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Cardiovascular Division
Washington University
School of Medicine
Faculty Research Interests
2020-2021
2
Introduction
The Cardiovascular Division and related disciplines at the
Washington University School of Medicine have a distinguished
track record of research productivity in both the clinical and basic
sciences. The objectives of this document are twofold:
1.) To provide an overview of current research activities of individual investigators within the Cardiovascular Division, as well as investigators in related fields of research; and
2.) To assist residents, fellows, graduate students, MSTPs and junior faculty members in identifying potential mentors with specific research interests. The document is updated at least annually to reflect
evolving research interests. Questions regarding ongoing or
proposed research projects should be directed to individual
investigators. Questions about the Mentorship Program should be addressed to members of the
Research Mentorship Committee, comprising Drs. D. Brown, Davila, de las Fuentes, Gleva, Gorcsan,
Joynt Maddox, Kates, Mann, and Rich, or to Dr. Barger, Associate Program Director for Mentorship.
Comments or suggestions about the utility of this document and how it could be improved
should be addressed to Michael W Rich, MD, Professor of Medicine, at [email protected].
How to Use This Document
Residents, fellows, and others who wish to identify
potential mentor(s) are encouraged to browse through the
Index, which lists investigators according to their areas of
interest. Names in the Table of Contents and in the Index are
hyperlinked to the Investigator’s page within the document.
Names on each Investigator’s page are hyperlinked to the
Cardiology website (or Washington University faculty website
for investigators outside the Cardiovascular Division). The
website provides additional details about each investigator’s training, publications, and clinical
activities. Key words at the bottom of each investigator’s page indicate terms listed in the Index.
3
Table of Contents
Introduction and How to Use This Document 2
Index 6
Jose A. Alvarez-Cardona, MD 14
Amit Amin, MD 15
Richard G. Bach, MD 16
Philip M. Barger, MD, MSc 17
Anita Bhandiwad, MD 18
Alan C. Braverman, MD 19
Angela L. Brown, MD 20
David L. Brown, MD 21
Robert M. Carney, PhD 22
Murali M. Chakinala, MD 23
Sharon Cresci, MD 24
Phillip S. Cuculich, MD 25
Victor G. Davila-Roman, MD 26
Lisa de las Fuentes, MD, MS 27
Abhinav Diwan, MD 28
Gerald W. Dorn, II, MD 29
Gregory A. Ewald, MD 30
Mitchell N. Faddis, MD, PhD 31
Kenneth E. Freedland, PhD, FAHA 32
Brian F. Gage, MD 33
Edward M. Geltman, MD 34
Marye J. Gleva, MD 35
John Gorcsan III 36
Jeffrey I. Gordon, MD 37
Robert J. Gropler, MD 38
Richard W. Gross, MD, PhD 39
Justin Hartupee, MD, PhD 40
Mustafa Husaini, MD 41
Sudhir Jain MD, FACC, MBA 42
4
Ali Javaheri, MD, PhD 43
Karen Joynt Maddox, MD 44
Attila Kovacs, MD 45
Sándor J. Kovács, PhD, MD, h.c. 46
Ronald J. Krone, MD 47
Gregory M. Lanza, MD, PhD 48
John M. Lasala, MD, PhD 49
Kory Lavine, MD, PhD 50
Steven J. Lavine, MD 51
Daniel J. Lenihan, MD 52
Kathryn Lindley, MD 53
Thomas Maddox, MD 54
Majesh Makan, MD 55
Douglas L. Mann, MD 56
Joshua Mitchell, MD 57
Jonathan D. Moreno, MD, PhD 58
Jeanne M. Nerbonne, PhD 59
Colin G. Nichols, PhD 60
Julio E. Perez, MD 61
Linda R. Peterson, MD 62
Nishath Quader, MD 63
Babak Razani, MD, PhD 64
Stacey L. Rentschler, MD, PhD 65
Michael W. Rich, MD 66
Yoram Rudy, PhD 67
Rajan Sah, MD, PhD 68
Robert V. Same, MD 69
Joel D. Schilling, MD, PhD 70
Clay F. Semenkovich, MD 71
Jonathan Silva, PhD 72
Jasvindar Singh, MD 73
Timothy W. Smith, MD, DPhil 74
5
Sandeep Sodhi, MD 75
Phyllis K. Stein, PhD 76
Nathan Stitziel, MD, PhD 77
Amanda Verma, MD 78
Carla J. Weinheimer, MS 79
Pamela K. Woodard, MD 80
Alan Zajarias, MD 81
Kathleen W. Zhang, MD 82
6
Index
Aging Gage, Rich, Stein Amyloid Alvarez-Cardona, Diwan, Lenihan, Mitchell, Zhang Aortic Dissection Braverman Aortic regurgitation S. Lavine Aortic stenosis Lasala, Zajarias Apolipoprotein M Javaheri Arrhythmias Faddis, Moreno, Nerbonne, Nichols, Rentschler, Silva, Smith Atherosclerosis Razani, Semenkovich, Stitziel, Woodard Athletes Husaini Atrial fibrillation Cuculich, Faddis, Gage, Gleva, Rentschler, Rich, Sodhi Autonomic function assessment Stein Autophagy Diwan, Javaheri, Razani Behavioral medicine Carney, Freedland Basic science
Gross, A. Kovacs, Lanza, Mann, Moreno, Nichols, Razani, Rentschler, Rudy, Schilling, Semenkovich, Silva, Stitziel, Weinheimer
Bicuspid Aortic Valve Braverman
7
Biomarkers Lenihan, Mitchell, Zhang Cardiac CT
Woodard Cardiac development Nichols, Rentschler Cardiac metabolism
Davila-Roman, Gropler, Gross, Peterson, Razani Cardiac MRI Bhandiwad, Woodard Cardiac physiology S. Kovács Cardiac recovery Husaini, K. Lavine Cardiomyopathy Krone, Lindley, Weinheimer Cardio-oncology Alvarez Cardona, Krone, Lenihan, Mitchell, Stein, Zhang Cardiovascular phenotyping Weinheimer Cell death Diwan Childhood undernutrition Gordon Cholesterol Javaheri Circadian rhythms Stein Collateral circulation K. Lavine Comparative effectiveness research D. Brown Complex catheter ablation Sodhi
8
Complexity theory S. Kovács Conduction system Rentschler Congenital heart disease Barger, Rentschler Coronary artery disease Bach, D. Brown, Carney, Freedland, Krone, Lasala, Singh Coronary development K. Lavine Cost-effectiveness analysis Amin Depression Carney, Freedland, Stein Diabetes Bach, Gross, Peterson, Sah, Schilling, Semenkovich, Stein Diastolic function Davila-Roman, de las Fuentes, Geltman, S. Kovács, S. Lavine Disparities Joynt-Maddox Echocardiography
Bhandiwad, Davila-Roman, de las Fuentes, Gorcsan, Makan, Perez, Quader, Zhang Electrocardiography Rudy, Sah, Smith Electrophysiology Faddis, Gleva, Moreno, Nerbonne, Nichols, Rentschler, Rudy, Silva, Smith Epidemiology de las Fuentes, Gage, Rich, Stein Epigenetics Rentschler Genetic epidemiology Davila-Roman, de las Fuentes
9
Genetics Cresci, Stitziel Global health A. Brown, Davila-Roman, de las Fuentes, Gordon Health care innovation
Maddox Health policy
Joynt-Maddox Health services research
D. Brown, Joynt-Maddox, Maddox Heart failure
Alvarez-Cardona, Chakinala, Davila, Diwan, Dorn, Ewald, Faddis, Freedland, Geltman, Gorcsan, Gross, Hartupee, K. Lavine S. Lavine, Lenihan, Mann, Moreno, Peterson, Rich, Sah, Schilling, Stein, Verma
Heart rate variability Stein Heart transplantation Alvarez-Cardona, Ewald, Moreno Hospital readmissions Joynt-Maddox Human gut microbiome Gordon Hypertension
A. Brown, Davila-Roman, de las Fuentes, Nichols, Sah, Stein
Hypertrophic cardiomyopathy Bach, Cresci, Husaini, Moreno Imaging
Bach, Bhandiwad, Davila-Roman, Gorcsan, A. Kovacs, S. Kovács, Lanza, Makan,
Mitchell, Perez, Weinheimer, Woodard Implantable devices Faddis, Geltman, Gleva Insulin resistance Razani Interventional cardiology Amin, Lasala, Singh, Zajarias
10
Ion channels Nerbonne, Nichols, Rentschler, Moreno, Silva, Ischemia-reperfusion Diwan, Weinheimer Kupffer Cells Schilling Left ventricular assist devices Alvarez Cardona, Hartupee, Moreno Lipid metabolism Gross, Razani, Semenkovich Lipidomics Peterson Lysosomes Diwan, Javaheri, Razani Macrophage K. Lavine, Razani, Schilling Marfan Syndrome Braverman Mathematical modeling S. Kovács, Moreno, Silva Metabolic Regulation Gordon Meta-analysis D. Brown Mitophagy
Dorn Molecular cardiology Dorn, Gross, A. Kovacs, Lanza, Rentschler, Silva, Weinheimer Molecular genetics Nerbonne Noninvasive cardiac ablation Cuculich
11
Nanomedicine Lanza Novel murine surgical models Weinheimer Nutrition Peterson Obesity Gordon, Peterson, Razani, Sah Outcomes research
Amin, D. Brown, Joynt-Maddox, Maddox Patient-centered Care D. Brown Peripartum cardiomyopathy Lindley, Verma Pharmacogenomics Gage
Practice improvement Lenihan Prebiotics/probiotics/synbiotics Gordon Precision Medicine Cresci, Gordon, Moreno Pregnancy Lindley, Verma Premature ventricular contractions Sodhi Prevention A. Brown, Rich, Same Proteomics Nerbonne Pulmonary arterio-venous malformations Chakinala Pulmonary hypertension Chakinala
12
Quality of care Joynt-Maddox, Maddox Remodeling Nerbonne Reprogramming Rentschler Reverse remodeling Barger Right heart failure Chakinala, Gorcsan Risk factors de las Fuentes, Same, Stein Robotic navigation Sodhi Skeletal and cardiac muscle performance Peterson Sleep disorders Carney, Freedland, Stein Sports Cardiology Husaini Systems biology Gordon Thoracic Aortic Aneurysm Braverman Translational research Cresci, Cuculich, Davila-Roman, Mann, Moreno, Razani, Rentschler, Silva, Stitziel Transdisciplinary research Cuculich, Rentschler, Transplant vasculopathy K. Lavine Valvular heart disease Lasala, Makan, Quader, Zajarias
Vascular biology A. Kovacs, Nichols, Razani
13
Ventricular tachycardia Cuculich, Rentschler, Sodhi Women and minorities A. Brown, Joynt-Maddox, Lindley, Stein, Verma Zebrafish Nichols
14
Jose A. Alvarez-Cardona, MD
Assistant Professor of Medicine
Current Research Interests
Advanced heart failure and transplant cardiology
Mechanical circulatory support
Cardio-oncology
Cardiac amyloidosis
Representative Publications
1. Alvarez-Cardona J, Mitchell J, Lenihan D. Vascular Toxicity in Patients with Cancer: Is There a
Recipe to Clarify Treatment? CME. Methodist Debakey Cardiovasc J. 2019 Oct-Dec;15(4):289-99.
doi: 10.14797/mdcj-15-4-289. PMID: 31988690; PMCID: PMC6977563.
2. Alvarez-Cardona J, Lenihan DJ. Anthracycline Cardiotoxicity: It Is Possible to Teach an Old Dog
Some New Tricks. Cardiol Clin. 2019 Nov;37(4):355-63. doi: 10.1016/j.ccl.2019.08.001. PMID:
31587778.
3. Zhang KW, Miao J, Mitchell JD, Alvarez-Cardona J, Tomasek K, Su YR, Gordon M, Cornell RF,
Lenihan DJ. Plasma hepatocyte growth factor for diagnosis and prognosis in light chain and
transthyretin cardiac amyloidosis. J Am Coll Cardiol CardioOnc. 2020 Mar; 2:56–66. doi:
10.1016/j.jaccao.2020.01.006.
4. Adusumalli S, Alvarez-Cardona J, Khatana SM, Mitchell JD, Blaes AH, Casselli SJ, O'Quinn R,
Lenihan DJ. Clinical Practice and Research in Cardio-Oncology: Finding the "Rosetta Stone" for
Establishing Program Excellence in Cardio-oncology. J Cardiovasc Transl Res. 2020 May 22. doi:
10.1007/s12265-020-10010-x. Epub ahead of print. PMID: 32444945.
5. Lenihan D, Carver J, Porter C, Liu JE, Dent S, Thavendiranathan P, Mitchell J, Nohria A, Fradley
M, Pusic I, Stockerl-Goldstein K, Blaes A, Lyon A, Ganatra S, Lopez-Fernandez T, O’Quinn R,
Minotti G, Szmit S, Cardinale D, Alvarez-Cardona J, Curigliano G, Neilan T, Herrmann J. Cardio-
Oncology Care in the Era of the Coronavirus (COVID-19) Pandemic: An International Cardio-
Oncology Society (ICOS) Statement. CA A Cancer J Clin. In press
Key Words: cardio-oncology, amyloidosis, advanced heart failure, heart transplant, mechanical
circulatory support, left ventricular assist devices
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Amit Amin, MD
Associate Professor of Medicine
Current Research Interests Improving outcomes of percutaneous coronary intervention (PCI)
• Reducing PCI complications, including bleeding and acute kidney injury
• Reducing costs of PCI and acute coronary syndromes
• Cost-effectiveness of adjunctive therapies in interventional cardiology
• Optimizing care pathways of PCI
• Transradial PCI
Representative Publications
1. Amin AP, Spertus JA, Kulkarni H, McNeely C, Rao SV, Pinto D, House JA, Messenger JC, Bach RG, Goyal A, Shroff A, Pancholy S, Bradley SM, Gluckman TJ, Maddox TM, Wasfy JH, Masoudi FA. Improving care pathways for acute coronary syndrome: patients undergoing percutaneous coronary intervention. Am J Cardiol. 2019 Oct 26. Pii:S0002-9149(19)31166-X. doi: 10.1016/j.amjcard.2019.10.019. PMID: 31812224
2. Amin AP, Spertus JA, Curtis JP, Desai N, Masoudi FA, Bach RG, McNeely C, Al-Badarin F, House JA, Kulkarni H, Rao SV. The evolving landscape of Impella® use in the United States among patients undergoing percutaneous coronary intervention with mechanical circulatory support. Circulation. 2019 Nov 17. doi:10.1161/CIRCULATIONAHA.119.044007. PMID: 31735078
3. Kwok CS, Amin AP, Shah B, Kinnaird T, Alkutshan R, Balghith M, Ratib K, Nolan J, Bagur R, Mamas MA. Cost of coronary syndrome treated with percutaneous coronary intervention and 30-day unplanned readmission in the United States. Catheter Cardiovavsc Interv. 2019 Dec 26. doi:10.1002/ccd.28660. PMID: 31876371
4. Amin AP, McNeely C, Spertus JA, Bach RG, Frogge N, Lindner S, Jain S, Bradley SM, Wasfy JH, Goyal A, Maddox T, House JA, Kulkarni H, Masoudi FA. Incremental cost of acute kidney injury after percuranteous coronary intervention in the United States. Am J Cardiol. 2020 Jan 1;125(1):29-33. doi: 10.1016/j.amjcard.2019.09.042. PMID: 31711633
5. Lindner SM, McNeely CA, Amin AP. The value of transradial: impact on patient satisfaction and health care economics. Interv Cardiol Clin. 2020 Jan;9(1):107-15. doi:10.1016/j.iccl.2019.08.004. PMID: 31733737
6. Dhruva SS, Ross JS, Mortazavi BJ, Hurley NC, Krumholz HM, Curtis JP, Berkowitz A, Masoudi FA, Messenger JC, Parzynski CS, Ngufor C, Girotra S, Amin AP, Shah ND, Desai NR. Association of use of intravascular microaxial left ventricular assist device vs intra-aortic balloon pump with in-hospital mortality and major bleeding among patients with acute myocardial infarction complicated by cardiogenic shock. JAMA. 2020 Feb 10.doi: 10.1001/jama.2020.0254. PMID: 32040163.
Key words: cost-effectiveness analysis, interventional cardiology, outcomes research
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Richard G. Bach, MD
Professor of Medicine
Current Research Interests
Hypertrophic cardiomyopathy: physiology, treatment, and genetics
Acute coronary syndromes
Diabetes and coronary artery disease
Coronary physiology and imaging
Representative Publications 1. Subherwal S, Bach RG, Chen AY, Gage BF, Rao SV, Newby LK, Wang TY, Gibler WB, Ohman EM, Roe MT,
Pollack CV Jr, Peterson ED, Alexander KP. Baseline Risk of Major Bleeding in Non-ST-Segment Elevation Myocardial Infarction: The CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress Adverse outcomes with Early implementation of the ACC/AHA guidelines) Bleeding Score. Circulation 2009;119:1873-82.
2. Cresci S, Wu J, Province MA., Spertus JA, Steffes M, McGill JB, Alderman EL, Brooks MM, Kelsey SF, Frye RL, Bach RG. PPAR-Pathway Gene Polymorphisms Associated with Extent of Coronary Artery Disease in Patients with Type 2 Diabetes in the BARI 2D Trial. Circulation 2011;124:1426-34.
3. Bach RG, Brooks MM, Lombardero M, Genuth S, Donner TW, Garber A, Kennedy L, Monrad ES, Pop-Busui R, Kelsey SF, Frye RL; BARI 2D Investigators. Rosiglitazone and outcomes for patients with diabetes mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Circulation. 2013;128(8):785-94.
4. Cresci S, Depta JP, Lenzini PA, Li AY, Lanfear DE, Province MA, Spertus JA, Bach RG. Cytochrome p450 gene variants, race, and mortality among clopidogrel-treated patients after acute myocardial infarction. Circ Cardiovasc Genet. 2014;7(3):277-86.
5. Depta JP, Lenzini PA, Lanfear DE, Wang TY, Spertus JA, Bach RG, Cresci S. Clinical outcomes associated with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups following acute myocardial infarction. Pharmacogenomics J. 2015;15:20–5.
6. Depta JP, Patel JS, Novak E, Gage BF, Masrani S, Raymer D, Facey G, Patel Y, Zajarias A, Lasala J, Amin AP, Kurz HI, Singh J, Bach RG. Risk model for estimating the one-year risk of deferred lesion intervention following deferred revascularization after fractional flow reserve assessment. Eur Heart J, 2015;36(8):509-15.
7. Bach RG, Cannon CP, Giugliano RP, White JA, Lokhnygina Y, Bohula EA, Califf RM, Braunwald E, Blazing MA. Effect of Simvastatin-Ezetimibe Compared With Simvastatin Monotherapy After Acute Coronary Syndrome Among Patients 75 Years or Older: A Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. 2019;4(9):846–54.
8. 8. Ho CY, Mealiffe ME, Bach RG, Bhattacharya M, Choudhury L, Edelberg JM, Hegde SM, Jacoby D, Laksawala NK, Lester SJ, Ma Y, Marian AJ, Nagueh SF, Owens A, Rader F, Saberi S, Sehnert AJ, Sherrid MV, Solomon SD, Wang A, Wever-Pinzon O, Wong TC, Heitner SB. Safety and Efficacy of Mavacamten in Patients with Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy: The MAVERICK-HCM Study. J Am Coll Cardiol. 2020;75(21):2649-60.
Key words: coronary artery disease, diabetes, hypertrophic cardiomyopathy, imaging
17
Philip M. Barger, MD, MSc
Associate Professor of Medicine
Current research interests
Adult congenital heart disease
Mechanisms of cardiac reverse remodeling and recovery
Representative Publications
1. Mann DL, Barger PM, Burkhoff D. Myocardial recovery and the failing heart: myth, magic, or molecular target? J Am Coll Cardiol. 2012 Dec 18;60(24):2465-72.
2. Tzeng HP, Evans S, Gao F, Chambers K, Topkara VK, Sivasubramanian N, Barger PM, Mann DL. Dysferlin mediates the cytoprotective effects of TRAF2 following myocardial ischemia reperfusion injury. J Am Heart Assoc. 2014 Feb 26;3(1):e000662.
3. Zhang W, Lavine KJ, Epelman S, Evans SA, Weinheimer CJ, Barger PM, Mann DL. Necrotic myocardial cells release damage-associated molecular patterns that provoke fibroblast activation in vitro and trigger myocardial inflammation and fibrosis in vivo. J. Am. Heart Assoc.2015: 4:e001993.
4. Topkara VK, Chambers KT, Yang KC, Tzeng HP, Evans S, Weinheimer C, Kovacs A, Robbins J, Barger P, Mann DL. Functional significance of the discordance between transcriptional profile and left ventricular structure/function during reverse remodeling. JCI Insight. 2016: 1(4):e86038.
5. Carvajal HG, Lindley KJ, Shah T, Brar AK, Barger PM, Billadello JJ, Eghtesady P. Impact of pregnancy on autograft dilatation and aortic valve function following the Ross
procedure. Congenit Heart Dis. 2018 Mar;13(2):217-21. doi: 10.1111/chd.12554. 6. Evans S, Tzeng HP, Veis DJ, Matkovich S, Weinheimer C, Kovacs A, Barger PM, Mann DL.
TNF receptor-activated factor 2 mediates cardiac protection through noncanonical NF-κB signaling. JCI Insight. 2018 Feb 8;3(3). pii: 98278. doi: 10.1172/jci.insight.98278.
7. Sodhi SS, Zhang TJ, McDonald R, Al Rashida V, Kondapalli N, Barger P, Ludbrook P, Cedars AM. Effects of eplerenone on markers of myocardial fibrosis, 6-minute walk distance, and quality of life in adults with tetralogy of Fallot and complete transposition of the great arteries. Proc (Bayl Univ Med Cent). 2018 Jan 3;31(1):12-9. doi: 10.1080/08998280.2017. 1396176. eCollection 2018 Jan.
8. Adamo L, Staloch LJ, Rocha-Resende C, Matkovich SJ, Jiang W, Bajpai G, Weinheimer CJ, Kovacs A, Schilling JD, Barger PM, Bhattacharya D, Mann DL. Modulation of subsets of cardiac B lymphocytes improves cardiac function after acute injury. JCI Insight. 2018 Jun 7;3(11). pii: 120137. doi: 10.1172/jci.insight.120137.
9. Rocha-Resende C, Weinheimer C, Bajpai G, Adamo L, Matkovich SJ, Schilling J, Barger PM, Lavine KJ, Mann DL. Immunomodulatory role of non-neuronal cholinergic signaling in myocardial injury. JCI Insight. 2019 Jun 4;5(14):e128961. doi: 10.1172/jci.insight.128961.
Key words: congenital heart disease, reverse remodeling
18
Anita Bhandiwad, MD
Associate Professor of Medicine
Current Research Interests
Cardiac magnetic resonance imaging
Echocardiography
Nuclear cardiology
Representative Publications 1. Danias PG, Bhandiwad AR: Cardiac Magnetic Resonance Imaging. In Heller, GV and Hendel, RC
(Eds): Nuclear Cardiology: Practical Applications. McGraw-Hill, p. 227-42, 2004. 2. Fuisz AR, Pohost GM, Bhandiwad AR. Clinical utility of cardiovascular magnetic resonance
imaging. In: UpToDate, Rose, BD (Ed), UpToDate, Waltham, MA, 2005, 2006, 2007. 3. Bhandiwad AR, Cummings WK, Crowley M, Woodard PK. Cardiovascular magnetic resonance
with an MR compatible pacemaker. Journal of Cardiovascular Magnetic Resonance. 2013;15:18. 4. Thangam M, Bhandiwad AR. Cardiac Computed Tomography and Magnetic Resonance Imaging.
Washington Manual Cardiology Subspecialty Consult 4th Edition (in press). Key words: imaging, cardiac MRI, echocardiography
19
Alan C. Braverman, MD
Alumni Endowed Professor in Cardiovascular Diseases, Department of Medicine
Current Research Interests
Genetically triggered aneurysm syndromes (Marfan, Loeys-Dietz, Vascular Ehlers-Danlos, Heritable Thoracic Aortic Diseases)
Aortic dissection
Bicuspid aortic valve and aortopathy
Aortic disease in pregnancy
Exercise and aortic disease
Representative Publications
1. Braverman AC, Harris KM, Kovacs RJ, Baron BJ. Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 7: Aortic Diseases, Including Marfan Syndrome: A Scientific Statement From the American Heart Association and American College of Cardiology. J Am Coll Cardiol.2015 Dec 1;66(21):2398-405.
2. Braverman AC, Schermerhorn. Diseases of the Aorta. In, Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF. Braunwald’s Heart Disease, 11th Edition, Elsevier, Philadelphia, 2018, pp 1295-327.
3. Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Di Eusanio M, Sechtem U, Ehrlich MP, Trimarchi S, Braverman AC, Myrmel T, Harris KM, Hutchinson S, O’Gara P, Suzuki T, Nienaber CA, Eagle on behalf of the IRAD Investigators. Insights From the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research. Circulation; 2018;137:1846-60.
4. Silberbach M, Roos-Hesselink JW, Andersen NH, Braverman AC, Brown N, Collins RT, De Backer J, Eagle KA, Hiratzka LF, Johnson WH Jr, Kadian-Dodov D, Lopez L, Mortensen KH, Prakash SK, Ratchford EV, Saidi A, van Hagen I, Young LT; American Heart Association Council on Cardiovascular Disease in the Young; Council on Genomic and Precision Medicine; and Council on Peripheral Vascular Disease. Cardiovascular Health in Turner Syndrome: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2018 Oct;11(10):e000048.
5. Braverman AC. Aortic replacement for bicuspid aortic valve aortopathy: When and why? J Thorac Cardiovasc Surg. 2019 Feb;157(2):520-5.
6. Braverman AC, Roman MJ. Bicuspid Aortic Valve in Marfan Syndrome. Circ Cardiovasc Imaging. 2019 Mar;12(3):e008860. doi: 10.1161/CIRCIMAGING.119.008860.
7. Braverman AC, Cheng A. The Bicuspid Aortic Valve and Associated Aortic Disease. In, Valvular Heart Disease, 5th Edition. Otto CM, Bono RO, eds. A companion to Braunwald’s Heart Disease. Saunders/Elsevier, Philadelphia, 2020.
8. Milewicz DM, Braverman AC, De Backer J, Morris S, Boileau C, Jondeau G, Evangelista A, Pyeritz R. Marfan Syndrome. Nature Reviews Disease Primers 2020 (in press)
9. Braverman AC, Mittauer E, Harris K, Evangelista A, Pyeritz RE, Brinster D, Conklin L, Suzuki T, Fanola C, Ouzounian M, Chen C, Myrmel M, Bekeredjian R, Hutchison S, Coselli J, Gilon D, O’Gara P, Davis M, Isselbacher E, Eagle K. Aortic Dissection Related to Pregnancy: Results from the International Registry of Acute Aortic Dissection (IRAD) 2020, JAMA Cardiology (in press).
Key Words: Marfan syndrome, bicuspid aortic valve, aortic dissection, thoracic aortic aneurysm
20
Angela L. Brown, MD
Associate Professor of Medicine
Current Research Interests
Hypertensive Heart Disease
Resistant hypertension
Tools/strategies for implementing community education on cardiovascular disease prevention
Representative Publications
1. de las Fuentes L, Brown AL, Waggoner AD, Davila-Roman VG. Plasma Triglyceride Level is an Independent Predictor of Altered Left Ventricular Relaxation. J Am Soc Echocardiogr 2005 Dec; 18(12):1285-91.
2. de las Fuentes L, Brown AL, Reagan JL, Towler DA, Waggoner AD, Dávila-Román VG. Increased Carotid Intima-Media Thickness in Metabolic Syndrome. Circulation 2005:122: II-384.
3. Dong SJ, de las Fuentes L, Brown AL, Waggoner AD, Ewald GA, Dávila-Román VG. NT-proBNP Levels: Correlation with Echocardiographically-determined Left Ventricular Filling Pressures in An Ambulatory Cohort. J Am Soc Echocardiog 2006;19:1017-25.
4. de las Fuentes L, Brown AL, Mathews SJ, Waggoner AD, Soto P, Gropler RJ, Dávila-Román VG. Metabolic Syndrome is Associated with Abnormal Left Ventricular Diastolic Function Independent of LV Mass. Eur Heart J. 2007 Mar;28(5):553-9.
5. Brown AL. Obesity and Metabolic Syndrome in African American Women. J Cardiometab Syndr. 2008 Spring;3(2):126-8.
6. Flack JM, Sica DA, Bakris G, Brown AL, Ferdinand KC, Grimm RH, Hall WD, Jones WE, Kountz DS, Lea JP, Nasser S, Nesbitt SD, Saunders E, Scisney-Matlock M, Jamerson KA. Management of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statement. Hypertension 2010 Nov;56(5):780-800.
7. Brown A, Captain B. 50 years of thiazides: should thiazide diuretics be considered third-line hypertension treatment? Am J Ther 2011 Nov;18(6):e244-e254, doi:10.1097/MJT.0b013e3181e90863
8. Brown AL, Lau JMC. Cardiovascular Disease in Special Populations. In: Cuculich PS, Kates AM. The Washington Manual of Cardiology Subspecialty Consult. 3rd ed. Philadelphia: Wolters Kluwer, 2014:467-85.
9. Egan BM, Bland VJ, Brown AL, Ferdinand KC, Hernandez GT, Jamerson KA, Johnson WR, Kountz DS, Li J, Osei K, Reed JW, Saunders E. Hypertension in African Americans aged 60 to 79 years: statement from the International Society of Hypertension in Blacks. J Clin Hypertens (Greenwich). 2015 Apr;17(4):252-259. doi: 10.1111/jch.12511.
Key words: global health, hypertension, prevention, women and minorities
21
David L. Brown, MD
Professor of Medicine
Current Research Interests
Use of Existing Public and Proprietary Databases to Answer Clinical Questions in Cardiovascular Disease
Comparative effectiveness research of treatments for cardiovascular disease
Meta-analysis
Ischemic Heart Disease including microvascular dysfunction and coronary spasm
Representative Publications
1. Dunn T, Saeed MJ, Shpigel A, Novak E, Alhamad T, Stwalley D, Rich MW, Brown DL. The
Association of Preoperative Cardiac Stress Testing with 30-day Death and Myocardial Infarction Among Patients Undergoing Kidney Transplantation. PLoS ONE 2019;14(2): e0211161. https://doi.org/10.1371/journal.pone.0211161
2. Shpigel AA, Saeed MJ, Novak E, Alhamad T, Rich MW, Brown DL. Center-Related Variation in Cardiac Stress Testing in the 18 months Prior to Renal Transplantation. JAMA Intern Med. Published online May 13, 2019. doi:10.1001/jamainternmed.2019.0423
3. Rashid A, Agarwala A, Novak E, Brown DL. The Association of High Birth Weight with Incident Heart Failure in the Atherosclerosis Risk in Communities Study. J Am Heart Assoc. 2019;8:e011524. doi: 10.1161/JAHA.118.011524.
4. Soares A, Brown DL. The fallacies of fractional flow reserve. Int J Cardiol 2019; Online before print. DOI: https://doi.org/10.1016/j.ijcard.2019.12.040
5. Ge A, Brown DL. Assessment of cardiovascular diagnostic tests and procedures offered in executive screening programs at top-ranked cardiology hospitals. JAMA Intern Med. Published online January 13, 2020. doi:10.1001/jamainternmed.2019.6607
6. Sechtem U, Brown DL, Good S, Lanza GA, Shimokawa H, Sidik N, Coronary microvascular dysfunction in stable ischaemic heart disease (NOCAD and OCAD), Cardiovascular Research 2020; https://doi.org/10.1093/cvr/cvaa005
7. Camici PG, Bairey Merz N, Beltrame J, Brown DL, Crea F, Kaski JC, Maas A, Ong P, Pepine C, Rimoldi O, Sechtem U, Shimokawa H, Elias-Smale S, Berry C. Commentary - The ISCHEMIA trial. Int J Cardiol 2020; Online ahead of print.
8. Gdowski M, Murthy VL, Doering M, Monroy-Gonzalez AG, Slart R, Brown DL. Association of isolated coronary microvascular dysfunction with mortality and major adverse cardiac events: a systematic review and meta-analysis of aggregate data. Originally published 29 Apr 2020. Journal of the American Heart Association. https://doi.org/10.1161/JAHA.119.014954
9. Wolfe NK, Mitchell JD, Brown DL. The independent reduction in mortality associated with guideline-directed medical therapy in patients with coronary artery disease and heart failure with reduced ejection fraction, European Heart Journal - Quality of Care and Clinical Outcomes 2020; https://doi.org/10.1093/ehjqcco/qcaa032
Key Words: outcomes research, comparative effectiveness research, meta-analysis, coronary artery disease, health services research, patient-centered care, ischemic heart disease, microvascular dysfunction, coronary spasm
22
Robert M. Carney, PhD
Professor of Psychiatry
Current Research Interests
The effects of psychiatric depression on the course and outcome of coronary heart Disease
Potential mechanisms underlying the risk of depression on cardiac related morbidity and Mortality
The effects of treating depression on course and outcome of coronary heart disease
Representative Publications
1. Whooley MA, deJonge P, Vittinghoff E, Otte C, Moos R, Carney RM, Ali S, Dowray S, Na B, Feldman MD, Schiller NB, Browner WS. Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease. JAMA. 2008; 300:2379-88.
2. Carney RM, Freedland KE, Rubin EH, Rich MW, Steinmeyer BC, Harris WS. Omega-3 augmentation of sertraline in the treatment of depression in patients with coronary heart disease: a randomized controlled trial. JAMA, 2009; 302(15):1651-7.
3. Freedland KE, Skala JA, Carney RM et al. Treatment of depression after coronary artery bypass surgery: a randomized controlled trial. Arch Gen Psychiatry 2009 April; 66(4):387- 96.
4. Carney RM, Freedland KE. Treatment-resistant depression and mortality after acute coronary syndrome. Am J Psychiatry 2009 April; 166(4):410-7.
5. Carney RM, Freedland KE. Depression and coronary heart disease. Nature Reviews Cardiology, 2017; 14(3):145-55. PM: 27853162.
6. Carney RM. Additional approaches to treatment of depression. JAMA, 2019; 32(16): 1634-6. 7. Carney RM. The course of emotional distress and late mortality following acute myocardial
infarction: Implications for screening and treatment: Editorial. European Journal of Preventive Cardiology 2019; (online: https://doi.org/10.1177/2047487319845122).
Key words: behavioral medicine, coronary artery disease, depression, sleep disorders
23
Murali M. Chakinala, MD
Professor of Medicine
Current Research Interests
Therapeutics in pulmonary arterial hypertension
Non-invasive evaluation in pulmonary hypertension
Representative Publications
1. Taichman DB, McGoon M, Harhay MO, Archer-Chicko C, Sager JS, Murugappan M, Chakinala MM, Palevsky HI, and Gallop R. Wide Variation in Clinicians’ Assessment of New York Heart Association / World Health Organization Functional Class in Patients with Pulmonary Arterial Hypertension. Mayo Clinic Proceedings. 2009; 84(7): 586-92.
2. Bradley EA, Chakinala MM, and Billadello JJ. Delayed atrial septal defect closure in the presence of pulmonary arterial hypertension: Medical therapy may improve closure candidacy. Am J Cardiol. 2013; 112(9): 1471-6.
3. Lahm T and Chakinala MM. World Health Organization Group 5 Pulmonary Hypertension. Clin Chest Med. 2013; 34 (4): 753-78.
4. Chakinala MM and Barst RJ. From short-term outcomes to long-term benefits: the evolution of clinical trials in pulmonary arterial hypertension. Pulmonary Circulation. 2013; 3(3): 507-22. PMID: 24618537.
5. Frantz RP, Schilz RJ, Chakinala MM, Badesch DB, Frost AE, McLaughlin VV, et al. Hospitalization and Survival in Patients Utilizing Epoprostenol for Injection in the PROSPECT Observational Study. Chest. 2015; 147(2): 484-94.
6. Bourge RC, Waxman AB, Gomberg-Maitland M, Shapiro S, Tarver JH, Zwicke DL, Feldman JP, Chakinala MM, Frantz RP, Torres F, Cerkvenik J, Morris M, Thalin M, Peterson L, and Rubin LJ. Implantable Intravascular Delivery System for Treprostinil Therapy of PAH. Chest 2016: 150(1): 27-34. PMID: 27396777.
7. Chakinala MM, Feldman J, Rischard F, Mathier M, Howell M, Leedom N, Laliberte K, and White RJ. Transition from Parenteral to Oral Treprostinil in Pulmonary Arterial Hypertension. J Heart Lung Transplant 2017: 36(2): 193-201. PMID: 27469018.
8. Rahaghi FF, Feldman JP, Allen RP, Tapson V, Safdar Z, Balasubramanian VP, Shapiro S, Mathier MA, Elwing JA, Chakinala MM, White RJ. Recommendations for the use of oral treprostinil in clinical practice: a Delphi consensus project pulmonary circulation. Pulm Circ 2017: 7(1): 167-74.
9. Chakinala MM, Coyne DW, Benza RL, Frost AE, McGoon MD, Hartline BK, Frantz RP, Selej M, Zhao C, Mink DR, Farber HW. Impact of declining renal function on outcomes in pulmonary arterial hypertension: A REVEAL Registry analysis. J Heart Lung Transplant. 2018: 37(6):696-705. PMID: 29174533.
10. Bradley EA, Ammash N, Martinez SC, Chin K, Hebson C, Singh HS, Aboulhosn J, Grewal J, Billadello J, Chakinala MM, Daniels CJ, Zaidi AN. “Treat-to-Close”: Unrepaired ASD-PAH in the Adult. Intl J Cardiol. 2019: 291:127-33.
Key words: pulmonary hypertension, pulmonary arterio-venous malformations, right heart failure
24
Sharon Cresci, MD
Associate Professor of Medicine and Genetics
Current Research Interests
• Genetic variation and clinical outcomes in individuals with cardiovascular disease
• Precision medicine
• Hypertrophic cardiomyopathy
Representative Publications
1. Cresci S, Wu J, Province MA, Spertus JA, Steffes M, McGill JB, Alderman EL, Brooks MM, Kelsey SF, Frye
RL, Bach RG. Peroxisome proliferator-activated receptor pathway gene polymorphism associated with
extent of coronary artery disease in patients with type 2 diabetes in the Bypass Angioplasty
Revascularization Investigation 2 Diabetes Trial. Circulation 2011; 124(13):1426- 34. PMID:21911782.
2. Cresci S, Dorn GW, Jones PG, Beitelshees AL, Li AY, Lenzini PA, Province MA, Spertus JA, Lanfear DE.
Adrenergic-pathway gene variants influence β-blocker-related outcomes after acute coronary syndrome
in a race-specific manner. J Am Coll Cardiol 2012; 60:898-907. PMCID: PMC3678950.
3. Cresci S, Depta J, Lenzini PA, Li AY, Lanfear DE, Province MA, Spertus JA, Bach RG. Cytochrome P450
gene variants, race, and mortality among clopidogrel treated patients following acute myocardial
infarction. Circ Cardiovasc Genet 2014; 7:277-86. PMCID: PMC4104276.
4. Depta J, Lenzini PA, Lanfear DE, Wang TY, Spertus JA, Bach RG, Cresci S. Clinical outcomes associated
with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups
following acute myocardial infarction. Pharmacogenomics J 2015; 15:20-5. PMCID: PMC4287459.
5. Buchanan DM, Arnold S, Li Y, Jones PG, Longmore LS, Spertus JA, Cresci S. The association of smoking
status with angina and health-related quality of life after acute myocardial infarction. Circ Cardiovasc
Qual Outcomes 2015; 8:493-500.
6. Coverstone ED, Bach RG, Chen LS, Bierut LJ, Li AY, Lenzini PA, O’Neill HC, Spertus JA, Sucharov CC, Stitzel JA, Schilling JD, Cresci S. A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction. Basic Res Cardiol. 2018;113:38. PMCID: PMC6292447.
7. Tang Y, Lenzini PA, Busui RP, Perkins BA, Callaghan B, Wagner MJ, Motsinger-Reif, AA, Buse JB, Mychaleckyj JC, Cresci S, Shah H, Doria A. A genetic locus on chromosome 2q24 predicting peripheral neuropathy risk in type 2 diabetes: results from the ACCORD and BARI 2D studies. Diabetes. 2019; PMID: 31127053.
8. Cresci S (Chair), Pereira N (Vice-Chair) Ahmad F, Byku M, de las Fuentes L, Lanfear DL, Owens A, Reilly C, Wolf M. AHA Scientific Statement: Heart failure in the era of precision medicine. Circ Genom Precis Med. 2019.
Key words: genetics, precision medicine, hypertrophic cardiomyopathy, translational research
25
Phillip S. Cuculich, MD
Associate Professor of Medicine Clinical Cardiac Electrophysiology
Current Research Interests
Development of an entirely noninvasive cardiac ablation platform combining cardiac imaging, cardiac mapping and focused radiation
Noninvasive electrical mapping of uterine contractions to guide therapeutic interventions to prevent preterm birth
Representative Publications 1. Cuculich PS, Wang Y, Lindsay BD, Faddis MN, Schuessler RB, Damiano RJ Jr, Li L, Rudy Y. Noninvasive
characterization of epicardial activation in humans with diverse atrial fibrillation patterns. Circulation. 2010 Oct 5;122(14):1364-72. PMID: 20855661
2. Wang Y, Cuculich PS, Zhang J, Desouza KA, Vijayakumar R, Chen J, Faddis MN, Lindsay BD, Smith TW, Rudy Y. Noninvasive electroanatomic mapping of human ventricular arrhythmias with electrocardiographic imaging. Sci Transl Med. 2011 Aug 31;3(98):98ra84. PMID: 21885406
3. Cuculich PS, Zhang J, Wang Y, Desouza KA, Vijayakumar R, Woodard PK, Rudy Y. The electrophysiological cardiac ventricular substrate in patients after myocardial infarction: noninvasive characterization with electrocardiographic imaging. J Am Coll Cardiol. 2011 Oct 25; 58(18):1893-902. PubMed PMID: 22018301; PubMed Central PMCID: PMC3365586.
4. Zhang J, Sacher F, Hoffmayer K, O’Hara ZT, Strom M, Cuculich P, Silva J, Cooper D, Faddis M, Hocini, M, Haissaguerre M, Scheinman M, Rudy Y. The Cardiac Electrophysiologic Substrate Underlying the ECG Phenotype and Electrogram Abnormalities in Brugada Syndrome Patients. Circulation 2015; 131: 1950-9.
5. Zhang J, Cooper DH, Desouza KA, Cuculich PS, Woodard PK, Smith TW, Rudy Y. Electrophysiologic Scar Substrate in Relation to VT: Noninvasive High-Resolution Mapping and Risk Assessment with ECGI. Pacing Clin Electrophysiol. 2016 Aug; 39(8):781-91. PMC: 27197804
6. Vijayakumar R, Vasireddi SK, Cuculich PS, Faddis MN, Rudy Y. Methodology Considerations in Phase Mapping of Human Cardiac Arrhythmias. Circ Arrhythm Electrophysiol. 2016 Nov; 9(11). pii: e004409. PMID: 27906655.
7. Junjie Zhang, Mélèze Hocini, Maria Strom, Phillip S. Cuculich, Daniel H. Cooper, Frédéric Sacher, Michel Haïssaguerre, Yoram Rudy. The Electrophysiological Substrate of Early Repolarization Syndrome. JACC: Clinical Electrophysiology Mar 2017 Aug; 3(8):894-904. doi: 10.1016/j.jacep.2016.12.017.
8. Cuculich PS, Schill MR, Kashani R, Mutic S, Lang A, Cooper D, Faddis M, Gleva M, Noheria A, Smith TW, Hallahan D, Rudy Y, Robinson CG. Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia. N Engl J Med. 2017 Dec 14; 377(24): 2325-36. PMID: 29236642; PMCID: PMC5764179
Key words: Translational research, transdisciplinary research, noninvasive cardiac ablation, noninvasive
mapping, ventricular tachycardia, atrial fibrillation, uterine mapping
26
Victor G. Davila‐Roman, MD
Professor of Medicine, Anesthesiology, and Radiology Current Research Interests
Cardiovascular imaging: echocardiography, vascular ultrasound, nuclear cardiology, cardiac CT
Cardiac metabolism, Hypertensive heart disease, Diastolic function
Cardiovascular genetic epidemiology
Representative Publications 1. Gu CC, Flores HR, de las Fuentes L, Davila-Roman VG. Enhanced detection of genetic association
of hypertensive heart disease by analysis of latent phenotypes. Genetic Epidemiol 2008; 32(6):528-38.
2. de las Fuentes L, Waggoner AD, Mohammed BS, Stein RI, Miller BV 3rd, Foster GD, Wyatt HR, Klein S, Davila-Roman VG. Effect of moderate diet-induced weight loss and weight regain on cardiovascular structure and function. J Am Coll Cardiol 2009; 54(25):2376-81.
3. Mathews SJ, de las Fuentes L, Podaralla P, Cabellon A, Bierhals A, Spence K, Slatopolsky E, Davila-Roman VG, Delmez JA. Effects of Sodium Thiosulfate on Vascular Calcification in ESRD: A Pilot Study of Feasibility, Safety, and Efficacy. Am J Nephrol 2011; 33:131-8.
4. Lin CH, Kurup S, Herrero P, Schechtman KB, Eagon JC, Klein S, Dávila-Román VG, Stein RI, Dorn GW, Gropler RJ, Peterson LR. Myocardial Oxygen Consumption Change Predicts Ventricular Relaxation Improvement in Obese Humans after Weight Loss. Obesity 2011; 19:1804-12.
5. de las Fuentes L, Yang W, Dávila-Román VG, Gu CC. Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets. Eur J Hum Genet. 2012 Nov; 20(11):1168-73. doi:10.1038/ejhg.2012.66.
6. Barve RA, Gu CC, Yang W, Chu J, Davila-Roman VG, de Las FL. Genetic association of left ventricular mass assessed by M-mode and two-dimensional echocardiography. J Hypertens 2016 January; 34(1):88-96. doi:10.1097/hjh.
7. Vader JM, LaRue SJ, Stevens SR, Mentz RJ, DeVore AD, Lala A, Groarke JD, AbouEzzeddine OF, Dunlay SM, Grodin JL, Davila-Roman VG, de Las FL. Timing and Causes of Readmission After Acute Heart Failure Hospitalization-Insights From the Heart Failure Network Trials. J Card Fail 2016 Nov; 22(11):875-83. doi:10.1016/j.
8. Kadkhodayan A, Lin CH, Coggan AR, Kisrieva-Ware Z, Schechtman KB, Novak E, Joseph SM, Davila-Roman VG, Gropler RJ, Dence C, Peterson LR. Sex affects myocardial blood flow and fatty acid substrate metabolism in humans with nonischemic heart failure. J Nucl Cardiol 2017 Aug;24(4):1226-35.
Key words: cardiac imaging, cardiac metabolism, hypertension, genetic epidemiology, translational research, diastolic function, echocardiography, global health
27
Lisa de las Fuentes, MD, MS
Associate Professor of Medicine and Biostatistics
Current Research Interests
Genetic epidemiology of cardiovascular disease and drug response
Hypertensive heart disease
Metabolic and inflammatory cardiovascular risk factors
Representative Publications 1. de las Fuentes L, Herrero P, Peterson LR, Kelly DP, Gropler RJ, Dávila-Román VG. Myocardial fatty acid
metabolism: Independent predictor of left ventricular mass in hypertensive heart disease. Hypertension 2003;41:83-7.
2. de las Fuentes L, Brown AL, Mathews SJ, Waggoner AD, Soto PF, Gropler RJ, Dávila-Román VG. Metabolic Syndrome is Associated with Abnormal Left Ventricular Diastolic Function Independent of LV Mass. European Heart J 2007;28:553-9.
3. de las Fuentes L, Waggoner AD, Mohammed BS, Stein RI, Miller BV, Foster GD, Wyatt H, Klein S, Dávila-Román VG. Effect of moderate diet-induced weight loss and weight regain on cardiovascular structure and function. J Am Coll Cardiol 2009;54:2376–81. PMCID: PMC2818984.
4. de las Fuentes L, Spence KE, Dávila-Román VG, Waggoner AD. Are Normative Values for LV Geometry and Mass Based on Fundamental Imaging Valid With Use of Harmonic Imaging? J Am Soc Echocardiog 2010;23:1317-22. PMCID: PMC2993783.
5. Vader JM, LaRue SJ, Stevens SR, Mentz RJ, DeVore AD, Lala A, Groarke JD, AbouEzzeddine OF, Dunlay SM, Grodin JL, Dávila-Román VG, de las Fuentes L. Timing and Causes of Readmission after Acute Heart Failure Hospitalization – Insights from the Heart Failure Network Trials. J Cardiac Fail 2016;22:875-83. PMCID: PMC5085925.
6. Levine GN, O'Gara PT, Beckman JA, Al-Khatib SM, Birtcher KK, Cigarroa JE, de las Fuentes L, et al. Recent Innovations, Modifications, and Evolution of ACC/AHA Clinical Practice Guidelines: An Update for Our Constituencies: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139:e879-3886. PMID: 30892927.
7. Boutjdir M, Aromolaran AS, de las Fuentes L, et al. Research Education and Mentoring Program in Cardiovascular Diseases for Under-Represented Junior Faculty From NHLBI SIPID/PRIDE. J Am Coll Cardiol 2019;14:1861-1865. DOI: 10.1016/j.jacc.2019.01.042. PMCID: PMC6464379.
8. Sung YJ, de las Fuentes L, Winkler TW, et al. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet. 2019 Apr 10. pii: ddz070. doi: 10.1093/hmg/ddz070. PMID: 31127295.
9. de las Fuentes L, Sung YJ, Sitlani CM, et al. Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry. Pharmacogenomics J. 2019 Dec 6. doi: 10.1038/s41397-019-0132-y. PMCID: PMC7260079.
10. de las Fuentes L, Sung YJ, Noordam R, et al. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Molecular Psychiatry 2020 May 5. doi: 10.1038/s41380-020-0719-3. PMID: 32372009. PMCID: Pending.
Key words: hypertension, risk factors, genetic epidemiology, global health, diastolic function, echocardiography
28
Abhinav Diwan, MD, FACC , FAHA
Professor of Medicine, Cell Biology and Physiology, Obstetrics and Gynecology Current Research Interests
Regulation of lysosome function in cardiac myocytes and macrophages in heart failure
Maternal dietary exposures as a determinant of offspring cardiovascular risk.
Regulation of lysosomal machinery in Alzheimer’s disease and amyloid heart disease
Role of lysosomal pathways in beta cell regeneration in pancreatic islets Representative publications 1. Ma X, Liu H, Foyil SR, Godar RJ, Weinheimer CJ, Hill JA, Diwan A. Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia-reperfusion Injury. Circulation. 2012 Jun 26;125(25):3170-81.
2. Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Burchett JM, Schuler DR, Cirrito JR, Diwan A*, Lee JM* (*contributed equally, co-corresponding authors). Astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis. The Journal of Neuroscience. 2014 Jul 16;34(29):9607-20. PMCID:PMC4099542
3. Yang KC, Ma X, Liu H, Kovacs A, Barger PM, Mann DL, Diwan A. TNF-receptor associated factor-2 mediates mitochondrial autophagy. Circulation Heart Failure. 2015 Jan;8(1):175-87.
4. Godar RJ, Ma X, Liu H, Murphy JT, Weinheimer CJ, Kovacs A, Crosby SD, Saftig P, Diwan A. Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury. Autophagy. 2015 Sep 2;11(9):1537-60.
5. Liu H, * Javaheri A,* Godar RJ, Murphy JT, Ma X, Rohatgi N, Mahadevan J, Hyrc K, Saftig P, Marshall C, McDaniel ML, Remedi MS, Razani B, Urano F, Diwan A. (*contributed equally) Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway. Autophagy. 2017;13(11):1952-68.
6. Ma, X*; Mani, M*; Kovacs, A; Liu, H; Murphy, JT; Foroughi L; French, B; Benjamin, IJ; Hill, JA; Javaheri, A; Diwan A. (*contributed equally). TFEB rescues advanced mutant αB-crystallin-induced cardiomyopathy by normalizing desmin localization. J Am Heart Assoc. 2019 Feb 19;8(4):e010866.
7. Ferey J, Boudoures A, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch B, Thompson M, Diwan A*, and Moley K* (*contributed equally). A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independent of maternal mitochondrial inheritance. Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1202-H1210.
8. Murphy, JT*; Liu, H*; Ma, X; Shaver, S; Oh, C; Boyko, A; Mazer, T; Ang, S; Khopkar, R; Javaheri, A; Kumar, S; Jiang X; Ory, D; Mani, K; Matkovich, SJ; Kornfeld K *; Diwan A *. (*contributed equally.) Simple nutrients activate a HLH-30-independent pathway for coupling lysosomal nutrient sensing to TOR activation. PLoS Biol. 2019 May 14;17(5):e3000245.
9. Javaheri, A; Bajpai, G; Picataggi, A; Mani, S; Foroughi, L; Evie, H; Kovacs, A; Weinheimer, C; Hyrc, K; Xiao, Q; Ballabio, A; Lee, JM; Matkovich, SJ; Razani, B; Schilling, JD; Lavine, K; Diwan A. Transcription factor EB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated Autophagy. JCI Insight, 2019 Nov 1;4(21):e127312.
Key words: autophagy, lysosome, amyloid, ischemia-reperfusion, heart failure, cell death
29
Gerald W. Dorn, II, MD
Philip and Sima K. Needleman Professor of Medicine Current Research Interests
Biology of mitochondria in the heart; metabolic remodeling
Molecular and biochemical signaling for cardiac hypertrophy and heart failure
Genetic diseases affecting mitochondrial dynamism and mitophagy
Representative Publications
1. Chen Y and Dorn GW II. PINK1-phosphorylated Mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 2013; 340:471-75.
2. Kasahara A, Cipolat S, Chen Y, Dorn GW II*, Scorrano L* (* co-contributing authors). Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin/notch signaling. Science 2013; 342:734-37.
3. Matkovich SJ, Hu Y, Dorn GW II, Regulation of cardiac microRNAs by cardiac microRNAs. Circ Res 2013; 113:62-71.
4. Bhandari P, Song M, Chen Y, Burelle Y, Dorn GW II. Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circ Res 2014; 114:257-65.
5. Song M, Chen Y, Gong G, Murphy E, Rabinovitch P, Dorn GW II. Super-suppression of mitochondrial ROS signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circ Res 2014; 115:348-53.
6. Matkovich SJ, Edwards JR, Grossenheider TC, de Guzman Strong C, Dorn GW II. Epigenetic coordination of embryonic heart transcription by dynamically regulated lncRNAs. Proc Natl Acad Sci USA 2014; 111:12264-9.
7. Song M, Mihara K, Chen Y, Scorrano L, Dorn GW II. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab 2015; 21:273-285.
8. Picard M, McManus M, Csordas G, Varnai P. Dorn GW II, Williams D, Hajnoczky G, Wallace DC. Trans-mitochondrial coordination of cristae at regulated membrane junctions. Nat Commun 2015; 6:6259.
9. Song M, Matkovich SJ, Zhang Y, Hammer DJ, and Dorn GW II. Combined cardiomyocyte PKC
and PKC gene deletion uncovers their central role in restraining developmental and reactive heart growth. Sci Signal, 2015; 8(373):ra39.
10. Song M, Guong G, Burelle Y, Gustafsson AB, Kitsis RN, Matkovich SJ, and Dorn GW II. Interdependence of Parkin-mediated mitophagy and mitochondrial fission in adult mouse hearts. Circ Res 2015;117:246-351.
Key words: mitophagy, heart failure, molecular cardiology
30
Gregory A. Ewald, MD
Professor of Medicine
Current Research Interests
Mechanical circulatory support in advanced heart failure
Medical therapy in patients with heart failure
Device therapy in patient with heart failure
Remote monitoring in management of heart failure
Cardiac transplantation/donor evaluation and management
Depression in heart failure
Representative Publications 1. Park SJ, Milano CA, Tatooles AJ, Rogers JG, Adamson RM, Steadley E, Ewald GA, Sundareswaran KS,
Farrar DJ, Slaughter MS. Outcomes in advanced heart failure patients with left ventricular assist devices for destination therapy. Circ Heart Fail 2012; 5:241-8.
2. Lavine KJ, Sintek M, Novak E, Ewald G, Geltman E, Joseph S, Pfeifer J, Mann DL. Coronary collaterals predict improved survival and allograft function in patients with coronary allograft vasculopathy. Circ Heart Fail 2013; 6:773-84.
3. Starling RC, Moazami N, Silvestry SC, Ewald G, Rogers JG, Milano CA, Rame JE, Acker MA, Blackstone EH, Ehrlinger J, Thuita L, Mountis MM, Soltesz EG, Lytle BW, Smedira NG. Unexpected abrupt increase in left ventricular assist device thrombosis. N Engl J Med 2014 Jan 2; 370(1):33-40.
4. Topkara VK, O’Neill JK, Carlisle A, Novak E, Silvestry SC, Ewald GA. Heartware and Heartmate II left ventricular assist devices as bridge to transplantation: a comparative analysis. Ann Thorac Surg 2014 Feb; 97(2):506-12.
5. Fang JC, Ewald GA, Allen LA, Butler J, Westlake Canary CA, Colvin-Adams M, Dickinson MG, Levy P, Stough WG, Sweitzer NK, Teerlink JR, Whellan DJ, Albert NM, Krishnamani R, Rich MW, Walsh MN, Bonnell MR, Carson PE, Chan MC, Dries DL, Hernandez AF, Hershberger RE, Katz SD, Moore S, Rodgers JE, Rogers JG, Vest AR, Givertz MM; Heart Failure Society of America Guidelines Committee. Advanced (stage D) heart failure: a statement from the Heart Failure Society of America Guidelines Committee. J Card Fail. 2015 Jun; 21(6):519-34.
6. Adamo L, Nassif M, Tibrewala A, Novak E, Vader J, Silvestry S, Itoh A, Ewald GA, Mann DL, LaRue SJ. The Heartmate risk score predicts morbidity and mortality in unselected left ventricular assist device recipients and risk stratifies INTERMACS Class 1 patients. JACC Heart Fail 2015; 3:283-90.
7. McNamara DM, Elkayam U, Alharethi R, Damp J, Hsich E, Ewald G, Modi K, Alexis JD, Ramani GV, Semigran MJ, Haythe J, Markham DW, Marek J, Gorcsan J, Wu W-C, Lin Y, Halder I, Pisarcik J, Cooper LT, Fett JD, for the IPAC Investigators. Clinical outcomes for peripartum cardiomyopathy in North America: Results of the Investigations of Pregnancy Associated Cardiomyopathy (IPAC) study. JACC 2015; 66:905-14.
8. Nassif ME, LaRue SJ, Raymer DS, Novak E, Vader JM, Ewald GA, Gage BF. Relationship Between Anticoagulation Intensity and Thrombotic or Bleeding Outcomes Among Outpatients With Continuous-Flow Left Ventricular Assist Devices. Circ Heart Fail. 2016 May; 9(5). Pii: e002680.
9. Carney RM, Freedland KE, Steinmeyer BC, Rubin EH, Ewald G. Collaborative care for depression symptoms in an outpatient cardiology setting: A randomized clinical trial. 2016 Sep 15; 219:164-71. doi: 10.1016/j.ijcard.2016.06.045.
Key words: heart failure, heart transplantation
31
Mitchell N. Faddis, MD, PhD
Professor of Medicine
Current Research Interests
Catheter ablation techniques
Treatment of atrial fibrillation
Cardiac resynchronization therapy for advanced heart failure
Representative Publications 1. Marrus S, Andrews C, Cooper D, Faddis MN, Rudy Y. Repolarization changes underlying long-
term cardiac memory due to right ventricular pacing: noninvasive mapping with ECGI. Circulation Arrhythmia Electrophysiol. 2012; 5(4):773-81.
2. Burkhard, J, Talcott M, Faddis M. Evaluation of a novel robotic system for remote control of a fixed curve sheath in a porcine model; BAF#11. J Cardiovascular Electrophysiology. 2012; 23(6):681-2.
3. Zhang J, Sacher F, Hoffmayer K, O’Hara T, Strom M, Cuculich P, Silva J, Cooper D, Faddis M, Hocini M, Haissaguerre M, Scheinman M, Rudy Y. Cardiac electrophysiological substrate underlying the ECG phenotype and electrogram abnormalities in Brugada syndrome patients. 2015; Circulation 131(22):1950-9.
4. Vijayakumar R, Vasireddi S, Cuculich P, Faddis M, Rudy Y. Methodology consideration in phase mapping of human cardiac arrhythmias. Circulation: Arrhythmia and Electrophysiology. 2016; 9(11):e004409.
5. Roberts C, Wofford J, Hoy H, Faddis M. Implementation of a screening program for patients at risk for posttraumatic stress disorder. Clinical Medicine Insights. Cardiology. 2016; 10:129-37.
6. Rao P, Faddis M. Cardiac resynchronization therapy: current indications, management, and basic troubleshooting. Heart 2017; 103(24):2000-7.
Key words: arrhythmias, atrial fibrillation, electrophysiology, heart failure, implantable devices
32
Kenneth E. Freedland, PhD, FAHA
Professor of Psychiatry
Current Research Interests
Depression, anxiety, stress, and physical inactivity in patients with coronary heart disease or heart failure
Roles of depression and inadequate self-care in heart failure rehospitalizations
Interventions for depression and inadequate self-care in heart failure
Clinical trials in behavioral medicine and behavioral trial methodology
Representative Publications
1. Freedland KE, Carney RM, Rich MW, Steinmeyer BC, Skala JA, Dávila-Román VG. Depression and multiple rehospitalizations in patients with heart failure. Clin Cardiol. 2016 May;39(5):257-62. doi: 10.1002/clc.22520. PMID: 26840627
2. Freedland KE, Hesseler MJ, Carney RM, Steinmeyer BC, Skala JA, Dávila-Román VG, Rich MW. Major depression and long-term survival of patients with heart failure. Psychosom Med. 2016 Oct;78(8):896-903. doi: 10.1097/PSY.0000000000000346. PMID: 27187847
3. Freedland KE. Purpose-guided trial design in health-related behavioral intervention research. Health Psychol. 2020 Jun;39(6):539-48. doi: 10.1037/hea0000867. PMID: 32212768
4. Freedland KE. Pilot trials in health-related behavioral intervention research: Problems, solutions, and recommendations. Health Psychol. 2020 Jul 2. doi: 10.1037/hea0000946. PMID: 32614197
5. Freedland KE, Steinmeyer BC, Carney RM, Skala JA, Rich MW. Antidepressant use in patients with heart failure. Gen Hosp Psychiatry. 2020 Jul-Aug;65:1-8. doi: 10.1016/j.genhosppsych.2020.04.006. PMID: 32361659
Key words: behavioral medicine, coronary artery disease, depression, depressive disorders, heart
failure, sleep disorders, heart failure self-care
33
Brian F. Gage, MD, MSc
Professor of Medicine
Current Research Interests
Anticoagulants
Atrial fibrillation
Pharmacogenomics
Representative Publications 1. Gage BF, Waterman AD, Shannon W, Boechler M, Rich MW, Radford MJ. Validation of Clinical
Classification Schemes for Predicting Stroke: Results from the National Registry of Atrial Fibrillation (NRAF) Project. JAMA 2001; 285:2864-70.
2. Rieder MJ, Reiner AP, Gage BF, Nickerson DA, et al. VKORC1 Haplotypes Predict Warfarin Dose. N Engl J Med 2005; 352:2285-93.
3. International Warfarin Pharmacogenetics Consortium, Klein TE, Altman RB, Eriksson N, Gage BF, et al. Estimation of the warfarin dose with clinical and pharmacogenetic data. N Engl J Med. 2009; 360:753-64.
4. Shah SV, Gage BF. Cost-effectiveness of dabigatran for atrial fibrillation. Circulation 2011; 123;2562-70.
5. Subherwal S, Peterson ED, Chen AY, Roe MT, Washam JB, Gage BF, Bach RG, et al. Admission international normalized ratio levels, early treatment strategies, and major bleeding risk among non-ST-segment-elevation myocardial infarction patients on home warfarin therapy: insights from the National Cardiovascular Data Registry. Circulation 2012; 125:1414-23.
6. Kimmel SE, French B, Kasner SE, Johnson JA, Anderson JL, Gage BF, Rosenberg YD, Eby CS, Madigan RA, McBane RB, Abdel-Rahman SZ, Stevens SM, Yale S, Mohler ER, III, Fang MC, Shah V, Horenstein RB, Limdi NA, Muldowney JA, III, Gujral J, Delafontaine P, Desnick RJ, Ortel TL, Billett HH, Pendleton RC, Geller NL, Halperin JL, Goldhaber SZ, Caldwell MD, Califf RM, Ellenberg JH. A pharmacogenetic versus a clinical algorithm for warfarin dosing. N Engl J Med 2013 December 12; 369(24):2283-93.
7. Depta JP, Patel JS, Novak E, Gage BF, Masrani SK, Raymer D, Facey G, Patel Y, Zajarias A, Lasala JM, Amin AP, Kurz HI, Singh J, Bach RG. Risk model for estimating the 1-year risk of deferred lesion intervention following deferred revascularization after fractional flow reserve assessment. Eur Heart J 2015 February 21; 36(8):509-15.
8. Sanfilippo KM, Wang TF, Gage BF, Liu W, Carson KR. Improving accuracy of International Classification of Diseases codes for venous thromboembolism in administrative data. Thromb Res 2015 April; 135(4):616-20.
Key words: aging, atrial fibrillation, epidemiology, pharmacogenomics
34
Edward M. Geltman, MD
Professor of Medicine
Current Research Interests
New pharmacologic agents for the management of systolic and diastolic heart failure
Importance of biomarkers for predicting events for CHF
Representative Publications
1. Stolker JM, Heere B, Geltman EM, Schechtman KB, Peterson LR. Prospective comparison of ventilatory equivalent versus peak oxygen consumption in predicting outcomes of patients with heart failure. Am J Cardiol 2006; 97:1607-10.
2. Moazami N, Shah NR, Ewald GA, Geltman EM, Moorhead SL, Pasque MK. Should UNOS status 2 patients undergo transplantation? Heart Surg Forum 2006; 9:E823-E827.
3. Geltman EM, Thomas S. What is the Optimal Angiotensin-Converting Enzyme Inhibitor Dose in Heart Failure? Congestive Heart Failure 2006; 12:213-18.
4. Joseph SM, Cedars AM, Ewald GA, Geltman EM, Mann DL. Acute decompensated heart failure: contemporary medical management. Tex Heart Inst J 2009; 36(6):510-20.
5. Foster ER, Cunnane KB, Edwards DF, Morrison MT, Ewald GA, Geltman EM, Zazulia AR. Executive dysfunction and depressive symptoms associated with reduced participation of people with severe congestive heart failure. Am J Occup Ther 2011; 65:306-13.
6. Brinkley DM, Novak E, Topkara VK, Geltman EM. Graft survival after cardiac transplantation for alcohol cardiomyopathy. Transplantation 2014; 94:465-9.
7. Wilen CB, Szymanski JJ, Hung S, Rajan A, Lavigne PM, Char DM, Geltman EM, Scott MG. Impact on patient management and outcome of switching between 2 contemporary sensitive cardiac troponin assays. Clin Chem June 2015; 61(6):870-6.
8. Schindler EI, Szymanski JJ, Hock KG, Geltman EM, Scott MG. Short- and long-term biologic variability of galectin-3 and other cardiac biomarkers in patients with stable heart failaure and healthy adults. Clin Chem February 2016; 62(2):360-6.
Key words: diastolic function, heart failure, implantable devices
35
Marye J. Gleva, MD
Professor of Medicine
Current Research Interests • Complications associated with cardiac implantable electronic devices (CIED)s
• Cardiac implantable electronic devices in congenital heart disease
• Outcomes after atrial fibrillation ablation
• Increasing the participation of women in cardiovascular device trials
• Wearable electronic device technology
• CIEDs and MRI imaging
Representative Publications
1. Poole JE, Gleva MJ, Mela T, Chung MK, Uslan DK, Borge R, Gottipaty V, Shinn T, Dan D, Feldman LA, Seide H, Winston, SA, Gallagher JJ, Langberg JL, Mitchell K, Holcomb R. Complication Rates Associated with Pacemaker or Implantable Cardioverter-Defibrillator Generator Replacements and Upgrade Procedures: Results from the REPLACE Registry. Circulation 2010; 122:1553-61.
2. Uslan DZ, Gleva MJ, Warren DK, Mela T, Chung MK, Gottipaty V, Borge R, Dan D, Shinn T, Mitchell K, Holcomb RG, Poole JE. Cardiac Implantable Electronic Device Replacement Infections and Prevention: Results from the REPLACE Registry. PACE 2012; 35: 81-7.
3. Jordan CP, Freedenberg V, Wang Y, Curtis JP, Gleva MJ, Berul CI. Implant and Clinical Characteristics for Pediatric and Congenital Heart Patients in the NCDR ICD Registry®, Circulation: Arrhythmia and Electrophysiology 2014; published online before print October 6, 2014, doi: 10.1161/CIRCEP.114.001841.
4. Gleva MJ and Poole JE. Bruise Control Infection Study, Bugs and Blood. J Am Coll Cardiol 2016; 67: 1309-11.
5. Gleva MJ and Huddleston CB. Atrial arrhythmias after lung transplant: A call to action starting with the electrocardiogram. J Thorac Cardiovasc Surg 2016; 152:910-11.
6. Smith WM, Riddell F, Madon M, Gleva MJ. Comparison of diagnostic value using a small, single channel P-wave centric sternal ECG monitoring patch with a standard 3-lead Holter system over 24 hours. Am Heart J 2017; 185:67-73.
7. Gleva MJ, Wang YF, Curtis JP, Berul CI, Huddleston CB and Poole JE. Complications Associated with Implantable Cardioverter Defibrillators in Adults with Congenital Heart Disease or Left Ventricular Non-Compaction Cardiomyopathy (From the NCDR ICD Registry). American Heart Journal, 2017; 120:1891-8.
8. Gleva MJ, Robinson M, Poole J. The Saga of Defibrillation Testing: When Less is More. Current
Cardiol Reports 2018; 20:44. https://doi.org.10.1007/s11886-018-0987-6
9. Brouillard AM, Al-Hammadi N, Hunt C, Barger P, Ludbrook P, Gleva MJ. Ten year outcomes in adult patients with congenital heart disease and implantable cardioverter-defibrillators. International Journal of Cardiology 2020; 313:39-45. https:// doi.org/10.1016/j.ijcard.2020.03.007
Key words: atrial fibrillation, electrophysiology, implantable devices
36
John Gorcsan III, MD
Professor of Medicine
Current research interests:
Quantifying cardiac mechanics with advanced echocardiographic technology
Assessing effects of device therapy in heart failure patients
Refining patient selection for cardiac resynchronization therapy
Determining prognosis by right ventricular structure and function in patients with pulmonary hypertension
Representative Publications: 1. Haugaa KH, Marek JJ, Ahmed M, Ryo K, Adelstein EC, Schwartzman D, Saba S, Gorcsan J.
Mechanical dyssynchrony after cardiac resynchronization therapy for severely symptomatic heart failure is associated with risk for ventricular arrhythmias. J Am Soc Echocardiogr. 2014;27:872-9.
2. Ryo K, Goda A, Onishi T, Delgado-Montero A, Tayal B, Champion HC, Simon MA, Mathier MA, Gladwin MT, Gorcsan J. Characterization of right ventricular remodeling in pulmonary hypertension associated with patient outcomes by 3-Dimensional wall motion tracking echocardiography. Circ Cardiovasc Imaging. 2015;8:e003176. doi: 10.1161/CIRCIMAGING.114.003176.
3. Gorcsan J, Sogaard P, Bax J, Singh J, Abraham W, Borer J, Dickstein K, Gras D, Krum H, Brugada J, Robertson M, Ford I, Holzmeister J, Ruschitzka F. Association of persistent or worsened echocardiographic dyssynchrony with unfavorable clinical outcomes in heart failure patients with narrow QRS width: A subgroup analysis of the EchoCRT Trial. Eur Heart J 2016;37:49-59.
4. Lumens J, Tayal B, Walmsley J, Delgado-Montero A, Huntjens P, Schwartzman D, Althouse A, Delhaas T, Prinzen F, Gorcsan J. Differentiating electromechanical from non-electrical substrates of mechanical discoordination to identify responders to cardiac resynchronization therapy. Circ Cardiovasc Imaging. 2015 Sep;8(9):e003744.
5. Blauwet LA, Delgado-Montero A, Ryo K, Marek JJ, Alharethi R, Mather PJ, Modi K, Sheppard R, Thohan V, Pisarcik J, McNamara DM, Gorcsan J. Right ventricular function in peripartum cardiomyopathy at presentation is associated with subsequent left ventricular recovery and clinical outcomes. Circ Heart Fail. 2016 (5). pii: e002756.
6. Delgado-Montero A, Tayal B, Goda A, Ryo K, Marek JM, Sugahara M, Qi Z, Althouse AD, Saba S, Schwartzman D, Gorcsan J. Additive Prognostic value of echocardiographic global longitudinal and global circumferential strain to electrocardiographic criteria in heart failure patients undergoing cardiac resynchronization therapy. Circ Cardiovasc Imaging 2016 (6). pii: e004241.
7. Tayal B, Sogaard P, Delgado-Montero A, Goda A, Saba S, Risum N, Gorcsan J. Interaction of left ventricular remodeling and regional dyssynchrony on long-term prognosis after cardiac resynchronization therapy. J Am Soc Echocardiogr 2017;30(3):244-50.
Key Words: echocardiography, heart failure, imaging, right heart failure
37
Jeffrey I. Gordon, MD
Dr. Robert J. Glaser Distinguished University Professor; Director, Edison Family Center for Genome Sciences and Systems Biology
Current Research Interests
The biological foundations and effects of mutually beneficial relationships between humans and, their gut microbial communities
Mechanistic studies of the role of perturbed development of the gut microbiota in the pathogenesis of malnutrition in infants/children and development of microbiota-directed therapeutics for repairing their microbiota and restoring healthy growth
Identification of microbiota-targeted food ingredients, delineation of their mechanisms of action, and pre-clinical and human studies of their biological effects
Representative Publications
1. Patnode, M.L., Beller, Z.W., Han, N.D., Cheng, J., Peters, S.L., Terrapon, N., Henrisssat, B., Le Gall, S., Saulnier, L., Hayashi, D.K., Meynier, A., Vinoy, S., Giannone, R.J., Hettich, R.L., and Gordon, J.I., Interspecies competition impacts targeted manipulation of human gut bacteria by fiber-derived glycans. Cell 2019;179:59-73.
2. Raman, A.S., Gehrig, J.L., Subramanian, S., Venkatesh, M.C. Hibberd, S., Kang, G., Bessong, P.O., Lima, A.A.M., Kosek, M.N., Petri, W.A., Huq, S., Mostafa, I., Islam, M., Mahfuz, M., Haque, R., Ahmed, T., Barratt, M.J., and Gordon, J.I. A sparse covarying unit that describes healthy and impaired human gut microbiota development, Science 2019;364, eaau4735.
3. Gehrig, J.L., Venkatesh, S Chang, H-W., Hibberd, M.C., Kung, V.L., Cheng, J., Chen, R.Y., Subramanian, S., Cowardin, C.A., Meier, M., O’Donnell, D., Talcott, M., Spears, L.D., Semenkovich, C.F., Henrissat, B., Giannone, R.J., Hettich, R.L., Ilkayeva, O., Muehlbauer, M., Newgard, C.B., Sawyer, C., Head, R., Rodionov, D.A., Arzamosov, A.A., Leyn, S.A., Osterman, A.L., Hossain, I., Islam, M., Choudhury, N., Sarker, S., Huq, S., Mahmud, I., Mostafa, I., Mahfuz, M., Barratt, M.J., Ahmed, T., and Gordon, J.I., Effects of microbiota-directed foods in gnotobiotic animals and undernourished children, Science 2019;365, eaau4732.
4. Feng, L., Raman, A.S., Hibberd, M.C., Cheng, J., Griffin, N.W., Peng, Y., Leyn, S.A., Rodionov, D.A., Osterman, A.L., and Gordon, J.I. Identifying determinants of bacterial fitness in a model of human gut microbial succession. Proc. Natl. Acad. Sci USA, 2020;117:2622-33.
5. Di Luccia B., Ahern, P.P., Griffin N.W., Cheng, J., Guruge, J.L., Byrne, A.E., Rodionov, D.A., Leyn, S.A., Osterman, A.L., Ahmed T., Colonna, M., Barratt, M.J., Delahaye, N.F., and Gordon, J.I., Oral cholera vaccination response to a combined prebiotic and microbial intervention in a gnotobiotic mouse model of childhood undernutrition. Cell Host Microbe 2020;27:899-908.
6. Chen, R.Y., Kung, V.L., Das, S., Hossain, M.S., Hibberd, M.C., Guruge, J., Mahfuz, M., Begum, S.M.K.N., Rahman, M.M., Fahim, S.M., Gazi, M. A., Haque, R., Sarker, S.A., Mazunder, R.N., Di Luccia, B., Ahsan, K., Kennedy, E., Santiago-Borges, J., Rodionov, D.A., Leyn, S.A., Osterman, A.L., Barratt, M.J., Ahmed, T., and Gordon, J.I. Duodenal microbiota in stunted undernourished children with enteropathy. New Engl. J. Med. 2020;28:321-33.
Key words: human gut microbiome; systems biology; metabolic regulation; childhood undernutrition; obesity; global health; prebiotics/probiotics/synbiotics; precision medicine
38
Robert J. Gropler, MD
Professor of Radiology, Medicine, and Biomedical Engineering
Current Research Interests
Imaging of myocardial metabolic remodeling using PET, magnetic resonance spectroscopy, and other modalities
Development of new cardiovascular molecular imaging agents
Representative Publications
1. Woodard PK, Liu Y, Pressly ED, Luehmann HP, Detering L, Sultan DE, Laforest R, McGrath AJ, Gropler RJ, Hawker CJ. Design and modular construction of a polymeric nanoparticle for targeted atherosclerosis Positron Emission Tomography imaging: A Story of 25% (64)Cu-CANF-Comb. Pharm Res. 2016;33:2400-10.
2. Liu Y, Gunsten SP, Sultan DH, Luehmann HP, Zhao Y, Blackwell TS, Bollermann-Nowlis Z, Pan JH, Byers DE, Atkinson JJ, Kreisel D, Holtzman MJ, Gropler RJ, Combadiere C, Brody SL. PET-based imaging of chemokine receptor 2 in experimental and disease-related lung inflammation. Radiology 2017;283:758-68.
3. Liu H, Jin H, Han J, Yue X, Yang H, Zayed MA, Gropler RJ, Tu Z. Upregulated sphingosine 1-phosphate receptor 1 expression in human and murine atherosclerotic plaques. Mol Imaging Biol. 2018;20:448-56.
4. Luo Z, Han J, Liu H, Rosenberg AJ, Chen DL, Gropler RJ, Perlmutter JS, Tu Z. Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates. Org Biomol Chem. 2018;16:9171-84.
5. Li W, Luehmann HP, Hsiao HM, Tanaka S, Higashikubo R, Gauthier JM, Sultan D, Lavine KJ, Brody SL, Gelman AE, Gropler RJ, Liu Y, Kreisel D. Visualization of monocytic cells in regressing atherosclerotic plaques by intravital 2-photon and Positron Emission Tomography-based imaging-brief report. Arterioscler Thromb Vasc Biol. 2018;38:1030-6.
6. Luo Z, Han J, Liu H, Rosenberg AJ, Chen DL, Gropler RJ, Perlmutter JS, Tu Z. Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates. Org Biomol Chem. 2018 16:9171-84.
7. Heo GS, Kopecky B, Sultan D, Ou M, Feng G, Bajpai G, Zhang X, Luehmann H, Detering L, Su Y, Leuschner F, Combadière C, Kreisel D, Gropler RJ, Brody SL, Liu Y, Lavine KJ. Molecular imaging visualizes recruitment of inflammatory monocytes and macrophages to the injured heart. Circ Res. 2019;124:881-90.
Key words: molecular imaging, cardiac metabolism
39
Richard Gross, MD, PhD
Professor of Medicine, Chemistry, and Developmental Biology
Current Research Interests
Metabolomics
Diabetic Cardiomyopathy
Heart Failure
Phospholipases
Signaling
Representative Publications
1. Moon SH, Mancuso DJ, Sims HF, Liu X, Nguyen AL, Yang K, Guan S, Dilthey BG, Jenkins CM, Weinheimer CJ, Kovacs A, Abendschein D, Gross RW. Cardiac myocyte-specific knock-out of
calcium-independent phospholipase A2 (iPLA2) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size. J Biol Chem. 2016, 291:19687-700. PMCID: PMC5016701.
2. Liu X, Moon SH, Jenkins CM, Sims HF, Gross RW. Cyclooxgenase-2 mediated oxidation of 2-arachidonoyl-lysophospholipids identifies unknown lipid signaling pathways. Cell Chem Biol. 2016, 23:1217-27. PMCID: PMC5074890.
3. Moon SH, Liu X, Cedars AM, Yang K, Kiebish MA, Joseph SM, Kelley J, Jenkins CM, Gross RW.
Heart failure-induced activation of phospholipase iPLA2 generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore. J Biol Chem. (Editor’s Pick) 2017, 293:115-29. PMCID: PMC5766913.
4. Liu GY, Moon SH, Jenkins CM, Li M, Sims HF, Guan S, Gross RW. The phospholipase iPLA2 is a major mediator releasing oxidized aliphatic chains from cardiolipin integrating mitochondrial bioenergetics and signaling. J Biol Chem. 2017, 292:10672-84. PMCID: PMC5481572.
5. Jenkins CM, Yang K, Liu G, Moon SH, Dilthey BG, and Gross RW. Cytochrome c is an oxidative stress-activated plasmalogenase that cleaves plasmenylcholine and plasmenylethanolamine at the sn-1 vinyl-ether linkage. J Biol Chem. (Editor’s Pick) 2018, 293:8693-709. PMCID: PMC5986220.
6. Liu GY, Moon SH, Jenkins CM, Sims HF, Guan S., Gross RW. Synthesis of oxidized phospholipids by sn-1 acyl transferase using 2-15-HETE lysophospholipids. J. Biol. Chem. 2019 Jun 28; 294(26):10146-59.
Key words: basic science, cardiac metabolism, diabetes, heart failure, lipid metabolism, molecular
cardiology
40
Justin C. Hartupee, MD, PhD
Assistant Professor of Medicine
Current Research Interests
Cardiac transplantation/ donor management and evaluation
LVAD imaging in the evaluation of pump dysfunction
Heart failure disease progression
Representative Publications
1. Hartupee J, Mann DL. Positioning of inflammatory biomarkers in the heart failure landscape. J Cardiovasc Transl Res. 2013 Aug; 6(4):485-92.
2. Hartupee J, Mann DL. Role of inflammatory cells in fibroblast activation. J Mol Cell Cardiol. 2016 Apr;93:143-8.
3. Godishala A, Nassif ME, Raymer DS, Hartupee J, Ewald GA, LaRue SJ, Vader JM. A Case Series of Acute Myocardial Infarction in Left Ventricular Assist Device-Supported Patients. ASAIO J. 2017 Mar/Apr; 63(2):e18-e24.
4. Hartupee J, Mann DL. Neurohormonal activation in heart failure with reduced ejection fraction. Nat Rev Cardiol. 2017 Jan;14(1):30-8.
5. Hartupee J, Patel R, Staloch L, Dávila-Román V, De las Fuentes L, Novak E, Mann D. Diagnostic accuracy of damage-associated molecular patterns (DAMPs) in patients with heart failure with a reduced ejection fraction. Journal of Clinical and Translational Science. 2017; 1(3), 208-9.
6. Hartupee J, Szalai GD, Wang W, Ma X, Diwan A, Mann DL. Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor. Circ Heart Fail. 2017 Dec;10(12). pii: e004252.
Key Words: heart failure, transplantation, LVAD
41
Mustafa Husaini, MD
Assistant Professor of Medicine
Current Research Interests
Athletic remodeling
Sudden Cardiac Death in athletes
Cardiopulmonary exercise testing
Hypertrophic Cardiomyopathy
Cardiac rehab
Representative Publications
1. Husaini M, Baker J, Cresci S, Bach R, LaRue S. Recurrent takotsubo cardiomyopathy in a patient with hypertrophic cardiomyopathy leading to cardiogenic shock requiring VA-ECMO. J Am Coll Cardiol Case Rep June 2020 DOI: 10.1016/j.jaccas.2020.04.028
Key words: sports cardiology, athletes, hypertrophic cardiomyopathy, cardiac rehabilitation
42
Sudhir Jain MD, FACC, MBA
Associate Professor of Medicine
Current Research interest
Preventive Cardiology
Nuclear Cardiology
Vascular Medicine
Representative Publications
1. Jain S, Baird JB, Fischer KC and Rich MW. Prognostic Value of Dipyridamole Thallium Imaging after Acute Myocardial infarction in older patients. 1999; J Am. Geriatr. Soc. 47:295-301.
2. Gor C, Jain S. Chapter in The Washington Manual of Medical subspecialty Consult series Standard imaging and Diagnostic Testing Modalities: Nuclear Cardiology p369-80. Cardiology Subspecialty Consult 3rd Ed. Wolters Kluwer.
3. Amin AP, Crimmins-Reda P, Miller S, Rahn B, Caruso M, Funk M, Pierce A, Kurz HI, Lasala JM, Zajarias A, Bach RG, Sintek MA, Frogge N, Jain S, Kulkarni H, Singh J. Reducing Acute Kidney Injury and Costs of Percutaneous Coronary Interventinos by Patient-Centered, Evidence-Based Contrast Use. Circ Cardiovasc Qual Outcomes. 2019 Mar;12(3):e004961.
4. Schindler T, Valenta I, and Jain S. Emergence of Endocardium/Epicardium Flow Gradient as Novel Risk Biomarker in Patients with Hypertrophic Cardiomyopathy. Editorial International Journal of Cardiology Heart and Vasculature 2020 Jan 6;26:100467.
5. Schindler T, Varney B and Jain S. Molecular Imaging of Active Coronary Micro-Calcification with 18F-NaF and PET: Emergence of a New Biomarker of the Vulnerable Atherosclerotic Plaque. March 2020 Editorial European journal of Preventive Cardiology.
43
Ali Javaheri MD, PhD
Instructor of Medicine
Current Research Interests
Role of bioactive lipids in preventing myocardial injury
How lipids alter lysosome function in inflammatory cells and myocytes
We utilize both clinical samples and animal models to determine the role of bioactive lipids in multiple disease models
Representative Publications 1. Bedi KC, Jr., Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair
IA, Margulies KB and Rame JE. Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure. Circulation. 2016; 133:706-16.
2. Javaheri A, Molina M, Zamani P, Rodrigues A, Novak E, Chambers S, Stutman P, Maslanek W, Williams M, Lilly SM, Heeger P, Sayegh MH, Chandraker A, Briscoe DM, Daly KP, Starling R, Ikle D, Christie J, Rame JE, Goldberg LR, Billheimer J and Rader DJ. Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients. J Heart Lung Transplant. 2016; 35:1295-302.
3. Liu Y, Conlon DM, Bi X, Slovik KJ, Shi J, Edelstein HI, Millar JS, Javaheri A, Cuchel M, Pashos EE, Iqbal J, Hussain MM, Hegele RA, Yang W, Duncan SA, Rader DJ and Morrisey EE. Lack of MTTP activity in pluripotent stem cell-derived hepatocytes and cardiomyocytes abolishes apoB secretion and increases cell stress. Cell Rep. 2017; 19:1456-66.
4. Sergin I, Evans TD, Zhang X, Bhattacharya S, Stokes CJ, Song E, Ali S, Dehestani B, Holloway KB, Micevych PS, Javaheri A, Crowley JR, Ballabio A, Schilling JD, Epelman S, Weihl CC, Diwan A, Fan D, Zayed MA and Razani B. Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nat Commun. 2017; 8:15750.
5. Liu H*, Javaheri A*, Godar RJ, Murphy J, Ma X, Rohatgi N, Mahadevan J, Hyrc K, Saftig P, Marshall C, McDaniel ML, Remedi MS, Razani B, Urano F and Diwan A. Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway. autophagy. 2017; 13(11):1952-68. *indicates equal contribution
6. Sudarshan S and Javaheri A. Cholesterol efflux in the transplanted patient Current Opinion in Endocrinology, Diabetes, and Obesity. 2018 Apr; 25(2):143-6.
Keywords: cholesterol efflux capacity, cardiac allograft vasculopathy, HDL, apolipoprotein M, autophagy, lysosome
44
Karen Joynt Maddox, MD
Assistant Professor of Medicine, Washington University School of Medicine
Assistant Professor, Washington University Brown School of Social Work
Current Research Interests
Improving the measurement of the quality and efficiency of physicians, hospitals and health systems
Understanding the impact of policy interventions on health care, with a focus on value-based and alternative payment models
Reducing disparities in care, with a focus on vulnerable populations including racial and ethnic minorities, individuals living in poverty, individuals with disabilities, frail elders, and those in rural areas
Representative Publications
1. Joynt KE, Orav EJ, Jha AK. Thirty-day readmission rates for Medicare beneficiaries by race and site of care. JAMA 2011;305:675-81.
2. Joynt KE, Blumenthal DM, Orav EJ, Resnic FS, Jha AK. Association of public reporting for percutaneous coronary intervention with utilization and outcomes among Medicare beneficiaries with acute myocardial infarction. JAMA. 2012;308(14):1460-8.
3. Joynt KE, Jha AK. Characteristics of hospitals receiving penalties under the hospital readmissions reduction program. JAMA. 2013;309(4):342-3.
4. Joynt KE, Gawande AA, Orav EJ, Jha AK. The contribution of preventable acute-care spending to total spending for high-cost Medicare patients. JAMA. 2013;309(24):2572-8.
5. Joynt KE, Orav EJ, Jha AK. Association between hospital conversions to for-profit status and clinical and economic outcomes. JAMA. 2014 Oct 22-29;312(16):1644-52.
6. Chen LM, Epstein AM, Orav EJ, Filice CE, Samson LW, Joynt Maddox KE. Association of practice-level social and medical risk with performance in the Medicare physician value-based payment modifier program. JAMA. 2017 Aug 1;318(5):453-61.
7. Joynt Maddox KE, Orav EJ, Zheng J, Epstein AM. Evaluation of Medicare’s bundled payments initiative for medical conditions. N Engl J Med 2018 Jul 19;379(3):260-9.
8. Johnston K, Hockenberry J, Wen H, Joynt Maddox KE. Association between patient cognitive and functional status and Medicare total annual cost of care: Implications for value-based payment. JAMA Internal Med 2018 Nov 1;178(11):1489-97.
9. Joynt Maddox KE, Reidhead M, Qi AC, Nerenz DR. Impact of stratification by dual enrollment status on financial penalties in the hospital readmissions reduction program. JAMA Int Med 2019 Jun 1;179(6):769-76.
10. Joynt Maddox KE, Orav EJ, Zheng J, Epstein AM. Characteristics of hospitals that did and did not participate in the bundled payments for care improvement-advanced program (BPCI-A). JAMA 2019 Jul 23;322(4):362-4.
Key words: disparities, health policy, health services research, hospital readmissions, outcomes
research, quality of care, women and minorities
45
Attila Kovacs, MD
Professor of Medicine
Current Research Interests
cardiovascular phenotyping in mice
ultrasonic tissue characterization
Representative Publications 1. Kovacs A, Courtois MR, Weinheimer CJ, Posdamer SH, Wallace KD, Holland MR, Miller JG.
Ultrasonic tissue characterization of the mouse myocardium: Successful in-vivo cyclic variation measurements. J Am Soc Echocardiogr 2004; 17:883-92.
2. Lavine KJ, Kovacs A, Ornitz DM. Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. J Clin Invest. 2008; 118:2404-14.
3. Schaeffer PJ, Desantiago J, Yang J, Flagg TP, Kovacs A, Weinheimer CJ, Courtois M, Leone TC, Nichols CG, Bers DM, Kelly DP. Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol. 2009; 297:H1263-H1273.
4. Wagenseil JE, Ciliberto CH, Knutsen RH, Levy MA, Kovacs A, Mecham RP. Reduced vessel elasticity alters cardiovascular structure and function in newborn mice. Circ Res. 2009; 104:1217-24.
5. Metcalf JA, Ma X, Linders B, Wu S, Schambach A, Ohlemiller KK, Kovacs A, Bigg M, He L, Tollefsen DM, Ponder KP. A Self-inactivating gamma-retroviral vector reduces manifestations of mucopolysaccharidosis I in mice. Mol Ther. 2010; 18:334-42.
6. Schugar RC, Moll AR, Andre dD, Weinheimer CJ, Kovacs A, Crawford PA. Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling. Mol Metab 2014; 3(7):754-69.
7. Weinheimer CJ, Lai L, Kelly DP, Kovacs A. Novel mouse model of left ventricular pressure overload and infarction causing predictable ventricular remodelling and progression to heart failure. Clin Exp Pharmacol Physiol 2015; 42(1):33-40.
8. Kovacs A, Olah A, Lux A, Matyas C, Nemeth BT, Kellermayer D, Ruppert M, Torok M, Szabo L, Meltzer A, Assabiny A, Birtalan E, Merkely B, Radovits T. Strain and strain rate by speckle-tracking echocardiography correlate with pressure-volume loop-derived contractility indices in a rat model of athlete's heart. Am J Physiol Heart Circ Physiol 2015; 308(7):H743-H748.
9. Moon SH, Mancuso DJ, Sims HF, Liu X, Nguyen AL, Yang K, Guan S, Dilthey BG, Jenkins CM, Weinheimer CJ, Kovacs A, Abendschein DR, Gross RW. Cardiac myocyte-specific knockout of iPLA2gamma decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size. J Biol Chem 2016 Sep 9; 291(37):19687-700.
Key words: basic science, imaging, molecular cardiology, vascular biology
46
Sándor J. Kovács, PhD, MD, h.c.
Professor of Medicine, Cell Biology and Physiology
Adjunct Professor of Physics and Biomedical Engineering
Current Research Interests
Mathematical models of cardiac physiology and function/complexity theory
Theoretical and applied cardiac physiology/pathophysiology
Multimodal cardiac imaging: echo/magnetic resonance/catheterization/angiography Representative Publications
1. Arvidsson PM, Carlsson M, Kovács SJ, Hakan Arheden H. Atrioventricular plane displacement is NOT the sole mechanism of atrial and ventricular refill" Am J Physiol-Heart and Circ Physiol, Perspective 2015; 309(6):H1094-H1096.
2. Kazui T, Watanabe Y, Kovács SJ.,Lawrance CP, Greenberg JW, Schuessler JB, Damiano RJ Jr. The Impact of Six Weeks of Atrial Fibrillation on Atrial and Ventricular Chamber Properties and Function in a Porcine Model. J Thor Cardiovasc Surg 2015; 150(6):1602-8.
3. Chung C, Shmuylovich L, Kovács SJ. "What global diastolic function is, what it is not, and how to measure it." Am J Physiol-Heart and Circ Physiol 2015; Invited Review Article, doi:10.1152/ajpheart. 00436.
4. Nappo R, Degiovanni A, Bolzani V, Sartori C, Di Giovine G, Cerini P, Fossaceca R, Kovács SJ, Marino PN. Quantitative Asessment of Atrial Conduit Function: A New Index of Diastolic Dysfunction. Clin Res in Cardiol 2016; 105(1):17-28.
5. Arvidsson PM, Kovács SJ, Töger J, Borgquist R, Heiberg E, Carlsson M, and Arheden H. Vortex ring behavior provides the epigenetic blueprint for the human heart, NATURE Scientific Reports 2016; 6:22021 doi: 10.1038/srep22021.
6. Kohli K, Kovács SJ. The Quest for Load-Independent Left Ventricular Chamber Properties: Exploring the Normalized Pressure-Volume Loop, Physiological Reports 2017; 5(3), e13160, doi: 10.14814/phy2.13160.
7. Maksuti E, Carlsson M, Arheden H, Kovács SJ, Broomé M, and Ugander M. Hydraulicforces contribute to left ventricular diastolic filling" NATURE Scientific Reports 2017; 7:43505 doi: 10.1038/srep43505.
8. Golman M, Padovano W, Shmuylovich L, Kovács SJ. Quantifying diastolic function: From E-Waves as triangles to physiologic contours via the “Geometric Method”. Cardiovasc Eng Technol 2018; 9(1): 105-19. doi: 10.1007/s13239-017-0339-5.
9. Carlsson, M, Heiberg, E, Ostenfeld, E, Steding-Ehrenborg, Kovács SJ, Flachskampf, F, Arheden, H. Functional Contribution of Circumferential Versus Longitudinal Strain: Different Concepts Suggest Conflicting Results. Journal of the American College of Cardiology 71(2): 254-5, 2018.
10. Bhagavan D, Padovano WM, Kovács SJ. Alternative Diastolic Function Models of Ventricular Longitudinal Filling Velocity are Mathematically Identical. American Journal of Physiology-Heart and Circulatory Physiology 318:H1059-H1067, 2020
Key words: cardiac physiology, complexity theory, diastolic function, imaging, mathematical modeling
47
Ronald J. Krone, MD
Professor of Medicine
Current Research Interests
Cardio-oncology (cardiac toxicity from cancer)
Cardiac protection during doxorubicin therapy
Cardiac imaging in cancer patients
Representative Publications General Cardiology References:
1. Krone RJ, Gregory JJ, Freedland KE, et al. for the Multicenter Myocardial Ischemia Research Group. Limited usefulness of exercise testing and thallium scintigraphy in the evaluation of ambulatory patients several months after recovery from an acute coronary event: implications for the management of stable coronary heart disease. J Am Coll Cardiol 1994; 24:1274-81.
2. Krone RJ, Johnson L, Noto T, and the Registry Committee of the Society for Cardiac Angiography and Interventions. Five year trends in cardiac catheterization, a report from the Registry of the Society for Cardiac Angiography and Interventions, Cathet Cardiovasc Diagn 1996; 39: 31-5.
3. Krone RJ. Diagnosis and prognosis of silent ischemia. [Review] [65 refs] Cardiologia.1998 43(11):1159-68. 4. Krone RJ, Laskey WK, Johnson C, et al. A simplified lesion classification for predicting success and
complications of coronary angioplasty. Am J Cardiol 2000; 85:1179-84. 5. Krone RJ, Shaw RE, Klein LW, et al. ACC-National Cardiovascular Data Registry. Evaluation of the ACC/AHA)
and the SCAI lesion classification system in the current “stent era” of coronary interventions: A report from the ACC National Cardiovascular Data Registry. Am J Cardiol. 2003;92(4):389-94.
6. Krone RJ, Shaw RE, Klein LW, et al. Ad Hoc Percutaneous Coronary Interventions (PCIs) in Patients with Stable Coronary Artery Disease- a study of prevalence, safety and variation in use from the American College of Cardiology National Cardiovascular Data Registry (ACC-NCDR®), Cathet and Cardiovasc Interventions, 2006; 68:696-703.
7. Krone RJ, Rao SV, Dai D, et al. Acceptance, panic, and partial recovery the pattern of usage of drug-eluting stents after introduction in the U.S. (a report from the American College of Cardiology/National Cardiovascular Data Registry). JACC Cardiovasc Interv 2010;3:902-10.
8. Krone RJ, Althouse AD, Tamis-Holland J, et al. for the BARI 2D Study Group, Appropriate Revascularization in Stable Angina, Lessons from the BARI 2D Trial, Canadian Journal of Cardiology 2014;30:1595-601.
CardioOncology References: 1. Krone RJ. Managing coronary artery disease in the cancer patient. Prog Cardiovasc Dis 2010;53:149-56. 2. Management of Cardiac Disease in Cancer Patients, Progress in Cardiovascular Disease, Volume 53, Issue
2, Pages A1-A6, 79-180 (September-October 2010) Edited by Daniel J. Lenihan, MD and Ronald J. Krone, MD, Elsevier BV, Amsterdam
3. Lakoski SG, Jones LW, Krone RJ, Stein PK, Scott JM. Autonomic Dysfunction in Early Breast Cancer: Incidence, Clinical Importance, and Underlying Mechanisms. American heart journal 2015;170:231-41.
4. Krone RJ. Protecting the heart in Cancer Patients: the Role of Cardio-Oncology. European Medical Journal, Cardiology 2017;5:47-52.
5. Curigliano G, Lenihan D, Fradley M, …Krone R, et al Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann Oncol. 2020;31:171-90.
Key words: cardio-oncology, coronary artery disease, cardiomyopathy
48
Gregory M. Lanza, MD, PhD
James R. Hornsby Family Professorship in Biomedical Sciences
Current Research Interests
Nanomedicine
Targeted Drug Delivery
Molecular Imaging
Magnetic Resonance Imaging
Echocardiography
Representative Publications
1. Lanza GM, Jenkins J, Schmieder AH, Moldobaeva A, Cui G, Zhang H, Yang X, Zhong Q, Keupp J, Sergin I, Paranandi, KS, Eldridge L, Allen JS, Williams T, Scott MJ, Razani B, Wagner EM: Anti-angiogenic nanotherapy inhibits airway remodeling and hyper-responsiveness of dust mite triggered asthma in the Brown Norway Rat. Theranostics 2017; 7 (2): 377-89; PMID: 28042341. PMCID: PMC5197071.
2. Ross MH, Esser AK, Fox GC, Schmieder AH, Yang X, Hu G, Pan D, Su X, Xu Y, Novack V, Walsh T, Colditz GA, Lukaszewicz GH, Cordell E, Novack JS, Fitzpatrick JAJ, Waning DL, Mohammad KS, Guise TA, Lanza GM, Weilbaecher KN. Bone-induced expression of integrin β3 enables targeted nanotherapy of breast cancer metastases Cancer Res 2017; 77:6299-312 doi:10.1158/0008-5472.CAN-17-1225. PMCID: PMC5841166.
3. Wu L, Wen X, Sun X, Wang K, Wang X, Wang C, Zhang H, Williams T, Stacy AJ, Chen J, Schmieder
AH, Lanza GM, Shen B. Intratracheal delivery of perfluorocarbon nanoparticles to lung cancer demonstrated with magnetic resonance multimodal imaging. Theranostics. 2018; 8(2): 563-74. doi: 10.7150/thno.21466. PMCID: PMC5743567.
4. Cui G, Akers WJ, Scott MJ, Nassif M, Allen JS, Schmieder AH, Paranandi KS, Itoh A, Beyder DD, Achilefu S, Ewald GA, Lanza GM. Diagnosis of LVAD thrombus using a high-avidity fibrin-specific 99mTc probe. Theranostics 2018; 8(4):1168-79.
5. Kotagiri N, Cooper M, Rettig M, Egbulefu C, Prior J, Hu G, Karmakar P, Zhou M, Yang S, Sudlow G, Marsala L, Chanswangphuwana C, Lu L, Habimana-1Griffin L, Shokeen M, Su X, Weilbaecher K, Tomasson M, Lanza G, DiPersio J, Achilefu S. Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer. Nat Commun 2018; 9:275. doi:10.1038/s41467-017-02758-9.
Key words: basic science, imaging, molecular cardiology, nanomedicine
49
John M. Lasala, MD, PhD
Professor of Medicine
Current Research Interests
Interventional cardiology with complex coronary interventions
Drug-eluting stents
Percutaneous aortic valve replacement and mitral valve repair
Structural heart/congenital heart defects
Representative Publications 1. Agboola KM, Lasala JM, Sintek MA, Noheria A. Acute right ventricular failure and pulseless
electrical activity arrest following auto-transfusion of blood. J Cardiol Cases. 2018 Jan 12;17(4):119-22. doi: 10.1016/j.jccase.2017.12.002. PMID: 30279871.
2. Henn MC, Zajarias A, Quader N, Sintek M, Lasala JM, Koogler K, Damiano MS, Kachroo P, Miller DC, King CR, Melby SJ, Moon MR, Damiano RJ Jr, Maniar HS. Observed to expected 30-day mortality as a benchmark for Transcatheter aortic valve replacement. J Thorac Cardiovasc Surg. 2018 Jul 27. pii:S0022-5223(18)32031-2. doi: 10.1016/j.jtcvs.2018.06.097. PMID: 30454980.
3. Amin AP, Miller S, Rahn B, Caruso M, Pierce A, Sorenson K, Kurz H, Zajarias A, Bach R, Singh J, Lasala JM, Kulkarni H, Crimmins-Reda P. Reversing the “Risk-Treatment Paradox” of Bleeding in Patients Undergoing Percutaneous Coronary Intervention: Risk-Concordant Use of Bleeding Avoidance Strategies Is Associated With Reduced Bleeding and Lower Costs. J Am Heart Assoc. 2018 Nov 6;7(21):e008551. doi: 10.1161/JAHA.118.008551. PMID: 30376760.
4. Manghelli JL, Carter DI, Khiabani AJ, Maniar HS, Damiano RJ Jr, Sintak MA, Lasala JM, Zajarias A, Melby SJ. Outcomes After the MitraClip Procedure in Patients at Very High Risk for Conventional Mitral Valve Surgery. Innovations (Phila). 2018 Nov/Dec;13(6):433-7. doi: 10.1097/IMI.0000000000000571. PMID: 30543578.
5. Amin AP, Crimmings-Reda P, Miller S, Rahn B, Caruso M, Funk M, Pierce A, Kurz HI, Lasala JM, Zajarias A, Bach RG, Sintek MA, Frogge N, Jain S, Kulkarni H, Singh J. Reducing Acute Kidney Injury and Costs of Percutaneous Coronary Intervention by Patient-Centered, Evidence-Based Contrast Use. Circ Cardiovasc Qual Outcomes. 2019 Mar; 12(3):e004961. doi: 10.1161/CIRCOUTCOMES.118.004961. PMID: 30857411.
Key words: aortic stenosis, coronary artery disease, interventional cardiology, valvular heart disease
50
Kory J. Lavine, MD, PhD
Associate Professor in Medicine Current Research Interests • Immune mechanisms governing heart failure pathogenesis and cardiac recovery • Precision Therapies for Dilated Cardiomyopathy • Pathogenesis of allograft rejection and primary graft dysfunction • Role of macrophages in coronary development, collateral growth, and regeneration
Representative Publications 1. Lavine KJ, Epelman S, Uchida K, Weber KJ, Nichols CG, Schilling JD, Ornitz DM, Randolph GJ, Mann
DL. Distinct cardiac macrophage subsets govern the response to cardiac injury in the neonatal and adult heart. PNAS, 2014;111(45): 16029-34.
2. Epelman S, Lavine KJ, Beaudin AE, Sojka DK, Carrero JA, Calderon B, Brija T, Gautier EL, Ivanov S, Satpathy AT, Schilling JD, Schwendener R, Sergin I, Razani B, Forsberg EC, Yokoyama W, Unanue ER, Colonna M, Randolph GJ and Mann DL. Origin and lifecycle of cardiac macrophages subpopulations in steady state and inflammation. Immunity, 2014;40(1): 91-104.
3. Leid JM, Carrelha J, Boukarabila H, Epelman S, Jacobsen SE, Lavine KJ. Primitive embryonic macrophages are required for coronary development and maturation. Circ Res. 2016;118(10):1498-511.
4. Li W, Hsiao H, Higashikubo R, Saunders B, Bharat A, Goldstein D, Krupnick A, Gelman A, Lavine KJ*, Kreisel D*. Heart-resident CCR2+ macrophages promote neutrophil extravasation through TLR9-MyD88-CXCL5 signaling. JCI Insight. JCI Insight. 2016 Aug 4;1(12). pii: e87315. *Co-senior authors.
5. Patel MD, Mohan J, Schneider C, Bajpai G, Purevjav E, Canter CE, Towbin J, Bredemeyer A, Lavine KJ. Pediatric and adult dilated cardiomyopathy represent distinct pathological entities. JCI Insight 2017;2(14): pii: 94382.
6. Bajpai G, Schneider C, Wong N, Bredemeyer A, Hulsmans M, Nahrendorf M, Epelman S, Kreisel D, Liu Y, Itoh A, Shankar TS, Selzman CH, Drakos SG, Lavine KJ. The human heart contains distinct macrophage subsets with divergent origins and functions. Nat Med. 2018 Aug;24(8):1234-45.
7. Li W, Feng G, Gauthier JM, Lokshina I, Higashikubo R, Evans S, Liu X, Hassan A, Tanaka S, Cicka M, Hsiao HM, Ruiz-Perez D, Bredemeyer A, Gross RW, Mann DL, Tyurina YY, Gelman AE, Kagan VE, Linkermann A, Lavine KJ*, Kreisel D*. Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation. J Clin Invest. 2019: 130. pii: 126428. *Co-senior authors.
8. Heo GH, Kopecky B, Sultan D, Ou N, Bajpai G, Zhang X, Luehmann H, Detering L, Su Y, Leuschner F, Combadière C, Kreisel D, Gropler RJ, Brody SL, Liu Y, Lavine KJ. Molecular Imaging Visualizes Recruitment of Inflammatory Monocytes and Macrophages to the Injured Heart. Circ Res. 2019: 124(6): 881-90.
9. Bajpai G, Bredemeyer A, Li W, Zaitsev K, Koenig A, Lokshina I, Mohan J, Ivey B, Hsiao H, Weinheimer C, Kovacs A, Epelman S, Artyomov M, Kreisel D, Lavine KJ. Distinct Subsets of Tissue Resident Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury. Circ Res. 2019: 124(2):263-78.
10. Kopecky BJ, Frye C, Terada Y, Balsara KR, Kreisel D, Lavine KJ. Role of donor macrophages after heart and lung transplantation. Am J Transplant. 2020 May;20(5):1225-35.
Key words: heart failure, macrophage, transplant vasculopathy, coronary development, collateral, cardiac recovery
51
Steven J. Lavine, MD
Professor of Medicine
Current Research Interests • Diastolic function in heart failure
• Noninvasive determinants of survival in aortic regurgitation
• Shape of the LV outflow tract and its relation to ventricular geometry
• Determinants of survival and readmission in community hospital based cohorts with heart
Failure
Representative Publications 1. Ortiz AA. Lavine SJ. The index of myocardial performance and aortic regurgitation: the influence of a volume
overload lesion. Anat. J Cardiol 2006 Jun; 6(2):115-20. 2. Lavine SJ. Effect of changes in contractility on the index of myocardial performance in the dysfunctional left
ventricle. Cardiovasc Ultrasound. 2006 Nov 17; 4:45. 3. Lavine SJ, Lavine JA. The effect of acute hypertension on left ventricular diastolic pressures in a canine model
of left ventricular dysfunction with preserved ejection fraction and elevated LV filling pressures. J Am Soc Echocardiogr. 2006 Nov; 19(11):1350-8.
4. Mansouri V, Lavine SJ. Effect of external constraint on the index of myocardial performance in a canine model of left ventricular dysfunction. Echocardiography. 2007 Aug; 24(7):712-22.
5. Lavine SJ, Conetta DA. Comparison of the effect of pressure loading on left ventricular size, systolic and diastolic function in canines with left ventricular dysfunction with preserved and reduced ejection fraction. Cardiovasc Ultrasound. 2008 Nov 18; 6:57.
6. Lavine SJ, Walsh T. Exercise tolerance and the post exercise diastolic filling pattern in patients with the resting impaired relaxation. Cardiology Research, 2011 http://cardiologyres.org/index.php/Cardiologyres/issue/view/8
7. Babcock MJ, Lavine S, Strom JA, Bass TA, Guzman LA. Candidates for transcatheter aortic valve replacement: fitting the PARTNERS criteria. Catheter Cardiovasc Interv. 2013 Oct 1; 82(4):655-61.
8. Lavine SJ. Diastolic Filling Patterns and the Valsalva Maneuver, Cardiology 2014; 128:352-4. 9. Lavine SJ, Al Balbissi KA. Reduced longitudinal function in chronic aortic regurgitation. J Cardiovasc
Ultrasound. 2015 Dec; 23(4):219-27. doi: 10.4250/jcu.2015.23.4.219. 10. Lavine SJ, Al Balbissi KA. Adverse cardiac events and the impaired relaxation left ventricular filling pattern. J
Am Soc Echocardiogr. 2016 Jul; 29(7):699-708. doi: 10.1016/j.echo.2016.02.008. 11. Panchal HB, Veeranki SP, Bhatheja S, Barry N, Mahmud E, Budoff M, Lavine SJ, Mamudu HM, Paul TK.
Fractional flow reserve using computed tomography for assessing coronary artery disease: a meta-analysis. J Cardiovasc Med (Hagerstown). 2016 Sep; 17(9):694-700. doi:10.2459/JCM.0000000000000415.
12. Lavine SJ, Sivaganam K, Strom JA. Indexing peak rapid filling velocity to both relaxation and filling volume to estimate left ventricular filling pressures. Eur Heart J Cardiovasc Imaging. 2019 Jun 1;20(6):646-54. doi: 10.1093/ehjci/jey154. PMID: 30371774
13. Lavine SJ, Obeng GB. The relation of left ventricular geometry to left ventricular outflow tract shape and stroke volume index calculations. Echocardiography. 2019 May;36(5):905-15. doi: 10.1111/echo.14323. PMID: 30968441
14. Murtaza G, Paul TK, Ur Rahman Z, Kelvas D, Lavine SJ. Clinical Characteristics, Comorbidities and Prognosis in Patients With Heart Failure With Mid-Range Ejection Fraction. Am J Med Sci. 2020 Jun;359(6):325-33. doi: 10.1016/j.amjms.2020.03.008. PMID: 32354595 DOI: 10.1016/j.amjms.2020.03.008.
Key words: aortic regurgitation, diastolic function, heart failure
52
Daniel J. Lenihan, MD
Professor of Medicine
Current Research Interests
Biomarkers of disease processes in Heart Failure, Amyloidosis, and Cardiotoxicity of Chemotherapy
Optimal monitoring and treatment of cardiac disease in patients with cancer
Best Practice for cardiac safety during cancer therapy
Early phase clinical trials in Cardioprotection, Heart Failure, and Amyloidosis
Fellowship training requirements for Cardio-Oncology
Representative Publications 1. Lenihan DJ, Alencar AJ, Yang D, Kurzrock R, Keating MJ, Duvic M. Cardiac toxicity of
alemtuzumab in patients with mycosis fungoides/Sezary syndrome. Blood 2004; 104:655-8. 2. Ewer MS, Vooletich MT, Durand JB, Woods ML, Davis JR, Valero V, Lenihan DJ. Reversibility of
trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment. J Clin Oncol 2005; 23:7820-6.
3. Burjonroppa SC, Tong AT, Xiao LC, Johnson MM, Yusuf SW, Lenihan DJ. Cancer patients with markedly elevated B-type natriuretic peptide may not have volume overload. American Journal Clinical Oncology 2007; 30:3:287-93.
4. Khakoo AY, Kassiotis CM, Tannir N, Plana JC, Halushka M, Bickford C, Trent J, Champion JC, Durand JB, Lenihan DJ. Heart failure associated with sunitinib malate, a multi-targeted receptor tyrosine kinase inhibitor Cancer 2008; 112(11):2500-8.
5. Lenihan, D., T. Suter, et al. Pooled analysis of cardiac safety in patients with cancer treated with pertuzumab. Annals of Oncology: Official journal of the European Society for Medical Oncology / ESMO 23(3): 791-800.Lenihan DJ, Cardinale DM. Late Cardiac Effects of Cancer Treatment. Journal of Clinical Oncology 2012; 30(30):3657-64.
6. Grandin, W., Ky, Bonnie, Cornell, R Frank, Carver, J, Lenihan, DJ. Patterns of Cardiac Toxicity associated with irreversible proteasome inhibition in the treatment of multiple myeloma. Journal of Cardiac Failure 2015; 21(2):138-44. PMID:25433360
7. Lenihan DJ, Stevens PL, Massey M, Piana JC, Araujo DM, Fanale MA, Fayad LE, Fisch MJ, Yeh ET. The utility of point-of-care biomarkersto detect cardiotoxicity during anthracycline chemotherapy: A feasibility study. J Card Fail. 2016; 6(22):433-8
8. Lenihan, D.J., Anderson, S.A., Lenneman, C.G., Brittain, E., Muldowney, J.A.S., III, Mendes, L., Zhao, P.Z., Iaci, J., Frohwein, S., Zolty, R., Eisen, A., Sawyer, D.B., Caggiano, A.O. A Phase I, single ascending dose study of cimaglermin alfa (Neuregulin 1β3) in patients with systolic dysfunction and heart failure (2016) JACC: Basic to Translational Science, 1 (7), pp. 576-86.
9. Armenian SH, Lacchetti C, Barac A, Carver J, Constine LS, Denduluri N, Dent S, Douglas PS, Durand JB, Ewer M, Fabian C, Hudson M. Jessup M, Jones LW, Ky B, Mayer EL, Moslehi J, Oeffinger K, Ray K, Ruddy K, Lenihan D. Prevention and monitoring of cardiac dysfunction in survivors of adult cancers: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol 2017; 35(8):893-911. PMID:27918725.
Key words: cardio-oncology, biomarkers, amyloidosis, heart failure, practice improvement
53
Kathryn Lindley, MD
Associate Professor of Medicine and Obstetrics and Gynecology
Current Research Interests
Women's Heart Disease
Heart Disease in Pregnancy
Peripartum cardiomyopathy
Cardiovascular sequelae of pre-eclampsia
Spontaneous Coronary Artery Dissection
Representative Publications 1. Arendt KW, Lindley KJ. Obstetric anesthesia management of the patient with cardiac disease. Int J
Obstet Anesth. 2019 Feb;37:73-85.
2. Lindley KJ, Verma AK, Blauwet LA. Peripartum cardiomyopathy: Progress in understanding the
etiology, management, and prognosis. Heart Fail Clin. 2019;15(1):29-39.
3. Volgman AS, Vairey Merz CN, Benjamin EJ, Curtis AB, Fang MC, Lindley KJ, Pepine CJ, Vaseghi M,
Waldo AL, Wenger NK, Russo AM. Sex and race/ethnicity differences in atrial fibrillation. JACC 2019;
74(22):2812-5.
4. Rosenbloom JI, Lewkowitz AK, Lindley KJ, Nelson DM, Macones GA, Cahill AG, Olsen MA, Stout MJ.
Expectant management of hypertensive disorders of pregnancy and future cardiovascular morbidity.
Obstet Gynecol 2020 Jan;135(1):27-35.
5. Verma AK, Williams D, Nelson DM, Rathor R, Benhardt A, Chakinala M, Moon M, Kotkar K, Pepine CJ,
Lindley KJ, on behalf of the ACC Cardiovascular Disease in Women Committee. A Cardio-Obstetric
approach to management of the complex pregnant cardiac patient. JACC: Case Reports 2020;2:86-90.
6. Sharma G, Lindley K, Grodzinsky A. Cardio-Obstetrics: Developing a niche in maternal cardiovascular
health. JACC 2020 Mar 24;75(11):1355-9.
7. Pepine CJ, Merz CNB, El Hajj S, Ferdinand KC, Hamilton MA, Lindley KJ, Nelson MD, Quesada O,
Wenger NK, Fleg JL; American College of Cardiology Committee on Cardiovascular Disease in Women.
Heart failure with preserved ejection fraction: Similarities and differences between women and men.
Int J Cardiol. 2020 Apr 1;304:101-8.
8. Lindley KJ, Williams D, Conner SN, Verma A, Cahill AG, Davila-Roman VG. The spectrum of pregnancy-
associated heart failure phenotypes: An echocardiographic study. International Journal of
Cardiovascular Imaging. 2020 May 6. DOI: 10.1007/s10554-020-01866-w, in press.
9. Rosenbloom JI, Stwalley D, Lindley KJ, Michael Nelson D, Olsen MA, Stout MJ. Latency of preterm
hypertensive disorders of pregnancy and subsequent cardiovascular complications. Pregnancy
Hyertens. 2020 May 31;21:139-44.
10. Cho L, Davis M, Elgendy I, Epps K, Lindley KJ, Mehta PK, Michos ED, Minissian M, Pepine C, Vaccarino
V, Volgman AS; ACC CVD Womens Committee Members. Summary of updated recommendations for
primary prevention of cardiovascular disease in women: JACC State-of-the-Art Review. JACC 2020 May
26;75(20):2602-18.
Key words: women and minorities, pregnancy, cardiomyopathy, preeclampsia, cardioobstetrics
54
Thomas M. Maddox, MD, MSc
Professor of Medicine Director, Health Systems Innovation Lab, Washington University School of Medicine/BJC Healthcare
Current Research Interests
Healthcare delivery innovation
Cardiac and general health services research
Cardiac and general quality of care and outcomes research
Representative Publications: 1. Rumsfeld JR, Joynt KE, Maddox TM. Big Data Analytics To improve cardiovascular quality and
outcomes of care: Promise and challenges. Nature Reviews Cardiology. 2016 Jun; 13(6):350-9. 2. Maddox TM, Albert NM, Borden WB, Curtis LH, Ferguson TB, Kao DP, Marcus GM, Peterson ED,
Redberg R, Rumsfeld JS, Shah ND, Tcheng JE, and On behalf of the American Heart Association Council on Quality of Care and Outcomes Research; Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; Council on Functional Genomics and Translational Biology; and Stroke Council. The Learning Healthcare System and Cardiovascular Care: A scientific statement from the American Heart Association. Circulation. Circulation. 2017 Apr 4; 135(14):e826-e857.
3. Bhavnani SP, Parakh K, Atreja A, Druz R, Graham GN, Hayek SS, Krumholz HM, Maddox TM, Majmudar MD, Rumsfeld JS, Shah BR. 2017 Roadmap for innovation-ACC health policy statement on healthcare transformation in the era of digital health, big data, and precision health: A report of the American College of Cardiology Task Force on health policy statements and systems of care. J Am Coll Cardiol. 2017 Nov 28;70(21):2696-718.
4. Maddox TM, Macgibbon S. Tech and healthcare need their own “Hippocratic Oath”. Stat News First Opinion, Dec 2019.
5. Maddox TM, Song Y, Allen J, Chan PS, Khan A, Lee JJ, Mitchell J, Oetgen WJ, Ponirakis A, Segawa C, Spertus JA, Thorpe F, Virani SS, Masoudi FA. Trends in U.S. Ambulatory Cardiovascular Care 2013 to 2017: JACC Review Topic of the Week. J Am Coll Cardiol. 2020 Jan 7;75(1):93-112.
6. Amin AP, Spertus JA, Kulkarni H, McNeely C, Rao SV, Pinto D, House JA, Messenger JC, Bach RG, Goyal A, Shroff A, Pancholy S, Bradley SM, Gluckman TJ, Maddox TM, Wasfy JH, Masoudi FA. Improving care pathways for acute coronary syndrome: Patients undergoing percutaneous coronary intervention. Am J Cardiol. 2020 Feb 1;125(3):354-61.
7. Faridi KF, Garratt KN, Kennedy KF, Maddox TM, Secemsky EA, Butala NM, Yeh RW. Physician and hospital utilization of P2Y12 inhibitors in ST-Segment-Elevation myocardial infarction in the United States: A study from the National Cardiovascular Data Registry's Research to practice initiative. Circ Cardiovasc Qual Outcomes. 2020 Mar;13(3):e006275.
8. Yen PY, Pearl N, Jethro C, Cooney E, McNeil B, Chen L, Lopetegui M, Maddox TM, Schallom M. Nurses' stress associated with nursing activities and electronic health records: Data triangulation from continuous stress monitoring, perceived workload, and a time motion study. AMIA Annu Symp Proc. 2020 Mar 4;2019:952-61.
9. Bavishi C, Maddox TM, Messerli FH. Coronavirus disease 2019 (COVID-19) infection and renin angiotensin system blockers. JAMA Cardiol. 2020 Apr 3, in press.
Key words: healthcare innovation, health services research, quality of care, outcomes research
55
Majesh Makan, MD
Professor of Medicine
Current Research Interests:
3-dimensional echo and transesophageal echo
Echocardiographic assessment of right ventricular function
2-dimensional speckle Doppler and strain rate imaging
Quantification of mitral regurgitation severity
Representative Publications: 1. Rasalingam R, Johnson SN, Bilhorn KR, Huang PH, Makan M, Moazami N, Pérez JE: Transthoracic
echocardiographic assessment of continuous-flow left ventricular assist devices. Review Paper, J Am Soc Echocardiogr 2011; 24:2,135-48.
2. Ren J, Rich MW, Makan M: Right ventricular outflow tract obstruction by lymphoma: Case series and review of the literature. Echocardiography 2011; (10): 1164-7.
3. Sadhu J, Makan M, Rich MW: Prognostic utility of left atrial volume index in older patients with heart failure and moderate or severe mitral regurgitation. Presented as a poster abstract at Annual Scientific meeting of HFSA, September 2011.
4. Rasalingam R (Editor), Makan M, Pérez JE (Associate Editors): The Washington Manual of Echocardiography. Lippincott Williams and Wilkins, Wolters Kluwer, 2012.
5. Makan M, Johnson SN: The Role of Contrast Echocardiography. IN: The Washington Manual of Echocardiography. Edited by Rasalingam R, Makan M and Pérez JE. Lippincott Williams and Wilkins, Wolters Kluwer, pp. 31-41, 2012.
6. Manzanal A, Ruiz L, Madrazo J, Makan M, Pérez JE: Fundamental role of echocardiography in the diagnosis of inverted Tako-Tsubo cardiomyopathy. Texas Heart Inst J 2013; 40:1,56-9.
7. Saghir M, Makan M: Echocardiography. IN: The Washington Manual: The Cardiology Subspecialty Consult Series. Third Edition. Edited by Cuculich PS and Kates AM. Lippincott Williams and Wilkins, Wolters Kluwer, pp. 381-8, 2014.
8. Quader N (Editor), Makan M, Pérez JE (Associate Editors): The Washington Manual of Echocardiography. 2nd Edition, Lippincott Williams and Wilkins, Wolters Kluwer, 2016.
9. Makan M: The Role of Contrast Echocardiography. IN: The Washington Manual of Echocardiography. 2nd Edition. Edited by Quader N, Makan M and Pérez JE. Lippincott Williams and Wilkins, Wolters Kluwer, pp. 31-41, 2016.
10. Tyson T, Lindley K, Makan M: Congenital Heart Disease. IN: The Washington Manual of Echocardiography, 2nd Edition. Edited by Quader N, Makan M and Perez JE. pp. 242-268, 2016.
11. Adamo L, Perry A, Novak E, Makan M, Lindman BR, Mann DL. Abnormal global longitudinal strain predicts future deterioration of left ventricular function in heart failure patients with a recovered left ventricular ejection fraction. Circ Heart Fail. 2017 Jun; 10(6): pii: e003788. PMID 28559418.
Key Words: echocardiography, imaging, valvular heart disease
56
Douglas L. Mann, MD
Lewin Distinguished Professor of Medicine, Cell Biology and Physiology
Current Research Interests
Cardiac inflammation and innate immunity
LV remodeling and reverse LV remodeling
Heart failure, clinical trials, and circulatory assist devices
Translational research (T1 or T2)
Representative Publications
1. Epelman S, Lavine KJ, Beudin A, Sojka DK, Brija T, Carrero JA, Calderon B, Gautier EL, Ivanov S, Satpahy AT, Schwendener R, Schilling JD, Forsberg S, Yokoyama, Unanue, ER, Colonna M, Randolph GJ, Mann DL. Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during Inflammation. Immunity 2014; 40: 91-104. PMID:24439267 NIHMSID # 551984.
2. Lavine KJ, Epelman S, Uchida K, Weber KJ, Nichols CG, Schilling JD, Ornitz DM, Randolph GJ, Mann DL: Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart. Proc Natl Acad Sci U S A 2014; 111:16029-34. PMID:25349429 PMCID:PMC423456.
3. Anker SD, Coats AJ, Cristian G, Dragomir D, Pusineri E, Piredda M, Bettari L, Dowling R, Volterrani M,
Kirwan BA, Filippatos G, Mas JL, Danchin N, Solomon SD, Lee RJ, Ahmann F, Hinson A, Sabbah HN,
Mann DL. A prospective comparison of alginate-hydrogel with standard medical therapy to
determine impact on functional capacity and clinical outcomes in patients with advanced heart
failure (AUGMENT-HF trial). Eur Heart J 2015; 36:2297-309. PMID: 26082085 PMCID:PMC4561351.
4. Topkara VK, Chambers KT, Yang KC, Tzeng KP, Evans S, Weinheimer C, Kovacs A, Robbins J, Barger
P, Mann DL. Functional significance of the discordance between transcriptional profile and left
ventricular structure/function during reverse remodeling. JCI Insight 2016; 1:e86038. NIHMSID
777086.
5. Gold MR, Van Veldhuisen DJ, Hauptman PJ, Borggrefe M, Kubo SH, Lieberman RA, Milasinovic G,
Berman BJ, Djordjevic S, Neelagaru S, Schwartz PJ, Starling RC, Mann DL. Vagus nerve stimulation
for the treatment of heart failure: The INOVATE-HF Trial. J Am Coll Cardiol 2016; 68: 149-60.
6. Hartupee J, Mann DL. Neurohormonal activation in heart failure with reduced ejection fraction. Nat
Rev Cardiol 2017;14:30-8. PMCID: PMC5286912.
7. Adamo L, Staloch LJ, Rocha-Resende C, Matkovich SJ, Jiang W, Bajpai G, Weinheimer CJ, Kovacs A,
Schilling JD, Barger PM, Bhattacharya D, Mann DL. Modulation of subsets of cardiac B lymphocytes
improves cardiac function after acute injury. JCI Insight. 2018;3(11):e120137. pii: 120137 doi:
10.1172.
Key words: basic science, heart failure, translational research
57
Joshua D. Mitchell, MD
Assistant Professor of Medicine Current Research Interests
Use of administrative data, EMR, and meta-analyses to answer relevant clinical questions
Early phase clinical trials in cardiotoxicity and amyloidosis
Early detection of cardiotoxicity during cancer therapy using biomarkers, echo or MRI strain
or other novel imaging techniques.
Optimal prevention and treatment of cardiotoxicity in patients with cancer
Improving the diagnosis and management of cardiac amyloidosis
Representative Publications 1. Gupta S*, Mitchell JD*, Lavingia B, Ewing GE, Feliciano N, Kaiser PA, Ring WS, Stastny P, Patel PC,
Markham DW, Mammen PA, Dimaio JM, Drazner, MH. Utility of routine immunofluorescence staining for C4d in cardiac transplant recipients. J Heart Lung Transplant. 2009 Aug; 28(8):776-80. PMID: 19632572. *equal contribution
2. Sasaki H*, Mitchell JD*, Jessen ME, Lavingia B, Kaiser PA, Comeaux A, DiMaio JM, Meyer DM. Bridge to heart transplantation with left ventricular assist device versus inotropic agents in status 1 patients. Journal of Cardiac Surgery. 2009 Nov-Dec; 24(6):756-62. PMID: 19754680. *equal contribution
3. Hulten E, Mitchell J, Scally J, Gibbs B, Villines TC. HIV positivity, protease inhibitor exposure, and subclinical atherosclerosis: A systematic review and meta-analysis of observational studies. Heart. 2009 Nov;95(22):1826-35. PMID: 19632982.
4. Hulten E, Carbonaro S, Petrillo S, Mitchell J, Villines T. Prognostic value of cardiac CT angiography: A systematic review and meta-analysis. J Am Coll Cardiol. 2011; 57(10):1237-47. PMID: 21145688
5. Mitchell JD, Collen JF, Petteys S, Holley AB. A simple reminder system improves venous thromboembolism prophylaxis rates and reduces thrombotic events for hospitalized patients. J Thromb Haemost. 2012 Feb; 10(2):236-43. PMID: 22188121.
6. Holley AB, Petteys S, Mitchell JD, Holley PR, Collen JF. Thromboprophylaxis and VTE rates in soldiers wounded in Operation Enduring Freedom and Operation Iraqi Freedom. Chest. 2013 Sep;144(3):966-73. PMID: 23539197.
7. Holley AB, Petteys S, Mitchell JD, Holley PR, Hostler JM, Clark P, Collen JF. Venous thromboembolism prophylaxis for patients receiving regional anesthesia following injury in Iraq and Afghanistan. J Trauma Acute Care Surg. 2014 Jan;76(1):152-9. PMID: 24368371.
8. Mitchell JD, Paisley R, Moon P, Novak E, Villines TC. Coronary artery calcium and long-term risk of death, myocardial infarction and stroke: The Walter Reed Cohort Study. JACC: Cardiovascular Imaging. 2018 Dec; 11(2):1799-806. pii: S1936-878X(17)30891-4. doi: 10.1016/j.jcmg.2017. 09.003. PMID: 29153576
9. Mitchell JD, Fergestrom N, Gage BF, Paisley R, Moon P, Novak E, et al. Impact of statins on cardiovascular outcomes following coronary artery calcium scoring. J Am Coll Cardiol. 2018 Dec
25;72(25):3233-42. doi: 10.1016/j.jacc.2018.09.051. PMID: 30409567; PMCID: PMC6309473
Key words: Amyloid, biomarkers, cardio-oncology, imaging, screening, big data
58
Jonathan D. Moreno, MD, PhD
Instructor of Medicine
Current research interests
Multiscale computational models to understand mechanisms of arrhythmia in cardiomyopathy, heart failure, and inherited arrhythmia syndromes
Hypertrophic cardiomyopathy
Computational cellular electrophysiology
3D ventricular models
Drug repositioning strategies
Translational research on cardiac transplant and LVAD patients
Recent publications
1. Raymer, DS*; Moreno, JD*; Sintek, MA; Nassif, ME; Sparrow, CT; Adamo, L; Novak, EL; LaRue, SJ; Vader, JM. The combination of TAPSE and HeartMate risk score to predict right ventricular failure after LVAD: Noninvasive testing is superior to invasive hemodynamic measurements. ASAIO Journal, 2019;65(3):247-51. *Co-first authorship
2. Moreno, JD; Brown, DL. Chapter 18: Right Ventricular Infarction. Cardiac Intensive Care, 3rd Edition. Elsevier Press.
3. Zhu, W; Mazzanti, A; Voelker, TL; Hou, P; Moreno, JD; Naegle, KM; Priori, SG. Silva, JR. Predicting patient response to the antiarrhythmic mexiletine based on genetic variation: personalized medicine for long QT syndrome. Circulation Research 2019; 124:539-52.
4. Moreno, JD; Zhu, W; Mangold, K; Chung, W; Silva, JR. A computational model of the DIII voltage sensor regulation of NaV1.5 reveals a new class I antiarrhythmic target. JACC Basic Transl Sci. 2019 Oct 28;4(6):736-51.
5. Moreno, JD; Lavine, KJ. Advanced heart failure therapies: LVAD and orthotopic heart transplant (book chapter). The Washington Manual Cardiology Subspecialty Consult Series. 3rd Edition. Manuscript accepted.
6. Ransdell, JL*; Moreno, JD*; Silva, JR; Nerbonne, JM. A novel, “blocking-particle independent” mechanism of the resurgent Na+ current in cerebellar Purkinje neurons: a combined experimental and simulation study. Manuscript in preparation.*Co-first authorship
7. Moreno, JD; Verma, AM; Kopecky, BJ; Dehner, C; Kostelecky, N; Lavine, KM; Vader, JM; Lin, CY; Schilling, JD. Angiotensin II type 1 receptor antibody mediated rejection following orthoptic heart transplant: a single center experience. Manuscript in revision.
8. Moreno, JD; Kang, PW; Silva, JR. Chapter 19: Connecting cardiac excitation to the atomic interactions of ion channels. Cardiac Electrophysiology: From cell to bedside, 8th edition. Manuscript submitted.
Keywords: Hypertrophic cardiomyopathy; mathematical modeling; ion channels; arrhythmias; basic science; electrophysiology; heart failure; heart transplantation; LVAD; precision medicine; translational research.
59
Jeanne M. Nerbonne, Ph.D.
Professor of Medicine, Alumni Endowed Professor of Molecular Biology and Pharmacology in Developmental Biology and Medicine Director, Center for Cardiovascular Research
Current Research Interests • Molecular determinants of voltage-gated ion channel diversity, expression, distribution and
functioning in cardiac and neuronal cells • Inherited and acquired membrane excitability disorders in the cardiovascular and nervous
systems • Ion channels in the regulation of circadian rhythms • Molecular mechanisms contributing to electrical remodeling in physiological and pathological
cardiac hypertrophy
Representative Publications 1. Yang, K.-C., and Nerbonne, J.M. Mechanisms contributing to myocardial potassium diversity,
regulation and remodeling. Trends in Cardiovascular Medicine 2016; 26: 209-18. 2. Hueneke, R., Adenwala, A., Mellor, R., Seidman, J.G., Seidman, C.E., and Nerbonne, J.M. Early
remodeling of repolarizing K+ currents in the αMHC403/+ mouse model of hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology 2017; 103: 93-101.
3. Ransdell, J.L., Dranoff, E., Lau, B., Lo, W.-L., Donermeyer, D.L., Allen, P.M., and Nerbonne, J.M. Loss
of Nav4-mediated regulation of sodium currents in Purkinje neurons disrupts firing and impairs motor coordination and balance. Cell Reports 2017; 19: 532-44.
4. Hermanstyne, T.D., Granados-Fuentos, D., Mellor, R., Herzog, E.D., and Nerbonne, J.M. Acute in vivo “knockdown” of Kv4.1 modulates neuronal firing rates and clock gene expression in the suprachiasmatic nucleus and disrupts circadian rhythms in behavior. eNeuro 2017; 4: pii: eNeuro.0377-16.2017.
5. Chaimvimonvat, N., Chen-Izu, Y., Clancy, C.E., Deschenes, I., Dobrev, D., Heijman, J., Izu, L., Qu, Z., Ripplinger, C.M., Vandenberg, J.I., Weiss, J.N., Koren, G., Banyasz, T., Grandi, E., Sanguinetti, M.C., Bers, D.M., and Nerbonne, J.M. Potassium currents in the heart: Functional roles in repolarization, arrhythmia and therapeutics. Journal of Physiology 2017; 595: 2229-52.
6. Johnson E.K., Springer S.J., Wang W., Dranoff E.J., Zhang Y., Kanter E.M., Yamada K.A., Nerbonne J.M. Differential expression and remodeling of transient outward potassium currents in human left ventricles. Circulation: Arrhythmia and Electrophysiology 2018; 11: e005914. doi: 10.1161/CIRCEP.117.005914.
7. Shih Y.C., Chen C.L., Zhang Y., Mellor R.L., Kanter E.M., Fang Y., Wang H.C., Hung C.T., Nong J.Y., Chen H.J., Lee T.H., Tseng Y.S., Chen C.N., Wu C.C., Lin S.L., Yamada K.A., Nerbonne J.M., Yang K.C. Endoplasmic reticulum protein TXNDC5 augments myocardial fibrosis by facilitation extracellular matrix protein folding and redox-sensitive cardiac fibroblast activation. Circ Res 2018; 122:1052-68.
8. Johnson, E.K., Matkovich, S.J., and Nerbonne, J.M. Regional Differences in mRNA and lncRNA Expression Profiles in Non-Failing Human Atria and Ventricles. Scientific Reports 2018; 13919 doi: 10.10.1038/s41598-018-32154-2.
Key words: Ion channels, electrophysiology, molecular genetics, proteomics, arrhythmias, hypertrophy, remodeling
60
Colin G. Nichols, PhD
Carl Cori Professor of Cell Biology and Physiology Director of the Center for the Investigation of Membrane Excitability Diseases
Current Research Interests
Ion channels and cardiac arrhythmias
ion channels and cardiovascular disease
Ion channels and blood pressure control
Representative Publications
1. Nichols CG et al. KATP channels and cardiovascular disease: suddenly a syndrome. Circ Res. 2013 Mar 29;112(7):1059-72.
2. Shelton EL et al. Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins. Semin Perinatol. 2018;42(4):221-7. pii: S0146-0005(18)30028-4. doi: 10.1053/j.semperi.2018.05.004.
3. Bohnen MS et al. Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension. Circ Genom Precis Med. 2018;11:e002087. doi: 10.1161/CIRCGEN.118.002087.
4. Huang Y et al. Cardiovascular consequences of KATP overactivity in Cantu syndrome. JCI Insight. 2018 Aug 9;3(15):e121153. pii: 121153. doi: 10.1172/jci.insight.121153.
5. Smeland MF et al. ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9. Nat Commun. 2019;10:4457.
6. Ma A et al. Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain-of-function variant: Initial experience. Am J Med Genet A. 2019;179:1585-90.
7. McClenaghan C et al. Pulmonary Hypertension and ATP-Sensitive Potassium Channels. Hypertension 2019;74:14-22.
8. Grange DK et al. Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry. Am J Med Genet C Semin Med Genet. 2019;181:658-81.
9. McClenaghan C et al. Glibenclamide reverses cardiovascular abnormalities of Cantu Syndrome driven by KATP channel overactivity. J Clin Invest. 2020;130(3):116-21. pii: 130571. doi: 10.1172/JCI130571.
10. Davis MJ et al. Kir6.1-dependent KATP channels in lymphatic smooth muscle and vessel dysfunction in mice with Kir6.1 gain-of-function. J Physiol. 2020 May 5. doi: 10.1113/JP279612. Online ahead of print. PMID: 32372450.
Key words: arrhythmias, basic science, cardiac development, vascular biology, electrophysiology,
hypertension, iPSC-cardiac myocytes, iPSC-vascular myocytes, mice, zebrafish, ion channels
61
Julio E. Pérez, MD
Professor of Medicine
Current Research Interests
Echocardiographic assessment of ventricular function
Applications of contrast echocardiography and myocardial perfusion imaging
Applications of myocardial strain measurements
Representative Publications
1. Boyer JK, Thanigaraj S, Schechtman K, Pérez JE: Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus. Am J Cardiol 2004; 93:870-5.
2. Zajarias A, Thanigaraj S, Lasala J, Pérez, JE: Predictors and clinical outcomes of residual shunt in patients undergoing percutaneous transcatheter closure of patent foramen ovale. J Invasive Cardiol 2006; 18;533-7.
3. Mulvagh SL, Rakowski H, Vannan MA, Abdelmoneim SS, Becher H, Bierig SM, Burns PN, Castello R, Coon PD, Hagen ME, Jollis JG, Kimball TR, Kitzman DW, Kronzon I, Labovitz AJ, Lang RM, Mathew J, Moir WS, Nagueh SF, Pearlman AS, Pérez JE, Porter TR, Rosenbloom J, Strachan GM, Thanigaraj S, Wei K, Woo A, Yu EH, Zoghbi WA: American Society of Echocardiography Consesus Statement on the Clinical Applications of Ultrasonic Contrast Agents in Echocardiography. J Am Soc Echocardiogr 2008; 21:1179-201.
4. Vargas-Barrón J, Roldán FJ, Romero-Cárdenas A, Molina-Carrión M, Vázquez-Antona CA, Zabalgoitia M, Martínez Rios MA, Pérez JE: Dissecting intramyocardial hematoma: Clinical presentation, pathophysiology, outcomes and delineation by echocardiography. Echocardiography 2009; 26:254-61.
5. Lindman BR, Arnold SV, Madrazo JA, Zajarias A, Johnson SN, Pérez JE, Mann DL: The adverse impact of diabetes mellitus on left ventricular remodeling and function in patients with severe aortic stenosis. Circ Heart Fail 2011; 4:286-92.
6. Rasalingam R, Johnson SN, Bilhorn KR, Huang PH, Makan M, Moazami N, Pérez JE: Transthoracic echocardiographic assessment of continuous-flow left ventricular assist devices. J Am Soc Echocardiogr 2011; 24(2):135-48.
7. Rasalingam R (Editor), Makan M, Pérez JE (Associate Editors): The Washington Manual of Echocardiography. Lippincott Williams and Wilkins, Wolters Kluwer, 2012.
8. Manzanal A, Ruiz L, Madrazo J, Makan M, Pérez JE: Inverted Takotsubo Cardiomyopathy and the Fundamental Diagnostic Role of Echocardiography. Tex Heart Inst J 2013; 40(1):56-9.
9. Quader N (Editor), Makan M, Pérez JE (Associate Editors): The Washington Manual of Echocardiography. 2nd Edition, Lippincott Williams and Wilkins, Wolters Kluwer, 2016.
Key words: echocardiography, imaging
62
Linda R. Peterson, MD
Professor of Medicine and Radiology
Current Research Interests
Nutritional treatments for impaired myocardial and skeletal muscle function
Lipidomics Effects of obesity and diabetes on cardiac metabolism, structure, and function
Metabolic therapy for cardiac disease and for cancer
Representative Publications
1. Coggan AR, Leibowitz JL, Anderson Spearie C, Kadkhodayan A, Thomas DP, Ramamurthy S, Mahmood K, Park S, Waller S, Farmer M, Peterson LR. Acute dietary nitrate intake improves muscle contractile function in patients with heart failure: A double-blind, placebo-controlled, randomized trial. Circ Heart Fail 2015; 8:914-20.
2. Airhart S, Cade WT, Jiang H, Coggan AR, Racette SL, Anderson Spearie C, Waller S, O'Connor R, Bashir A, Ory D, Schaffer JE, Novak E, Farmer M, Korenblat K, McGill JB, Davila-Roman VG, Leibowitz JL, Javidan-Nejad C, Peterson LR. A diet rich in medium-chain fatty acids improves systolic function and alters the lipidomic profile in patients with type 2 diabetes. J Clin Endocrinol Metab 2016; 101(2):504-12. (http://press.endocrine.org/ doi /10.1210 •jc.2015-3292).
3. Coggan AR, Broadstreet SR, Mahmood K, Mikhalkova D, Madigan M, Bole I, Park S, Leibowitz J, Kadkhodayan A, Thomas D, Thies D, Peterson LR. Dietary nitrate increases V02 peak and performance but does not alter ventilation or efficiency in patients with heart failure with reduced ejection fraction. J Card Fail 2018; 24(2): 65-73. http://www.onlinejcf.com/article/ S1071-9164 (17) 31188-0/pdf PMCID: PMC5811385
4. Peterson LR, Xanthakis V, Stevenson M, Jiang H, Jiang X, Ory DS, Dorr M, Ramachandran SV, Schaffer JE. Ceramide remodeling and risk of cardiovascular events and mortality. J Am Heart Assoc 2018 May 3; 7(10). pii: e007931. PMID 29728014
5. Nwabuo C, Duncan M, Xanthakis V, Peterson LR, Mitchell GF, McManus D, Cheng S, Vasan RS. Association of circulating ceramides with cardiac structure and function in the general population: The Framingham Heart Study. JAHA 2019; 8 (19), e013050. PMID: 31549564
6. Peterson LR, Jiang X, Chen L, Goldberg AC, Farmer MS, Ory DS, Schaffer JE. Alterations in plasma triglycerides and ceramides: Links with cardiac function in humans with type 2 diabetes. J Lipid Res 2020 61:(7) 1065-74. First Published on May 11, 2020, doi:10.1194/jlr.RA120000669
Key words: cardiac metabolism, inorganic nitrate, lipidomics, diabetes, obesity, skeletal and cardiac
muscle performance, heart failure, cancer, positron emission tomography, magnetic resonance
spectroscopy
63
Nishath Quader, MD
Assistant Professor of Medicine
Current Research Interests
Valvular heart disease: Aortic valve, Mitral valve, Tricuspid valve
Structural heart disease
3D echocardiography
Echocardiographic assessment of left and right ventricular function and strain analysis
Representative Publications
1. Quader N, Jalal U, Raslan S, Srivathsan K, Wilansky S, Unzek S, Chandrasekran K, Mookadam F. Worsening left ventricular apical peak strain early after right ventricular pacing. Ultrasound Med Biol. 2013 Feb; 39(2): 261-8.
2. Quader N, Katta P, Najib M, Chaliki H. Effect of mitral inflow pattern on diagnosis of severe mitral regurgitation in patients with chronic organic mitral regurgitation. J Cardiovascular Ultrasound 2013; 21 (4): 65-70.
3. Quader N, Rigolin VH. Two and three-dimensional echocardiography for pre-operative assessment of mitral valve regurgitation. Cardiovascular Ultrasound 2014 Oct 25; 12: 42.
4. Quader N, Davidson CD, Rigolin V. Percutaneous closure of perivalvular mitral prosthetic leak closures: How should interventionalists and the echocardiographers communicate. Journal of the American Society of Echocardiography. 2015; 28(5):497-508.
5. Quader N, Wilansky S. “Women and Coronary Artery Disease”. Coronary Artery Disease. Ed. Willerson JT, Holmes DR. 2015; 167-80.
6. Quader N, McGee E, Rigolin V. Intraoperative Echocardiography in Infective Endocarditis. ASE Comprehensive Echocardiography. 2nd Edition.
7. Quader N, Chaliki H. Visual assessment of severity of aortic valve stenosis and valve calcification on 2D echocardiography compared to hemodynamic evaluations and CT derived aortic valve calcium scores. In press.
Key words: valvular and structural heart disease, 3D echocardiography
64
Babak Razani, MD, PhD
Associate Professor of Medicine and Pathology/Immunology
Current Research Interests
Mechanisms of atherosclerosis and risk factors for cardiovascular disease (particularly obesity and insulin resistance) - emphasis on the role of macrophages
Focus on emerging cellular pathways critical for cardiometabolic disease and atherosclerotic progression
-dysfunction in autophagy -lysosomal dysfunction -activation of inflammasomes -inclusion body formation
Disorders of cardiac metabolism in heart failure (with emphasis on De novo Lipogenesis)
Novel therapeutics in cardiovascular disease (emphasis on nanoparticles)
Representative Publications 1. Sergin I, Evans TD, and Razani B. Degradation and beyond: The macrophage lysosome as a nexus
for nutrient sensing and processing in atherosclerosis. Curr Opin Lipidol. 2015; 26:394-404. 2. Block RC and Razani B. Options to consider when treating Lysosomal Acid Lipase deficiency. J
Clin Lipidol. 2016; 10:1280-1. 3. Sergin I, Bhattacharya S, Emanuel R, Esen E, Stokes CJ, Evans TD, Arif B, Curci JA, and Razani B.
Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis. Science Signaling. 2016; 9:ra2.
4. Evans TD, Sergin I, Zhang X, and Razani B. Modulating oxysterol sensing to control macrophage apoptosis and atherosclerosis. Circulation Research. 2016; 119:1258-61.
5. Leng S, Iwanowycz S, Saaoud F, Wang J, Wang Y, Sergin I, Razani B, and Fan D. Ursolic acid enhances macrophage autophagy and attenuates atherosclerosis. J Lipid Res. 2016; 57:1006-16.
6. Evans TD, Sergin I, Zhang X, and Razani B. Target Acquired: Selective autophagy in cardiometabolic disease. Science Signaling. 2017; 10: eaag2298.
7. Block RC and Razani B. Linking lysosomal acid lipase insufficiency to the development of cryptogenic cirrhosis. Atherosclerosis. 2017; 262:140-2.
8. Sergin I, Bhattacharya S, Evans TD, Zhang X, Stokes CJ, Holloway KB, Micevych PS, Javaheri A, Crowley JR, Ballabio A, Schilling JD, Epelman S, Weihl CC, Diwan A, Fan D, Zayed MA, and Razani B. Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nature Communications. 2017; 8:15750.
Key words: atherosclerosis, cardiac metabolism, insulin resistance, macrophage, autophagy, lysosomes, basic science, translational research, lipid metabolism, obesity, vascular biology
65
Stacey L. Rentschler, MD, PhD
Associate Professor of Medicine, Developmental Biology, and Biomedical Engineering
Current Research Interests
Transcriptional and epigenetic basis of arrhythmias
Development of the cardiac conduction system
Reprogramming cardiomyocytes to pacemaker-like cells
Notch and Wnt signaling
Human organotypic slice culture as a translational platform
Effects of cardiac irradiation on electrophysiology
Representative publications
1. Rentschler S, Vaidya DM, Tamaddon H, Degenhardt K, Sassoon D, Morley GE, Jalife J, Fishman GI. Visualization and functional characterization of the developing murine cardiac conduction system. Development 2001; 128:1785-92.
2. Rentschler S, Zander J, Burns K, France D, Levine R, Porter G, Rivkees SA, Morley GE, Fishman GI. Neuregulin-1 promotes formation of the murine cardiac conduction system. PNAS 2002; 99:10464-9.
3. Rentschler S, Harris BS, Kuznekoff L, Jain R, Manderfield L, Lu M, Morley GE, Patel VV, Epstein JA. Notch signaling regulates murine atrioventricular conduction and formation of accessory pathways. JCI, 2011; 121(2):525-33.
4. Rentschler S*, Yen AH, Lu J, Petrenko NB, Lu MM, Manderfield, LJ, Patel VV, Fishman GI, Epstein JA. Myocardial notch signaling reprograms cardiomyocytes to a conduction-like phenotype. Circulation, 2012; 126(9):1058-66. *corresponding author
5. Gillers B, Aly H, Chiplunkar A, Valenta T, Basler K, Efimov I, Boukens B, Rentschler S. Canonical Wnt signaling regulates atrioventricular junction programming and electrophysiological properties. Circulation Research, 2015; 116(3):398-406.
6. Meyers, JD, Jay, PY, Rentschler, S. Reprogramming the conduction system: Onward toward a biological pacemaker. Trends in Cardiovascular Medicine. 2016; 26(1):14-20.
7. Kang C, Qiao Y, Li G, Baechle K, Camellitti P, Rentschler S, Efimov IR. Human organotypic cultured cardiac slices: New platform for high throughput preclinical human trials. Scientific Reports, 2016; 6:28798.
8. Khandekar A*, Springer S*, Wang W, Hicks S, Weinheimer C, Diaz-Trelles R, Nerbonne JM, Rentschler S. Notch-mediated epigenetic regulation of voltage-gated potassium currents. Circulation Research, 2016; 119(12):1324-38.
9. Qiao Y*, Lipovsky C*, Hicks S, Bhatnagar S, Li G, Khandekar A, Guzy R, Woo KV, Nichols CG, Efimov IR, Rentschler S. Transient notch activation induces long-term gene expression changes leading to sick sinus syndrome in mice. Circulation Research 2017; 121(5):549-63.
Key words: basic science, cardiac development, molecular cardiology, electrophysiology, arrhythmias, conduction system, reprogramming, epigenetics, translational research
66
Michael W. Rich, MD
Professor of Medicine
Current Research Interests
Cardiovascular disease in older adults, esp. heart failure, atrial fibrillation, coronary artery
disease, valvular heart disease, hypertension, epidemiology, and prevention
Cardiovascular aging, including interventions designed to slow the aging process
Heart failure disease management
Representative Publications 1. Forman DE, Rich MW, Alexander KP, et al. Cardiac care for older adults: time for a new paradigm. J Am
Coll Cardiol 2011; 57(18):1801-10. 2. Ades PA, Keteyian SJ, Balady GJ, Houston-Miller N, Kitzman DW, Mancini DM, Rich MW. Cardiac
rehabilitation exercise and self-care for chronic heart failure. J Am Coll Cardiol HF 2013; 1(6):540-7. 3. Whellan DJ, Goodlin SJ, Dickinson MG, Heidenreich PA, Jaenicke C, Gattis-Stough W, Rich MW. End-of-
life care in patients with heart failure. J Cardiac Failure 2014; 20:121-34. 4. Jurgens CY, Goodlin S, Dolansky M, Ahmed A, Fonarow GC, Boxer R, Arena R, Blank L, Buck HG, Cranmer
K, Fleg JL, Lampert RJ, Lennie TA, Lindenfeld J, Piña IL, Semla TP, Trebbien P, Rich MW. Heart failure management in skilled nursing facilities: a scientific statement from the American Heart Association and the Heart Failure Society of America. Circ Heart Fail 2015; 8(3):655-87.
5. Rich MW, Chyun DA, Skolnick AH, et al. Knowledge gaps in cardiovascular care of the older adult population. A Scientific Statement from the American Heart Association, American College of Cardiology, and American Geriatrics Society. J Am Coll Cardiol 2016; 67(20):2419-40 and Circulation 2016; 133(21):2103-22.
6. Forman DE, Maurer MS, Boyd C, Brindis R, Salive ME, McFarland-Horne F, Bell SP, Fulmer T, Reuben DB, Zieman Z, Rich MW. Multimorbidity in older adults with cardiovascular disease. J Am Coll Cardiol 2018;71(19):2149-61.
7. McCaw ZR, Orkaby AR, Wei LJ, Kim DH, Rich MW. Applying evidence-based medicine to shared decision making: value of restricted mean survival time. Am J Med 2019 Jan;132(1):13-5.
8. Schwartz JB, Schmader KE, Hanlon JT, Abernethy DR, Gray S, Dunbar-Jacob J, Holmes HM, Murray MD, Roberts R, Joyner M, Peterson J, Lindeman D, Tai-Seale M, Downey L, Rich MW. Pharmacotherapy in older adults with cardiovascular disease: report from an ACC, AGS, NIA workshop. J Am Geriatr Soc 2019;67(2):371-80. doi: 10.1111/jgs.15634.
9. Brouillard AM, Kraja AT, Rich MW. Trends in dietary sodium intake in the United States and the impact of USDA guidelines: NHANES 1999-2016. Am J Med 2019 May 16;. doi: 10.1016/j.amjmed.2019.04.040. [Epub ahead of print] PubMed PMID: 31103645.
10. Krishnaswami A, Steinman MA, Goyal P, Zullo AR, Anderson TS, Birtcher KK, Goodlin SJ, Maurer MS, Alexander KP, Rich MW, Tjia J. Deprescribing in older adults with cardiovascular disease. J Am Coll Cardiol 2019 May 28;73(20):2584-95. doi: 10.1016/j.jacc.2019.03.467. PubMed PMID: 31118153.
11. Forman DE, de Lemos JA, Shaw LJ, Reuben DB, Lyubarova R, Peterson ED, Spertus JA, Zieman S, Salive M, Rich MW. Cardiovascular biomarkers and imaging in older adults. J Am Coll Cardiol 2020 (in press).
Key words: aging, atrial fibrillation, epidemiology, heart failure, prevention
67
Yoram Rudy, PhD
Fred Saigh Distinguished Professor of Engineering; Professor of Biomedical Engineering, Medicine, Cell Biology & Physiology, Radiology, and Pediatrics Director, Cardiac Bioelectricity and Arrhythmia Center (CBAC) Current Research Interests
Mechanisms of cardiac arrhythmias
Noninvasive imaging (ECGI) of cardiac arrhythmias in patients
Representative Publications 1. O’Hara T.J., Virág L., Varró A., Rudy Y., Simulation of the undiseased human cardiac ventricular
action potential: Model formulation and experimental validation. PLoS Computational Biology 2011; 7(5): e1002061.doi:10.1371/ journal.pcbi.1002061
2. Wang Y., Cuculich P.S., Zhang J., Desouza K. A., Vijayakumar R., Chen J., Faddis M.N., Lindsay B.D., Smith T.W., Rudy Y., Noninvasive Electroanatomic Mapping of Human Ventricular Arrhythmias Using ECG Imaging (ECGI). Science Translational Medicine 2011 (31 August); Volume 3 (issue 98):191-200 (98ra84).
3. Rudy Y. Mathematical modeling of complex biological systems: From genes and molecules to organs and organisms: Heart. In: Edward H. Egelman, editor: Comprehensive Biophysics, Volume 9, Simulation and Modeling. Harel Weinstein volume editor. Oxford: Academic Press, 2012; pp. 268-327.
4. Rudy Y., Noninvasive electrocardiographic imaging of arrhythmogenic substrates in humans. Circulation Research, 2013; 112:863-74.
5. Vijayakumar R., Silva J., Desouza K., Abraham R., Strom M., Sacher F., Van Hare G.F., Haïssaguerre M., Roden D.M., Rudy Y. Electrophysiologic substrate in congenital long QT syndrome: Noninvasive mapping with electrocardiographic imaging (ECGI). Circulation 2014; 130:1936-43. PMID: 25294783; PMCID: PMC4245321
6. Zhang J., Sacher F., Hoffmayer K., O’Hara T., Strom M., Cuculich P., Silva J., Cooper D., Faddis M., Hocini M., Haissaguerre M., Scheinman M., Rudy Y. The cardiac electrophysiologic substrate underlying the ECG phenotype and electrogram abnormalities in Brugada Syndrome patients. Circulation 2015; 131:1950-9. PMID: 25810336.
7. Ramasubramanian S. and Rudy Y. The Structural Basis of IKs ion-channel activation: Mechanistic insights from molecular simulations. Biophysical Journal 2018 (June 5);114:2584–94.
8. Xu J. and Rudy Y. Effects of beta-subunit on gating of a potassium ion channel: Molecular simulations of cardiac IKs activation. J Mol Cell Cardiol (JMCC) 2018;124:35-44. https://doi.org/10.1016/j.yjmcc.2018.10.003
Key words: basic science, electrocardiography, electrophysiology
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Rajan Sah, MD, PhD
Associate Professor of Medicine, Cell Biology and Physiology
Current Research Interests • Ion channel regulation of cellular metabolism: adipocytes, islet cells, skeletal/cardiac muscle • Cardiometabolic disease • Mechanobiology, Mechano-signaling and Mechano-transduction • Small molecule modulators of systemic metabolism and glucose homeostasis Representative Publications 1. Sah R, Oudit GY, Lim HW, Wickenden AD, Wilson GJ, Molkentin JD, Backx PH. Inhibition of calcineurin
and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in Kv4.2N transgenic mice. Circulation 2002 Apr 16;105(15):1850-6.
2. Sah R, Ramirez RJ, Backx PH. Modulation of Ca2+ release in cardiac myocytes by changes in repolarization rate: Role of phase 1 AP repolarization in E-C coupling. Circ Res 2002; 90(2):165-73.
3. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell 2012 Sep 28;151(1):96-110. PMC3477522
4. Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation 2013 Jul 9;128(2):101-14. PMC3800036
5. Sah R, Mesirca P, Van den Boogert M, Rosen J, Mably J, Mangoni ME, Clapham DE. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E3037-E3046. PMC3740880
6. Zhang Y, Xie L, Gunasekar S, Tong D, Mishra A, Gibson W, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, and Sah R. SWELL1 is a regulator of adipocyte size, insulin signaling and glucose homeostasis. Nat Cell Biol. 2017 May 31;19(6):740. doi: 10.1038/ncb3514. PMID: 28436964.
7. Abiria S.A., Krapivinsky G., Sah R, Santa-Cruz A.G, Chaudhuri D., Zhang J., Adstamongkonkul P., DeCaen PG, Clapham D.E. TRPM7 Senses Oxidative Stress to Release Zn2+ from Unique Intracellular Vesicles. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6079-E6088. pii: 201707380. doi: 10.1073/pnas.1707380114. PMID: 28696294
8. Xie L, Zhang Y, Gunasekar S, Mishra A, Cao L, Sah R., Induction of adipose and hepatic SWELL1 expression is required for maintaining systemic insulin-sensitivity in obesity. Channels (Austin). 2017 Nov 2;11(6):673-7. doi: 10.1080/19336950.2017.1373225. PMID: 28873008
9. Kang C, Gunasekar S.K., Mishra A, Xie L, Zhang Y, Pai S, Gao Y, Norris A.W., Stephens S.B, Sah R., SWELL1
is a glucose sensor required for -cell excitability and systemic glycaemia. Nat Commun. 2018 Jan 25;9(1):367. doi: 10.1038/s41467-017-02664-0. PMID: 29371604
10. Gunasekar, S.K., Xie, L., Sah, R. SWELL signaling in adipocytes: can fat “feel” fat? Adipocyte 2019 Dec;8(1):223-8. PMID: 31112068
Key words: electrophysiology, CRISPR/Cas9, genetic mouse models, patch-clamp, calcium imaging, diabetes, obesity, heart failure, hypertension, NAFLD, SWELL1, LRRC8a, TRP channel
69
Robert V. Same, MD
Assistant Professor of Medicine
Current Research Interests
Preventive cardiology
Early cardiovascular risk factor modification
Representative Publications
1. Same RV, Bell DL, Rosenthal SL, Marcell AV. Sexual and reproductive health care: Adolescent and adult men’s willingness to talk and preferred approach. Am J Prev Med. 2014 Aug;47(2):175-81.
2. Same RV, Miner MM, Blaha MJ, Feldman DI, Billups KL. Erectile dysfunction: An early sign of cardiovascular disease. Current Cardiovascular Risk Reports. 2015 Oct;9(12):49.
3. Same RV, Feldman DI, Shah N, Martin SS, Al Rifai M, Blaha MJ, Graham G, Ahmed HM. Relationship between sedentary behavior and cardiovascular risk. Curr Cardiol Rep. 2016 Jan;18(1):6.
4. Same RV, Al Rifai M, Feldman DI, Billups KL, Brawner CA, Dardari ZA, Ehrman JK, Keteyian SJ, Al-Mallah MH, Blaha MJ. Prognostic value of exercise capacity among men undergoing pharmacologic treatment for erectile dysfunction: The FIT Project. Clin Cardiol. 2017 Nov;40(11):1049-54.
Key Words: prevention, risk factor modification
70
Joel D. Schilling, MD, PhD
Associate Professor of Medicine and Pathology & Immunology
Current Research Interests
Macrophage biology in non-alcoholic steatohepatitis
Macrophage dysfunction in diabetes and obesity
The interplay between macrophage metabolism and effector function
Diabetic cardiovascular disease
Liver macrophage-mediated inflammation in heart failure and pulmonary hypertension
Representative Publications 1. Weber, K and Schilling JD. The lysosome mediates metabolic-inflammatory crosstalk in primary
macrophages. J. Biol Chem. 2014 March 28; 289(13):9158-71. 2. Schilling JD. The mitochondria in diabetic heart failure: From pathogenesis to therapeutic promise.
Antioxid Redox Signal. 2015; 22(17): 1515-26. PCMID: 25761843. 3. He L, Weber KJ, Schilling JD. Glutamine modulates macrophage lipotoxicity. Nutrients 2016; 8(4): 215.
PCMID: 27077881. 4. Artyomov MN, Sergushichev A, Schilling JD. Integrating immunometabolism and macrophage diversity.
Semin Immunol. 2016 Oct; 28(5): 417-24. pil:S1044-5323 (16) 30105-1 PMCID: 27771140. 5. Huang SC, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, Pearce EJ. Metabolic reprogramming
mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation. Immunity. 2016 Oct 18; 45(4): 817-30. PMCID: 27760338.
6. He L, Weber KJ, Diwan A, Schilling JD. Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism. J Leuk Biol 2016; 100(5): 1113-24. PMCID: 27312848.
7. Sparrow CT, Larue SJ, Schilling JD. Intersection of pulmonary hypertension and right ventricular dysfunction in patients on left ventricular assist device support: Is there a role for pulmonary vasodilators? Circ Heart Fail, 2018. 11(1): e004255. doi: 10.1161/CIRCHEARTFAILURE.117.004255. PMID: 29321132.
8. Coverstone ED, Bach RG, Chen L, Bierut LJ, Li AY, Lenzini PA, O’Neill JC, Spertus JA, Sucharov CG, Stitzel JA, Schilling JD, Cresci S. A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction. Basic Res Cardiol, 2018. 113(5):38doi: 10.1007/s00395-018-0697-7. PMCID: PMC6292447.
9. Weber KJ, Sauer M, He L, Tycksen E, Kalugotla G, Razani B, and Schilling JD. PPAR Deficiency
Suppresses the Release of IL-1 and IL-1 in Macrophages via a Type 1 Interferon Dependent Mechanism. J Immunol, 2018. 201(7):2054-69. PMCID: PMC30143592.
10. Kalugotla G, He L, Weber KJ, Daemen S, Reller A, Razani B, and Schilling JD. Frontline Science: Acyl-CoA synthetase 1 exacerbates lipotoxic inflammasome activation in primary macrophages. J Leukoc Biol. 2019. Jun 5 PMCID: PMC31166619.
Key words: basic science, macrophage, diabetes, heart failure, Kupffer Cells, non-alcoholic steatohepatitis
71
Clay F. Semenkovich, MD
Professor of Medicine, Cell Biology and Physiology
Current Research Interests
Lipid metabolism
Atherosclerosis
Diabetes
Representative Publications 1. Bernal-Mizrachi C et al. Vascular respiratory uncoupling increases blood pressure and
atherosclerosis. Nature 2005; 435:502-6. 2. Schneider J et al. ATM-dependent suppression of stress signaling reduces vascular disease in
metabolic syndrome. Cell Metabolism 2006; 4:377-89.
3. Chakravarthy M et al. Brain fatty acid synthase activates PPAR to maintain energy homeostasis. J. Clin. Invest. 2007; 117:2539-52.
4. Chakravarthy M et al. Identification of a physiologically relevant endogenous ligand for PPARα in liver. Cell 2009; 138:476-88.
5. Schneider J et al. Macrophage fatty acid synthase deficiency decreases diet-induced atherosclerosis. J. Biol. Chem. 2010; 285:23398-409.
6. Hsu FF, Lodhi IJ, Turk J, Semenkovich CF. Structural distinction of diacyl-, alkylacyl, and alk-1-enylacyl glycerophosphocholines as [M - 15](-) ions by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. J Am Soc Mass Spectrom 2014 August; 25(8):1412-20.
7. Lodhi IJ, Wei X, Yin L, Feng C, Adak S, Abou-Ezzi G, Hsu FF, Link DC, Semenkovich CF. Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Cell Metab 2015 January 6; 21(1):51-64.
8. Izawa T, Rohatgi N, Fukunaga T, Wang QT, Silva MJ, Gardner MJ, McDaniel ML, Abumrad NA, Semenkovich CF, Teitelbaum SL, Zou W. ASXL2 regulates glucose, lipid, and skeletal homeostasis. Cell Rep 2015 June 16; 11(10):1625-37.
9. Semenkovich CF. Insulin resistance and a long, strange trip. N Engl J Med 2016 April 7; 374(14):1378-9.
Key words: atherosclerosis, basic science, diabetes, lipid metabolism
72
Jonathan R. Silva, PhD
Associate Professor of Biomedical Engineering and Computer Science and
Engineering
Current Research Interests
Identifying the right anti-arrhythmic drug for individual patients
Biophysics of small molecule drug interaction with ion channels
Advanced imaging of membrane proteins
New cardiovascular technologies
Computational models of arrhythmia
Representative Publications
New Arrhythmia Technologies 1. Silva JNA, Southworth M, Raptis C, Silva JR. Emergence of virtual and augmented reality in
cardiology, JACC: Basic to Translational Science, 2018;3(3),420-30. 2. Southworth MK, Silva JNA, Blume W, Van Hare GF, Dalal AS, Silva JR. Performance
evaluation of mixed reality display for guidance during transcatheter cardiac mapping and ablation”, IEEE Journal of Translational Engineering in Health and Medicine, 2020 Jul 3.
3. Silva JN, Southworth MK, Blume WM, Andrews C, Van Hare GF, Dalal AS, Miller N, Sodhi SS, Silva JR. First-In-Human use of a mixed reality display during cardiac ablation procedures. JACC: Clinical Electrophysiology. 2020 Jul 8.
Precision Antiarrhythmic Medicine 1. Varga, Z, Zhu W, Schubert AR, Pardieck JL, Hsu EJ, Zaydman MA, Cui J, Silva JR. Direct
measurement of cardiac Na+ channel conformations reveals molecular pathologies of inherited mutations. Circulation: Arrhythmia and Electrophysiology, 2015:8:1228-39.
2. Teed ZR, Silva JR. A computationally efficient algorithm for fitting ion channel gating parameters”, MethodsX, 2016;3: 577-88.
3. Zhu W, Voelker TL, Varga Z, Schubert AR, Nerbonne JM, Silva JR. Mechanisms of non-covalent β subunit regulation of nav channel gating, Journal of General Physiology, 2017 August; 149(8):813-31.
4. Silva JR. How to connect cardiac excitation to the atomic interactions of ion channels, Biophysical Journal, 2018;114(3):632a-633a.
5. Zhu W, Mazzanti A, Voelker T, Hou P, Moreno JD, Angsutararux P, Naegle KM, Priori SG, Silva JR. Predicting patient response to the antiarrhythmic mexiletine based on genetic variation: Personalized medicine for long QT syndrome. Circulation Research 2019;124:539:52.
6. Moreno JD, Zhu W, Mangold K, Chung W, Silva JR. A molecularly detailed Nav1. 5 model reveals a new class I antiarrhythmic target. JACC: Basic to Translational Science. 2019 Oct 28;4(6):736-51.
Keywords: Arrhythmias, Basic science, Electrophysiology, Ion Channels, Mathematical Modeling, Molecular
Cardiology, and Translational Research
73
Jasvindar Singh, MD
Associate Professor of Medicine
Current Research Interests
Interventional cardiology, especially complex interventions
Outcomes from intervention procedures
Stent design
Coronary Physiology
FFR/IVUS
Left Main and Bifurcation Research
Representative Publications
1. Diaz-Miron JL, Dillon PA, Saini A, Balzer DT, Singh J, Kolovos NS, Duncan JG, Keller MS: Left Main Coronary artery dissection in pediatric sport-related chest trauma. J Emer Med 2014 47(2):150-4.
2. Depta JP, Patel JS, Novak E, Gage BF, Masrani SK, Raymer D, Facey G, Patel Y, Zajarias A, Lasala JM, Amin AP, Kurz HI, Singh J, Bach RG. Risk model for estimating the 1-year risk of deferred lesion intervention following deferred revascularization after fractional flow reserve assessment. Eur Heart J 2015 February 21; 36(8):509-15.
3. Sintek MA, Sparrow CT, Mikuls TR, Lindley KJ, Bach RG, Kurz HI, Novak E, Singh J. Repeat revascularisation outcomes after percutaneous coronary intervention in patients with rheumatoid arthritis. Heart 2016 March; 102(5):363-9.
4. Davies JE, Sen S, Dehbi HM, Al-Lamee R, Petraco R, Nijjer SS, Bhindi R, Lehman SJ, Walters D, Sapontis J, Janssens L, Vrints CJ, Khashaba A, Laine M, Van Belle E, Krackhardt F, Bojara W, Going O, Härle T, Indolfi C, Niccoli G, Ribichini F, Tanaka N, Yokoi H, Takashima H, Kikuta Y, Erglis A, Vinhas H, Canas Silva P, Baptista SB, Alghamdi A, Hellig F, Koo BK, Nam CW, Shin ES, Doh JH, Brugaletta S, Alegria-Barrero E, Meuwissen M, Piek JJ, van Royen N, Sezer M, Di Mario C, Gerber RT, Malik IS, Sharp ASP, Talwar S, Tang K, Samady H, Altman J, Seto AH, Singh J, Jeremias A, Matsuo H, Kharbanda RK, Patel MR, Serruys P, Escaned J. Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCI. N Engl J Med. 2017 May 11; 376(19):1824-34.
5. Tepper S, Masood MF, Baltazar Garcia M, Pisani M, Ewald GA, Lasala JM, Bach RG, Singh J, Balsara KR, Itoh A. Left ventricular unloading by impella device versus surgical vent during extracorporeal life support. Ann Thorac Surg. 2017 Sep;104(3):861-7.
6. Escaned, J, Ryan N, Mejia-Renteria H, Singh, J, et al. Safety of the deferral of coronary revascularization on the basis of instantaneous wave-free ratio and fractional flow reserve measurements in stable coronary artery disease and acute coronary syndromes. JACC Cardiovasc Interv. 2018 Aug 13;11(15):1437-49.
7. Amin AP, Pinto D, House JA, Singh J, et al. Association of same-day discharge after elective percutaneous coronary intervention in the United States with costs and outcomes. JAMA Cardiol. 2018 Nov 1; 3(11) 1041-9.
8. Sen S, Ahmad Y, Dehbi HM, Singh J, et al. Clinical events after deferral of LAD revascularization following physiological coronary assessment. J Am Coll Cardiol. 2019 Feb 5; 73(4)444-53.
Key words: coronary artery disease, interventional cardiology
74
Timothy W. Smith, MD, DPhil
Professor of Medicine
Current Research Interests
Techniques of ICD/pacemaker implantation
New approaches to therapy (especially ablation) of ventricular tachycardia
Prevention of sudden death and ICD utilization
Electrocardiography and ECG education
Cardiac Resynchronization
Representative Publications 1. Cooper JA, Latacha MP, Soto GE, Garmany RG, Gleva MJ, Chen J, Faddis MN, Smith TW. The
Azygos defibrillator lead for elevated defibrillation thresholds: Implant technique, lead stability, and patient series. Pacing and Clinical Electrophysiology 2008; 31:1405-10.
2. Cooper DH, Cuculich PS, Cooper AR, Smith TW. Fluoroscopic markers to guide extrathoracic subclavian vein access for implantation of pacemaker and defibrillator leads [Abstract]. Heart Rhythm 2010; 7(5S):S247.
3. Latacha M, Memon NB, Cuculich PS, Hertel J, Wang Y, Rudy Y, Smith TW. Pathologic examination after epicardial ablation of ventricular tachycardia in cardiac sarcoidosis. Heart Rhythm 2010; 7:705-7.
4. Cuculich PS and Smith TW. Featured arrhythmia: An irregular wide complex rhythm: What is the mechanism? Heart Rhythm 2010; 7:1514-5.
5. Wang Y, Cuculich PS, Zhang J, Desouza KA, Vijayakumar R, Chen J, Faddis MN, Lindsay BD, Smith TW, Rudy Y. Noninvasive electroanatomic mapping of human ventricular arrhythmias with electrocardiographic imaging (ECGI). Science Translational Medicine 2011;3: 1-10.
6. Memon NB, Briceno DF, Torres-Russotto D, Chen J, SmithTW. Speech-Induced atrial tachycardia: An unusual presentation of supraventricular tachycardia. Journal of Cardiovascular Electrophysiology 2013;24: 1412-5.
7. Fansler DR, Smith TW. Rotors: Linking VF and VT? Heart Rhythm 2013 December; 10(12):1917-8.
8. Coverstone E, Sheehy J, Kleiger RE, Smith TW. The postimplantation electrocardiogram predicts clinical response to cardiac resynchronization therapy. Pacing Clin Electrophysiol 2015 May; 38(5):572-80.
9. Zhang J, Cooper DH, Desouza KA, Cuculich PS, Woodard PK, Smith TW, Rudy Y. Electrophysiologic scar substrate in relation to VT: Noninvasive high-resolution mapping and risk assessment with ECGI. Pacing Clin Electrophysiol 2016 Aug; 39(8):781-91.
Key words: arrhythmias, electrocardiography, electrophysiology
75
Sandeep S. Sodhi, MD
Assistant Professor of Medicine Clinical Cardiac Electrophysiology Current Research Interests
Clinical outcomes of premature ventricular catheter (PVC) ablation using remote magnetic-guided
catheter guidance
Psychological drivers impacting the health of adult patients with congenital heart disease
Representative Publications
1. Sodhi SS, Cedars AM. Primary prevention of sudden cardiac death in adults with transposition of the great arteries: A review of implantable cardioverter-defibrillator placement. Tex Heart Inst J. 2015 Aug 1;42(4):309-18. doi: 10.14503/THIJ-14-4352. Review. PMID: 26413012.
2. White KS, Pardue C, Ludbrook P, Sodhi S, Esmaeeli A, Cedars A. Cardiac denial and psychological predictors of cardiac care adherence in adults with congenital heart disease. Behav Modif. 2016 Jan;40(1-2):29-50. doi: 10.1177/0145445515613329. PMID: 26538274.
3. Sodhi SS, Zhang TJ, McDonald R, Al Rashida V, Kondapalli N, Barger P, Ludbrook P, Cedars AM. Effects of eplerenone on markers of myocardial fibrosis, 6-minute walk distance, and quality of life in adults with tetralogy of Fallot and complete transposition of the great arteries. Proc (Bayl Univ Med Cent). 2018 Jan 3;31(1):12-9. doi: 10.1080/08998280.2017.1396176. PMID: 29686545.
4. Ko JM, Tecson KM, Rashida VA, Sodhi S, Saef J, Mufti M, White KS, Ludbrook PA, Cedars AM. Clinical and psychological drivers of perceived health status in adults with congenital heart disease. Am J Cardiol. 2018 Feb 1;121(3):377-81. doi: 10.1016/j.amjcard.2017.10.038. PMID: 29198985.
5. Saef J, Sodhi S, Tecson KM, Al Rashida V, Mi Ko J, White KS, Ludbrook PA, Cedars AM. Contributors to disease-specific health knowledge in adults with congenital heart disease: a correlational study. Congenit Heart Dis. 2018 Nov;13(6):967-77. doi: 10.1111/chd.12668. PMID: 30259669.
6. Thakker P, Sodhi S, Smith TW, Noheria A. Alternating Wenckebach cycles with right bundle branch block. J Electrocardiol. 2018 Nov - Dec;51(6):981-2. doi: 10.1016/j.jelectrocard.2018.08.002. EPMID: 30497760.
7. Huntley GD, Tecson KM, Sodhi S, Saef J, White KS, Ludbrook PA, Cedars AM, Ko JM. Cardiac denial and expectations associated with depression in adults with congenital heart disease. Am J Cardiol. 2019 Jun 15;123(12):2002-5. doi: 10.1016/j.amjcard.2019.03.011. PMID: 30967286.
8. Steyers CM III, Sodhi S, Faddis MN, Cooper DH, Cuculich PS, Noheria A. Ablation using 3D maps adjusted for spatial displacement of premature ventricular complexes relative to sinus beats: Improving precision by correcting for the shift. J Cardiovasc Electrophysiol. 2019 Nov;30(11):2319-25. doi: 10.1111/jce.14120. PMID: 31424125
9. Noheria A, Sodhi S, Orme GJ. The evolving role of electrocardiography in cardiac resynchronization therapy. Curr Treat Options Cardiovasc Med. 2019 Dec 12;21(12):91. doi: 10.1007/s11936-019-0784-6. PMID: 31828564.
Key words: complex catheter ablation, atrial fibrillation, premature ventricular contractions, ventricular
tachycardia, robotic navigation
76
Phyllis K. Stein, PhD
Associate Professor of Medicine
Current Research Interests
Research quality heart rate variability (HRV) analyisis and outcomes in different clinical populations from infants to eldery, including use of HRV to identify high risk individuals,
HRV in association with genetic disorders in humans and animals.
Application of novel, non-linear HRV methods (e.g., multiscale entropy) to detect patterns of neurocardiac integration not detectable using standard HRV measures, in order to track clinical status,assess interventions and predict outcomes including: incident CVD events, dementia and survival.
Detection of sleep-disordered breathing, circadian rhythm disorders, and sinoatrial node dysfunction from ambulatory ECG recordings and examination of their relationship to clinical status and outcomes.
Clinical applications of HRV from bedside monitoring in the NICU, PICU and ICU, including potentially in COVID –19 patients.
Effect of clinical and stress management interventions on cardiac autonomic functioning.
Race and gender influences on HRV.
Representative Publications (out of 158 peer-reviewed papers( 1. Stein PK, Barzilay JI, Chaves PH, Domitrovich PP, Gottdiener JS. Heart rate variability and its changes over 5
years in older adults. Age Ageing 2009; 38(2):212-8. 2. Stein PK, Sanghavi D, Sotoodehnia N, Siscovick DS, Gottdiener J. Association of Holter-based measures
including T-wave alternans with risk of sudden cardiac death in the community dwelling elderly: the Cardiovascular Health Study. J Electrocardiol 2010; 43(3):251-9.
3. Stein PK, Deedwania P. New York Heart Association functional class influences of the impact of diabetes on cardiac autonomic function. J Electrocardiol. 2010; 43(5):379-84.
4. Stein PK, Barzilay JI. Relationship of abnormal heart rate turbulence and elevated CRP to cardiac mortality in low, intermediate, and high-risk older adults. J Cardiovasc Electrophysiol. 2011; 22:122-7.
5. Stein PK, Pu Y. Heart rate variability, sleep and sleep disorders. Sleep Med Rev. 2012; 16(1):47-66. 6. Stein PK, Soare A, Meyer TE, Cangemi R, Holloszy JO, Fontana L. Caloric restriction may reverse age-related
autonomic decline in humans. Aging Cell. Aging Cell. 2012; 11(4):644-50. 7. Harris PR, Stein PK, Fung GL, Drew BJ. Heart rate variability measured early in patients with evolving acute
coronary syndrome and 1-year outcomes of rehospitalization and mortality. Vasc Health Risk Manag. 2014 Aug 5; 10:451-64.
8. Patel VN, Pierce BR, Bodapati RK, Brown DL, Ives DG, Stein PK. Association of holter-derived heart rate variability parameters with the development of congestive heart failure in the cardiovascular health study. JACC Heart Fail. 2017 June; 5(6):423-31. doi: 10.1016/j.jchf.2016.12.015. PubMed PMID: 28396041.
9. Bodapati RK, Kizer JR, Kop WJ, Kamel H, Stein PK. Addition of 24-hour heart rate variability parameters to the CHS stroke risk score and prediction of incident stroke: The Cardiovascular Health Study. JAHA 2017 Jul 21; 6(7). pii: e004305. doi: 10.1161/JAHA.116.004305.
10. Blanchard M, Molina-Vicenty HD, Stein PK, et al. Medical correlates of chronic multisymptom illness in Gulf War Veterans. Am J Med. 2019;132(4):510-8. doi:10.1016/j.amjmed.2018.11.045.
Key words: aging, ambulatory ECG, anxiety, autonomic function assessment, cardio-oncology, cardiovascular epidemiology, circadian rhythms, dementia, depression, diabetes, epidemiology, heart failure, heart rate variability, hypertension, risk factors, sleep disorders, trauma, trauma healing, women and minorities
77
Nathan Stitziel, MD, PhD
Associate Professor of Medicine and Genetics
Current Research Interests
Genetics of Mendelian cardiovascular disease
Genetics of complex cardiovascular disease
Clinical application of genetics
Representative Publications
1. Stitziel NO, MacRae CA. A clinical approach to inherited premature coronary artery disease. Circ Cardiovasc Genet 2014; 7(4):558-64.
2. Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P et al. Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med 2014; 371(22):2072-82.
3. Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield M, Devlin JJ, Nordio F, Hyde C, Cannon CP, Sacks F, Poulter N, Sever P, Ridker PM, Braunwald E, Melander O, Kathiresan S, Sabatine MS. Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials. Lancet 2015 June 6; 385(9984):2264-71.
4. Do R, Stitziel NO, Won H-H, et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature 2015; 518(7537):102-6.
5. Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, et al. Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease. N Engl J Med. 2016 Mar 24; 374(12):1134-44.
6. Lee VS, Halabi CM, Hoffman E, Carmichael N, Leshchiner I, Lian CG, Bierhals AJ, Vuzman D, Mecham RP, Frank NY, Stitziel NO. Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans. Proc Natl Acad Sci. 2016 Aug 2; 113(31):8759-64.
7. Stitziel NO, Khera AV, Wang X, et al. ANGPTL3 deficiency and protection against coronary artery disease. J Am Coll Cardiol. 2017;69:2054-63. doi: 10.1016/j.jacc.2017.02.030. PMID: 28385496
8. Lin CJ, Lin CY, Stitziel NO. Genetics of the extracellular matrix in aortic aneurysmal diseases. Matrix Biol. 2018 Oct;71-72:128-43. doi: 10.1016/j.matbio.2018.04.005. Epub 2018 Apr 12. PMID: 29656146
9. Young EP, Stitziel NO. Capitalizing on Insights from Human Genetics to Identify Novel Therapeutic Targets for Coronary Artery Disease. Annu Rev Med. 2019 Jan 27;70:19-32. doi: 10.1146/annurev-med-041717-085853. Epub 2018 Oct 24. PMID: 30355262
Key words: atherosclerosis, basic science, genetics, translational research
78
Amanda Verma, MD
Assistant Professor of Medicine
Current Research Interests
Cardiovascular disease and pregnancy, peripartum cardiomyopathy
COVID19 and heart disease
Representative Publications
1. Schmeckpeper J, Verma A, Yin L, Beigi F, Zhang L, Payne A, Zhang Z, Pratt RE, Dzau VJ, Mirotsou M. Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways. J Mol Cell Cardiol. 2015 Aug; 85: 215-25.
2. Ahmad T, Kelly JP, McGarrah RW, Hellkamp AS, Fiuzat M, Testani JM, Wang TS, Verma A, Samsky MD, Donahue MP, Ilkayeva OR, Bowles DE, Patel CB, Milano CA, Rogers JG, Felker GM, O’Connor CM, Shah SH, Kraus WE. Prognostic implications of long-chain acylcarnitines in heart failure and reversibility with mechanical circulatory support. J Am Coll Cardiol. 2016 Jan 26; 67(3): 291-9.
3. Verma AK, Schulte PJ, Bittner V, Keteyian SJ, Fleg JL, Pina IL, Swank AM, Fitz-Gerald M, Ellis SJ, Kraus WE, Whellan DJ, O’Connor CM, Mentz RJ. Socioeconomic and partner status in chronic heart failure: Relationship to exercise capacity, quality of life, and clinical outcomes. Am Heart J. 2017 Jan; 183: 54-61.
4. Shatila W, Verma A, Adam S. Plasmapheresis in severe methemoglobinemia following occupational exposure. Transfus Apher Sci. 2017 Jun; 56(3): 341-44.
5. Verma AK, Sun JL, Hernandez A, Teerlink JR, Schulte PJ, Ezekowitz J, Voors A, Starling R, Armstrong P, O’Connor CM, Mentz RJ. Rate pressure product and the components of heart rate and systolic blood pressure in hospitalized heart failure patients with preserved ejection fraction: Insights from ASCEND HF. Clin Cardiol. 2018 Jul; 41(7): 945-52.
6. Lindley KJ, Verma AK, Blauwet LA. Peripartum cardiomyopathy: Progress in understanding the etiology, management, and prognosis. Heart Fail Clin. 2019 Jan; 15(1): 29-39.
7. Verma AK, Williams D, Nelson DM, Rathor R, Benhardt A, Chakinala M, Moon M, Kotkar K, Pepine CJ, Lindley KJ. A cardio-obstetric approach to management of the complex pregnant cardiac patient. JACC Case Rep. 2020 Jan; 2(1): 86-90.
8. Lindley KJ, Williams D, Conner SN, Verma A, Cahill AG, Davila-Roman VG. The spectrum of pregnancy-associated heart failure phenotypes: An Echocardiographic study. Int J Cardiovasc Imaging. 2020 May, in press.
Key words: heart failure, peripartum cardiomyopathy, pregnancy, women and minorities
79
Carla J. Weinheimer, MS
Associate Professor of Medicine
Current Research Interests
Murine cardiovascular phenotyping through microsurgery, hemodynamic evaluations,imaging, and histology
Models of ischemic disease and heart failure in mice Representative Publications
1. Weinheimer CJ, Kovacs A, Courtois MA, and Mansfield C: In-Vivo physiologic evaluationof murine cardiovascular phenotypes. In: Textbook of Cardiovascular Molecular Imaging. Edited by Robert Gropler, Albert Sinusas, David Glover, and Heinrich Taegtmeyer. July, 2007.
2. Godar RJ, Ma X, Liu H, Murphy JT, Weinheimer CJ, Kovacs A, Crosby SD, Saftig P, Diwan A: Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury. Autophagy. 2015 Jun 23; 11(9):1537-60.
3. Weinheimer CJ, Ling L, Kelly DP, Kovacs A: A novel murine model of left ventricular pressure overload and infarction causing predictable ventricular remodeling and progression to heart failure. Clin Exp Pharmacol Physiol 2015; 42(1):33-40.
4. Weinheimer CJ, Kovacs A, Evans S, Matkovich SJ, Barger PM, Mann DL. Load-dependent changes in left ventricular structure and function in a pathophysiologically relevant murine model of reversible heart failure. Circ Heart Fail. 2018 May 11(5):e004351.
5. Adamo L, Staloch LJ, Rocha-Resende C, Matkovich SJ, Jiang W, Bajpai G, Weinheimer CJ, Kovacs A, Schilling JD, Barger PM, Bhattacharya D, Mann DL. Modulation of subsets of cardiac B lymphocytes improves cardiac function after acute injury. JCI Insight. 2018 Jun 7;3(11):e120137.
6. Bajpai G, Bredemeyer A, Li W, Zaitsev K, Koenig AL, Lokshina I, Mohan J, Ivey B, Hsiao HM, Weinheimer C, Kovacs A, Epelman S, Artyomov M, Kreisel D, Lavine KJ. Tissue resident CCR2- and CCR2+ cardiac macrophages differentially orchestrate monocyte recruitment and fate specification following myocardial injury. Circ Res. 2019 Jan 18;124(2):263-78.
7. Ma X, Mani K, Liu H, Kovacs A, Murphy JT, Foroughi L, French BA, Weinheimer CJ, Kraja A, Benjamin IJ, Hill JA, Javaheri A, Diwan A. Transcription factor EB activation rescues advanced αB-crystallin mutation-induced cardiomyopathy by normalizing desmin localization. J Am Heart Assoc. 2019 Feb 19;8(4):e010866.
8. Rocha-Resende C, Weinheimer C, Bajpai G, Adamo L, Matkovich SJ, Schilling J, Barger PM, Lavine KJ, Mann DL. Immunomodulatory role of non-neuronal cholinergic signaling in myocardial injury. JCI Insight. 2019 Jun 4;5(14):e128961.
9. Javaheri A, Bajpai G, Picataggi A, Mani S, Foroughi L, Evie H, Kovacs A, Weinheimer CJ, Hyrc K, Xiao Q, Ballabio A, Lee JM, Matkovich SJ, Razani B, Schilling JD, Lavine KJ, Diwan A. TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagy. JCI Insight. 2019 Nov 1;4(21):e127312.
Key words: cardiovascular phenotyping, novel murine surgical models, cardiomyopathy, ischemia, imaging, molecular cardiology, basic science
80
Pamela K. Woodard, MD
Hugh Monroe Wilson Professor of Radiology and Professor of Biomedical
Engineering
Current Research Interests
Molecular Imaging of atherosclerosis
Cardiac MRI
Cardiac CT – coronary CT angiography
Representative Publications 1. Liu Y, Abendschein D, Woodard GE, Rossin R, McCommis K, Zheng J, Welch MJ, Woodard PK.
Molecular imaging of atherosclerotic plaque with 64Cu-labeled natriuretic peptide and positron emission tomography. J Nucl Med 2010; 51(1):85-91.
2. Hoffmann U, Truong QA, Schoenfeld DA, Chou ET, Woodard PK, Nagurney JT, Pope JH, Hauser TH, White CS, Weiner SG, Kalanjian S, Mullins ME, Mikati I, Peacock WF, Zakroysky P, Hayden D, Goehler A, Lee H, Gazelle GS, Wiviott SD, Fleg JL, Udelson JE; ROMICAT-II Investigators. Coronary CT angiography versus standard evaluation in acute chest pain. N Engl J Med 2012 Jul 26; 367(4):299-308.
3. Stillman AE, Gatsonis C, Lima JAC, Black WC, Cormack J, Gareen I, Hoffman U, Liu T, Mavromatis K, Schnall MD, Udelson JE, Woodard PK. Rationale and design of the Randomized Evaluation of patients with Stable angina Comparing Utilization of noninvasive Examinations (RESCUE) Trial. American Heart Journal 2016; 179:19-28.
4. Cury RC, Abbara S, Achenbach S, Agatston A, Berman D, Budoff M, Dill K, Jacobs J, Maroules C, Rubin G, Rybicki FJ, Schoepf J, Shaw L, Stillman A, White C, Woodard PK, Leipsic J. CAD-RADSTM Coronary Artery Disease - Reporting and Data System. An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT), the American College of Radiology (ACR) and the North American Society for Cardiovascular Imaging (NASCI). Endorsed by the American College of Cardiology. J Cardiovasc Comput Tomogr. 2016 Jul-Aug; 10(4):269-81. Simultaneously published, J Am Coll Radiol 2016 Dec; 13(12 Pt A):1458-1466.e9.
5. Zayed MA, Harring SD, Abendschein DR, Vemuri C, Lu D, Detering L, Liu Y, Woodard PK. Natriuretic peptide receptor-C is up-regulated in the intima of advanced carotid artery atherosclerosis. J Med Surg Pathol 2016 Jul; 1(3). pii: 131.
6. Woodard PK, Liu Y, Pressly ED, Luehmann HP, Detering L, Sultan DE, Laforest R, McGrath AJ, Gropler RJ, Hawker CJ. Design and modular construction of a polymeric nanoparticle for targeted atherosclerosis positron emission tomography imaging: A Story of 25% 64Cu-CANF-Comb. Pharm Res 2016 Oct; 33(10):2400-10.
7. Nie X, Elvington A, Laforest R, Zheng J, Vollar TF, Zayed MA, Abendschein DR, Bandara N, Xu J, Li R, Randolph GJ, Gropler RJ, Lapi SE, Woodard PK. Cu-64 PET/MR imaging of hypoxia in human atherosclerosis. Circulation: Cardiovascular Imaging 2020 Jan 13 (1), e009791.
Key words: atherosclerosis, cardiac MRI, cardiac CT, molecular imaging
81
Alan Zajarias, MD
Professor of Medicine Professor in Surgery (Cardiothoracic)
Current Research Interests
Transcatheter aortic valve implantation (TAVI)
Use of CT for procedural planning of TAVI
Echocardiographic assessment of RV function in patients with pulmonary hypertension undergoing TAVI for aortic stenosis
Racial differences in aortic stenosis
Mitral regurgitation and outcomes in patients with cardiomyopathy
Patient selection and procedural outcomes in patients undergoing TAVI
Representative Publications
1. Kodali SK, Williams MR, Smith CR, Svensson LG, Webb JG, Makkar RR, Fontana GP, Dewey TM, Thourani VH, Pichard AD, Fischbein M, Szeto WY, Lim S, Greason KL, Teirstein PS, Malaisrie SC, Douglas PS, Hahn RT, Whisenant B, Zajarias A, Wang D, Akin JJ, Anderson WN, Leon MB; PARTNER Trial Investigators. Two-year outcomes after transcatheter or surgical aortic-valve replacement. N Engl J Med 2012 May 3; 366(18):1686-95.
2. Lindman BR, Maniar HS, Jaber WA, Lerakis S, Mack MJ, Suri RM, Thourani VH, Babaliaros V, Kereiakes DJ, Whisenant B, Miller DC, Tuzcu EM, Svensson LG, Xu K, Doshi D, Leon MB, Zajarias A. Effect of tricuspid regurgitation and the right heart on survival after transcatheter aortic valve replacement: insights from the placement of aortic transcatheter valves II inoperable cohort. Circ Cardiovasc Interv 2015 Apr; 8(4). pii: e002073. doi: 10.1161/CIRCINTERVENTIONS.114.002073.
3. Paradis JM, Maniar HS, Lasala JM, Kodali S, Williams M, Lindman BR, Damiano RJ Jr, Moon MR, Makkar RR, Thourani VH, Babaliaros V, Xu K, Ayele GM, Svensson L, Leon MB, Zajarias A. Clinical and functional outcomes associated with myocardial injury after transfemoral and transapical transcatheter aortic valve replacement: A subanalysis from the PARTNER Trial (Placement of Aortic Transcatheter Valves). JACC Cardiovasc Interv 2015 Sep; 8(11):1468-79. doi: 10.1016/j.jcin.2015.06.018.
4. Leon MB, Smith CR, Mack MJ, Makkar RR, Svensson LG, Kodali SK, Thourani VH, Tuzcu EM, Miller DC, Herrmann HC, Doshi D, Cohen DJ, Pichard AD, Kapadia S, Dewey T, Babaliaros V, Szeto WY, Williams MR, Kereiakes D, Zajarias A, Greason KL, Whisenant BK, Hodson RW, Moses JW, Trento A, Brown DL, Fearon WF, Pibarot P, Hahn RT, Jaber WA, Anderson WN, Alu MC, Webb JG; PARTNER 2 Investigators. Transcatheter or surgical aortic-valve replacement in intermediate-risk patients. N Engl J Med 2016 Apr 28; 374(17):1609-20. doi: 10.1056/NEJMoa1514616. Epub 2016 Apr 2.
Key words: aortic stenosis, interventional cardiology, valvular heart disease
82
Kathleen W. Zhang, MD
Assistant Professor of Medicine Current Research Interests
Improving diagnosis and management of patients with cardiac amyloidosis
Pathophysiology of cardiac amyloidosis
Cardiovascular disease in men with prostate cancer
Cardiotoxicity of cancer therapy Representative Publications
1. Zhang KW, French B, May Khan A, Plappert T, Fang JC, Sweitzer NK, Borlaug BA, Chirinos JA, St John Sutton M, Cappola TP, Ky B. Strain improves risk prediction beyond ejection fraction in chronic systolic heart failure. J Am Heart Assoc. 2014 Jan 13;3(1):e000550.
2. Gulati G, Zhang KW, Scherrer-Crosbie M, Ky B. Cancer and cardiovascular disease: The use of novel echocardiography measures to predict subsequent cardiotoxicity in breast cancer treated with anthracyclines and trastuzumab. Curr Heart Fail Rep. 2014 Dec;11(4):366-73.
3. Zhang KW, Finkelman BS, Gulati G, Narayan HK, Upshaw J, Narayan V, Plappert T, Englefield V, Smith AM, Zhang C, Hundley WG, Ky B. Abnormalities in three-dimensional left ventricular mechanics with anthracycline chemotherapy are associated with systolic and diastolic dysfunction. J Am Coll Cardiol Img. 2018;11:1059-68.
4. Zhang KW, Stockerl-Goldstein KE, Lenihan DJ. State-of-the-art review: Emerging therapeutics for the treatment of light chain and transthyretin amyloidosis. J Am Coll Cardiol Basic Trans Science. 2019;4:438-48.
5. Zhang KW, Miao J, Mitchell JD, Alvarez-Cardona JA, Tomasek K, Su YR, Gordon M, Cornell RF, Lenihan DJ. Serum hepatocyte growth factor has diagnostic and prognostic utility for light chain and transthyretin cardiac amyloidosis. J Am Coll Cardiol CardioOnc 2020;2:56-66.
6. Zhang KW, Sadhu JS, Miller BW, Brennan DC, Bierhals AJ, Chen JF, Lin CY, Vader JM. Apical sparing pattern of longitudinal strain and positive bone scintigraphy in metastatic myocardial calcification. J Am Coll Cardiol Case Rep 2020;2:809-13.
Key words: amyloidosis, biomarkers, cardio-oncology, echocardiography
