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M01 2018Facts from IQVIA

1Indicator RUB USD EUR PACKSValue M01/YTD 2018, Bln. 73 1,3 1,1 0,4Growth M01/YTD,% -19% -14% -25% -8%

Market decreases by -19% in value and -8,3% in volumeRussia pharma market growth in January 2018

Source: IQVIA databases. Total Market. (exclude food supplements and diagnostic agents), TRD Prices

58 56198-19%

M01/YTD’1873

6 56M01/YTD’17905 Regional ReimbursementReimbursementPublic (EXCL. DLO AND RLO)Retail 0,38 0,35

-8,3%M01/YTD’18

0,400,03M01/YTD’17

0,430,04

VALUE, BLN RUB VOLUME, BLN PACKS

23%-74%-3,4%-23% 24%-9,0%

-8,4%-11%

2

Retail Sell-In: Share of Pharmacy chains in Retail Sell-In is 84% in value and 79% in volumeRussia retail market structure in January 2018

Source: IQVIA Retail Audit. Retail Market in Russia (exclude food supplements and diagnostic agents), Trd Prices

VALUE, BLN RUB VOLUME, BLN PACKS

9(16%)M01/YTD’18

5647(84%)

Individual pharmaciesPharmacy Chains M01/YTD’18

0,40,1(21%)0,3(79%)

3

Retail Sell-Out: Market grew by 1,6% in value and -0,4% in volumeRussia retail market growth in January 2018

Source: IQVIA databases. Pharmatrend. Retail Market in Russia (exclude food supplements and diagnostic agents), FIN Prices

VALUE, BLN RUB YoY growth, % YoY growth, %VOLUME, BLN PACKS1,6%

M01/YTD’18

7547%53%

M01/YTD’17

7443%57%

OTC RX

-0,4%

M01/YTD’18

0,432%68%

M01/YTD’17

0,430%70%-5,5%

11%-2,8%5,1%

4

Month-Over-Month Growth Rates, volumeSell-In vs Sell-Out, OTC registered drugs

Source: IQVIA databases. Pharmatrend. OTC Retail Market in Russia (exclude food supplements and diagnostic agents), TRD and FIN Prices

16,7%19,9%12,1%

-8,2%-6,0%2,9%

-8,1%-25-20-15-10-50

5101520

2018/01-10,2%-17,5%

2017/12

10,0%

2017/11-5,9%

2017/10

4,0%-3,6%

2017/09

17,9%

2017/08

6,7%10,8%

2017/07

-1,4%

2017/06-5,4%-7,2%

2017/05-2,2%-1,9%

2017/04-7,2%-12,7%

2017/032017/02-5,3%

2017/01-11,9%-20,2%

Sell-In Sell-Out

5

TOP-15 corporations on Russian market, January 2018

Source: IQVIA databases. Total Market(exclude food supplements and diagnostic agents), TRD Prices

NYCOMED/TAKEDA 2,0%ASTRAZENECA 2,0%KRKA 2,0%PFIZER 2,0%GEDEON RICHTER 2,0%MENARINI 2,2%ABBOTT 2,2%GLAXOSMITHKLINE 2,2%OTCPHARM 2,5%SANDOZ 2,5%JOHNSON & JOHNSON 2,8%SERVIER 2,8%TEVA 3,2%BAYER HEALTHCARE 4,4%SANOFI-AVENTIS 4,4%Total pharma market 100,0%

13%-15% -2% 10%-1%-4%-5%-12%-17%-14%-23% -1%-3% 9%-23%-19%

0%-17% -2%-7%-8%-8%-8%-7%-13%-9% 9%-6%-1%-5%-11%-8%Value growth / decline Volume growth / decline1234567891011121314

Market share, M01/YTD’18

15

6

TOP-10 products by growth in advertisement investments in January 2018Total salesBln RUB Sales, Growth Y-to-Y

122%180%252%409%43.623%

68%71%79%48%68%

WOBENZYM 0,11NOVO PASSIT 0,13NASIVIN 0,10MAGNELIS B6 0,13MEZYM 0,22BRONCHO MUNAL 0,17HEXORAL 0,19DOCTOR MOM 0,13

PENTALGIN 0,35LOCERYL 0,18

-2% 9%-11,5%-15%-13,6% 6,0%-18% 61%30,4%33%Advertisement, Growth Y-to-Y

Source: Pharmatrend data, Mediascope data, FIN Prices

7

TOP-10 products by decline in advertisement investments in January 2018

Source: Pharmatrend data, Mediascope data, FIN Prices

Total salesBln RUB Sales, Growth Y-to-Y

-96%

-100%-100%-100%

-100%-100%-100%-100%-100%-100%0,09AMIXIN 0,18CORVALOL 0,15BALSAM GOLD STAR 0,11

0,18SINUPRET 0,19ANTIGRIPPINARBIDOL 0,10VOLTAREN 0,10THERAFLEX 0,15VENARUS 0,18GASTAL

-52,5% 5%-43,9% 8%-7,8% 36,7%-3,8%-40% -19%-39,3%Advertisement, Growth Y-to-Y

8

Rating of largest distributors by direct DRUG supply share (incl. reimbursement), 2017Rank Wholesaler Direct drug supply share, %2017 20161 Protek 18,36% 18,65%2 Katren 17,46% 18,30%3 Pulse 13,81% 13,08%4 R-Pharm 4,80% 4,80%5 Pharmkomplekt 4,51% 3,81%6 BSS 3,69% 4,18%7 Grand Capital 2,70% 1,81%8 Profitmed 2,09% 2,14%9 Irvin 2 1,70% 0,95%10 Euroservice 1,34% 1,44%Total 70,47% 69,18%

9

Excluding reimbursement drug provision

Rating of largest pharmacy chains and associations by the size of direct sales of drugs for 20171 Incl. AVE Group; Gorzdrav; A5 Group, Pharmacor2 incl. O3, Zhivika, DOMpharma3 Incl. Ozerki, Doctor Stoletov, Raduga

№ Regions Pharmacy chains and associations Number of outlets as of January 2018 MS in retail drug pharmaceutical market, % 2017 Drug sales growth 2017/ 2016 Indicator of the relative sales volume for the drug assortment for 2017 (regarding the leading audited company) Average check, RUB.1 79 ASNA 8365 14,72% 98,71% 2,785 357,002 13 APTEKI 36,61 1765 5,28% 8,01% 1 -3 49 Rigla2 2031 4,89% 28,65% 0,925 494,744 44 Erkapharm3 1240 3,86% 63,74% 0,730 -5 8 Neo-pharm 446 2,54% 50,18% 0,481 -6 25 April 870 1,98% 123,38% 0,375 430,017 7 Farmland 950 1,80% 26,15% 0,342 491,428 14 Farmakopeika-Tvoy Doctor 892 1,72% 8,70% 0,325 -9 55 Melodia Zdorovia 1262 1,49% 38,22% 0,282 338,0010 8 Sotsial'naya Apteka (Nektar) 337 0,94% 7,02% 0,179 438,81Total: 18 158 39,23% 50,56%

10Indicator KZT USD EUR PACKSValue M01/YTD 2018, Bln. 24 0,08 0,06 0,05Growth M01/YTD,% -33% -32% -41% -22%

Market decreases by -33% in value and -22% in volumeKazakhstan pharma market growth in January 2018

Source: IQVIA databases. Total Market. (exclude food supplements and diagnostic agents), TRD Prices

M01/YTD’1822-33%36

424 249 1M01/YTD’17 2 RetailFree & Co-PaymentHospital 0,05 0,04M01/YTD’170,01

0,06 -22%M01/YTD’180,00

0,05VALUE, BLN KZT VOLUME, BLN PACKS

-82%-8,8%-75% -86%

-15%-62%

11

TOP-15 corporations on Kazakhstan market, January 2018

Source: IQVIA databases. Total Market (exclude food supplements and diagnostic agents), TRD Prices

KRKA 1,9%STADA 2,1%WORLD MEDICINE 2,2%GLAXOSMITHKLINE 2,4%SERVIER 2,5%NOBEL-AFF 2,6%SANDOZ GROUP 2,7%MENARINI 2,8%GEDEON RICHTER 2,9%ABBOTT 3,2%BAYER HEALTHCARE 3,8%SANOFI-AVENTIS 4,2%NYCOMED/TAKEDA 4,3%TEVA 4,6%SANTO 5,4%Total pharma market 100,0%

-31%-26% -5%-39%-25%-43% -26% -5%-23% -8%-27%-35%-32%-18%-43%-33%

-2%-19%-32%

3%-18%-30%-14%-48% -22%

-14%-31%-40%-34%-22%-23%-10%Value growth / decline Volume growth / decline1234567891011121314

Market share, M01/YTD’18

15

12Indicator BLR USD EUR PACKSValue M01/YTD 2018, Bln. 0,2 0,08 0,06 0,03Growth M01/YTD,% 7% 5% -8% -3%

Market grew by 7,3% in value and -3,3% in volumeBelarus pharma market growth in January 2018

Source: IQVIA databases. Total Market. (exclude food supplements and diagnostic agents), TRD Prices

+7,3%M01/YTD’18

0,160,030,12

M01/YTD’170,150,020,12 HospitalRetail

-3,3%M01/YTD’18

0,030,030,03M01/YTD’170,00 0,030,00

VALUE, BLN BLR VOLUME, BLN PACKS1,7%35%

-4,7%+6,5%

13

TOP-15 corporations on Belarus market, January 2018

Source: IQVIA databases. Total Market (exclude food supplements and diagnostic agents), TRD Prices

2,1%MINSKINTERCAPS MRUE 2,3%BERLIN-CH/MENARINI 2,4%NATIVITA JLLC 2,4%GEDEON RICHTER 2,5%TAKEDA 2,5%BAYER HEALTHCARE 2,6%SANOFI 2,7%PHARMTECHNOLOGY LTD 2,8%GSK 2,9%PHARMLAND JV LTD 3,3%NOVARTIS 3,8%LEKPHARM JLLC 5,2%BORISOV ZMP 6,9%BELMEDPREPARATY RUE

OCTAPHARMA AG

8,4%Total pharma market 100,0%

62%1%18% 435%-12% 34%3%-19%-5% 11%-4% 16%-12% 1%6%7%

34%-14%-10%-1%-3% 3%-9%-5% 1%

8% 434%-4% 33%-7%-13%-3%Value growth / decline Volume growth / decline1234567891011121314

Market share, M01/YTD’18

15

14

Please Contact Us for More InformationSvetlana NikulinaSenior Sales Managersvetlana.nikulina@IQVIA.com+7 499 272 05 00Anton KalyapinSenior Offering ManagerAnton.Kalyapin@IQVIA.com+7 499 272 05 00Gennady UshakovClient Service RepresentativeGennady.Ushakov@IQVIA.com+7 499 272 05 00