ECG Cardiotachometer

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    Welcome to A Precision Low-Level DAS/ECG Cardio tachometer Demoboard presentation. The presentation will focus on an interesting application ofanalog circuits where they are utilized to amplify and condition the very lowlevel electrical signals associated with the human cardiac system. Often these

    applications involve detecting very small electrical signals and amplifying themin the presence of very large, potentially interfering signals.

    A cardiotachometer demonstration board has been developed for this purposeand our session today will underscore its capabilities and the difficulties that itovercomes in the harsh monitoring environment. The cardiotachometer is aninstrument for measuring the rapidity of the heartbeat and can provide thedetails of the heart rhythm as it progresses from one beat to the next.

    In case you are not familiar with the acronyms DAS/ECG it is appropriate toexplain them. DAS represents Data Acquisition System, which is anelectronics system used to collect information, and condition the information

    such that it can be analyzed. For example, collecting and analyzing theheartbeat or other biophysical characteristics over a period of time.

    Electrocardiography, is a non-invasive procedure for recording the electricalchanges in the heart. The record, which is called an electrocardiogram (ECGor EKG), shows the series of waves that relate to the electrical impulses whichoccur during each beat of the heart1.

    1 www.healthatoz.com

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    This is an outline of the subjects that will be touched upon during this

    presentation.

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    Most often the stimulus behind biophysical activity taking place in a living

    organism is the result of small electrical changes that occur within muscle and

    nerve cells. These electrical changes are the result of biopotential differences.

    As the name implies biopotenials are biologically based electrical potentials

    acting as minute batteries.

    The diagram illustrates the resting potential which remains steady at about

    -70mV. But when commanded by the brain, a shift in the biopotential takes

    place and moves from -70mV to +20mV when the muscle reaction is

    undertaken. The shift amounts to a change of nearly 100mV as the muscle

    transitions from a resting state to an action state.

    These minute electrical changes within the muscle cells can be electrically

    observed through external instrumentation. The heart (myocardium) is a multi-

    chambered muscle and its health is central to life itself. Therefore the heart isoften monitored using electrocardiography. The electrocardiograph is the

    instrument that detects, signal conditions, records and displays the hearts

    activity.

    An important point to keep in mind is that even though the biopotential is

    strongest at the source, by time it is detected at the body surface it has been

    greatly attenuated making biophysical occurrences more difficult to detect and

    separate from interfering electrical sources.

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    Biopotentials are developed from electrochemical gradients established across

    cell membranes. These are voltage differences that exist between separated

    points in living cells, tissues, and organelles. The potential difference

    measured with electrodes between a living cells interior cytoplasm and the

    exterior aqueous medium is generally called the membrane potential or resting

    potential (ERP). This potential is relatively constant in striated muscle cells with

    a potential of about -50 to -100mV. Nerve cells show a similar range2.

    Related to these biopotentials are the ionic charge transfers, or currents that

    give rise to much of the electrical changes occurring in nerve, muscles and

    other electrically active cells3. This current is the direct result of the

    electrochemistry associated with ions internal and external to the cell.

    The biopotential plot has a rising section depicting depolarization and a falling

    section indicating repolarization. Depolarization can simply be though of as theelectrical stimulation of the heart muscle cells. During depolarization the

    muscle fibers shorten causing contraction. While during repolarization the

    muscle cells relax, lengthen, and return to the resting state4.

    2,3 Biopotentials and Ionic currents,Answers.com

    4 Welch Allyn Protocol Clinical Support

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    The human heart cutaway shown in the diagram exposes the four chambers

    the right atrium, right ventricle, left atrium and left ventricle. The function of the

    right side of the heart is to deliver deoxygenated blood from the body to the

    lungs. The function of the left side of the heart is to deliver oxygenated blood

    from the lungs to the body.

    The cardiac cycle consists of two phases - the Systole and Diastole. Although

    these phases will not be further explored here, the waveform diagram

    accompanying the cutaway shows the relative timing and amplitude of the

    biophysical signals as the heart components go through a complete cycle.

    The individual waves associated with each portion of the hearts function

    sequence combine to produce the ECG waveform monitored on the body

    surface. The resulting ECG waveform is shown at the bottom of the waveform

    diagram.

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    The Cardiac Conduction System is the name given to the hearts electrical

    conduction system. It controls the contraction of the heart. The SA node is

    often referred to as the hearts pacemaker. It generates the electrical impulse

    and sets the pace of the heart.

    The Bundle of HIS is a thick bundle of nerves that transmits the electrical

    impulses from the AV node to the Purkinje fibers. These fibers distribute the

    electrical impulses to the individual heart muscle cells5.

    Each wave and interval appear on the ECG display as the result of a particular

    electrical function of the heart6. These individual functions are observed on the

    ECG display and labeled as P,Q,R,S,T and U, corresponding to the particular

    heart interval. Cardiologist assess the functionality and gross condition of the

    heart muscle from these different segments of the ECG waveform.

    5 Welch Allyn Protocol Clinical Support

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    The electrodes are transducers that detect the minute ionic currents

    associated with the biopotenials. They can be thought of as an ion to electron

    converter. This conversion allows the electrical currents to be amplified and

    conditioned by external circuitry. The DAS/ECG board that will be described is

    designed to perform these external functions.

    The electrode is composed of silver (Ag) with a silver chloride (AgCl) surface.

    When placed against the skin chloride is exchanged from the skin to the

    electrode, and silver is exchanged from the electrode to the skin. In doing so

    there is a free two-way exchange of ions, so no double layer is formed at the

    surfaces.

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    For ECG applications three or more electrodes are placed on the body. The

    diagram shows one of the most commonly used connections between the

    body and ECG equipment. One electrode is placed on each arm, while a third

    is placed on the right leg.

    The arm electrodes are intended to detect the minute differential biopotentials

    associated with the hearts activity. The third electrode, connected to the right

    leg, provides a common mode drive voltage.

    This third electrode serves two purposes; first, it may be used to impose a

    common DC level on the patient. An example would the +2.5V shown in the

    diagram which provides DC biasing, to the two differential sensors. And

    second, it provides common-mode signal feedback to aid in common-mode

    noise cancellation. The latter is very important because common-mode noise

    may be hundreds to thousands of times greater than the detected ECGbiopotentials.

    From the arm electrodes, the tiny differential signals are coupled to an

    instrumentation amplifier (INA) for the first level of amplification.

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    The ECG Einthoven triangle dates back to the earliest days of

    electrocardiography and provides the basis for electrode placement. The

    equilateral triangle is formed by raising the arms and positioning the points on

    the limbs equidistant. Either leg may be used for a lead connection and the

    other leg then becomes the reference to which the other limbs are referenced.

    The lead vectors associated with Einthovens lead system are conventionally

    found based on the assumption that the heart is located at the center of a

    infinite, homogenous volume conductor (at the center of a homogeneous

    sphere representing the torso). With these assumptions, the voltages

    measured by the three limb leads are proportional to the projections of the

    electric heart vector on the sides of the lead vector triangle7. Einthovens Law

    provides the voltage relationships between the leads.

    With time this was perfected into the more commonly used connections today,which may include as many as 12 electrodes. This allows the heart

    biopotential activity to be monitored through many different planes.

    7buttler.cc.tut.fi

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    When the ECG electrode is physically contacted with the body a complex

    electrical model is created. The model includes the body biopotential and

    resistance, skin contact resistances and a parallel resistance and capacitance

    associated with the probe. The right-hand diagram shows how each of these

    subcircuits interconnect to create an overall equivalent circuit.

    The electrode itself can be modeled as a 1F capacitor in parallel with a 10k

    resistor. The 1F capacitor in conjunction with the 1kskin resistor inserts a

    simple RC, low-pass filter function in the ECG path to the amplifier. Its cutoff

    frequency is:

    fC= 1/(2RC)

    For the values shown fCis 159Hz. Although this may appear to be a low cutoff

    frequency it is sufficient to pass the frequency components associated with theECG. For example, with a heartbeat rate of 60bpm, the fundamental frequency

    is 1Hz. Even the fast R-wave potion with a duration of about 0.03 seconds at

    60bpm, has a fundamental frequency of about 33Hz. But because this is a

    quickly ramping up and down pulse, a greater harmonic bandwidth is needed.

    The 159Hz satisfies the requirement for even shorter R-waves.

    The bandwidth limited electrode/skin interface helps reduce the circuits

    response to unwanted higher frequency electrical interference.

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    This is comparison of the fundamental frequency and bandwidth requirements

    for monitoring blood pressure in the head and an ECG. The blood pressure

    waveform has a period that coincides with the R pulses of the ECG, but note

    the smoothness of the waveform as compared to the ECG waveform.

    Therefore, the bandwidth requirements are much less for a blood pressure

    monitoring application.

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    Here is an example of a normal ECG chart recoding for a heartbeat of 62bpm.

    The rate can be determined from the rate of R wave occurrences. The

    P,Q,R,S,T,and U portions of the ECG are labeled for convenience. A 1mV

    calibration pulse is posted for comparison and has an amplitude of 500uV per

    vertical division. Note that the R wave pulse has an amplitude about equal to

    1mV, while the others are much smaller. Any electrical interference can easily

    mask these important portions of the waveform.

    The drift in the baseline is normal and can be due to the long charging time

    constant of AC coupled circuits and/or the subtle changes in the electrode half-

    cell potentials associated with the ionic charge transfers (current).

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    These displays provide examples of irregular ECG tracings caused by both

    internal and external factors. Muscle shaking is an example of an irregularity

    caused by internal muscle tremors, referred to as a somatic tremor. The

    gradual baseline drift discussed in the previous slide is due to charging of the

    high-pass, coupling circuit and/or changes in the ionic current levels. So this

    characteristic is connected with the equipment rather an internal bodily

    function.

    Sixty hertz AC pick-up is the result of induced electric field energy present in

    the vicinity of the ECG equipment; often received by the electrodes or

    electrode leads. Not only 60Hz, but any induced frequency such as RF can

    disturb the ECG adding noise to the baseline.

    Short-term DC instability may be an indication of an issue with the ECG

    equipment.

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    The DAS/ECG demo board functions as a self-contained heart-rate monitor

    providing a visual, audible, and digital indication of heart rate. The three ECG

    electrodes are built in and conveniently accessed off one end of the board. If

    necessary, external leads and contacts may be connected to the board as

    well.

    The demo board contacts provide the input for the differential ECG signals via

    the right and left thumbs. Common-mode drive is accessed via a finger

    electrode under the board. Since the board is only being used to detect heart

    rate and not a detailed ECG pattern, precise Einthoven electrode connection

    are not required.

    A variety of different sensors may be directly interfaced to the board making

    possible other types of medical-related and non-medical measurements.

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    The biopotentials detected at the body surface by the ECG are highly

    attenuated relative to their point of origination. Often, the amplitude is on the

    order of a few hundred microvolts (V). Other body signals such as brain

    waves may have amplitudes a fraction of this level.

    Very high voltage gain (V/V) is required to bring these minute signals to a level

    where signal processing may be reliably applied. This is accomplished through

    the use of high performance instrumentation and operational amplifiers on the

    demo board. Additionally, on-board circuitry is provided so that the amplifiers

    may be configured for sensor interfacing and filtering functions. These will be

    discussed in more detail a little later.

    Once the low-level signals are amplified the output is applied to the cardiotach

    circuit. The amplified waveform is passed through a 150V peak-to-peak

    threshold detector. If the amplitude of the waveform is sufficient, it will trigger aone-shot multivibrator. The one-shot output may be counted, used to pulse an

    LED, to key a 1kHz burst oscillator.

    The DAS/ECG board also provides a probe point where the amplified ECG

    waveform may be observed with an oscilloscope.

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    Moving to the next level of circuit complexity reveals the IC building blocks

    used in the demo board:

    1. U1, U2, U3Input instrumentation amplifier and gain stages.

    2. U4, U5, U6Peak-to-peak detector and monostable multivibrator circuit.

    3. U7Low dropout regulator supplies +5V to power the circuitry.

    4. U8Auto power down circuit which is especially useful when using battery

    power.

    5. U9An uncommitted op-amp useful for providing sensor interface.

    6. U10Provides a stable +2.5V reference voltage for mid-scale common-

    mode biasing.

    7. U11An optional socket for the OPT101 Monolithic Photodiode/Single-

    Supply Transimpedance Amplifier.

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    Here the analog front-end has been separated from the remaining circuits. A

    precision, rail-to-rail INA326 instrumentation amplifier is at the front end

    providing low offset (10,000V/V. The INA326 gain is

    set to -5V/V in this example.

    The INA326 is followed by an OPA335 auto-zeroing operational amplifier that

    features a maximum voltage offset of 5V, a voltage offset drift of 0.05V/C

    and maximum operating current of 285A. Here the OPA335 is set to an

    inverting gain of -480V/V. A first-order, low-pass filter may be configured within

    the stage by the addition and selection of a feedback capacitor.

    Since the board is powered by a single supply, it is necessary to establish a

    mid-scale voltage. That is accomplished by connecting the +2.5V reference

    voltage as a common-mode voltage to both the INA326 and OPA335.The overall gain is the product of the individual gains of the two stages;

    (-5V/V)(-480V/V), or 2400V/V. A 1mVP-Pinput is amplified to 4.8VP-P, centered

    about +2.5V. The high common-mode rejection of the INA326 rejects the 60Hz

    and other common-mode interference picked up by the electrodes. Likewise,

    common-mode DC voltage is rejected by the amplifier.

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    Just the front-end portion of the INA326 is shown illustrating how the right-leg

    DC drive voltage is developed and controlled. The INA326 gain set resistor, RGis split into two equal resistors. Any DC common mode voltage present at the

    two inputs will shift the DC level at the resistor junction. This voltage is

    buffered by A1, and then applied to A2 which has an inverting gain of minus

    19.5V/V. The inversion is important because it will be used to counter a DC

    common-mode, electrode potential on the electrodes. A +2.5V common mode

    voltage is applied to A2s non-inverting input via a resistive divider. The +2.5V

    voltage is the mid-scale voltage level for all the analog circuitry.

    A2 will amplify the difference in voltage applied to its two inputs and in turn

    drive the common-mode potential applied to the right leg until it is equal to the

    +2.5V reference voltage. This auto-zero feature keeps the DC level constant

    which is necessary for a stable ECG display baseline.

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    This very busy circuit portion of the DAS/ECG circuit diagram provides the

    remainder of the analog front-end circuit. The INA326 circuit includes a

    provision for DC or AC coupling. AC coupling removes the DC electrode offset.

    This offset is taken care of using a DC restorer circuit that will be discussed in

    the next slide. The AC high-pass frequency response is selected at 0.05Hz,

    0.5Hz, or 2.0Hz using a resistor-jumper provision.

    The INA326 is followed by of a OPA2335, gain stage. The gain is set by

    selecting an input resistor via a jumper. Additionally, a low pass filter function is

    provided by this stage. Its cutoff frequency is set by connecting the appropriate

    capacitor into the feedback path with another jumper.

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    The INA326 output voltage may be referenced to a voltage applied to thereference pin, pin 5. If 0V is applied to the non-inverting input, then the outputwill be referenced to zero volts and the swing can move up from 0V. If thereference pin is set to +2.5V, then the output can swing above and below

    +2.5V within the output bounds. This reference voltage is sometimes referredto as a pedestal voltage, because it raises the output up from ground (0V).

    The integrator shown in the schematic is referenced to +2.5V on the non-inverting input. At DC the integrators gain is very large and any deviation from+2.5V seen at the inverting inputas the result of a common-mode DCvoltage on the INAs inputs - will result in a large DC voltage at the output. ThisDC voltage is then applied to the INA326 reference input in such a manner asto drive the INAs output back to +2.5V.

    As the frequency is increased the gain of the integrator rapidly falls off. Thus,AC signals having a frequency above the integrators -3dB cutoff frequency

    have virtually no affect on the reference voltage applied to the INA.

    The net result is a DC restorer circuit that compensates for a DC common-mode voltage, such as may be present with the electrodes. It also provides ahigh-pass transfer characteristic with a cutoff frequency that is a function of theintegrator RC constant. This results in a circuit equivalent to a capacitivelycoupled amplifier, but without any capacitors directly in the signal path. Highquality, high capacitance capacitors are often large and costly and are avoidedusing this technique.

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    The output from the amplifier section may be sampled and processed by

    external circuitry, or the onboard facilities provided on the DAS/ECG demo

    board may be utilized.

    The amplified ECG waveform is passed to a differentiator and peak-to-peakdetector that produces pulses at the heartbeat rate. These pulses trigger a

    one-shot multivibrator which stretches the pulses to a uniform time duration.

    The stretched pulses from the one-shot are then used to key a 1kHz burst

    oscillator for a time period that corresponds to the one-shot pulse duration.

    The burst oscillator has audible tone that is available through the speaker.

    These pulses may also be used to flash an LED as a visual indictor of BPM, or

    be counted by a BPM meter.

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    The first section of U4 is connected as an absolute value amplifier, producing a

    positive going replication of the positive or negative going ECG wave. U4s

    second section is a peak detector where the peak value of the ECG waveform

    is stored on C11 (0.1F). The circuit has a lower threshold of about 150V.

    U5s first section buffers the peak detector output, while the second section

    amplifies and squares up the waveform. The input signal is amplified to a

    level such that the second stage output runs rail-to-rail, nearly 0 to 5V. This is

    ideal for triggering the first TLC556 section, which is configured as a 100ms,

    one-shot.

    The TLC556s second section is arranged as a 1kHz, astable multivibrator,

    keyed by the preceding one-shot stage.

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    The DAS/ECG board may be powered by either a 9V alkaline battery, or an

    external supply. Current varies from

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    The DAS/ECG demo board has a number of features that make it easy to use for

    testing circuit ideas and experimentation. In addition to the EGC cardiotachometer

    application, it may be used for other portable applications where high voltage gain

    and high common-mode rejection are required.

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    This image displays the top side of the DAS/ECG cardiotachometer board.

    The left arm (LA) and right arm (RA) electrodes are located on the end of the

    board, while the right finger drive electrode is placed underneath the board.

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    This shows some of the user selectable functions on the board. The gain and

    low-pass and high-pass cut-off frequencies care established using jumpers

    and can be changed as needed. There is an ON/OFF switch and start switch

    for the 40 minute, power ON timer function. The speaker, LED and supply

    connections are also shown.

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    Heres a more detailed layout showing the location of the analog circuits and

    the tachometer circuits that follow them.

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    The back side of the ECG/DAS board contains the important common-mode

    drive pad. This is typically biased at +2.5V when powered by a +5V supply. It

    is important from the standpoint that it sources complementary phase, AC

    common-mode signals back to the body. These add to the AC common-mode

    signals on the body and help in the cancellation of these unwanted signals.

    The image also shows the back side of the pin sockets that are used for wires

    connections to the board and the +9V battery holder.

    A brief set of instructions for the cardiotachometer use are provided on the

    board, in the upper right-hand corner.

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    Here, John Brown the DAS/ECG demo board developer, demonstrates how

    the board is held while in the standing position. The key to obtaining a good

    cardiotachometer result is to gently grasp the electrode pads as shown while

    holding the board steady. The board is easier to steady and maintain an even

    contact while sitting, so do so if possible.

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    The cardiotachometer amplifier circuit is capable of detecting a biopotential of

    about 200uVp, in the presence common-mode AC interference with an

    amplitude of about 2Vp. Therefore, it is equally suitable for other applications

    where very small signals may be buried amongst large common-mode signals.

    Certainly other biomedical monitoring applications fall into this category, butalso analytical and scientific instrumentation, industrial monitoring, and some

    automotive and industrial sensor applications as well.

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    Some other applications will be explored now to show the versatility of the

    DAS/ECG design. This application will demonstrate how a bridge transducer

    can be directly interfaced with the DAS/ECG board.

    A puffing tube in conjunction with a bridge transducer will be used to detect achange in gas pressure. Puffing tubes find application in industrial gas lines

    and valves where the gas pressure and flow characteristics require

    monitoring. Medical uses include applications where the tube serves to direct

    the breath pressure of a user to the bridge transducer. The magnitude of the

    breath pressure can then be used to control a medical assist apparatus such

    as a wheelchair.

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    Silicon Microsystems manufactures a thin film pressure bridge transducer that

    interfaces with a air lines, such as the puffing tube. The bridge connects

    directly to each INA326 differential input. Current for the bridge transducer

    may be supplied by the DAS/ECG, on-board +5V reference.

    The transducers sensitivity in this application results in a differential voltage of

    about 0.16 to 2.4mVp-p. A nominal value of 1.5mVp-pis used for illustrative

    purposes. The gain is set to 2000V/V and this produces an output voltage of

    2.5VDC 1.5VPfor a range of 1.0 to 4.0V. If the differential voltage measured

    2.4mVp-p, then the output range would span from 0.2V to 4.8V. The 2.5V

    center voltage is from the pedestal voltage applied to the INA326 reference

    pin.

    The bridge transducer may have an offset, or imbalance between the two

    sides as great as 50mV. Any input common-mode DC voltage and bridgeoffset voltage will be auto-zeroed by U3 as previously discussed.

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    The ECG/DAS board bridge sensor input is shown coupled to a mechanical

    pressure gauge in the puffing pressure bridge application. The output phase

    between the mechanical gauge and the DAS/ECG board are set the same so

    that both result in an upscale reading. The sensitivity of the mechanical gauge

    is established at5mm Hg for a 0.0375psi pressure change, while the bridge

    produces a 0.75mVpkchange for the same input.

    As mentioned, the DAS/ECG board gain has been set to 2000V/V. This is

    adequate for the bridge sensor output range. The DAS/ECG board has been

    set with a bandwidth of 2Hz to 17Hz in this application.

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    Heres the actual oscilloscope display for the DAS/ECG board output with a

    simulated puffing input (upper trace). The input puffing rate is a much faster

    0.2s than a human can deliver, but illustrates the ability of the board to detect

    and amplifier the bridge sensor outputeven at this higher rate. The output

    swings approximately 1.5VP-P, and is centered about the +2.5V pedestal

    voltage.

    The lower trace indicates that the burst oscillator is being activated and it

    provides pulses. The pulses can be counted and used to arrive at the puffing

    rate.

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    This is pressure bridge application where DC or very low frequency

    signals require monitoring. In this example the pressure change

    associated within a squeezing a tube will be observed and measured.

    The DAS/ECG will now be configured to provide DC coupling - versusthe AC coupling used in the previous applications. Now the bridge offset

    must be taken into account to assure the DAS/ECG board output does

    not saturate.

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    If the DAS/ECG board is configured for DC coupling any offset associated with

    the bridge will be amplified by the very high circuit gain. That could result in an

    voltage level that would exceed the amplifiers minimum or maximum output

    level. Therefore, one must be cognizant of a sensors DC offset and thedirection it will drive the output.

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    The auto-zero feature has been disabled and the INA326 reference pin is

    connected to zero volts. Notice that the overall gain has been reduced

    substantially from its previous AC setting of 2000V/V, down to 100V/V. The

    bridge offset is so large that the gain has to be limited to this much lower

    value. This is to prevent the offset from driving the output into the positive

    output rail.

    For this example the bridge offset is 43mV and when multiplied 100x the

    output is about +4.3V, placing the output close to the positive rail. However,

    the bridge phase has been selected such that when the squeezing pressure

    is applied the bridge resistances shift in the direction that moves the output

    downward and away from the positive rail.

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    This image depicts how the squeezing tube is connected to the bridge and

    also some of the DAS/ECG board settings for DC operation. The same

    pressure bridge transducer is used here as earlier, but the bridge circuit

    connections have been changed to assure the amplifiers operate within their

    linear range. Gain resistors have been changed and the low-pass bandwidth

    jumper set as needed.

    Bridge bias is provided by the on-board TPS71550 LDO regulator. It has been

    observed that the particular bridge used for this example resulted in a

    differential offset of 43mV. The device is specified with a maximum offset of

    50mV. If the offset was as high as 50mV, then the output would be up against

    the rail. An alternative to lowering the gain would be to reduce the voltage

    applied to the bridge.

    A resistive divider in located on the board and divides the +5V down to +2.5V.Since U2, the dual OPA2335 (or OPA2336) is not used in this application, it

    can easily be configured as a unity-gain buffer. The output is then used to bias

    the bridge, but note that doing so does reduce the bridge output by 50%.

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    The output response of the DC coupled DAS/ECG board during a squeeze is

    displayed in this oscilloscope image. The upper trace is the response with a

    +5V bridge excitation, while directly below it is the response with a +2.5V

    bridge excitation. Notice that the amplitude change during the squeezing event

    is about half with +2.5V excitation as compared to that with +5V excitation.

    This is as expected.

    Also observe that the event had a duration of about 5 seconds. This translates

    to a frequency of about 0.2Hz. This is still within the boards AC passband

    when the high-pass filter is set to a cut-off frequency such as 0.05Hz. Setting

    the board for DC coupling may be the best option for use at even lower

    frequencies.

    Some examples of low frequency uses are geophysical, mechanical and

    industrial process control applications.

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    Heres an interesting AC coupled application for the DAS/ECG board where

    relative blood pressure may be optically detected and monitored. The circuit

    configuration is that of a plethysmograph; an instrument used for measuring

    changes in volume within an organ, body members or the whole body.

    An LED is positioned so that its light output is directed through the finger. A

    sensitive photodiode or a combined photodiode/transimpedance amplifier such

    as the OPT101 is located on the other side of the finger. Fluctuations in the

    blood volume within the finger changes the transmission path between the

    LED light source and that reaching the photodiode. The blood volume

    coincides with the pressure and the DAS/ECG board provides a relative

    indication of the pressure.

    Notice the connection of the photo diode and the 3 series-connected, 499k

    resistors across the photodiode. The cathode end of the diode is referenced to+2.5V. This same common-mode voltage appears at both of the INA326 inputs

    through the resistors. When light shines on the photodiode, photo generated

    current flows through the diode and through the 3 resistors.

    One 499k resistor is connected directly across the INA326 differential inputs.

    As the photo generated current changes in response to the blood volume

    fluctuations a differential voltage is created across the resistor and is amplified

    by the DAS/ECG board amplifiers.

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    The DAS/ECG board is shown outfitted with the monolithic OPT101

    photodiode/transimpedance amplifier. The three, 499k bias resistors have

    been added to the board. An overall gain of 6kV/V is used with the application

    and the bandwidth has been set from 2Hz to 17Hz.

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    This oscilloscope display provides the output traces when the DAS/ECG is

    connected in the plethysmograph application. The upper trace tracks the

    changing blood volume within the finger indicating the blood pressure level. A

    700mVP-P

    output amplitude results when the overall gain is set to 6kV/V.

    The middle two traces are the 1sttimers input and output pulses. The output

    pulse corresponds with the peak blood pressure. This pulse is used to key the

    output burst oscillator.

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    In summary, the DAS/ECG board is useful for demonstrating the ability of high-

    performance analog circuits in low signal level, front-end applications. The

    boards versatility allows one to experiment, evaluate and optimize circuit

    performance in medical and non-medical sensor applications.