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285-OR
Ethnic Differences in Progression to Type 1 Diabetes in Relatives at Risk
Mustafa Tosur, MDTexas Children’s Hospital & Baylor College of Medicine
Susan Geyer1, Henry Rodriguez1; Ingrid Libman2; David Baidal3; Maria J. Redondo4; and the Type 1 Diabetes TrialNet Study Group
1University of South Florida, Tampa, FL; 2University of Pittsburgh, Pittsburgh, PA;3University of Miami, Miami, FL; 4Baylor College of Medicine, Houston, TX
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PAGE TITLEDisclosures
• No conflict of interest to report
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PAGE TITLEPurpose/Objective(s)
• While a wealth of information is available on type 1 diabetes (T1D) risk factors and progression, the influence of race and ethnicity is largely unknown
• We hypothesized that race and ethnicity contribute to the heterogeneity of T1D
• We aimed to compare the progression of diabetes autoantibodies from single to multiple positivity and T1D development among races/ethnicities in at-risk individuals
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PAGE TITLEMethods/Materials• We studied 4,227 TrialNet Pathway to Prevention
participants (non-diabetic, autoantibody [Ab] positive relatives of patients with T1D)
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n=1788 (42%)n= 2439
(58%)
0%
Multiple Ab +
Single Ab +
Median Follow-up1.8 years 2.5 years
79%
12%
3% 2% 4%Non-Hispanic White (NHW)[79%]
Hispanic [12%]
Non-Hispanic Black [3%]
Non-Hispanic Asian/PacificIslander [2%]
Non-Hispanic Others [4%]
PAGE TITLEResults
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Covariate Hazard RatioNHWs 1.00Hispanics 0.59
• Progression from single to multiple Ab+: Slower in Hispanics than NHWs
PAGE TITLE
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T1D risk:• Increased by 34% in NHW• Quadrupled in Hispanics
Results, cont.• Progression from multiple Ab+ to T1D: Among children
<12 y/o, Hispanics are disproportionally affected by elevated BMI
Covariate Hazard Ratio
NHWs – lean 1.00
NHWs –overweight/obese
1.34
Hispanic – lean 0.50
Hispanic –overweight/obese
2.03
PAGE TITLEConclusions • Hispanics, compared with NHW, had lower risk of
progression from single to multiple Ab+ and, amongst lean individuals <12 years old, from multiple Ab+ to T1D
• In children <12 years old, overweight/obesity is more detrimental to Hispanics than NHWs for T1D progression
• The effect of race/ethnicity on T1D progression should be considered when counseling family members at risk and for the design of predictive models and prevention trials
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PAGE TITLEEMBARGO POLICY• All recordings are for personal use only and not
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