado What Is Aging Anyway? (For additional information, please contact: Marsha Cook at Marsha.Cook@Colorado.EDU) DIRECTIONS: DIRECTIONS TO MUENZINGER E-214 To get to the colloquium room, enter the main lobby of Muenzinger from Colorado. You'll know you're there as there are photos of faculty in the lobby, a glass case of books and cement benches. The elevator is in the lobby to your right as you enter; the stairway is in the lobby to your left. Go to the second floor. Now you are in the "D" wing which parallels Colorado. Go to your left (West) past

the psychology main office (big plate glass room on your right) until you reach a corridor that comes in from your right. This is the "E" corridor. Proceed down the "E" corridor till you find E-214 on your right side. DIRECTIONS FROM OFF-CAMPUS: Directions: Take the Denver-Boulder turnpike (36) west until it ends. As it bends into Boulder it becomes 28th street. Be in the left lane. At the first stoplight you'll see the campus on your left (West). Turn left at that stoplight from 28th street onto Colorado Ave. Colorado runs straight onto campus -- stay on Colorado. After a couple of stoplights you'll see the football stadium on your right and your forward path blocked by a visitor booth. Tell the booth person that you are coming for a seminar at Muenzinger Psychology Building and to let you through to get to the Euclid Auto Park *deck* (there are also visitor parking meters but that's painful). Also, You can park in lot 436 (Police Station) or 308 with a UCHSC permit. They can give you a campus map and mark the parking deck and Muenzinger. Basically -- while you are sitting at the visitor booth on Colorado - you are staring directly at Muenzinger. It's the building on your right that you look at beyond the plaza with the buffalo statue. So, proceed further along Colorado, which bends to your left. When you get to a stop sign, the building at the corner on your right is the visitor parking deck. Turn right to find the entrance to the parking deck. Retrace your steps to Muenzinger. Campus Map: http://www.colorado.edu/campusmap/map.pdf