FACULTY PUBLICATIONS 2018 · Department of Biochemistry 2018 3 29777720. Ulaganathan T, Helbert W, Kopel M, Banin E, Cygler M. Structure-function analyses of a PL24 family ulvan lyase

Department of Biochemistry 2018

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FACULTY PUBLICATIONS

2018

AKAVIA, U.D.

Roche PJR, Gytz, H, Hussain F, Cameron CJF, Paquette D, Blanchette M, Dostie J, Nagar B,

Akavia UD. Double-Stranded Biotinylated Donor Enhances Homology-Directed Repair in

Combination with Cas9 Monoavidin in Mammalian Cells. CRISPR Journal 1, 414-430 (2018)

BEAUCHEMIN, N.

Poffenberger MC, Metcalfe-Roach A, Aguilar E, Chen J, Hsu BE, Wong AH, Johnson RM,

Flynn B, Samborska B, Ma EH, Gravel SP, Tonelli L, Devorkin L, Kim P, Hall A, Izreig S,

Loginicheva E, Beauchemin N, Siegel PM, Artyomov MN, Lum JJ, Zogopoulos G, Blagih J,

Jones RG. LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis.

Science. 2018 Jul 27;361(6400):406-411. doi: 10.1126/science.aan3975. PubMed PMID:

30049881.

Felfoul O, Mohammadi M, Taherkhani S, Lanauze D, Zhong Xu Y, Lafleur M, Gaboury L,

Tabrizian M, Vuong T, Batist G, Beauchemin N, Radzioch D, Martel S. [Delivery in hypoxic

tumor regions of a chemotherapeutic agent encapsulated in nanoliposomes carried by

magnetoaerotactic bacteria]. Med Sci (Paris). 2018 Mar;34(3):197-199. doi:

10.1051/medsci/20183403002. Epub 2018 Mar 16. French. PubMed PMID: 29547100.

BERGHUIS, A.M.

Gomes CC, Gayden T, Bajic A, Harraz OF, Pratt J, Nikbakht H, Bareke E, Diniz MG, Castro

WH, St-Onge P, Sinnett D, Han H, Rivera B, Mikael LG, De Jay N, Kleinman CL, Valera ET,

Bassenden AV, Berghuis AM, Majewski J, Nelson MT, Gomez RS, Jabado N. TRPV4 and

KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw. Nat Commun.

2018 Nov 1;9(1):4572. doi: 10.1038/s41467-018-06690-4. PubMed PMID: 30385747; PubMed

Central PMCID: PMC6212533.

Ilie A, Gao AYL, Boucher A, Park J, Berghuis AM, Hoffer MJV, Hilhorst-Hofstee Y, McKinney

RA, Orlowski J. A potential gain-of-function variant of SLC9A6 leads to endosomal

alkalinization and neuronal atrophy associated with Christianson Syndrome. Neurobiol Dis. 2019

Jan;121:187-204. doi: 10.1016/j.nbd.2018.10.002. Epub 2018 Oct 5. PubMed PMID: 30296617.

Golkar T, Zieliński M, Berghuis AM. Look and Outlook on Enzyme-Mediated Macrolide

Resistance. Front Microbiol. 2018 Aug 20;9:1942. doi: 10.3389/fmicb.2018.01942. eCollection

2018. Review. PubMed PMID: 30177927; PubMed Central PMCID: PMC6109786.

Lacbay CM, Waller DD, Park J, Gómez Palou M, Vincent F, Huang XF, Ta V, Berghuis AM,


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Sebag M, Tsantrizos YS. Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with

Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. J Med Chem. 2018 Aug

9;61(15):6904-6917. doi: 10.1021/acs.jmedchem.8b00886. Epub 2018 Jul 25. PubMed PMID:

30016091.

Caldwell SJ, Berghuis AM. Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2″)-

Ia. Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00202-18. doi: 10.1128/AAC.00202-

18. Print 2018 Jul. PubMed PMID: 29661878; PubMed Central PMCID: PMC6021647.

BOUCHARD, M.

Tremblay M, Sanchez-Ferras O, Bouchard M. GATA transcription factors in development and

disease. Development. 2018 Oct 22;145(20). pii: dev164384. doi: 10.1242/dev.164384. Review.

PubMed PMID: 30348673.

Martynova E, Bouchard M, Musil LS, Cvekl A. Identification of Novel Gata3 Distal Enhancers

Active in Mouse Embryonic Lens. Dev Dyn. 2018 Nov;247(11):1186-1198. doi:

10.1002/dvdy.24677. Epub 2018 Nov 10. PubMed PMID: 30295986; PubMed Central PMCID:

PMC6246825.

BROUHARD, G.J.

Chaaban S, Jariwala S, Hsu CT, Redemann S, Kollman JM, Müller-Reichert T, Sept D, Bui KH,

Brouhard GJ. The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis

of Microtubule Growth. Dev Cell. 2018 Oct 22;47(2):191-204.e8. doi:

10.1016/j.devcel.2018.08.023. Epub 2018 Sep 20. PubMed PMID: 30245157.

Brouhard GJ, Rice LM. Microtubule dynamics: an interplay of biochemistry and mechanics. Nat

Rev Mol Cell Biol. 2018 Jul;19(7):451-463. doi:10.1038/s41580-018-0009-y. Review. PubMed

PMID: 29674711; PubMed Central PMCID: PMC6019280.

CYGLER, M.

Beyrakhova K, Li L, Xu C, Gagarinova A, Cygler M. Legionella pneumophila effector Lem4 is a

membrane-associated protein tyrosine phosphatase. J Biol Chem. 2018 Aug 24;293(34):13044-

13058. doi: 10.1074/jbc.RA118.003845. Epub 2018 Jul 5. PubMed PMID: 29976756; PubMed


Ulaganathan T, Banin E, Helbert W, Cygler M. Structural and functional characterization of

PL28 family ulvan lyase NLR48 from Nonlabens ulvanivorans. J Biol Chem. 2018 Jul

20;293(29):11564-11573. doi: 10.1074/jbc.RA118.003659. Epub 2018 Jun 6. PubMed PMID:

29875159; PubMed Central PMCID: PMC6065169.

Grishin AM, Barber KR, Gu RX, Tieleman DP, Shaw GS, Cygler M. Regulation of Shigella

Effector Kinase OspG through Modulation of Its Dynamic Properties. J Mol Biol. 2018 Jul

6;430(14):2096-2112. doi: 10.1016/j.jmb.2018.05.015. Epub 2018 May 16. PubMed PMID:


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29777720.

Ulaganathan T, Helbert W, Kopel M, Banin E, Cygler M. Structure-function analyses of a PL24

family ulvan lyase reveal key features and suggest its catalytic mechanism. J Biol Chem. 2018

Mar 16;293(11):4026-4036. doi: 10.1074/jbc.RA117.001642. Epub 2018 Jan 30. PubMed PMID:


DOSTIE, J.

Moisan S, Levon S, Cornec-Le Gall E, Le Meur Y, Audrézet MP, Dostie J, Férec C. Novel long-

range regulatory mechanisms controlling PKD2 gene expression. BMC Genomics. 2018 Jul

3;19(1):515. doi: 10.1186/s12864-018-4892-6. PubMed PMID: 29986647; PubMed Central

PMCID: PMC6038307.

Dostie J, Blanchette M. 3D genome mapping and analysis methods. Methods. 2018 Jun 1;142:1-

2. doi: 10.1016/j.ymeth.2018.05.017. PubMed PMID: 29880426.

DROUIN, J.

L'honoré A, Commère PH, Negroni E, Pallafacchina G, Friguet B, Drouin J, Buckingham M,

Montarras D. The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP

kinase and redox regulation of muscle regeneration. Elife. 2018 Aug 14;7. pii: e32991. doi:

10.7554/eLife.32991. PubMed PMID: 30106373; PubMed Central PMCID: PMC6191287.

Nemec S, Sung AH, Drouin J. Shh signaling influences the phenotype of Pitx1-/- hindlimbs. Dev

Biol. 2018 Jul 15;439(2):65-68. doi: 10.1016/j.ydbio.2018.04.024. Epub 2018 Apr 27. PubMed

PMID: 29705333.

Mayran A, Drouin J. Pioneer transcription factors shape the epigenetic landscape. J Biol Chem.

2018 Sep 7;293(36):13795-13804. doi: 10.1074/jbc.R117.001232. Epub 2018 Mar 5. Review.

PubMed PMID: 29507097; PubMed Central PMCID: PMC6130937.

Jain D, Nemec S, Luxey M, Gauthier Y, Bemmo A, Balsalobre A, Drouin J. Regulatory

integration of Hox factor activity with T-box factors in limb development. Development. 2018

Mar 22;145(6). pii: dev159830. doi: 10.1242/dev.159830. PubMed PMID: 29490982.

Mayran A, Khetchoumian K, Hariri F, Pastinen T, Gauthier Y, Balsalobre A, Drouin J. Pioneer

factor Pax7 deploys a stable enhancer repertoire for specification of cell fate. Nat Genet. 2018

Feb;50(2):259-269. doi: 10.1038/s41588-017-0035-2. Epub 2018 Jan 22. PubMed PMID:

29358650.

DUCHAINE, T.F.

Thivierge C, Tseng HW, Mayya VK, Lussier C, Gravel SP, Duchaine TF. Alternative

polyadenylation confers Pten mRNAs stability and resistance to microRNAs. Nucleic Acids Res.

2018 Nov 2;46(19):10340-10352. doi: 10.1093/nar/gky666. PubMed PMID: 30053103; PubMed


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Duchaine TF, Fabian MR. Mechanistic Insights into MicroRNA-Mediated Gene Silencing. Cold

Spring Harb Perspect Biol. 2018 Jun 29. pii: a032771. doi: 10.1101/cshperspect.a032771. [Epub

ahead of print] PubMed PMID: 29959194.

Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A,

Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N,

Tuschl T, Gingras AC, Duchaine TF, Sonenberg N. Translational control of ERK signaling

through miRNA/4EHP-directed silencing. Elife. 2018 Feb 7;7. pii: e35034. doi:


GALLOUZI, I.E.

Phillips BL, Banerjee A, Sanchez BJ, Di Marco S, Gallouzi IE, Pavlath GK, Corbett AH. Post-

transcriptional regulation of Pabpn1 by the RNA binding protein HuR. Nucleic Acids Res. 2018

Sep 6;46(15):7643-7661. doi: 10.1093/nar/gky535. PubMed PMID: 29939290; PubMed Central

PMCID: PMC6125628.

Cramer Z, Sadek J, Vazquez GG, Di Marco S, Pause A, Pelletier J, Gallouzi IE. eIF4A inhibition

prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS

pathways. Sci Rep. 2018 May 30;8(1):8414. doi: 10.1038/s41598-018-26625-9. PubMed PMID:


Hall DT, Griss T, Ma JF, Sanchez BJ, Sadek J, Tremblay AMK, Mubaid S, Omer A, Ford RJ,

Bedard N, Pause A, Wing SS, Di Marco S, Steinberg GR, Jones RG, Gallouzi IE. The AMPK

agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents

inflammation-associated cachectic muscle wasting. EMBO Mol Med. 2018 Jul;10(7). pii: e8307.

doi: 10.15252/emmm.201708307. PubMed PMID: 29844217; PubMed Central PMCID:

PMC6034131.

Omer A, Patel D, Lian XJ, Sadek J, Di Marco S, Pause A, Gorospe M, Gallouzi IE. Stress

granules counteract senescence by sequestration of PAI-1. EMBO Rep. 2018 May;19(5). pii:

e44722. doi: 10.15252/embr.201744722. Epub 2018 Mar 28. PubMed PMID: 29592859; PubMed


GEHRING, K.

Gentil BJ, Lai GT, Menade M, Larivière R, Minotti S, Gehring K, Chapple JP, Brais B, Durham

HD. Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and

dynamics. FASEB J. 2019 Feb;33(2):2982-2994. doi: 10.1096/fj.201801556R. Epub 2018 Oct

17. PubMed PMID: 30332300.

Poissonnier A, Guégan JP, Nguyen HT, Best D, Levoin N, Kozlov G, Gehring K, Pineau R,

Jouan F, Morere L, Martin S, Thomas M, Lazaro E, Douchet I, Ducret T, van de Weghe P,

Blanco P, Jean M, Vacher P, Legembre P. Disrupting the CD95-PLCγ1 interaction prevents


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Th17-driven inflammation. Nat Chem Biol. 2018 Dec;14(12):1079-1089. doi: 10.1038/s41589-

018-0162-9. Epub 2018 Nov 14. PubMed PMID: 30429604.

Chen YS, Kozlov G, Fakih R, Funato Y, Miki H, Gehring K. The cyclic nucleotide-binding

homology domain of the integral membrane protein CNNM mediates dimerization and is required

for Mg(2+) efflux activity. J Biol Chem. 2018 Dec 28;293(52):19998-20007. doi:

10.1074/jbc.RA118.005672. Epub 2018 Oct 19. PubMed PMID: 30341174; PubMed Central

PMCID: PMC6311497.

Trempe JF, Gehring K. Small-Angle X-Ray Scattering for the Study of Proteins in the Ubiquitin

Pathway. Methods Mol Biol. 2018;1844:197-208. doi: 10.1007/978-1-4939-8706-1_13. PubMed

PMID: 30242711.

Sauvé V, Sung G, Soya N, Kozlov G, Blaimschein N, Miotto LS, Trempe JF, Lukacs GL,

Gehring K. Mechanism of parkin activation by phosphorylation. Nat Struct Mol Biol. 2018

Jul;25(7):623-630. doi: 10.1038/s41594-018-0088-7. Epub 2018 Jul 2. Erratum in: Nat Struct

Mol Biol. 2018 Aug;25(8):744. PubMed PMID: 29967542.

Ménade M, Kozlov G, Trempe JF, Pande H, Shenker S, Wickremasinghe S, Li X, Hojjat H,

Dicaire MJ, Brais B, McPherson PS, Wong MJH, Young JC, Gehring K. Structures of ubiquitin-

like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations. J Biol

Chem. 2018 Aug 17;293(33):12832-12842. doi: 10.1074/jbc.RA118.003939. Epub 2018 Jun 26.


Wong K, Gehring K. Deciphering the catalytic mechanism of bacterial ubiquitination. Nature.

2018 May;557(7707):644-645. doi: 10.1038/d41586-018-05250-6. PubMed PMID: 29805175.

Xu J, Kozlov G, McPherson PS, Gehring K. A PH-like domain of the Rab12 guanine nucleotide

exchange factor DENND3 binds actin and is required for autophagy. J Biol Chem. 2018 Mar

23;293(12):4566-4574. doi: 10.1074/jbc.RA117.001446. Epub 2018 Jan 19. PubMed PMID:


Kozlov G, Wong K, Wang W, Skubák P, Muñoz-Escobar J, Liu Y, Siddiqui N, Pannu NS,

Gehring K. Ankyrin repeats as a dimerization module. Biochem Biophys Res Commun. 2018 Jan

1;495(1):1002-1007. doi: 10.1016/j.bbrc.2017.11.135. Epub 2017 Nov 21. PubMed PMID:

29175332.

Kozlov G, Wong K, Gehring K. Crystal structure of the Legionella effector Lem22. Proteins.

2018 Feb;86(2):263-267. doi: 10.1002/prot.25427. Epub 2017 Nov 29. PubMed PMID:


GIGUÈRE, V.

Hirukawa A, Smith HW, Zuo D, Dufour CR, Savage P, Bertos N, Johnson RM, Bui T, Bourque

G, Basik M, Giguère V, Park M, Muller WJ. Targeting EZH2 reactivates a breast cancer

subtype-specific anti-metastatic transcriptional program. Nat Commun. 2018 Jun 29;9(1):2547.

doi: 10.1038/s41467-018-04864-8. PubMed PMID: 29959321; PubMed Central PMCID:

PMC6026192.


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Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang

CY, Wu Y, Giguère V, Bay BH, Vanacker JM, Ghosh S, Gauthier K, Hollenberg AN, McDonnell

DP, Yen PM. Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission,

mitophagy, biogenesis, and function. Sci Signal. 2018 Jun 26;11(536). pii: eaam5855. doi:

10.1126/scisignal.aam5855. PubMed PMID: 29945885.

Audet-Walsh É, Vernier M, Yee T, Laflamme C, Li S, Chen Y, Giguère V. SREBF1 Activity Is

Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer. Mol Cancer Res. 2018

Sep;16(9):1396-1405. doi: 10.1158/1541-7786.MCR-17-0410. Epub 2018 May

21. PubMed PMID: 29784665.

B'chir W, Dufour CR, Ouellet C, Yan M, Tam IS, Andrzejewski S, Xia H, Nabata K, St-Pierre J,

Giguère V. Divergent Role of Estrogen-Related Receptor α in Lipid- and Fasting-Induced

Hepatic Steatosis in Mice. Endocrinology. 2018 May 1;159(5):2153-2164. doi: 10.1210/en.2018-

00115. PubMed PMID: 29635284.

Giguère V. Canonical signaling and nuclear activity of mTOR-a teamwork effort to regulate

metabolism and cell growth. FEBS J. 2018 May;285(9):1572-1588. doi: 10.1111/febs.14384.

Epub 2018 Jan 31. Review. PubMed PMID: 29337437.

Kim SY, Yang CS, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR,

Lee SH, Kim JM, Choi HS, Giguère V, Jo EK. ESRRA (estrogen-related receptor α) is a key

coordinator of transcriptional and post-translational activation of autophagy to promote innate

host defense. Autophagy. 2018;14(1):152-168. doi: 10.1080/15548627.2017.1339001. Epub 2017

Sep 1. PubMed PMID: 28841353; PubMed Central PMCID: PMC5846564.

GOTTE, M.

Tchesnokov EP, Raeisimakiani P, Ngure M, Marchant D, Götte M. Recombinant RNA-

Dependent RNA Polymerase Complex of Ebola Virus. Sci Rep. 2018 Mar 5;8(1):3970. doi:

10.1038/s41598-018-22328-3. PubMed PMID: 29507309; PubMed Central PMCID:

PMC5838098.

Lacbay CM, Menni M, Bernatchez JA, Götte M, Tsantrizos YS. Pharmacophore requirements for

HIV-1 reverse transcriptase inhibitors that selectively "Freeze" the pre-translocated complex

during the polymerization catalytic cycle. Bioorg Med Chem. 2018 May 1;26(8):1713-1726. doi:

10.1016/j.bmc.2018.02.017. Epub 2018 Feb 14. PubMed PMID: 29478802.

GROS, P.

Kong XF, Martinez-Barricarte R, Kennedy J, Mele F, Lazarov T, Deenick EK, Ma CS, Breton G,

Lucero KB, Langlais D, Bousfiha A, Aytekin C, Markle J, Trouillet C, Jabot-Hanin F, Arlehamn

CSL, Rao G, Picard C, Lasseau T, Latorre D, Hambleton S, Deswarte C, Itan Y, Abarca K,

Moraes-Vasconcelos D, Ailal F, Ikinciogullari A, Dogu F, Benhsaien I, Sette A, Abel L, Boisson-

Dupuis S, Schröder B, Nussenzweig MC, Liu K, Geissmann F, Tangye SG, Gros P, Sallusto F,

Bustamante J, Casanova JL. Disruption of an antimycobacterial circuit between dendritic and


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helper T cells in human SPPL2a deficiency. Nat Immunol. 2018 Sep;19(9):973-985. doi:

10.1038/s41590-018-0178-z. Epub 2018 Aug 20. PubMed PMID: 30127434; PubMed Central

PMCID: PMC6130844.

Torre S, Langlais D, Gros P. Genetic analysis of cerebral malaria in the mouse model infected

with Plasmodium berghei. Mamm Genome. 2018 Jun 19. doi: 10.1007/s00335-018-9752-9.

[Epub ahead of print] Review. PubMed PMID: 29922917.

Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ,

Schmeing M, Kain KC, Porco JA Jr, Pelletier J, Gros P. Rocaglates as dual-targeting agents for

experimental cerebral malaria. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2366-E2375.

doi: 10.1073/pnas.1713000115. Epub 2018 Feb 20. PubMed PMID: 29463745; PubMed Central

PMCID: PMC5877959.

El-Hassan AR, Leung V, Kharfallah F, Guyot MC, Allache R, Gros P, Kibar Z. Identification and

characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2.

Mamm Genome. 2018 Apr;29(3-4):229-244. doi: 10.1007/s00335-017-9721-8. Epub 2017 Oct

24. PubMed PMID: 29063958.

GUARNÉ, A.

Baid K, Nellimarla S, Huynh A, Boulton S, Guarné A, Melacini G, Collins SE, Mossman KL.

Direct binding and internalization of diverse extracellular nucleic acid species through the

collagenous domain of class A scavenger receptors. Immunol Cell Biol. 2018 Oct;96(9):922-934.

doi: 10.1111/imcb.12052. Epub 2018 Apr 26. PubMed PMID: 29617041.

HALLETT, M.

Busby M, Hallett MT, Plante I. The Complex Subtype-Dependent Role of Connexin 43 (GJA1)

in Breast Cancer. Int J Mol Sci. 2018 Feb 28;19(3). pii: E693. doi:10.3390/ijms19030693.

Review. PubMed PMID: 29495625; PubMed Central PMCID: PMC5877554.

HUANG, S.

Karimzadeh M, Jandaghi P, Papadakis AI, Trainor S, Rung J, Gonzàlez-Porta M, Scelo G,

Vasudev NS, Brazma A, Huang S, Banks RE, Lathrop M, Najafabadi HS, Riazalhosseini Y.

Aberration hubs in protein interaction networks highlight actionable targets in cancer. Oncotarget.

2018 May 18;9(38):25166-25180. doi: 10.18632/oncotarget.25382. eCollection 2018 May 18.


Perron G, Jandaghi P, Solanki S, Safisamghabadi M, Storoz C, Karimzadeh M, Papadakis AI,

Arseneault M, Scelo G, Banks RE, Tost J, Lathrop M, Tanguay S, Brazma A, Huang S, Brimo F,

Najafabadi HS, Riazalhosseini Y. A General Framework for Interrogation of mRNA Stability

Programs Identifies RNA-Binding Proteins that Govern Cancer Transcriptomes. Cell Rep. 2018

May 8;23(6):1639-1650. doi: 10.1016/j.celrep.2018.04.031. PubMed PMID: 29742422.


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KAZAK, L.

Cluett TJ, Akman G, Reyes A, Kazak L, Mitchell A, Wood SR, Spinazzola A, Spelbrink JN, Holt

IJ. Transcript availability dictates the balance between strand-asynchronous and strand-coupled

mitochondrial DNA replication. Nucleic Acids Res. 2018 Nov 16;46(20):10771-10781. doi:

10.1093/nar/gky852. PubMed PMID: 30239839; PubMed Central PMCID: PMC6237803.

Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB,

Spiegelman BM, Liu T, Rosen ED. Brown Adipose Tissue Controls Skeletal Muscle Function via

the Secretion of Myostatin. Cell Metab. 2018 Oct 2;28(4):631-643.e3. doi:

10.1016/j.cmet.2018.07.004. Epub 2018 Aug 2. PubMed PMID: 30078553; PubMed Central

PMCID: PMC6170693.

Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli

JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB,

Chouchani ET. Accumulation of succinate controls activation of adipose tissue thermogenesis.

Nature. 2018 Aug;560(7716):102-106. doi: 10.1038/s41586-018-0353-2. Epub 2018 Jul 18.


Paulo JA, Jedrychowski MP, Chouchani ET, Kazak L, Gygi SP. Multiplexed Isobaric Tag-Based

Profiling of Seven Murine Tissues Following In Vivo Nicotine Treatment Using a Minimalistic

Proteomics Strategy. Proteomics. 2018 May;18(10):e1700326. doi: 10.1002/pmic.201700326.

Epub 2018 May 2. PubMed PMID: 29660237; PubMed Central PMCID: PMC5992107.

Khandekar MJ, Banks AS, Laznik-Bogoslavski D, White JP, Choi JH, Kazak L, Lo JC, Cohen P,

Wong KK, Kamenecka TM, Griffin PR, Spiegelman BM. Noncanonical agonist PPARγ ligands

modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):561-566. doi: 10.1073/pnas.1717776115. Epub

2018 Jan 2. PubMed PMID: 29295932; PubMed Central PMCID: PMC5776997.

MULLER, W.J.

MacLeod JA, Gao Y, Hall C, Muller WJ, Gujral TS, Greer PA. Genetic disruption of calpain-1

and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes

cancer cells to doxorubicin and lapatinib. Oncotarget. 2018 Sep 7;9(70):33382-33395. doi:

10.18632/oncotarget.26078. eCollection 2018 Sep 7. PubMed PMID: 30279968; PubMed


Kostenko S, Heu CC, Yaron JR, Singh G, de Oliveira C, Muller WJ, Singh VP. c-Src regulates

cargo transit via the Golgi in pancreatic acinar cells. Sci Rep. 2018 Aug 9;8(1):11903. doi:


PMC6085363.


G, Basik M, Giguère V, Park M, Muller WJ. Targeting EZH2 reactivates a breast cancer

subtype-specific anti-metastatic transcriptional program. Nat Commun. 2018 Jun 29;9(1):2547.

doi: 10.1038/s41467-018-04864-8. PubMed PMID: 29959321; PubMed Central PMCID:


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PMC6026192.

Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet

P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF. The Receptor

Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-

Positive Breast Cancer Progression. Cell Rep. 2018 May 1;23(5):1476-1490. doi:

10.1016/j.celrep.2018.04.019. PubMed PMID: 29719259.

Ha JR, Ahn R, Smith HW, Sabourin V, Hébert S, Cepeda Cañedo E, Im YK, Kleinman CL,

Muller WJ, Ursini-Siegel J. Integration of Distinct ShcA Signaling Complexes Promotes Breast

Tumor Growth and Tyrosine Kinase Inhibitor Resistance. Mol Cancer Res. 2018 May;16(5):894-

908. doi: 10.1158/1541-7786.MCR-17-0623. Epub 2018 Feb 16. PubMed PMID: 29453318.

Liu J, Abdelmagid SA, Pinelli CJ, Monk JM, Liddle DM, Hillyer LM, Hucik B, Silva A, Subedi

S, Wood GA, Robinson LE, Muller WJ, Ma DWL. Marine fish oil is more potent than plant-

based n-3 polyunsaturated fatty acids in the prevention of mammary tumors. J Nutr Biochem.

2018 May;55:41-52. doi: 10.1016/j.jnutbio.2017.12.011. Epub 2017 Dec 27. PubMed PMID:

29413488.

Basak P, Leslie H, Dillon RL, Muller WJ, Raouf A, Mowat MRA. In vivo evidence supporting a

metastasis suppressor role for Stard13 (Dlc2) in ErbB2 (Neu) oncogene induced mouse mammary

tumors. Genes Chromosomes Cancer. 2018 Apr;57(4):182-191. doi: 10.1002/gcc.22519. Epub

2017 Dec 29. PubMed PMID: 29218825.

Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH,

Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O,

Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller

W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I. Translational and HIF-1α-Dependent

Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and

Biguanides. Cell Metab. 2018 Dec 4;28(6):817-832.e8. doi: 10.1016/j.cmet.2018.09.001. Epub

2018 Sep 20. PubMed PMID: 30244971.

NAGAR, B.

Roche PJR, Gytz H, Hussain F, Cameron CJF, Paquette D, Blanchette M, Dostie J, Nagar B,

Akavia UD. (2018). “Double-Stranded Biotinylated Donor Enhances Homology-Directed Repair

in Combination with Cas9 Monoavidin in Mammalian Cells”. The CRISPR Journal,

doi.org/10.1089/crispr.2018.0045.

Gytz H, Liang J, Liang Y, Gorelik A, Illes K, Nagar B. The structure of mammalian β-

mannosidase provides insight into β-mannosidosis and nystagmus. FEBS J. 2018 Dec 15. doi:

10.1111/febs.14731. [Epub ahead of print] PubMed PMID: 30552791.

Dementiev A, Joachimiak A, Nguyen H, Gorelik A, Illes K, Shabani S, Gelsomino M, Ahn EE,

Nagar B, Doan N. Molecular mechanism of inhibition of acid ceramidase by carmofur. J Med

Chem. 2018 Dec 7. doi: 10.1021/acs.jmedchem.8b01723. [Epub ahead of print] PubMed PMID:

30525581.


10

Gorelik A, Gebai A, Illes K, Piomelli D, Nagar B. Molecular mechanism of activation of the

immunoregulatory amidase NAAA. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10032-

E10040. doi: 10.1073/pnas.1811759115. Epub 2018 Oct 9. PubMed PMID: 30301806; PubMed


Gebai A, Gorelik A, Nagar B. Crystal structure of saposin D in an open conformation. J Struct

Biol. 2018 Nov;204(2):145-150. doi: 10.1016/j.jsb.2018.07.011. Epub 2018 Jul 17. PubMed

PMID: 30026085.

Labriola JM, Zhou Y, Nagar B. Structural Analysis of the Bacterial Effector AvrA Identifies a

Critical Helix Involved in Substrate Recognition. Biochemistry. 2018 Aug 21;57(33):4985-4996.

doi: 10.1021/acs.biochem.8b00512. Epub 2018 Aug 3. PubMed PMID: 30025209.

Gorelik A, Randriamihaja A, Illes K, Nagar B. Structural basis for nucleotide recognition by the

ectoenzyme CD203c. FEBS J. 2018 Jul;285(13):2481-2494. doi: 10.1111/febs.14489. Epub 2018

May 9. PubMed PMID: 29717535.

Gebai A, Gorelik A, Li Z, Illes K, Nagar B. Structural basis for the activation of acid ceramidase.

Nat Commun. 2018 Apr 24;9(1):1621. doi: 10.1038/s41467-018-03844-2. PubMed PMID:


Gorelik A, Illes K, Nagar B. Crystal structure of the mammalian lipopolysaccharide detoxifier.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E896-E905. doi: 10.1073/pnas.1719834115. Epub

2018 Jan 17. PubMed PMID: 29343645; PubMed Central PMCID: PMC5798384.

NEPVEU, A.

Kaur S, Ramdzan ZM, Guiot MC, Li L, Leduy L, Ramotar D, Sabri S, Abdulkarim B, Nepveu A.

CUX1 stimulates APE1 enzymatic activity and increases the resistance of glioblastoma cells to

the mono-alkylating agent temozolomide. Neuro Oncol. 2018 Mar 27;20(4):484-493. doi:

10.1093/neuonc/nox178. PubMed PMID: 29036362; PubMed Central PMCID: PMC5909652.

PARK, M.

Findlay S, Heath J, Luo VM, Malina A, Morin T, Coulombe Y, Djerir B, Li Z, Samiei A, Simo-

Cheyou E, Karam M, Bagci H, Rahat D, Grapton D, Lavoie EG, Dove C, Khaled H, Kuasne H,

Mann KK, Klein KO, Greenwood CM, Tabach Y, Park M, Côté JF, Masson JY, Maréchal A,

Orthwein A. SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break

repair pathway choice. EMBO J. 2018 Sep 14;37(18). pii: e100158. doi:

10.15252/embj.2018100158. Epub 2018 Aug 28. PubMed PMID: 30154076; PubMed Central

PMCID: PMC6138439.

Murali B, Ren Q, Luo X, Faget DV, Wang C, Johnson RM, Gruosso T, Flanagan KC, Fu Y,

Leahy K, Alspach E, Su X, Ross MH, Burnette B, Weilbaecher KN, Park M, Mbalaviele G,

Monahan JB, Stewart SA. Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast

Cancer Metastases and Chemotherapy-Induced Bone Loss. Cancer Res. 2018 Oct 1;78(19):5618-


11

5630. doi: 10.1158/0008-5472.CAN-18-0234. Epub 2018 Aug 9. PubMed PMID: 30093561;

PubMed Central PMCID: PMC6168362.

Sizemore GM, Balakrishnan S, Thies KA, Hammer AM, Sizemore ST, Trimboli AJ, Cuitiño MC,

Steck SA, Tozbikian G, Kladney RD, Shinde N, Das M, Park D, Majumder S, Krishnan S, Yu L,

Fernandez SA, Chakravarti A, Shields PG, White JR, Yee LD, Rosol TJ, Ludwig T, Park M,

Leone G, Ostrowski MC. Stromal PTEN determines mammary epithelial response to

radiotherapy. Nat Commun. 2018 Jul 17;9(1):2783. doi: 10.1038/s41467-018-05266-6. PubMed



G, Basik M, Giguère V, Park M, Muller WJ. Targeting EZH2 reactivates a breast cancer subtype-

specific anti-metastatic transcriptional program. Nat Commun. 2018 Jun 29;9(1):2547. doi:


PMC6026192.

Klauschen F, Müller KR, Binder A, Bockmayr M, Hägele M, Seegerer P, Wienert S, Pruneri G,

de Maria S, Badve S, Michiels S, Nielsen TO, Adams S, Savas P, Symmans F, Willis S, Gruosso

T, Park M, Haibe-Kains B, Gallas B, Thompson AM, Cree I, Sotiriou C, Solinas C, Preusser M,

Hewitt SM, Rimm D, Viale G, Loi S, Loibl S, Salgado R, Denkert C; International Immuno-

Oncology Biomarker Working Group. Scoring of tumor-infiltrating lymphocytes: From visual

estimation to machine learning. Semin Cancer Biol. 2018 Oct;52(Pt 2):151-157. doi:

10.1016/j.semcancer.2018.07.001. Epub 2018 Jul 7. Review. PubMed PMID: 29990622.

Dankner M, Lajoie M, Moldoveanu D, Nguyen TT, Savage P, Rajkumar S, Huang X, Lvova M,

Protopopov A, Vuzman D, Hogg D, Park M, Guiot MC, Petrecca K, Mihalcioiu C, Watson IR,

Siegel PM, Rose AAN. Dual MAPK Inhibition Is an Effective Therapeutic Strategy for a Subset

of Class II BRAF Mutant Melanomas. Clin Cancer Res. 2018 Dec 15;24(24):6483-6494. doi:

10.1158/1078-0432.CCR-17-3384. Epub 2018 Jun 14. PubMed PMID: 29903896.

Bernier C, Soliman A, Gravel M, Dankner M, Savage P, Petrecca K, Park M, Siegel PM, Shore

GC, Roulston A. DZ-2384 has a superior preclinical profile to taxanes for the treatment of triple-

negative breast cancer and is synergistic with anti-CTLA-4 immunotherapy. Anticancer Drugs.

2018 Sep;29(8):774-785. doi: 10.1097/CAD.0000000000000653. PubMed PMID: 29878901;


Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet

P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF. The Receptor

Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-

Positive Breast Cancer Progression. Cell Rep. 2018 May 1;23(5):1476-1490. doi:

10.1016/j.celrep.2018.04.019. PubMed PMID: 29719259.

Knight JF, Sung VYC, Kuzmin E, Couzens AL, de Verteuil DA, Ratcliffe CDH, Coelho PP,

Johnson RM, Samavarchi-Tehrani P, Gruosso T, Smith HW, Lee W, Saleh SM, Zuo D, Zhao H,

Guiot MC, Davis RR, Gregg JP, Moraes C, Gingras AC, Park M. KIBRA (WWC1) Is a

Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer.

Cell Rep. 2018 Mar 20;22(12):3191-3205. doi: 10.1016/j.celrep.2018.02.095. PubMed PMID:



12

Robichaud N, Hsu BE, Istomine R, Alvarez F, Blagih J, Ma EH, Morales SV, Dai DL, Li G,

Souleimanova M, Guo Q, Del Rincon SV, Miller WH Jr, Ramón Y Cajal S, Park M, Jones RG,

Piccirillo CA, Siegel PM, Sonenberg N. Translational control in the tumor microenvironment

promotes lung metastasis: Phosphorylation of eIF4E in neutrophils. Proc Natl Acad Sci U S A.

2018 Mar 6;115(10):E2202-E2209. doi: 10.1073/pnas.1717439115. Epub 2018 Feb 20. PubMed


Manem V, Adam GA, Gruosso T, Gigoux M, Bertos N, Park M, Haibe-Kains B. CrosstalkNet: A

Visualization Tool for Differential Co-expression Networks and Communities. Cancer Res. 2018

Apr 15;78(8):2140-2143. doi: 10.1158/0008-5472.CAN-17-1383. Epub 2018 Feb 19. PubMed

PMID: 29459407.

PASTOR, W.

Chen D, Liu W, Zimmerman J, Pastor WA, Kim R, Hosohama L, Ho J, Aslanyan M, Gell JJ,

Jacobsen SE, Clark AT. The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human

Germline Formation. Cell Rep. 2018 Dec 26;25(13):3591-3602.e5. doi:

10.1016/j.celrep.2018.12.011. PubMed PMID: 30590035; PubMed Central PMCID:

PMC6342560.

Pastor WA, Liu W, Chen D, Ho J, Kim R, Hunt TJ, Lukianchikov A, Liu X, Polo JM, Jacobsen

SE, Clark AT. TFAP2C regulates transcription in human naïve pluripotency by opening

enhancers. Nat Cell Biol. 2018 May;20(5):553-564. doi: 10.1038/s41556-018-0089-0. Epub 2018

Apr 25. PubMed PMID: 29695788; PubMed Central PMCID: PMC5926822.

PAUSE, A.










PMC6034131.

Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C,

Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N,

Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM.

Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating

Autophagy. Mol Cell. 2018 May 3;70(3):531-544.e9. doi: 10.1016/j.molcel.2018.03.037.


Omer A, Patel D, Lian XJ, Sadek J, Di Marco S, Pause A, Gorospe M, Gallouzi IE. Stress


13

granules counteract senescence by sequestration of PAI-1. EMBO Rep. 2018 May;19(5). pii:

e44722. doi: 10.15252/embr.201744722. Epub 2018 Mar 28. PubMed PMID: 29592859; PubMed


Possik E, Pause A. Biochemical Measurement of Glycogen: Method to Investigate the AMPK-

Glycogen Relationship. Methods Mol Biol. 2018;1732:57-67. doi: 10.1007/978-1-4939-7598-

3_4. PubMed PMID: 29480468.

Paquette M, El-Houjeiri L, Pause A. mTOR Pathways in Cancer and Autophagy. Cancers (Basel).

2018 Jan 12;10(1). pii: E18. doi: 10.3390/cancers10010018. Review. PubMed PMID: 29329237;


PELLETIER, J.

Zhang W, Liu S, Maiga RI, Pelletier J, Brown LE, Wang TT, Porco JA. Chemical Synthesis

Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for HCV Infection. J

Am Chem Soc. 2018 Dec 27. doi: 10.1021/jacs.8b11477. [Epub ahead of print] PubMed PMID:

30590924.

Robert F, Pelletier J. Exploring the Impact of Single-Nucleotide Polymorphisms on Translation.

Front Genet. 2018 Oct 30;9:507. doi: 10.3389/fgene.2018.00507. eCollection 2018. Review.


Cencic R, Pelletier J. A cautionary note on the use of cap analogue affinity resins. Anal Biochem.

2018 Nov 1;560:24-29. doi: 10.1016/j.ab.2018.09.001. Epub 2018 Sep 4. PubMed PMID:

30193929.

Picard-Jean F, Brand C, Tremblay-Létourneau M, Allaire A, Beaudoin MC, Boudreault S, Duval

C, Rainville-Sirois J, Robert F, Pelletier J, Geiss BJ, Bisaillon M. 2'-O-methylation of the mRNA

cap protects RNAs from decapping and degradation by DXO. PLoS One. 2018 Aug

9;13(8):e0202308. doi: 10.1371/journal.pone.0202308. eCollection 2018. PubMed PMID:






Katigbak A, Robert F, Paquet M, Pelletier J. Inducible Genome Editing with Conditional

CRISPR/Cas9 Mice. G3 (Bethesda). 2018 May 4;8(5):1627-1635. doi: 10.1534/g3.117.300327.


Ramon Y Cajal S, Castellvi J, Hümmer S, Peg V, Pelletier J, Sonenberg N. Beyond molecular

tumor heterogeneity: protein synthesis takes control. Oncogene. 2018 May;37(19):2490-2501.

doi: 10.1038/s41388-018-0152-0. Epub 2018 Feb 21. Review. PubMed PMID: 29463861;




14




PMCID: PMC5877959.

Chu J, Pelletier J. Therapeutic Opportunities in Eukaryotic Translation. Cold Spring Harb

Perspect Biol. 2018 Jun 1;10(6). pii: a032995. doi: 10.1101/cshperspect.a032995. Review.


Choi HY, Ruel I, Malina A, Garrod DR, Oda MN, Pelletier J, Schwertani A, Genest J.

Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein

biogenesis. Eur Heart J. 2018 Apr 7;39(14):1194-1202. doi: 10.1093/eurheartj/ehx340. PubMed

PMID: 29106519.

Chu J., Pelletier J. (2018) Chemical and CRISPR/Cas9 Tools for Functional Characterization of

RNA Helicases. [Applied RNA Bioscience, Springer, Singapore] (Masuda S., and Izawa S., eds).

221 - 245

PURISIMA, E.

Hill JJ, Tremblay TL, Corbeil CR, Purisima EO, Sulea T. An accurate TMT-based approach to

quantify and model lysine susceptibility to conjugation via N-hydroxysuccinimide esters in a

monoclonal antibody. Sci Rep. 2018 Dec 5;8(1):17680. doi: 10.1038/s41598-018-35924-0.


Hogues H, Gaudreault F, Corbeil CR, Deprez C, Sulea T, Purisima EO. ProPOSE: Direct

Exhaustive Protein-Protein Docking with Side Chain Flexibility. J Chem Theory Comput. 2018

Sep 11;14(9):4938-4947. doi: 10.1021/acs.jctc.8b00225. Epub 2018 Aug 28. PubMed PMID:

30107730.

Sulea T, Hussack G, Ryan S, Tanha J, Purisima EO. Application of Assisted Design of Antibody

and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-

domain antibody. Sci Rep. 2018 Feb 2;8(1):2260. doi: 10.1038/s41598-018-20599-4. PubMed


Hogues H, Sulea T, Gaudreault F, Corbeil CR, Purisima EO. Binding pose and affinity prediction

in the 2016 D3R Grand Challenge 2 using the Wilma-SIE method. J Comput Aided Mol Des.

2018 Jan;32(1):143-150. doi: 10.1007/s10822-017-0071-0. Epub 2017 Oct 5. PubMed PMID:

28983727.

RAK, J.

Théry C, Rak, J. et al Minimal information for studies of extracellular vesicles 2018

(MISEV2018): a position statement of the International Society for Extracellular Vesicles and

update of the MISEV2014 guidelines. J Extracell Vesicles. 2018 Nov 23;7(1):1535750. doi:

10.1080/20013078.2018.1535750. eCollection 2018. PubMed PMID: 30637094; PubMed Central

PMCID: PMC6322352.


15

Spinelli C, Adnani L, Choi D, Rak J. Extracellular Vesicles as Conduits of Non-Coding RNA

Emission and Intercellular Transfer in Brain Tumors. Noncoding RNA. 2018 Dec 25;5(1). pii:

E1. doi: 10.3390/ncrna5010001. Review. PubMed PMID: 30585246.

Choi D, Montermini L, Kim DK, Meehan B, Roth FP, Rak J. The Impact of Oncogenic GFRvIII

on the Proteome of Extracellular Vesicles Released from Glioblastoma Cells. Mol Cell roteomics.

2018 Oct;17(10):1948-1964. doi: 10.1074/mcp.RA118.000644. Epub 2018 Jul 13. PubMed MID:


Tawil N, Chennakrishnaiah S, Bassawon R, Johnson R, D'Asti E, Rak J. Single cell coagulomes

as constituents of the oncogene-driven coagulant phenotype in brain tumours. Thromb Res. 2018

Apr;164 Suppl 1:S136-S142. doi: 10.1016/j.thromres.2018.01.021. PubMed PMID: 29703472.

Garnier D, Meehan B, Kislinger T, Daniel P, Sinha A, Abdulkarim B, Nakano I, Rak J. Divergent

evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular

vesicles and coupled with radiosensitization. Neuro Oncol. 2018 Jan 22;20(2):236-248. doi:

10.1093/neuonc/nox142. PubMed PMID: 29016925; PubMed Central PMCID: PMC5777501.

Choi, D, Spinelli, C, Montermini, L and Rak, J: Oncogenic regulation of extracellular

vesicle proteome and heterogeneity, Proteomics 2018; doi: 10.1002/

pmic.201800169. [Epub ahead of print]

Feulner, L, Najafabadi, H, Tanguay, S., Rak, J (co-corresponding) & Riazalhosseini, Y:

Age-Related Variation in Gene Expression Patterns of Renal Cell Carcinoma Suggests the

Impact of the Life Cycle on Disease Biology; Urologic Oncology, 2018, pii: S1078-

1439(18)30452-6. doi: 10.1016/j.urolonc.2018.11.006. [Epub ahead of print]

Ali A. Al-Hashimi, Rak, J and Austin, RC: Cell Surface GRP78: a novel regulator of tissue

factor procoagulant activity. Book Chapter, Cell Surface GRP78, A New Paradigm in Signal

Transduction Biology, Elsevier. 2018, DOI: https://doi.org/10.1016/B978-0-12-812351-

5.00004-0

Spinelli, L, Montermini, B Meehan, Brisson, A, Choi, D, Nakano, I and Rak, J: Molecular

subtypes and differentiation programs of glioma stem cells as determinants of extracellular

vesicle profiles and endothelial cell stimulating activities. Journal of Extracellular Vesicles

(JEV) 2018, Jul 17;7(1):1490144. doi:10.1080/20013078. 2018.1490144. eCollection 2018.

PMID: 30034643

Chennakrishnaiah, S, Meehan, B, D’Asti, E, Montermini, L, Lee, T-H, Karatzas, N, M.

Buchanan, M, Tawil, N, Choi, D, Divangahi, M, Basik, M and Rak, J: Leukocytes as a

reservoir of circulating oncogenic DNA and regulatory targets of tumor-derived extracellular

vesicles. Journal of Thrombosis and Haemostasis (JTH) 2018, 16(9):1800-1813; Jul 3. doi:

10.1111/jth.14222. [Epub ahead of print], PMID: 29971917

Rak, J: The quest for personalized management of thrombosis in cancer - do cancer genes

hold the clue? ICTHIC Magazine, March, 2018; 1-2.

Rak, J and Emmenegger, U: Angiogenesis. Chapter 11, In Basic Science of Oncology, 6PthP


16

Edition 2018, Editors: Richard Hill, Ian Tannock, Robert Bristow and Lea Harrington,

McGraw Hill Professional: 243-270

RICHARD, S.

Chan LH, Zhou L, Ng KY, Wong TL, Lee TK, Sharma R, Loong JH, Ching YP, Yuan YF, Xie

D, Lo CM, Man K, Artegiani B, Clevers H, Yan HH, Leung SY, Richard S, Guan XY, Huen

MSY, Ma S. PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness

Activities in Hepatocellular Carcinoma through CRAF Methylation. Cell Rep. 2018 Oct

16;25(3):690-701.e8. doi: 10.1016/j.celrep.2018.09.053. PubMed PMID: 30332648.

Calabretta S, Vogel G, Yu Z, Choquet K, Darbelli L, Nicholson TB, Kleinman CL, Richard S.

Loss of PRMT5 Promotes PDGFRα Degradation during Oligodendrocyte Differentiation and

Myelination. Dev Cell. 2018 Aug 20;46(4):426-440.e5. doi: 10.1016/j.devcel.2018.06.025. Epub

2018 Jul 26. PubMed PMID: 30057274.

Bueno MTD, Baldascini M, Richard S, Lowndes NF. Recruitment of lysine demethylase 2A to

DNA double strand breaks and its interaction with 53BP1 ensures genome stability. Oncotarget.

2018 Mar 23;9(22):15915-15930. doi: 10.18632/oncotarget.24636. eCollection 2018 Mar 23.


Vadnais C, Chen R, Fraszczak J, Yu Z, Boulais J, Pinder J, Frank D, Khandanpour C, Hébert J,

Dellaire G, Côté JF, Richard S, Orthwein A, Drobetsky E, Möröy T. GFI1 facilitates efficient

DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1. Nat Commun.

2018 Apr 12;9(1):1418. doi: 10.1038/s41467-018-03817-5. PubMed PMID: 29651020; PubMed


Gou Y, Li J, Jackson-Weaver O, Wu J, Zhang T, Gupta R, Cho I, Ho TV, Chen Y, Li M, Richard

S, Wang J, Chai Y, Xu J. Protein Arginine Methyltransferase PRMT1 Is Essential for

Palatogenesis. J Dent Res. 2018 Dec;97(13):1510-1518. doi: 10.1177/0022034518785164. Epub

2018 Jul 9. PubMed PMID: 29986157.

Zhang T, Wu J, Ungvijanpunya N, Jackson-Weaver O, Gou Y, Feng J, Ho TV, Shen Y, Liu J,

Richard S, Jin J, Hajishengallis G, Chai Y, Xu J. Smad6 Methylation Represses NFκB Activation

and Periodontal Inflammation. J Dent Res. 2018 Jul;97(7):810-819. doi:

10.1177/0022034518755688. Epub 2018 Feb 8. PubMed PMID: 29420098.

Panganiban CH, Barth JL, Darbelli L, Xing Y, Zhang J, Li H, Noble KV, Liu T, Brown LN,

Schulte BA, Richard S, Lang H. Noise-induced dysregulation of Quaking RNA binding proteins

contributes to auditory nerve demyelination and hearing loss. J Neurosci. 2018 Feb 6. pii: 2487-

17. doi: 10.1523/JNEUROSCI.2487-17.2018. [Epub ahead of print] PubMed PMID: 29437856;



17

SAGAN, S.M.

Barnard TR, Rajah MM, Sagan SM. Contemporary Zika Virus Isolates Induce More dsRNA and

Produce More Negative-Strand Intermediate in Human Astrocytoma Cells. Viruses. 2018 Dec

19;10(12). pii: E728. doi: 10.3390/v10120728. PubMed PMID: 30572570; PubMed Central

PMCID: PMC6316034.

Juźwik CA, Drake S, Lécuyer MA, Johnson RM, Morquette B, Zhang Y, Charabati M, Sagan

SM, Bar-Or A, Prat A, Fournier AE. Neuronal microRNA regulation in Experimental

Autoimmune Encephalomyelitis. Sci Rep. 2018 Sep 7;8(1):13437. doi: 10.1038/s41598-018-

31542-y. PubMed PMID: 30194392; PubMed Central PMCID: PMC6128870.

Bernier A, Sagan SM. The Diverse Roles of microRNAs at the Host⁻Virus Interface. Viruses.

2018 Aug 19;10(8). pii: E440. doi: 10.3390/v10080440. Review. PubMed PMID: 30126238;


Breton S, van Vlymen J, Xia S, Holden RR, Phelan R, Sagan SM, Jaeger M. A survey of

medication preparation and administration practices among members of the Canadian

Anesthesiologists' Society. Can J Anaesth. 2018 Oct;65(10):1100-1109. doi: 10.1007/s12630-

018-1164-5. Epub 2018 Jun 4. PubMed PMID: 29868942.

Amador-Cañizares Y, Bernier A, Wilson JA, Sagan SM. miR-122 does not impact recognition of

the HCV genome by innate sensors of RNA but rather protects the 5' end from the cellular

pyrophosphatases, DOM3Z and DUSP11. Nucleic Acids Res. 2018 Jun 1;46(10):5139-5158. doi:

10.1093/nar/gky273. PubMed PMID: 29672716; PubMed Central PMCID: PMC6007490.

Alpuche-Lazcano SP, McCullogh CR, Del Corpo O, Rance E, Scarborough RJ, Mouland AJ,

Sagan SM, Teixeira MM, Gatignol A. Higher Cytopathic Effects of a Zika Virus Brazilian Isolate

from Bahia Compared to a Canadian-Imported Thai Strain. Viruses. 2018 Jan 27;10(2). pii: E53.

doi: 10.3390/v10020053. PubMed PMID: 29382068; PubMed Central PMCID: PMC5850360.

Canuti M, Williams C, Sagan SM, Oude Munnink BB, Gadi S, Verhoeven JTP, Cotton M, Lang

AS, Cullen J and van der Hoek L. Virus discovery reveals a high prevalence and a great diversity

of members of the Flaviviridae in wild lemurs. (2018) Arch Virol. Nov 20, doi: 10.1007/s00705-

018-4099-9.

Cheng ML, Abdel-Hakeem MS, Cousineau SE, Grebely J, Marshall AD, Saeed S, Sagan SM,

Shoukry NH, Feld JJ and MacParland SA. The 7th Canadian Symposium on Hepatitis C Virus:

“Toward Elimination of HCV: How to Get There”. (2018) Canadian Liver Journal. 1(3): 139-

152

Khan S, Bernier A, Dapp D, Fortier E, Krajden M, King A, Grebely J, Sagan SM, Cooper CL,

Crawley AM. 6th Canadian Symposium on HCV: Remaining battles in delivering HCV care in

the highly curative DAA era. (2018) Canadian Liver Journal. 1(2):94-105.


18

ST-PIERRE, J.

Brunham LR, Ruel I, Aljenedil S, Rivière JB, Baass A, Tu JV, Mancini GBJ, Raggi P, Gupta M,

Couture P, Pearson GJ, Bergeron J, Francis GA, McCrindle BW, Morrison K, St-Pierre J,

Henderson M, Hegele RA, Genest J, Goguen J, Gaudet D, Paré G, Romney J, Ransom T, Bernard

S, Katz P, Joy TR, Bewick D, Brophy J. Canadian Cardiovascular Society Position Statement on

Familial Hypercholesterolemia: Update 2018. Can J Cardiol. 2018 Dec;34(12):1553-1563. doi:

10.1016/j.cjca.2018.09.005. PubMed PMID: 30527143.





Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors

and Biguanides. Cell Metab. 2018 Dec 4;28(6):817-832.e8. doi: 10.1016/j.cmet.2018.09.001.

Epub 2018 Sep 20. PubMed PMID: 30244971.

Shamalnasab M, Gravel SP, St-Pierre J, Breton L, Jäger S, Aguilaniu H. A salicylic acid

derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the

mitochondrial unfolded protein response. Aging Cell. 2018 Dec;17(6):e12830. doi:

10.1111/acel.12830. Epub 2018 Sep 7. PubMed PMID: 30192051; PubMed Central PMCID:

PMC6260907.

Andrzejewski S, Siegel PM, St-Pierre J. Metabolic Profiles Associated With Metformin Efficacy

in Cancer. Front Endocrinol (Lausanne). 2018 Aug 21;9:372. doi: 10.3389/fendo.2018.00372.

eCollection 2018. Review. PubMed PMID: 30186229; PubMed Central PMCID: PMC6110930.

Im YK, Najyb O, Gravel SP, McGuirk S, Ahn R, Avizonis DZ, Chénard V, Sabourin V, Hudson

J, Pawson T, Topisirovic I, Pollak M, St-Pierre J, Ursini-Siegel J. Interplay between ShcA

Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer. Cancer

Res. 2018 Sep 1;78(17):4826-4838. doi: 10.1158/0008-5472.CAN-17-3696. Epub 2018 Jun 21.


B'chir W, Dufour CR, Ouellet C, Yan M, Tam IS, Andrzejewski S, Xia H, Nabata K, St-Pierre J,

Giguère V. Divergent Role of Estrogen-Related Receptor α in Lipid- and Fasting-Induced

Hepatic Steatosis in Mice. Endocrinology. 2018 May 1;159(5):2153-2164. doi: 10.1210/en.2018-

00115. PubMed PMID: 29635284.

Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO,

St-Pierre J, Roux PP. RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in

Melanoma. Cancer Res. 2018 May 1;78(9):2191-2204. doi: 10.1158/0008-5472.CAN-17-2215.

Epub 2018 Feb 12. PubMed PMID: 29440170.

SALAVATI, R.

Rostami S, Salavati R, Beech RN, Babaei Z, Sharbatkhori M, Shamsaddini S,Nasibi S, Harandi

MF. Genetic and morphometric categorization of Taenia ovis from Sheep in Iran. Parasitology.

2018 Nov 13:1-6. doi: 10.1017/S0031182018001907. [Epub ahead of print] PubMed PMID:


19

30419971.

Gazestani VH, Hampton M, Shaw AK, Salavati R, Zimmer SL. Tail characteristics of

Trypanosoma brucei mitochondrial transcripts are developmentally altered in a transcript-

specific manner. Int J Parasitol. 2018 Feb;48(2):179-189. doi: 10.1016/j.ijpara.2017.08.012. Epub

2017 Nov 1. PubMed PMID: 29100810.

SALEH, M.

Rodrigue-Gervais IG, Doiron K, Champagne C, Mayes L, Leiva-Torres GA, Vanié P Jr, Douglas

T, Vidal SM, Alnemri ES, Saleh M. The mitochondrial protease HtrA2 restricts the NLRP3 and

AIM2 inflammasomes. Sci Rep. 2018 May 31;8(1):8446. doi: 10.1038/s41598-018-26603-1.


Songane M, Khair M, Saleh M. An updated view on the functions of caspases ininflammation and

immunity. Semin Cell Dev Biol. 2018 Oct;82:137-149. doi: 10.1016/j.semcdb.2018.01.001. Epub

2018 Feb 3. Review. PubMed PMID: 29366812.

SCHMEING, T.M.

Reimer JM, Harb I, Ovchinnikova OG, Jiang J, Whitfield C, Schmeing TM. Structural Insight

into a Novel Formyltransferase and Evolution to a Nonribosomal Peptide Synthetase Tailoring

Domain. ACS Chem Biol. 2018 Nov 16;13(11):3161-3172. doi: 10.1021/acschembio.8b00739.

Epub 2018 Oct 30. PubMed PMID: 30346688.





PMCID: PMC5877959.

Reimer JM, Haque AS, Tarry MJ, Schmeing TM. Piecing together nonribosomal peptide

synthesis. Curr Opin Struct Biol. 2018 Apr;49:104-113. doi: 10.1016/j.sbi.2018.01.011. Epub

2018 Feb 13. Review. PubMed PMID: 29444491.

SCHURR, E.

Peters JS, Andrews JR, Hatherill M, Hermans S, Martinez L, Schurr E, van der Heijden Y, Wood

R, Rustomjee R, Kana BD. Advances in the understanding of Mycobacterium tuberculosis

transmission in HIV-endemic settings. Lancet Infect Dis. 2018 Dec 13. pii: S1473-

3099(18)30477-8. doi: 10.1016/S1473-3099(18)30477-8. [Epub ahead of print] Review. PubMed

PMID: 30554995.

Kroon EE, Coussens AK, Kinnear C, Orlova M, Möller M, Seeger A, Wilkinson RJ, Hoal EG,

Schurr E. Neutrophils: Innate Effectors of TB Resistance? Front Immunol. 2018 Nov 14;9:2637.


20

doi: 10.3389/fimmu.2018.02637. eCollection 2018. Review. PubMed PMID: 30487797; PubMed


Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE,

Gordon R, Hesseling A, Hoi LV, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn

DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P,

Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R,

Nahid P. Moving Toward Tuberculosis Elimination: Critical Issues for Research in Diagnostics

and Therapeutics for Tuberculosis Infection. Am J Respir Crit Care Med. 2018 Oct 18. doi:

10.1164/rccm.201806-1053PP. [Epub ahead of print] PubMed PMID: 30335466.

Möller M, Kinnear CJ, Orlova M, Kroon EE, van Helden PD, Schurr E, Hoal EG. Genetic

Resistance to Mycobacterium tuberculosis Infection and Disease. Front Immunol. 2018 Sep

27;9:2219. doi: 10.3389/fimmu.2018.02219. eCollection 2018. Review. PubMed PMID:


Dallmann-Sauer M, Correa-Macedo W, Schurr E. Human genetics of mycobacterial disease.

Mamm Genome. 2018 Aug;29(7-8):523-538. doi: 10.1007/s00335-018-9765-4. Epub 2018 Aug


Costiniuk CT, Salahuddin S, Farnos O, Olivenstein R, Pagliuzza A, Orlova M, Schurr E, De

Castro C, Bourbeau J, Routy JP, Ancuta P, Chomont N, Jenabian MA. HIV persistence in

mucosal CD4+ T cells within the lungs of adults receiving long-term suppressive antiretroviral

therapy. AIDS. 2018 Oct 23;32(16):2279-2289. doi: 10.1097/QAD.0000000000001962. PubMed


Simmons JD, Stein CM, Seshadri C, Campo M, Alter G, Fortune S, Schurr E, Wallis RS,

Churchyard G, Mayanja-Kizza H, Boom WH, Hawn TR. Immunological mechanisms of human

resistance to persistent Mycobacterium tuberculosis infection. Nat Rev Immunol. 2018

Sep;18(9):575-589. doi: 10.1038/s41577-018-0025-3. Review. PubMed PMID: 29895826;


Kim KS, Marcogliese PC, Yang J, Callaghan SM, Resende V, Abdel-Messih E, Marras C,

Visanji NP, Huang J, Schlossmacher MG, Trinkle-Mulcahy L, Slack RS, Lang AE; Canadian

Lrrk2 in Inflammation Team (CLINT), Park DS. Regulation of myeloid cell phagocytosis by

LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease. Proc Natl Acad Sci

U S A. 2018 May 29;115(22):E5164-E5173. doi: 10.1073/pnas.1718946115. Epub 2018 May 14.


bel L, Fellay J, Haas DW, Schurr E, Srikrishna G, Urbanowski M, Chaturvedi N, Srinivasan S,

Johnson DH, Bishai WR. Genetics of human susceptibility to active and latent tuberculosis:

present knowledge and future perspectives. Lancet Infect Dis. 2018 Mar;18(3):e64-e75. doi:

10.1016/S1473-3099(17)30623-0. Epub 2017 Oct 27. Review. PubMed PMID: 29111156.

SHORE, G.C.




21




Liu H, Su D, Zhang J, Ge S, Li Y, Wang F, Gravel M, Roulston A, Song Q, Xu W, Liang JG,

Shore G, Wang X, Liang P. Author Correction: Improvement of Pharmacokinetic Profile of

TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo. Sci Rep. 2018 Mar


PMCID: PMC5864869.

SIEGEL, P.M.

James-Bhasin M, Siegel PM, Nazhat SN. A Three-Dimensional Dense Collagen Hydrogel to

Model Cancer Cell/Osteoblast Interactions. J Funct Biomater. 2018 Dec 12;9(4). pii: E72. doi:

10.3390/jfb9040072. PubMed PMID: 30545096; PubMed Central PMCID: PMC6306762.

Ashktorab H, Rahi H, Nouraie M, Shokrani B, Lee E, Haydari T, Laiyemo AO, Siegel P, Brim H.

GPNMB methylation: a new marker of potentially carcinogenic colon lesions. BMC Cancer.

2018 Nov 6;18(1):1068. doi: 10.1186/s12885-018-4903-7. PubMed PMID: 30400781; PubMed









Andrzejewski S, Siegel PM, St-Pierre J. Metabolic Profiles Associated With Metformin Efficacy

in Cancer. Front Endocrinol (Lausanne). 2018 Aug 21;9:372. doi: 10.3389/fendo.2018.00372.

eCollection 2018. Review. PubMed PMID: 30186229; PubMed Central PMCID: PMC6110930.

Poffenberger MC, Metcalfe-Roach A, Aguilar E, Chen J, Hsu BE, Wong AH, Johnson RM,

Flynn B, Samborska B, Ma EH, Gravel SP, Tonelli L, Devorkin L, Kim P, Hall A, Izreig S,

Loginicheva E, Beauchemin N, Siegel PM, Artyomov MN, Lum JJ, Zogopoulos G, Blagih J,

Jones RG. LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis.

Science. 2018 Jul 27;361(6400):406-411. doi: 10.1126/science.aan3975. PubMed PMID:

30049881.









22




Toosi BM, El Zawily A, Truitt L, Shannon M, Allonby O, Babu M, DeCoteau J, Mousseau D, Ali

M, Freywald T, Gall A, Vizeacoumar FS, Kirzinger MW, Geyer CR, Anderson DH, Kim T,

Welm AL, Siegel P, Vizeacoumar FJ, Kusalik A, Freywald A. EPHB6 augments both

development and drug sensitivity of triple-negative breast cancer tumours. Oncogene. 2018

Jul;37(30):4073-4093. doi: 10.1038/s41388-018-0228-x. Epub 2018 Apr 27. PubMed PMID:


Dankner M, Rose AAN, Rajkumar S, Siegel PM, Watson IR. Classifying BRAF alterations in

cancer: new rational therapeutic strategies for actionable mutations. Oncogene. 2018

Jun;37(24):3183-3199. doi: 10.1038/s41388-018-0171-x. Epub 2018 Mar 15. Review. PubMed

PMID: 29540830.







Annis MG, Ouellet V, Rennhack JP, L'Esperance S, Rancourt C, Mes-Masson AM, Andrechek

ER, Siegel PM. Integrin-uPAR signaling leads to FRA-1 phosphorylation and enhanced breast

cancer invasion. Breast Cancer Res. 2018 Jan 30;20(1):9. doi: 10.1186/s13058-018-0936-8.


Ngan E, Kiepas A, Brown CM, Siegel PM. Emerging roles for LPP in metastatic cancer

progression. J Cell Commun Signal. 2018 Mar;12(1):143-156. doi: 10.1007/s12079-017-0415-5.

Epub 2017 Oct 13. Review. PubMed PMID: 29027626; PubMed Central PMCID: PMC5842179.

SONENBERG, N.

Machida K, Shigeta T, Yamamoto Y, Ito T, Svitkin Y, Sonenberg N, Imataka H. Dynamic

interaction of poly(A)-binding protein with the ribosome. Sci Rep. 2018 Nov 28;8(1):17435. doi:


PMC6261967.

Cerezo M, Guemiri R, Druillennec S, Girault I, Malka-Mahieu H, Shen S, Allard D, Martineau

S, Welsch C, Agoussi S, Estrada C, Adam J, Libenciuc C, Routier E, Roy S, Désaubry L,

Eggermont AM, Sonenberg N, Scoazec JY, Eychène A, Vagner S, Robert C. Translational

control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma. Nat Med. 2018

Dec;24(12):1877-1886. doi: 10.1038/s41591-018-0217-1. Epub 2018 Oct 29. PubMed PMID:

30374200.

Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D,

Truong VT, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Pelin A, Diallo JS,


23

Le Boeuf F, Bell JC, Mossman KL, Graber TE, Jaramillo M, Sonenberg N, Alain T. Active-site

mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP

axis. PLoS Pathog. 2018 Aug 23;14(8):e1007264. doi: 10.1371/journal.ppat.1007264. eCollection

2018 Aug. PubMed PMID: 30138450; PubMed Central PMCID: PMC6124814.

Tahmasebi S, Sonenberg N, Hershey JWB, Mathews MB. Protein Synthesis and Translational

Control: A Historical Perspective. Cold Spring Harb Perspect Biol. 2018 Aug 6. pii: a035584.

doi: 10.1101/cshperspect.a035584. [Epub ahead of print] PubMed PMID: 30082466.

Tahmasebi S, Khoutorsky A, Mathews MB, Sonenberg N. Translation deregulation in human

disease. Nat Rev Mol Cell Biol. 2018 Dec;19(12):791-807. doi: 10.1038/s41580-018-0034-x.

Review. PubMed PMID: 30038383.

Hershey JWB, Sonenberg N, Mathews MB. Principles of Translational Control. Cold Spring

Harb Perspect Biol. 2018 Jun 29. pii: a032607. doi: 10.1101/cshperspect.a032607. [Epub ahead

of print] PubMed PMID: 29959195.

Robichaud N, Sonenberg N, Ruggero D, Schneider RJ. Translational Control in Cancer. Cold

Spring Harb Perspect Biol. 2018 Jun 29. pii: a032896. doi: 10.1101/cshperspect.a032896. [Epub

ahead of print] PubMed PMID: 29959193.

Aguilar-Valles A, Haji N, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Popic J, Sharma V,

Cao R, Rummel C, Tanti A, Wiebe S, Nuñez N, Comai S, Nadon R, Luheshi G, Mechawar N,

Turecki G, Lacaille JC, Gobbi G, Sonenberg N. Translational control of depression-like behavior

via phosphorylation of eukaryotic translation initiation factor 4E. Nat Commun. 2018 Jun


PMCID: PMC6018502.

Moon SL, Sonenberg N, Parker R. Neuronal Regulation of eIF2α Function in Health and

Neurological Disorders. Trends Mol Med. 2018 Jun;24(6):575-589. doi:

10.1016/j.molmed.2018.04.001. Epub 2018 Apr 30. Review. PubMed PMID: 29716790.

Chong Y, Saviuk N, Pie B, Basisty N, Quinn RK, Schilling B, Sonenberg N, Cooper E, Haghighi

AP. Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity. Cell Rep. 2018

Apr 3;23(1):11-22. doi: 10.1016/j.celrep.2018.03.040. PubMed PMID: 29617653.

Liu D, Stowie A, de Zavalia N, Leise T, Pathak SS, Drewes LR, Davidson AJ, Amir S,

Sonenberg N, Cao R. mTOR signaling in VIP neurons regulates circadian clock synchrony and

olfaction. Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3296-E3304. doi:

10.1073/pnas.1721578115. Epub 2018 Mar 19. PubMed PMID: 29555746; PubMed Central

PMCID: PMC5889665.

Ramon Y Cajal S, Castellvi J, Hümmer S, Peg V, Pelletier J, Sonenberg N. Beyond molecular

tumor heterogeneity: protein synthesis takes control. Oncogene. 2018 May;37(19):2490-2501.

doi: 10.1038/s41388-018-0152-0. Epub 2018 Feb 21. Review. PubMed PMID: 29463861;





24





Ding M, Van der Kwast TH, Vellanki RN, Foltz WD, McKee TD, Sonenberg N, Pandolfi PP,

Koritzinsky M, Wouters BG. The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote

Hypoxia Tolerance in PTEN-driven Prostate Cancer. Mol Cancer Res. 2018 Apr;16(4):682-695.

doi: 10.1158/1541-7786.MCR-17-0696. Epub 2018 Feb 16. PubMed PMID: 29453322.

Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A,

Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N,

Tuschl T, Gingras AC, Duchaine TF, Sonenberg N. Translational control of ERK signaling

through miRNA/4EHP-directed silencing. Elife. 2018 Feb 7;7. pii: e35034. doi:


Jafarnejad SM, Kim SH, Sonenberg N. Aminoacylation of Proteins: New Targets for the Old

ARSenal. Cell Metab. 2018 Jan 9;27(1):1-3. doi: 10.1016/j.cmet.2017.12.012. PubMed PMID:

29320701.

Cieplak-Rotowska MK, Tarnowski K, Rubin M, Fabian MR, Sonenberg N, Dadlez M,

Niedzwiecka A. Structural Dynamics of the GW182 Silencing Domain Including its RNA

Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry. J

Am Soc Mass Spectrom. 2018 Jan;29(1):158-173. doi: 10.1007/s13361-017-1830-9. Epub 2017

Oct 27. PubMed PMID: 29080206; PubMed Central PMCID: PMC5785596.

Gantois I, Popic J, Khoutorsky A, Sonenberg N. Metformin for Treatment of Fragile X Syndrome

and Other Neurological Disorders. Annu Rev Med. 2019 Jan 27;70:167-181. doi:

10.1146/annurev-med-081117-041238. Epub 2018 Oct 26. PubMed

PMID: 30365357.

Ratcliffe CDH, Siddiqui N, Coelho PP, Laterreur N, Cookey TN, Sonenberg N, Park M. HGF-

induced migration depends on the PI(3,4,5)P(3)-binding microexon-spliced variant of the Arf6

exchange factor cytohesin-1. J Cell Biol. 2019 Jan 7;218(1):285-298. doi:

10.1083/jcb.201804106. Epub 2018 Nov 7. PubMedPMID: 30404949; PubMed Central PMCID:

PMC6314551.

Megat S, Ray PR, Moy JK, Lou TF, Barragán-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad

A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, Dussor G,

Campbell ZT, Price TJ. Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase

Complex as a Critical Generator of Neuropathic Pain. J Neurosci. 2019 Jan 16;39(3):393-411.

doi: 10.1523/JNEUROSCI.2661-18.2018. Epub 2018 Nov 20. PubMed PMID: 30459229;


Mathews, M.; Sonenberg, N., & Hershey, J. W. B. (2018). Translation Mechanisms and control.

(Cold Spring Harbor Perspectives in Biology.) Cold Spring Harbor, N.Y: Cold Spring Harbor

Laboratory Press.


25

THOMAS, D.Y.

Matthes E, Goepp J, Martini C, Shan J, Liao J, Thomas DY, Hanrahan JW. Variable Responses to

CFTR Correctors in vitro: Estimating the Design Effect in Precision Medicine. Front Pharmacol.

2018 Dec 19;9:1490. doi: 10.3389/fphar.2018.01490. eCollection 2018. PubMed PMID:


Carlile GW, Yang Q, Matthes E, Liao J, Radinovic S, Miyamoto C, Robert R, Hanrahan JW,

Thomas DY. A novel triple combination of pharmacological chaperones improves F508del-

CFTR correction. Sci Rep. 2018 Jul 30;8(1):11404. doi: 10.1038/s41598-018-29276-y. PubMed


Wong FH, AbuArish A, Matthes E, Turner MJ, Greene LE, Cloutier A, Robert R, Thomas DY,

Cosa G, Cantin AM, Hanrahan JW. Cigarette smoke activates CFTR through ROS-stimulated

cAMP signaling in human bronchial epithelial cells. Am J Physiol Cell Physiol. 2018 Jan

1;314(1):C118-C134. doi: 10.1152/ajpcell.00099.2017. Epub 2017 Oct 4. PubMed PMID:


TOPISIROVIC, I.




W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic. Translational and HIF-1α-Dependent




Boulay K, Topisirovic I, Mallette FA. Translation Links Nutrient Availability with

Inflammation. Trends Biochem Sci. 2018 Nov;43(11):849-852. doi: 10.1016/j.tibs.2018.08.010.


Uchenunu O, Pollak M, Topisirovic I, Hulea L. Oncogenic kinases and perturbations in protein

synthesis machinery and energetics in neoplasia. J Mol Endocrinol. 2018 Aug 2. pii: JME-18-

0058. doi: 10.1530/JME-18-0058. [Epub ahead of print] PubMed PMID: 30072418; PubMed







Roux PP, Topisirovic I. Signaling Pathways Involved in the Regulation of mRNA Translation.

Mol Cell Biol. 2018 May 29;38(12). pii: e00070-18. doi: 10.1128/MCB.00070-18. Print 2018 Jun



26

Krishnamoorthy J, Tenkerian C, Gupta J, Ghaddar N, Wang S, Darini C, Staschke KA, Ghosh A,

Gandin V, Topisirovic I, Kristof AS, Hatzoglou M, Simos G, Koromilas AE. Downregulation of

PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and

pro-death effects in tuberous sclerosis-deficient cells. Cell Death Dis. 2018 Feb 15;9(3):254. doi:


PMC5833713.

Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L,

Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco

JA Jr, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O.

METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.

Cell. 2019 Jan 24;176(3):491-504.e21. doi: 10.1016/j.cell.2018.11.038. Epub 2019 Jan 3.


TREMBLAY, M.L.

Pike KA, Tremblay ML. Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in

Inflammatory Bowel Disease. Front Immunol. 2018 Oct 31;9:2504. doi:

10.3389/fimmu.2018.02504. eCollection 2018. Review. PubMed PMID: 30429852; PubMed


Hardy S, Kostantin E, Hatzihristidis T, Zolotarov Y, Uetani N, Tremblay ML. Physiological and

oncogenic roles of the PRL phosphatases. FEBS J. 2018 Nov;285(21):3886-3908. doi:

10.1111/febs.14503. Epub 2018 May 27. Review. PubMed PMID: 29770564.

TSANTRIZOS, Y.S.

Matralis AN, Xanthopoulos D, Huot G, Lopes-Paciencia S, Cole C, de Vries H, Ferbeyre G,

Tsantrizos YS. Molecular tools that block maturation of the nuclear lamin A and decelerate

cancer cell migration. Bioorg Med Chem. 2018 Nov 1;26(20):5547-5554. doi:

10.1016/j.bmc.2018.10.001. Epub 2018 Oct 4. PubMed PMID: 30309670.

Lacbay CM, Waller DD, Park J, Gómez Palou M, Vincent F, Huang XF, Ta V, Berghuis AM,

Sebag M, Tsantrizos YS. Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with

Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. J Med Chem. 2018 Aug

9;61(15):6904-6917. doi: 10.1021/acs.jmedchem.8b00886. Epub 2018 Jul 25. PubMed PMID:

30016091.

Lacbay CM, Menni M, Bernatchez JA, Götte M, Tsantrizos YS. Pharmacophore requirements for

HIV-1 reverse transcriptase inhibitors that selectively "Freeze" the pre-translocated complex

during the polymerization catalytic cycle. Bioorg Med Chem. 2018 May 1;26(8):1713-1726. doi:

10.1016/j.bmc.2018.02.017. Epub 2018 Feb 14. PubMed PMID: 29478802.

Pelleieux S, Picard C, Lamarre-Théroux L, Dea D, Leduc V, Tsantrizos YS, Poirier J. Isoprenoids

and tau pathology in sporadic Alzheimer's disease. Neurobiol Aging. 2018 May;65:132-139. doi:

10.1016/j.neurobiolaging.2018.01.012. Epub 2018 Feb 2. PubMed PMID: 29476987.


27

URSINI-SIEGEL, J.













Ha JR, Ahn R, Smith HW, Sabourin V, Hébert S, Cepeda Cañedo E, Im YK, Kleinman CL,

Muller WJ, Ursini-Siegel J. Integration of Distinct ShcA Signaling Complexes Promotes Breast

Tumor Growth and Tyrosine Kinase Inhibitor Resistance. Mol Cancer Res. 2018 May;16(5):894-

908. doi: 10.1158/1541-7786.MCR-17-0623. Epub 2018 Feb 16. PubMed PMID: 29453318.

WATSON, I.R.






Dankner M, Rose AAN, Rajkumar S, Siegel PM, Watson IR. Classifying BRAF alterations in

cancer: new rational therapeutic strategies for actionable mutations. Oncogene. 2018

Jun;37(24):3183-3199. doi: 10.1038/s41388-018-0171-x. Epub 2018 Mar 15. Review. PubMed

PMID: 29540830.

WING, S.S.

Coyne ES, Bedard N, Wykes L, Stretch C, Jammoul S, Li S, Zhang K, Sladek RS, Bathe OF,

Jagoe RT, Posner BI, Wing SS. Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle

Wasting by Modulating Insulin and Glucocorticoid Signaling. Endocrinology. 2018 Aug

1;159(8):2966-2977. doi: 10.1210/en.2018-00290. PubMed PMID: 29901692.







28

PMC6034131.

Tanaka KI, Xue Y, Nguyen-Yamamoto L, Morris JA, Kanazawa I, Sugimoto T, Wing SS,

Richards JB, Goltzman D. FAM210A is a novel determinant of bone and muscle structure and

strength. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3759-E3768. doi:

10.1073/pnas.1719089115. Epub 2018 Apr 4. PubMed PMID: 29618611; PubMed Central

PMCID: PMC5910842.

YANG, X.J.

Han Z, Wu H, Kim S, Yang X, Li Q, Huang H, Cai H, Bartlett MG, Dong A, Zeng H, Brown PJ,

Yang XJ, Arrowsmith CH, Zhao Y, Zheng YG. Revealing the protein propionylation activity of

the histone acetyltransferase MOF (males absent on the first). J Biol Chem. 2018 Mar

2;293(9):3410-3420. doi: 10.1074/jbc.RA117.000529. Epub 2018 Jan 10. PubMed PMID:


YOUNG, J.C.

Paschkowsky S, Recinto SJ, Young JC, Bondar AN, Munter LM. Membrane cholesterol as

regulator of human rhomboid protease RHBDL4. J Biol Chem. 2018 Oct 5;293(40):15556-15568.

doi: 10.1074/jbc.RA118.002640. Epub 2018 Aug 24. PubMed PMID: 30143535; PubMed


Paschkowsky S, Hsiao JM, Young JC, Munter LM. The discovery of proteases and

intramembrane proteolysis. Biochem Cell Biol. 2018 Aug 13:1-5. doi: 10.1139/bcb-2018-0186.

[Epub ahead of print] PubMed PMID: 30102867.

Ménade M, Kozlov G, Trempe JF, Pande H, Shenker S, Wickremasinghe S, Li X, Hojjat H,

Dicaire MJ, Brais B, McPherson PS, Wong MJH, Young JC, Gehring K. Structures of ubiquitin-

like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations. J Biol

Chem. 2018 Aug 17;293(33):12832-12842. doi: 10.1074/jbc.RA118.003939. Epub 2018 Jun 26.

PubMed PMID: 29945973; PubMed Central PMCID: PMC6102131. PMCID: PMC5313101.

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FACULTY PUBLICATIONS 2018 · Department of Biochemistry 2018 3 29777720. Ulaganathan T, Helbert W, Kopel M, Banin E, Cygler M. Structure-function analyses of a PL24 family ulvan lyase