EAM-2201 - SWGDRUG · EAM-2201 The Drug Enforcement Administration's Special Testing and Research Laboratory generated this monograph using structurally confirmed reference material

EAM-2201The Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

Page 1 of 5SWGDRUG.org/monographs.htmLatest Revision: 12/16/2013

Form Chemical Formula Molecular Weight Melting Point (oC)

Base C26H26FNO 387 102.2

CH3

ON

F

1. GENERAL INFORMATION

IUPAC Name: (4-Ethylnaphthalen-1-yl)[1-(5-fluoropentyl)-1H-indol-3-yl]methanone

CAS#: 1364933-60-7

Synonyms: 5-Fluoro-JWH-210, JWH-210 N-(5-Fluoropentyl) analog, (4-ethylnaphthyl)-AM-2201

Source: DEA Reference Material Collection

Appearance: White powder

UVmax(nm): Not Determined

2. CHEMICAL AND PHYSICAL DATA

2.1 CHEMICAL DATA




3. QUALITATIVE DATA

3.1 NUCLEAR MAGNETIC RESONANCE

Sample Preparation: Dilute analyte to ~10 mg/mL inCDCl3 containing TMS for 0 ppm reference anddimethylfumarate as quantitative internal standard.

Instrument: 400 MHz NMR spectrometerParameters: Spectral width: at least containing -3 ppm through 13 ppm Pulse angle: 90o

Delay between pulses: 45 seconds

3.20 3.15

2

8 7 6 5 4 3 2 1 0

0

0.5

1.0

1.5

2.0

52222118111

CHCl3

TMS

Dimethylfumarate Dimethylfumarate

1H NMR: EAM-2201 Lot #RM-031113-1

7.6 7.5 7.4

8

8.5 8.4 8.3 8.2 8.1

111

4.4 4.3 4.2 4.1

211

1.75 1.50

522




m/z35030025020015010050

[x 1

04 ]In

tens

ity

1

2

3

438

7

370

358

350

324

312

298

28327

0

254

241

232

212

195

183

153

144

12811

6

102

897769

41

EI+

EI Mass Spectrum: EAM-2201 Lot#RM-031113-1

3.2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY

Sample Preparation: Dilute analyte ~4 mg/mL in chloroform.

Instrument: Agilent gas chromatograph operated in split mode with MS detectorColumn: DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 µmCarrier Gas: Helium at 1 mL/minTemperatures: Injector: 280oC MSD transfer line: 280oC MS Source: 230oC MS Quad: 150oC Oven program: 1) 100oC initial temperature for 1.0 min 2) Ramp to 300oC at 12 oC/min 3) Hold final temperature for 9.0 minInjection Parameters: Split Ratio = 20:1, 1 µL injectedMS Parameters: Mass scan range: 30-550 amu Threshold: 100 Tune file: stune.u Acquisition mode: scanRetention Time: 23.265 min




3.3 INFRARED SPECTROSCOPY (FTIR)

Insrument: FTIR with diamond ATR attachment (3 bounce)Scan Parameters: Number of scans: 32

Number of background scans: 32Resolution: 4 cm-1

Sample gain: 8Aperture: 150

Wavenumber (cm-1)3500 3000 2500 2000 1500

%Tr

ansm

ittan

ce

20

30

40

50

60

70

30512962

293529022870

16201608

15851514

14811392 1373

13151263

1198 11611061 1047976 941

903825777 737

663 609 555528

430

Wavenumber (cm-1)1700 1600 1500 1400 1300 1200 1100 1000 900 800 700

%Tr

ansm

ittan

ce

20

30

40

50

60

70

16201608

15851560

15141481

14641450

14291392 1373

134213151277

126312341227 1198 11611128

1093 1061 10471014993976 941

903864

825795

777762

737694 663

650625

609586

555528

482469

430

FTIR ATR (Diamond, 3 Bounce): EAM-2201 Lot # RM-031113-1




http://en.wikipedia.org/wiki/EAM-2201

4. ADDITIONAL RESOURCES

Wikipedia

Uchiyama, N. et.al. "URB-754: A New Class of Designer Drug and 12 Synthetic CannabinoidsDetected in Illegal Products." Forensic Sci Int. (2012),http://dx.doi.org/10.1016/j.forsciint.2012.08.047

Documents

EAM-2201 - SWGDRUG · EAM-2201 The Drug Enforcement Administration's Special Testing and Research Laboratory generated this monograph using structurally confirmed reference material