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Section 1 Pharmaceutical Factors Chapter 4
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Factors of Influencing Drug Effect
General View
Pharmaceutical factors: Physical and chemical
property of drug Drug preparation Methods of drug
administration Drug interaction
Biological factors: Physiological factors Psychological factors Genetic factors Pathological factors Body response changes
induced by long-term medication
Biorhythm living habit and
environment
Section 1Pharmaceutical Factors
Chapter 4
1. Physical and Chemical Property of Drug
Penicillin Nitroprusside Vitamin C
Light-avoiding infusion aparatus
2. Drug Preparation
Oral administration: tablet, capsule, oral liquor Injection: aqua, oils, emulsion New preparation:
– Controlled release formulation (CLF)
3. Drug Interaction Pharmacokinetics:
– absorption, distribution, metabolism, excretion
Pharmacodynamics: Synergism(协同作用 ): > 1+1
addition(相加作用 ): =1+1
Antagonism(拮抗作用 ): 1+1<1
Incompatibility(配伍禁忌 ): β lactam + aminoglycoside
Section 2Biological Factors
Chapter 4
1. Physiological Factors
Age:– Children:– The aged:
Gender: Body weight (BW):
2. Genetic Factors Genetic polymorphism -Drug metabolism genotype
- Drug transporter genotype- Drug receptor genotype
Racial differences in drug response Idiocyncrasy
3. Pathological Factors
Liver disease Kidney disease Dystrophia (营养不良) Acid-base disturbance ……
4. Body Response Changes Induced by Long-term Medication
1. Tolerance: body → drug, pharmacodynamic tolerance and metabolic tolerance
– Acute tolerance (tachyphylaxis)– Brady-phylaxis– Cross tolerance
2. Drug resistance: pathogen, tumor cells → drug3. Dependence:
– Physiological dependence (physical dependence)– Psychological dependence
4. Withdrawal symptoms (withdrawal syndrome)– Rebound phenomenon
5. Living Habit and Environment Smoking: hepatic drug enzyme activity↑ Drinking wine or liquor: Alcohol enhances
hepatic drug enzyme activity; when acute and large amount administration, it makes the hepatic drug enzyme saturation.
Drinking tea: Tannic acid(鞣酸 ) influences drug absorption. Theophylline (茶碱 ) excites the central nervous system and heart, promotes diuresis.
Diet/food: component, quantity, time;
The end