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CURRENT LIT

AXON SPROUTING AND SYNAPTIC REO

INTERNEURONS: A FOCUSED LOOK AT

Surviving Hilar Somatostatin Interneurons Enlarge, Spro

a Mouse Model of Temporal Lobe Epilepsy. Zhang W, Y

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Current L

(i.e., interneurons tagged with gene-targeted, green fluor

cent protein) and dentate granule cells, shows that the rema

ing somatostatin-immunoreactive interneurons formed m

synaptic connections to granule cells (i.e., the number of graule cells that received connections was increased two- or thr

fold) but probably not more connections per granule cell (i

the amplitude of the unitary evoked IPSC was not change

These data, however, are considered in relation to results sho

ing that the frequency of miniature IPSCs is decreased shor

after experimental status epilepticus and remains decreased

many months as the animals undergo epileptogenesis. T

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128 Current Literature in B

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7. Nissinen J, Halonen T, Koivisto E, Pitkanen A. A new model ofchronic temporal lobe epilepsy induced by electrical stimulationof the amygdala in rat. Epilepsy Res2000;38:177205.

8. Williams PA, White AM, Clark S, Ferraro DJ, Swiercz W,Staley KJ, Dudek FE. Development of spontaneous recur-