ESM 15.11.2017, Oliver Wolf€¦ · “Specific collagen peptide supplementation in athletes with chronic ankle instability results in significant improvements in ankle stability

CONFIDENTIAL 1

Innovative Active Nutrition Concepts with

Bioactive Collagen Peptides

Evolution US Sports/ Active Nutrition Sales

$3.2 $3.6 $4.0 $4.5 $4.9 $5.3 $5.7

$6.1 $6.6

$7.1 $7.6

2010 2011 2012 2013 2014 2015 2016E 2017E 2018E 2019E 2020E

Source: Nutrition Business Journal 2017

$ in billions, consumer sales all channels

Key Growth Drivers

• New consumer groups / Shift to everyday

consumers

• Increased focus on active lifestyle

• Evolution of product mix

• Expansion of distribution channels

Expansion of Consumer Group =

Expansion of Expectations towards Active Nutrition

4

• Young

• Male

• Focus on muscle

• Young – Old

• Male & Female

• Different needs and expectations

Performance

Mobility

Protein Intake

Variety / Choice

Appearance

Increasing Protein Intake – A Continuous Mega Trend

5

% of General US Population Who

Seek Out Foods High in Protein

Protein Supplements –

Different Delivery Formats

Source: Natural Marketing Institute,

2015, NBJ

Source: Nutrition Business Journal,

2017, Consumer Sales $mill

Consumers Expectation Towards Protein Quality

6

GELITA Focus Group Research USA, 2016

Consumer expect a consistent experience (‘always the same’) with

consistent quality

Consumer’s definition of a ‘high quality protein powder’:

• Neutral taste, pleasant sensory and mouthfeel

• Highly soluble

• “No mess” use / application (packaging)

Collagen peptides in liquid

applications

Collagen peptides in powder

applications

Collagen Peptides – An Easy To Use Protein Source

7

Collagen Peptides – The ‘Barley There’ Protein Source

8

Viscosity of different collagen

peptides at 25°C

Protein shot (25% collagen

peptides)

Collagen Peptides – Stable in Most Delivery Formats

9

Protein powder (90% collagen

peptides)

Collagen Peptides – For Many Delivery Systems

10

Scientifically substantiated daily dose of 2.5-15g

with Bioactive Collagen Peptides

U.S. Collagen Supplements Sales

11

Source: Nutrition Business Journal ($mill, consumer sales)

Sales grew by

30% in 2017



12

• Young

• Male

• Focus on muscle

• Young – Old

• Male & Female


Performance

Mobility

Protein Intake

Variety / Choice

Appearance

Mobility & Collagen

13

Mobility =

Functioning

Connective

Tissue

Mobility =

Collagen

~30%

© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.

Collagen Peptides Are Building Blocks of Connective Tissue

14

Adapted from Zdzieblik et al. 2015; internal analytical reports

Conditionally essential AAs

Proline and Glycine

Amino acids:

Non-essential AAs Proline (incl. Pro-OH)

Glycine Essential AAs Leucine

55%

Ligaments

Tendons

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/collagen-peptide-supplementation-in-combination-with-resistance-training-improves-body-composition-and-increases-muscle-strength-in-elderly-sarcopenic-men-a-randomised-controlled-trial/9426E375742D094F91029FD0364815C4

Elements of Mobility and Bioactive Collagen Peptides

15

Mobility

Strength

Joint Health

Flexibility

Strong Bones



16

1

Simple, but specific enzymatic hydrolysis process

Native

CollagenRaw material

Bioactive peptides of different

profiles for specific body functions

Extracted

collagen

Collagen

peptidesSpecific health

benefits

2

3

Important signaling molecules Rich in Proline and Hydroxyproline

Osteoblast

• Synthesizing bone matrix

Mode of Action: Selectively Stimulating Human

Connective Tissue Cells to Increase Anabolism

17

• Connective tissue metabolizing cells as target

• Influence anabolic-catabolic balance

• Increased anabolismOsteoclast

• Degrading bone

matrix

Chondrocyte

• Production and maintenance of cartilaginous matrix

Fibroblast

• Synthesis of collagen extracellular matrix in connective tissue (skin, fascia, ligaments, tendons

Elements of Mobility and Bioactive Collagen Peptides

18

Mobility

Strength

Joint Health

Flexibility

Strong Bones


Growing Attention for Collagen Peptides

19

IOC Consensus

Statement (Maughan et al 2018)

Collagen* may support

athletes to train harder

and perform better

*Findings based on research done with



Bioactive Collagen Peptides for Performance – Feel It!

20© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.

Mobility and Bioactive Collagen Peptides

21

Mobility

Strength

Joint Health

Flexibility

Strong Bones


BODYBALANCE® for Body Toning

22

Increasing Lean Body Mass

(double your training effect)

+ Decreasing Fat Mass

(triple your training effect)

+ Increasing Muscle Strength

In Combination with Resistance Exercise


BODYBALANCE® - An Ingredient for Aging Strong

23

Zdzieblik D. et al 2015–BJN

Study with > 50 elderly participants (>70 years) showed significantly increased power

output with BODYBALANCE® supplementation


+2.9

+4.2

-3.6

-5.5-6

-4

-2

0

2

4

6

Exercise +

BODYBALANCE®

Exercise +

BODYBALANCE®

Exercise +

Placebo

Exercise +

Placebo

BODYBALANCE® Effect on Body Toning

24


kg c

om

pare

d to

ba

se

line

∆ Lean Body Mass ∆ Fatx 1.5

Increase your training

effect : gain of lean body

mass and loss of body fat

x 1.5


Increased Power Output with BODYBALANCE®

25


26

Zdzieblik, 2015 BJN and unpublished data

BODYBALANCE® for the Ages

CONFIDENTIAL© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.


27

Mobility

Strength

Joint Health

Flexibility

StrongBones


Visualized Joint Health Effect

FORTIGEL® supports cartilage tissue regeneration in humans

Proteoglycan density

in the knee joint

cartilage was

significantly

increased after

FORTIGEL®

supplementation

Pla

ce

bo

FO

RT

IGE

L®

Day 1 Week 24 Week 48

Diseased Cartilage Healthy CartilageMcAlindon 2011

© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies. 28

FORTIGEL® in Healthy Subjects

29

Zdzieblik 2017

NEW

DATA

Healthy Student Athletes – 5g FORTIGEL® Daily – 12 Weeks


Side Note – Joint Health & Mobility for Pets

30

Osteoarthritis

affects ~20% of

dogs over 1 year

of age

31% of dog owners point out

that bone and joint

problems are an

issue for their pets

(Hansen, 2003)


Source: Innova Market Insights: Only the Best for Pets Infographic

Mobility for Pets with PETAGILE®

31

• PETAGILE® Bioactive Collagen Peptides® (BCP), are

specific, highly purified hydrolyzed collagen peptides,

with neutral taste and odor.

• Nutritional supplement for management of osteoarthritis

(OA) and supporting maintenance of joint health in

animals

• Is food and no food additive, and therefore carries no E-

number.

• In compliance with Regulation (EC) 852/2004, 853/

2004, 999/2001

• Is easy to handle in dog food applications.

• Is pure collagen protein


PETAGILE® Stimulates Matrix Synthesis

in Canine Chondrocytes

32

Scientific Design:

• Experimental approach with canine

chondrocytes

• Measuring the RNA-expression of

cartilage matrix molecules

RN

A-

exp

ressio

n (

x-fo

ld

of co

ntr

ol)

Collagen type II Aggrecan Bigylcan Decorin Elastin

Cell Stimulation Test in Canine Chondrocytes*

10

Results:

• Statistically significant increase in matrix molecules such as collagen Type II,

aggrecan, biglycan, decorin, and elastin

• Increased accumulation of newly synthesized Type II collagen (+7.5%),

aggrecan (+5.5%) and elastin (+6.3%) at end of 3 week trial period

• Down regulation of degenerative processes


PETAGILE® Intervention on Osteoarthritic Dogs with

Treatment-Resistant History

33

Observational study (veterinarian and dog owner) / 22 dogs with clear OA indication

and treatment-resistant history / 12 weeks 5g PETAGILE® daily

Orange line: Lameness of dogs

continuously decreased over trial

period

Blue line: Dog owners observed

increased vitality of their dogs

over trial period


Schunck, 2017

…..It Also Works In Horses!



35

Mobility

Strength

Joint Health

Flexibility

StrongBones


Tendons and Ligaments are a Weak Link

36

Musculoskeletal injuries are the most common

complaint in active population.

More than 50% of all injuries in sports can be

classified as sprains, strains, ruptures or breaks

of musculoskeletal tissue.

Shaw, G et. al (2017). “Vitamin C-enriched gelation supplementation before intermittent activity augments collagen synthesis

Collagen is a major component of

tendons and ligaments


TENDOFORTE® Supports Faster Return-to-Training

37

Praet et al. (2017) O26: Oral supplementation of specific collagen peptides accelerates improvement in Achilles tendon symptoms and function in

combination with eccentric exercise. South African Journal of Sports Medicine, V 29, Suppl 1.

0123456789

10

Group T-P Group P-T Group T-P Group P-T3 months 6 months

5g TENDOFORTE®

Placebo

Cross-over after

3 months

Group T-P: 3 months TENDOFORTE®, 3 months Placebo

Group P-T: 3 months Placebo, 3 months TENDOFORTE®

Pa

rtic

ipa

nts

retu

rnin

g to

run

nin

g (

n=

20

)

6

3

+1

+2

“Oral supplementation of sCPs may accelerate the clinical benefits of a well-structured calf

strengthening and return-to-running program in patients with chronic Achilles tendinopathy symptoms”


https://journals.co.za/content/journal/10520/EJC-c66880289

5g of TENDOFORTE® for 6 months

significantly improved ankle stability during daily activity and sports

and reduced the incidence of injuries

Parallel design, n= 50 men or women with chronic ankle joint instability. Endpoints: changes in ankle functional status (CAIT), changes in foot and ankle ability measure (FAAM), and incidence of injuries in a 3 month follow-up

period.

Reduced Incidence of Injuries and Improved Ankle Stability

38

Adapted from Dressler et al. 2018. J Sports Sci Med. University of Freiburg.

“Specific collagen peptide supplementation in athletes with chronic ankle instability results in significant improvements in

ankle stability baring clinical relevance, as demonstrated by a reduced re-injury rate of ankle sprains in the follow-up period”

5g TENDOFORTE® Placebo

Reduced ankle sprains

by 62%(<0.001)

96% (n=24)

36% (n=9)

0%

100%

Reduced ankle injuries

by 35%(<0.05)

92% (n=23)

60% (n=15)

0%

100%

Improved ankle stability

by 76%(<0.001)

84% (n=21)

20% (n=5)

0%

100%


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950747/

TENDOFORTE®


TENDOFORTE® The first protein solution for stronger ligaments and tendons in active and performance nutrition



40

• Young

• Male

• Focus on muscle

• Young – Old

• Male & Female


Performance

Mobility

Protein Intake

Variety / Choice

Appearance

Appearance = Beautiful Skin

41

Beauty© 2018 GELITA AG. 2018 GELITA Symposium. GELITA must authorize any copies.

Crazy for Collagen

42

Source: Nutrition Business Journal; Condition Specific Report 2017

US Beauty From

Within Ingredients:

2017


VERISOL® For Beauty-from-Within

43

Proksch et al, 2014; Proksch et al, 2014a, Schunck, 2015

Daily dose of 2.5g

VERISOL®

Increased

Skin

Elasticitiy

Wrinkle

Reduction

Improved

Skin Surface

Structure


Eye Wrinkle Reduction – With VERISOL®

44

Proksch et al., 2014a


Improved Skin Structure with VERISOL®

Ultrasound Evidence of Skin @ 6 months

45

PLACEBO


Schunck et al, 2015

Nail Support with VERISOL®

46

Hexsel et al, 2017

Improvement

in nail peeling

Perceived

nails as

longer

Indicated

faster and

longer nail

growth


Life…and Bioactive Collagen Peptides

47

47


Active Nutrition is a growing and diversifying market segment being exposed to an increasing number of needs and demand for variety in delivery formats.

Bioactive Collagen Peptides are a versatile, clinically studied protein source to help with innovation in this category

Thank You !

Documents

ESM 15.11.2017, Oliver Wolf€¦ · “Specific collagen peptide supplementation in athletes with chronic ankle instability results in significant improvements in ankle stability