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Part
ial
Diff
ere
nti
al
Equati
ons
inM
ath
em
ati
cal
Bio
logy
On
the
Keller-
Segel
Syst
em
wit
h
Exte
rnal
Applica
tion
of
Chem
oatt
ract
ant
J.I
gnaci
oT
ello
1and
Mic
hael
Win
kle
r2
1-.
Un
ivers
idad
Poli
tecn
ica
de
Mad
rid
.S
pain
2-.
Ess
en
-Du
isb
urg
Un
ivers
ity.
Germ
any
Bedle
wo,
Septe
mb
er
12th
-17th
,2010
Conte
nts
Fir
stP
rob
lem
:A
Sys
tem
wit
hex
tern
alap
plic
atio
nof
chem
oatt
ract
ant
∂u ∂t
=∆u−χ∇·(u∇v
),x∈IR
2t>
0
−∆v
=u
+2πF
0δ(x
)x∈IR
2
Seco
nd
Pro
ble
m:
On
aC
hem
otax
issy
stem
wit
hlo
gist
icte
rm
∂u ∂t
=∆u−χ∇·(u∇v
)+λu
(1−u
),x∈
Ωt>
0
−∆v
+v
=u
x∈
Ω
Fir
stP
art
1-.
Intr
odu
ctio
n
2-.
Au
xilia
ryP
rob
lem
W(s,t
):=
1 π
∫ B√s(0
)ρu
(ρ,t
)dρ,
s>
0,t>
0,
3-.
Inst
anta
neo
us
Blo
wu
p
4-.
Cas
e∫ IR
2u
0>
8π−
4πF
0
5-.
Cas
e∫ IR
2u
0<
8π−
4πF
0
1In
troduct
ion
Ch
emot
axis
isth
eab
ilit
yof
mic
roor
gan
ism
sto
resp
ond
toch
emic
alsi
gnal
sby
mov
ing
alon
gth
egr
adie
ntof
the
chem
ical
sub
stan
ce,
eith
erto
war
dth
eh
igh
er
con
cent
rati
on(p
osit
ive
taxi
s)or
away
from
it(n
egat
ive
taxi
s).
-D
icty
oste
lium
dis
coid
eum
Bac
teri
a.S
eeK
elle
r-S
egel
[197
0],
[197
1]
-T
um
our-
ind
uce
dan
giog
enes
is.
See
An
der
son
-Ch
apla
in[1
997]
,[1
998]
A.
Ku
bo
inth
eco
nfe
ren
ce(T
ues
day
Aft
ern
oon
)
-A
stro
phy
sics
and
grav
itat
ion
alin
tera
ctio
nof
par
ticl
es.
See
Bile
r[1
995]
,
Bile
r-H
ilhor
st-N
adzi
eja
[199
4]
-M
orp
hog
enes
isfo
rmat
ion
ofth
eem
bry
o.S
eeM
erki
n-N
eed
ham
-Sle
eman
[200
5],
Bol
lenb
ach
-Kru
se-P
anta
zis-
Gon
zale
zG
aita
n-J
ulic
her
[200
7],
C.
Sti
nn
erin
the
Pos
ter
Ses
ion
ofth
eco
nfe
ren
ce.
Mat
hem
atic
alm
odel
sof
chem
otax
is
Kel
ler
and
Seg
el[1
970]
,[1
971]
(aft
erP
atla
k[1
953]
)
p=
bac
teri
a,w
=ch
emoa
ttra
ctan
t
∂u ∂t
=Q
(u,v
)+∇·D
(u,v
)∇u−uχ
(v)∇v
),
∂v ∂t
=d
∆v
+h
(u,v
)x∈
Ωt>
0
We
con
sid
erΩ
=R
2,
fast
diff
usi
on,
and
the
sim
plifi
edsy
stem
∂u ∂t
=∆u−χ∇·(u∇v
),x∈IR
2t>
0
−∆w
=u
+f
(x)
x∈IR
2
+in
itia
ld
atu
mfo
ru
wh
eref
isan
exte
rnal
app
licat
ion
ofch
emoa
ttra
ctan
t.
Jage
ran
dL
uck
hau
s[1
992]
,Ω⊂IR
2
∂u ∂t
=∆u−∇·(u∇v
),Ω×
(0,T
)
−∆v
=u−
1Ω×
(0,T
)
zero
flux
onth
eb
oun
dar
y
•if
∫ Ωu
0<
8π,
then
glob
also
luti
ons
exis
t
•if
∫ Ωu
0>
8π,
solu
tion
blo
ws
up
infin
ite
tim
e
•S
eeal
soH
erre
ro-V
elaz
quez
[199
6]
Cas
e−
∆v
=u
inIR
2.
See
Bile
r[1
995a
][1
995b
],B
lan
chet
-Dol
bea
ult
-
Per
tham
e[2
006]
Bla
nch
et-C
arri
llo-M
asm
oun
di
[200
8],
Nai
to-S
uzy
ki[2
004]
,
Vel
azqu
ez[2
002]
,[2
004]
.
Un
der
assu
mp
tion
s∫ IR
2(1
+|x|2 )u
0<∞,
∫ IR2u
0lo
gu
0<∞
-T
he
sub
crit
ical
case
∫ IR2u
0<
8π−→
glob
alex
iste
nce
.
See
Bla
nch
et-D
olb
eau
lt-P
erth
ame
[200
6].
-T
he
sup
ercr
itic
alca
se∫ IR
2u
0>
8πso
luti
ons
blo
ws
up
asa
dir
acfu
nct
ion
s.
Vel
azqu
ez[2
002]
-T
he
crit
ical
case
∫ IR2u
0=
8π.
Th
eb
low
up
att
=∞
wit
hsi
mila
rp
rofil
e
than
inth
esu
per
crit
ical
case
.B
lan
chet
-Car
rillo
-Mas
mou
nd
i[2
008]
.
Th
em
ath
em
ati
cal
mod
el
-u
con
cent
rati
onof
livin
gor
gan
ism
s
-v
con
cent
rati
onof
chem
oatt
ract
ant
sub
stan
ce
-w
eas
sum
eχ
=1
∂u ∂t
=∆u−∇·(u∇v
)x∈IR
2,t>
0
−∆v
=u
+f
(x),
x∈IR
2,
wh
ere
f(x
)=
lim ε→0
f 0 |ωε|I
ωε
=f 0δ(x
)
wh
eref 0≥
0.
We
intr
odu
ceh
igh
ergr
adie
ntofv
.W
ed
ont
incr
ese
the
mas
sofu
.
2A
uxilia
ryP
roble
m
Rad
ially
sym
met
ric
solu
tionu
=u
(r,t
)
W(s,t
):=
1 π
∫ B√s(0
)ρu
(ρ,t
)dρ,
s>
0,t>
0,
wh
ich
sati
sfies
Wt
=4sW
ss+WW
s+
2F0W
s,s>
0,t>
0,
W(0,t
)=
0,lim s→∞W
(s,t
)=
µ π,
t>
0,
W(s,0
)=W
0(s
),s>
0,
wit
hF
0:=
f 0 2πan
d
W0(s
):=
2∫√
s0
ρu
0(ρ
)dρ,
s>
0.
We
may
con
sid
erth
ecu
t-off
fun
ctio
n
χ∈C∞
([0,∞
)),
χ≡
0on
0,1 2
,χ≡
1on
[1,∞
),χ′≥
0on
[0,∞
)
ε∈
(0,1
)χ
(ε) (s
):=χ
s ε
,s≥
0.
Th
en W
(ε)
t=
4sW
(ε)
ss+χ
(ε) (s
)W(ε
) W(ε
)s
+2F
0χ
(ε) (s
)W(ε
)s,
s>
0,t>
0,
W(ε
) (0,t
)=
0,lim s→∞W
(ε) (s,t
)=
µ π,
t>
0,
W(ε
) (s,0
)=W
0(s
),s>
0,
-T
her
eex
ists
au
niq
ue
solu
tionW
(ε)
toth
eε-
pro
ble
m
-W
(ε)
isn
on-i
ncr
easi
ng
wit
hre
spec
ttoε
-W
(ε)→
Wp
oint
wis
ean
dC
2in
Com
pac
tse
ts.
-W∈L∞
((0,∞
)×
(0,∞
))is
aw
eak
solu
tion
ofth
ep
rob
lem
inth
e
follo
win
gse
nse
W(s,t
)→
µ πas
s→∞
for
allt>
0
−∫ ∞ 0
∫ ∞ 0ζ tW−
∫ ∞ 0ζ
(·,0)W
0=
4∫ ∞ 0
∫ ∞ 0(sζ
) ssW−
1 2
∫ ∞ 0
∫ ∞ 0ζ sW
2−f 0 2π
∫ ∞ 0
∫ ∞ 0ζ sW
forζ∈C∞ 0
([0,∞
)×
[0,∞
)),
wh
ereW
0(s
):=
1 π∫ B√s(0
)u
0(x
)dx
fors≥
0.
3In
stanta
neous
Blo
wup
Lem
ma
1
LetF
0>
0,δ>
2−F
02
such
thatδ∈
(0,1
).T
hen
ther
eex
ist
pos
itiv
e
con
stan
tsa,b,ξ,k
0,K
0su
chth
atfo
ran
yγ>
0,
ϕ(s
):=
a γδs−
δ−b
if0<s<
ξ γ,
e−γs
ifs≥
ξ γ,
ϕ(s
)∈W
2,∞
loc
((0,∞
))
4sϕss
+(8−
2F0)ϕ
s≥k
0γϕ
a.e.
in(0,∞
)
∫ ∞ 0ϕ
2(s
)|ϕs(s)|−
1ds≤K
0
γ2.
Th
eore
m1.
LetF
0>
0,an
dth
atW
0
-.W
0∈W
1,∞
((0,∞
)),
-.W
0s≥
0in
(0,∞
)
-.W
0(s
)→
µ πass→∞
for
som
eµ>
0.
Th
enfo
ran
yp
osit
iveα>
2−F
02
and
anyt 0≥
0,
sup
s>0,t∈
(t0,t
0+τ)
W(s,t
)
sα=∞
for
allτ>
0.
Inp
arti
cula
r
‖Ws‖L∞
((0,∞
)×(t
0,t
0+τ))
=∞
for
allτ>
0.
wh
ich
imp
lies
‖u‖ L∞
(IR
2×
(t0,t
0+τ))
=∞
for
allτ>
0.
Idea
of
the
pro
of.
We
con
sid
er
y(t
):=
∫ ∞ 0ϕ
(s)W
(s,t
)ds,
t>
0,
and
y(ε
) (t)
:=∫ ∞ 0
ϕ(s
)χεW
(s,t
)ds,
t>
0,
mu
ltip
lyth
eε−
pro
ble
mbyχεϕ
and
inte
grat
eby
par
tsan
dta
kelim
its
as
ε−→
0af
ter
tech
nic
ales
tim
ates
we
arri
veto
y(t
)≥y
(t1)
+k
0γ∫ t t 1
∫ ∞ 0ϕW−
1 2
∫ t t 1
∫ ∞ 0ϕsW
2fo
ral
lt∈
(t1,t
0+τ
).
Not
ice
that
y2(t
)=
(∫ ∞ 0
ϕW
)2≤
( ∫ ∞ 0ϕ
2|ϕ
s|−1) ·( ∫ ∞ 0
|ϕs|W
2) ≤
K0
γ2·∫ ∞ 0|ϕ
s|W2
fort>
0,
ther
efor
ew
eh
ave
y(t
)≥y
(t1)
+∫ t t 1Ay
(t)
+By
2(t
)dt
for
allt∈
(t1,t
0+τ
).
for
A:=k
0γ
and
B:=
γ2
K0.
By
com
par
ison
wit
hth
efo
llow
ing
equ
atio
n
z′=Az
+Bz2
z(t 1
)=y
(t1)
we
hav
efin
ite
tim
eb
low
up
forT≤
C γ.
4Form
ati
on
of
Dir
ac-
typ
esi
ngula
riti
es
forµ>
8π−
4πF
0
Th
eore
m2.
LetF
0≥
0 µ:=
∫ IR2u
0(x
)dx<∞,
such
thatµ>
0.T
hen
,fo
rµ>
8π−
4πF
0,u
sati
sfies
u(x,t
)→
µδ(x
)ast→∞.
Th
eP
roof
of
the
Th
eore
mis
giv
en
in3
step
s.
Lem
ma
3
LetF
0≥
0,an
dW
0su
chth
at (H
1)W
0∈W
1,∞
((0,∞
)),
(H2)
W0s≥
0in
(0,∞
)as
wel
las
(H3)
W0(s
)→
µ πass→∞.
Th
enfo
ral
lµ∈
(8π−
4πF
0,µ
)th
ere
exis
ts 0>
0an
dW
0
W0(s
):=
0ifs∈
[0,s
0],
a−
1b+csβ
ifs>s 0,
such
that
W0∈W
1,∞
((0,∞
))∩C
2([
0,∞
)\s
0)
limin
fs
s 0W
0s(s
)>
0,W
0(s
)→
µ πas
s→∞,
4sW
0ss
+W
0W
0s+
2F0W
0s=
0in
(s0,∞
)
W0≤W
0in
(0,∞
)
For
a:=
µ πb
:=1
2(a
+2F
0−
4)β
:=a
+2F
0−
4
4s 0
:=
1 a−b
c
1 β
≥s 1.
for
som
ela
rges 1>
0su
chth
at
W0(s
)≥a
for
alls≥s 1,
andc>
0.
Lem
ma
4
LetF
0≥
0,an
das
sum
eth
atψ∈C
2((
0,∞
))is
an
onn
egat
ive
solu
tion
of
0=
4sψss
+ψψs
+2F
0ψs,
s>
0,
wit
hth
ead
dit
ion
alp
rop
erti
esψs≥
0on
(0,∞
)an
d
ψ(s
)
µ πass→∞
wit
hso
meµ≥
0.In
that
case
,if
µ>
8π−
4πF
0,
then
ψ≡µ π
in(0,∞
).
Lem
ma
5
LetF
0≥
0,an
dfo
rso
me
µ>
8π−
4πF
0
we
hav
e (H
1)W
0∈W
1,∞
((0,∞
)),
(H2)
W0s≥
0in
(0,∞
)as
wel
las
(H3)
W0(s
)→
µ πass→∞.
Th
en,W
sati
sfies
W(s,t
)→
µ πast→∞,
the
conv
erge
nce
bei
ng
un
ifor
mon
com
pac
tsu
bse
tsof
(0,∞
).
Idea
of
the
pro
of:
–L
etW
be
the
solu
tion
for
init
ial
dat
aW
0
–S
inceW
0<W
0=⇒
W<W
–W
t≥
0in
(0,∞
)×
(0,∞
).
–W
(s,t
)
ψ(s
)ast→∞
–L
emm
a4
end
sth
ep
roof
.
5E
merg
ence
of
mild
singula
riti
es
forµ<
8π−
4πF
0
Th
eore
m3:
LetF
0≥
0,an
dW
0su
chth
at (H
1)W
0∈W
1,∞
((0,∞
)),
(H2)
W0s≥
0in
(0,∞
)as
wel
las
(H3)
W0(s
)→
µ πass→∞.
forµ<
8π−
4πF
0.
Th
en,
for
allτ>
0th
ere
exis
tsC>
0su
chth
at
Ws(s,t)≤C
(1+s−
F0 2)
for
alls>
0an
dan
yt>τ.
ther
efor
e
u(x,t
)≤C|x|−F
0fo
ral
lx∈IR
2an
dt≥τ.
Mor
eove
r,fo
rp∈
[1,
2 F0)
andτ>
0
‖u(·,t)‖ L
p(B
1(0
))≤C
for
allt≥τ.
Seco
nd
Part
Conte
nts
1.-
Glo
bal
bou
nd
edso
luti
ons
2.-
Wea
kgl
obal
solu
tion
s
3.-
Ste
ady
stat
es
4.-
Asy
mp
toti
cb
ehav
iou
r
Th
em
ath
em
ati
cal
mod
el
∂u ∂t
=∆u−∇·(uχ∇v
)+λu
(1−u
),x∈
Ω,t>
0
−∆v
+v
=u,
x∈
Ω,
∂u
∂n
=∂v
∂n
=0,
x∈∂
Ω,
u(x,0
)=u
0(x
)≥
0,x∈
Ω,
Glo
bal
bounded
solu
tions
–A
ssu
mp
tion
s:
-0≤u
0≤c<∞
;G
lob
alC
lass
ical
-λ>
0fo
rn
=1,
2;=⇒
Sol
uti
onex
ists
-λ>
n−
2nχ
forn≥
3.
λ=
0b
low
su
pfo
rn≥
3an
dfo
rn
=2
if∫ Ωu
0>c(
Ω)
(Her
rero
-
Vel
azqu
ez96
)
Th
ere
sult
isva
lidif
we
rep
laceu
(1−u
)by
h(u
)sa
tisf
yin
gh
(u)≤
s 0−s 1u
2.
2.-
Glo
bal
weak
solu
tions
for
arb
itra
ryλ>
0
(u,v
)is
aweaksolution
toth
ep
rob
lem
in(0,T
)if
u∈L
1((
0,T
);W
1,1(Ω
)),
v∈L
1((
0,T
);W
1,1(Ω
));
such
that
u∇v∈L
1((
0,T
);L
1(Ω
)),
λu
(1−u
)∈L
1((
0,T
);L
1(Ω
))
and
−∫ T 0
∫ Ωuϕt+
∫ T 0
∫ Ω∇u·∇ϕ−χ
∫ T 0
∫ Ωu∇v·∇ϕ
=∫ Ωu
0ϕ
(0)+
∫ T 0
∫ Ωλu
(1−u
)ϕ;
T 0
∫ Ω∇v·∇
ψ+
∫ T 0
∫ Ωvψ
=∫ T 0
∫ Ωuψ
(1)
forϕ,ψ∈C∞ 0
(Ω×
[0,T
)).
Ifu
0∈Lγ(Ω
)fo
rγ∈
(1,
χ(χ−λ
) +)
then
ther
eex
ists
agl
obal
wea
kso
luti
on
sati
sfyi
ng
u∈L∞
((0,∞
);Lγ(Ω
))∩Lγ
+1
loc
([0,∞
);Lγ
+1(Ω
))∩Lp loc(
[0,∞
);W
1,p(Ω
)),
∇uγ 2∈L
2 loc(
[0,∞
);L
2(Ω
))
v∈L∞
((0,∞
);W
2,γ(Ω
))∩Lγ
+1
loc
([0,∞
);W
2,γ
+1(Ω
))
for
p∈
(1,2 3
(1+
min2,
χ(χ−λ
) +)
).
3.-
Ste
ady
state
s
0=
∆u−χ∇·(u∇v
)+λu
(1−u
)in
Ω,
0=
∆v−v
+u
inΩ,
∂u∂n
=∂v∂n
=0,
in∂
Ω
Defi
nit
ion
.(u,v
)is
ast
ead
yst
ate
ofth
ep
rob
lem
ifu,v≥
0;
u,v∈W
1,1(Ω
),u∇v∈L
1(Ω
),u
(1−u
)∈L
1(Ω
),
and
sati
sfy
the
iden
titi
es∫ Ω∇u·∇
ϕ−χ
∫ Ωu∇v·∇
ϕ=
∫ Ωλu
(1−u
)ϕan
d∫ Ω∇v·∇
ψ+
∫ Ωvψ
=∫ Ωuψ
for
allϕ∈C∞
(Ω)
andψ∈C∞
(Ω).
Reg
ula
rity
ofst
ead
yst
ates
Lem
ma
i)U
nd
eras
sum
pti
on
λ>
0an
dn≤
4or
λ>n−
4
n−
2χ
andn>
4;
the
solu
tion
isb
oun
ded
andu,v∈C
1,α( Ω
)fo
rα∈
(0,1
).
ii)F
oran
yn
onco
nst
ant
solu
tion
(u,v
),w
eh
ave
expχ
(min
x∈Ωv
(x)−
max
x∈Ω
v(x
))≤u
(x)≤expχ
(max
x∈Ω
v(x
)−m
inx∈Ωv
(x))
inΩ.
Inp
arti
cula
r,ifv
isb
oun
dedu,v∈C
1,α(Ω
)fo
ral
lα∈
(0,1
).
4.-
Asy
mpto
tic
behavio
r
Th
eore
m.
Un
der
assu
mp
tion
s
λ>
2χ,
u0∈C
0(Ω
),0<u<c
the
un
iqu
eso
luti
on(u,v
)sa
tisfi
es
|u−
1|L∞
(Ω)
+|v−
1|L∞
(Ω)−→
0ast−→∞.
Idea
of
the
pro
of:
ut−
∆u
=−χ∇u·∇
v+χu
(u−v
)+λu
(1−u
)
−∆v
+v
=u
We
con
sid
erth
efo
llow
ing
syst
emof
equ
atio
ns
ut
=χu
(u−u
+λ χ
(1−u
)),
ut
=χu
(u−u
+λ χ
(1−u
)).
Ste
p1.
-u
andu
exis
tfo
rt∈
(0,∞
);
Ste
p2.
-u≤u
;
Ste
p3.
-0<u≤
1≤u
;
Ste
p4.
-lim
t→∞|u−u|=
0.
ut u
=χ
(u−u
+λ χ
(1−u
)),
ut u
=χ
(u−u
+λ χ
(1−u
)).
Su
btr
acti
ng
d dt(L
nu u
)=χ
2(u−u
)+λ χ
(u−u
) =
(2χ−λ
)(u−u
).
Inte
grat
ing
Lnu u≤e−
αα
0t Lnu
0
u0
and
taki
ng
limit
s,w
eob
tain lim t→∞Lnu u
=0.
Ste
p5.
-(3
)+
(4)
imp
lies |u−
1|+|u−
1|→
0ast→∞.
By
com
par
ison
,ifu
0<u
0<u
0,u
isa
sub
solu
tion
andu
isa
sup
erso
-
luti
on.