Effect of gender, age, height and weight in healthy individuals on

exhaled nitric oxide (FENO) values: a systematic review

Class nr. 1: Afonso Castro; Ana Sá; Cátia Reis; Daniel Melo; Daniela Duarte; Joana Lyra; José Silvano; José Penêda; Margarita Yakubovich; Marta Costa;

Pedro Pires; Rita Filipe; Rui Magalhães; Tiago Branco.turma1intromed0809@gmail.com

Tiago António Queirós Jacinto - tiagojacinto@med.up.pt

INTRODUCTION TO MEDICINE 2008/2009

ASTHMA

FENO – fractional exhaled nitric oxide

GENDER

AGE

HEIGHT

WEIGHT

Are the exhaled nitric oxide (FENO)

values of healthy people affected by

age, gender, height and weight?

Systematic reviewSeptember 2008 – July 2009

Research Method 1. Define query

2. Search different databases

3. Read abstracts

4. Apply inclusion and exclusion criteria

5. Get full papers

6. Analyze the papers - apply inclusion and

exclusion criteria

7. Select the relevant studies

8. Extract data

9. Discuss the selected data

10. Take conclusions

11. Formulate results

12. Communicate our results by writing (and

hopefully publishing!) an article on our

systematic review!

Query:

((age OR age factors) OR (weight OR body weight) OR (height OR body height) OR (gender

OR sex)) AND (exhaled nitric oxide OR FENO) AND (healthy individuals OR (reference values

OR normal values OR normative values) OR effect)

The following terms were used as MeSH terms for search on PubMed:

age factors, body weight, body height and exhaled nitric oxide

Inclusion Criteria Exclusion Criteria

Population: healthy individuals Full-text not available

Assessment of FENO values of individuals of different age, gender,

height and weight Duplicated articles (same articles

from different databases)

Measuring equipment of FENO values: Niox®, Sievers®, Logan®

(...)

Articles written in English, French, Spanish or German

FENO measurement done by the standardized online method (50 mL/s)

AuthorPublication

Yearn Method

Measurement Equipment

Factors

Sepponen A 2008253 schoolchildren (7-13

years old)four flow rates (10, 50, 100, and

200 ml/sec)Not Mentioned

(alveolar NO concentration, bronchial NO flux, bronchial wall NO concentration, and

bronchial diffusing capacity of NO)

Sutherland TJ 2008

79 women (obese patients with asthma (n = 20), normal-weight patients with asthma (n = 19), obese patients without asthma (n = 20), and normal-

weight patients without asthma (n = 20))

Corticosteroid withdrawal, between-group differences in

spirometric values, lung volumes, exhaled nitric oxide, induced sputum cell counts,

biomarkers of inflammation in sputum supernatant and blood measurement and interactions

exploration

Not Mentioned Weight, Asthma

Hauswirth DW 2008270 healthy African American

subjects without asthma between 18 and 40 years old

Simultaneous measurement of EBC pH, EBC nitrite, nitrate, and FeNO (measured in triplicate and

averaged)

Sievers 280i Nitric Oxide Analyzer Race

Gabriele C 2008187 Infants (median age 6.9

weeks)

Questionnaires prospectively administered during pregnancy

and after birthNot Mentioned

Pre- and post-natal smoke exposure

Cobos Barroso N 2008Cooperating children and

children unable to cooperateSingle-breath online

measurementsChemiluminescence FENO analyzer Not Mentioned

Thank you for your

attention!