218 ABSTRACTS Effects of Glucose and Fructose Preloads on Food Intake in Women. H. R. KISSILEFF, J. GUSS and F. X. PI-SUNYER. Columbia LJniversityandSt. Luke’s Roosevelt Hospital, NY, U.S.A. Spitzer & Rodin (1987) reported that human subjects, tested once, ate less of a buffet meal 135 min after a fructose preload than after a glucose preload. We (Guss et al., 1988) found, in repeated subject testing, no differences in intake of a single item macaroni and beef test meal after 10% fructose or glucose preloads, given 30min before the meal. We now report repetition of our study using a 135min interval. Hunger ratings were significantly lower after fructose (72 on a 150 mm analog scale) than after glucose (loo), but food intakes were not significantly different (448 g vs. 491 g). The time interval may contribute to the differences in intake after fructose and glucose, but the effects of type of test meal and number of trials need to be studied. Hunger ratings do not always predict effects on intake. Central ANP Does Not Influence Osmotic Thirst Threshold in the Dog. E. KOWALIK-BOROWKA, J. SOBOCIhKA and E. SZCZEPAkKA-SADOWSKA. Department of Clinical and Applied Physiology, Medical Academy, Warsaw, Poland. To find out whether central administration of atria1 natriuretic peptide (ANP) influences osmotic thirst threshold and postloading restitution of body fluid osmolality, osmotic load eliciting thirst (L,,, during i.v. infusion of 5% NaCl), water intake (WI), plasma osmolality (P,,,), sodium, potassium and solutes excretion were determined in eight dogs in control experiments and during intraventricular infusion of ANP (120 ng/min/20 ~1 CSF). ANP influenced neither L,,, and increase in P,,, eliciting thirst, nor postloading WI, L,,, excretion and P,,, restitution. The results do not give evidence that central ANP affects the osmotic thirst threshold or restitution of body fluid osmolality in the dog. Liquid and Solid Calorie Reduction by Truncal Vagotomy in Man. L. GORTZ, A.-C. BJORKMAN, H. ANDERSSON and J. G. KRAL. University of Goteborg, Sweden and SUNY HSC at Brooklyn, N. Y., U.S.A. Seven (6F) morbidly obese patients kept 4-day dietary diaries with urinary nitrogen validation before and 3 and 9 months after truncal vagotomy without drainage. Significant reductions in body weight were accompanied by reductions in self-reported total calorie intake from 2800 kcal/day to 1800 at 3 months and 2000 kcal/day at 9 months. The correlation between reported and validated intake was @72 (p < 0.001) with 27% under-reporting of protein intake (72.4 vs. 98.6 g) There were statistically significant postoperative reductions in total volume and calorie density of liquid intake. Liquid calories were reduced by 50% and solid calories by 33% at 3 months and 23% at 9 months. Truncal vagotomy reduces calorie intake in man mainly through liquid reduction. Pregastric Food-contingent Stimulation Elicits Drinking in the Absence of Dehydration. F. SCOTT KRALY. Department of Psychology, Colgate University, Hamilton, NY 13346, U.S.A. Food-contingent stimulation is essentially “pregastric” when rats eat with open gastric fistula. Sham-feeding rats initiate drinking with a mean latency of 36 min when they have sham fed a mean of 3 1 ml of sweetened milk. Rats sham feeding between 1 and 68 ml (mean = 26) have hematocrit and plasma osmolality not different from rats not sham feeding. Moreover, there is no correlation between volume of milk sham fed and hematocrit or osmolality. Despite no apparent systemic dehydration, drinking elicited by sham feeding is attenuated by a dose of S.C. captopril (lOOmg/kg) sufficient to abolish conversion of angiotensin I to II in brain and in circulation.

Effects of glucose and fructose preloads on food intake in women

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Page 1: Effects of glucose and fructose preloads on food intake in women

218 ABSTRACTS

Effects of Glucose and Fructose Preloads on Food Intake in Women. H. R. KISSILEFF, J. GUSS and F. X. PI-SUNYER. Columbia LJniversityandSt. Luke’s Roosevelt Hospital, NY, U.S.A.

Spitzer & Rodin (1987) reported that human subjects, tested once, ate less of a buffet meal 135 min after a fructose preload than after a glucose preload. We (Guss et al., 1988) found, in repeated subject testing, no differences in intake of a single item macaroni and beef test meal after 10% fructose or glucose preloads, given 30min before the meal. We now report repetition of our study using a 135min interval. Hunger ratings were significantly lower after fructose (72 on a 150 mm analog scale) than after glucose (loo), but food intakes were not significantly different (448 g vs. 491 g). The time interval may contribute to the differences in intake after fructose and glucose, but the effects of type of test meal and number of trials need to be studied. Hunger ratings do not always predict effects on intake.

Central ANP Does Not Influence Osmotic Thirst Threshold in the Dog. E. KOWALIK-BOROWKA, J. SOBOCIhKA and E. SZCZEPAkKA-SADOWSKA. Department of Clinical and Applied Physiology, Medical Academy, Warsaw, Poland.

To find out whether central administration of atria1 natriuretic peptide (ANP) influences osmotic thirst threshold and postloading restitution of body fluid osmolality, osmotic load eliciting thirst (L,,, during i.v. infusion of 5% NaCl), water intake (WI), plasma osmolality (P,,,), sodium, potassium and solutes excretion were determined in eight dogs in control experiments and during intraventricular infusion of ANP (120 ng/min/20 ~1 CSF). ANP influenced neither L,,, and increase in P,,, eliciting thirst, nor postloading WI, L,,, excretion and P,,, restitution. The results do not give evidence that central ANP affects the osmotic thirst threshold or restitution of body fluid osmolality in the dog.

Liquid and Solid Calorie Reduction by Truncal Vagotomy in Man. L. GORTZ, A.-C. BJORKMAN, H. ANDERSSON and J. G. KRAL. University of Goteborg, Sweden and SUNY HSC at Brooklyn, N. Y., U.S.A.

Seven (6F) morbidly obese patients kept 4-day dietary diaries with urinary nitrogen validation before and 3 and 9 months after truncal vagotomy without drainage. Significant reductions in body weight were accompanied by reductions in self-reported total calorie intake from 2800 kcal/day to 1800 at 3 months and 2000 kcal/day at 9 months. The correlation between reported and validated intake was @72 (p < 0.001) with 27% under-reporting of protein intake (72.4 vs. 98.6 g) There were statistically significant postoperative reductions in total volume and calorie density of liquid intake. Liquid calories were reduced by 50% and solid calories by 33% at 3 months and 23% at 9 months. Truncal vagotomy reduces calorie intake in man mainly through liquid reduction.

Pregastric Food-contingent Stimulation Elicits Drinking in the Absence of Dehydration. F. SCOTT KRALY. Department of Psychology, Colgate University, Hamilton, NY 13346, U.S.A.

Food-contingent stimulation is essentially “pregastric” when rats eat with open gastric fistula. Sham-feeding rats initiate drinking with a mean latency of 36 min when they have sham fed a mean of 3 1 ml of sweetened milk. Rats sham feeding between 1 and 68 ml (mean = 26) have hematocrit and plasma osmolality not different from rats not sham feeding. Moreover, there is no correlation between volume of milk sham fed and hematocrit or osmolality. Despite no apparent systemic dehydration, drinking elicited by sham feeding is attenuated by a dose of S.C. captopril (lOOmg/kg) sufficient to abolish conversion of angiotensin I to II in brain and in circulation.