BIOKIMIA ENDOKRIN

dr.Syazili Mustofa.

Departemen Biokimia Kedokteran

UNIVERSITAS LAMPUNG

Kenapa penting??

Dasar untuk mempelajari penyakit gangguan endokrin.

Gangguan endokrin yang sering ditemui adalah:

Diabetes melitusHipertiroidisme

Mechanism of Hormone Action• Hormones are carried by the blood, yet they affect only

certain cells. The specific cells that respond to a given hormone have receptor sites for that hormone.

• Receptor sites may be located on the surface of the cell membrane or in the interior of the cell.

SISTEM HORMON

Hormon = membangkitkan aktivitas Hormon oleh jar. → sistem sirkulasi → jar. Lain Parakrin → organ sama jaringan berbeda Autokrin →organ dan jaringan yg sama

Hormon dapat ditargetkan pada lebih dari satu jaringan .

Kelenjar target: ± 200 tipe sel tubuh ± 50 hormon yang sudah dikenal

Reseptor Hormon

Ada dua macam reseptor hormon:1.Reseptor yang mengikat hormon di luar sel.

Hormon polipeptida, protein, dan katekolamin terikat reseptor pada membran plasma → menyalur fungsi ke intrasel melalui aktivitas enzim adenilil siklase cAMP dan fosfolipase C Ca++

2.Reseptor yang mengikat hormon intraselluler Hormon Steroid dan Tiroid, Transkripsi

Mechanism of Hormone Action• Protein hormones, in general, are water soluble and are

unable to diffuse through the cell membrane and react with receptor sites on the surface of the cell.

• Steroids are fat soluble and can diffuse through the cell membrane and react with receptors inside the cell.

Mechanism of Hormone Action

Mechanism of Hormone Action

HORMON RESEPTOR MEMBRAN;- ACTH- ADH- FSH- hcG- LIPOPROTEIN = LPH- LUTEINISASI = LH- TSH- PARATIROID (PTH)- GLUKAGON- INSULIN - ADRENALIN DAN NOR ADRENALIN

Mechanism of steroid Hormone Action

Mechanism of steroid Hormone Action

HORMON RESEPTOR INTRASEL:

- ESTROGEN- GLUKOKORTIKOID- MINERALOKORTIKOID- PROGESTIN- KALSITRIOL- ANDROGEN- TIROID = T4;T3